Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men

Diabetic Medicine

Volumn 29, Issue 8, 2012, Pages

  van Raalte, D H ^a   van Leeuwen, N ^b   Simonis Bik, A M ^a   Nijpels, G ^a   van Haeften, T W ^c   Schafer, S A ^d   Boomsma, D I ^e   Kramer, M H H ^a   J Heine, R ^a,f   Maassen, J A ^a,b   Staiger, H ^d   Machicao, F ^d   Haring H U ^d   Slagboom, P E ^b   Willemsen, G ^e   de Geus, E J ^e   Dekker, J M ^a   Fritsche, A ^d   Eekhoff, E M ^a   Diamant, M ^a   't Hart, L M ^b   more..

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

^f ELI LILLY AND COMPANY   (United States)

Author keywords

cell function; Glucocorticoid receptor; Polymorphisms

Indexed keywords

BCLI PROTEIN; ER22 PROTEIN; GLUCOCORTICOID RECEPTOR; N363S PROTEIN; NR3C1 PROTEIN; PROTEIN; THTIIII PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISPOSITION INDEX; FEMALE; GENOTYPE; GERMANY; GLUCOSE TOLERANCE; HUMAN; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN SENSITIVITY INDEX; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NETHERLANDS; PANCREAS ISLET BETA CELL; SINGLE NUCLEOTIDE POLYMORPHISM;

CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; GLUCOSE INTOLERANCE; HAPLOTYPES; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GLUCOCORTICOID; SEX FACTORS;

EID: 84864026114     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03690.x     Document Type: Article

References (31)

1. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002; 96: 23-43.
2. van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest 2009; 39: 81-93.
3. Gulliford MC, Charlton J, Latinovic R. Risk of diabetes associated with prescribed glucocorticoids in a large population. Diabetes Care 2006; 29: 2728-2729.
4. McMahon M, Gerich J, Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes Metab Rev 1988; 4: 17-30.
5. Linssen MM, van Raalte DH, Toonen EJ, Alkema W, van der Zon GC, Dokter WH et al. Prednisolone-induced beta-cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells. Cell Signal 2011; 23: 1708-1715.
6. van Raalte DH, Nofrate V, Bunck MC, van Iersel T, Elassaiss Schaap J, Nassander UK et al. Acute and 2-week exposure to prednisolone impair different aspects of beta-cell function in healthy men. Eur J Endocrinol 2010; 162: 729-735.
7. van Raalte DH, van Genugten RE, Linssen MM, Ouwens DM, Diamant M. Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans. Diabetes Care 2011; 34: 412-417.
8. Derijk RH. Single nucleotide polymorphisms related to HPA axis reactivity. Neuroimmunomodulation 2009; 16: 340-352.
9. van Rossum EF, Lamberts SW. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog Horm Res 2004; 59: 333-357.
10. Manenschijn L, van den Akker EL, Lamberts SW, van Rossum EF. Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci 2009; 1179: 179-198.
11. van Rossum EF, Koper JW, Huizenga NA, Uitterlinden AG, Janssen JA, Brinkmann AO et al. A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels. Diabetes 2002; 51: 3128-3134.
12. Derijk RH, Schaaf MJ, Turner G, Datson NA, Vreugdenhil E, Cidlowski J et al. A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J Rheumatol 2001; 28: 2383-2388.
13. van Rossum EF, Koper JW, van den Beld AW, Uitterlinden AG, Arp P, Ester W et al. Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index. Clin Endocrinol (Oxf) 2003; 59: 585-592.
14. Russcher H, Smit P, van den Akker EL, van Rossum EF, Brinkmann AO, de Jong FH et al. Two polymorphisms in the glucocorticoid receptor gene directly affect glucocorticoid-regulated gene expression. J Clin Endocrinol Metab 2005; 90: 5804-5810.
15. van Rossum EF, Roks PH, de Jong FH, Brinkmann AO, Pols HA, Koper JW et al. Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms. Clin Endocrinol (Oxf) 2004; 61: 573-581.
16. van Rossum EF, Voorhoeve PG, te Velde SJ, Koper JW, Delemarre-van de Waal HA, Kemper HC et al. The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with a beneficial body composition and muscle strength in young adults. J Clin Endocrinol Metab 2004; 89: 4004-4009.
17. Syed AA, Irving JA, Redfern CP, Hall AG, Unwin NC, White M et al. Association of glucocorticoid receptor polymorphism A3669G in exon 9β with reduced central adiposity in women. Obesity (Silver Spring) 2006; 14: 759-764.
18. Rosmond R, Chagnon YC, Holm G, Chagnon M, Perusse L, Lindell K et al. A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis. Obes Res 2000; 8: 211-218.
19. Roussel R, Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G. The N363S polymorphism in the glucocorticoid receptor gene is associated with overweight in subjects with type2 diabetes mellitus. Clin Endocrinol (Oxf) 2003; 59: 237-241.
20. Davani B, Portwood N, Bryzgalova G, Reimer MK, Heiden T, Ostenson CG et al. Aged transgenic mice with increased glucocorticoid sensitivity in pancreatic beta-cells develop diabetes. Diabetes 2004; 53: S51-S59.
21. Fritsche A, Madaus A, Renn W, Tschritter O, Teigeler A, Weisser M et al. The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion. J Clin Endocrinol Metab 2001; 86: 4822-4825.
22. Ruige JB, Dekker JM, Nijpels G, Popp-Snijders C, Stehouwer CD, Kostense PJ et al. Hyperproinsulinaemia in impaired glucose tolerance is associated with a delayed insulin response to glucose. Diabetologia 1999; 42: 177-180.
23. Simonis-Bik AM, Eekhoff EM, Diamant M, Boomsma DI, Heine RJ, Dekker JM et al. The heritability of HbA1c and fasting blood glucose in different measurement settings. Twin Res Hum Genet 2008; 11: 597-602.
24. van Haeften TW, Dubbeldam S, Zonderland ML, Erkelens DW. Insulin secretion in normal glucose-tolerant relatives of type2 diabetic subjects. Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests. Diabetes Care 1998; 21: 278-282.
25. van Haeften TW, Pimenta W, Mitrakou A, Korytkowski M, Jenssen T, Yki-Jarvinen H et al. Disturbances in beta-cell function in impaired fasting glycemia. Diabetes 2002; 51: S265-S270.
26. Mitrakou A, Vuorinen-Markkola H, Raptis G, Toft I, Mokan M, Strumph P et al. Simultaneous assessment of insulin secretion and insulin sensitivity using a hyperglycemia clamp. J Clin Endocrinol Metab 1992; 75: 379-382.
27. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993; 42: 1663-1672.
28. Koeijvoets KC, van Rossum EF, Dallinga-Thie GM, Steyerberg EW, Defesche JC, Kastelein JJ et al. A functional polymorphism in the glucocorticoid receptor gene and its relation to cardiovascular disease risk in familial hypercholesterolemia. J Clin Endocrinol Metab 2006; 91: 4131-4136.
29. Kuningas M, Mooijaart SP, Slagboom PE, Westendorp RG, van Heemst D. Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study. Biogerontology 2006; 7: 231-238.
30. Liu S, Mauvais-Jarvis F. Minireview: Estrogenic protection of beta-cell failure in metabolic diseases. Endocrinology 2010; 151: 859-864.
31. Morimoto S, Fernandez-Mejia C, Romero-Navarro G, Morales-Peza N, Diaz-Sanchez V. Testosterone effect on insulin content, messenger ribonucleic acid levels, promoter activity, and secretion in the rat. Endocrinology 2001; 142: 1442-1447.