Bioavailability of pharmaceuticals in waters close to wastewater treatment plants: Use of fish bile for exposure assessment

Environmental Toxicology and Chemistry

Volumn 31, Issue 8, 2012, Pages 1831-1837

  Lahti, Marja ^a   Brozinski, Jenny Maria ^b   Segner, Helmut ^c   Kronberg, Leif ^b   Oikari, Aimo ^a  

^a UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Accumulation; Bile; Pharmaceuticals; Polar organic chemical integrative sampler; Rainbow trout

Indexed keywords

ACCUMULATION; ANIMAL EXPOSURE; BILE; BLOOD PLASMA; CYTOCHROME P4501A; DICLOFENAC; EXPOSURE ASSESSMENT; FINLAND; FISH BILE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MUNICIPAL WASTEWATER TREATMENT PLANTS; NAPROXENS; NATURAL WATERS; PASSIVE SAMPLERS; PHASE I; POLAR ORGANIC CHEMICALS; POLLUTED SITES; RAINBOW TROUT; RECEIVING WATERS; SAMPLE MATRIX; THERAPEUTIC CLASS; VITELLOGENIN; VITELLOGENIN MRNA; WASTEWATER TREATMENT PLANTS;

BIOMARKERS; DRUG PRODUCTS; FISH; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ORGANIC CHEMICALS; SEWAGE PUMPING PLANTS; TOXICITY; WATER TREATMENT PLANTS;

BODY FLUIDS;

ATENOLOL; BEZAFIBRATE; BISOPROLOL; CARBAMAZEPINE; CITALOPRAM; DICLOFENAC; DICLOFENAC DERIVATIVE; FLUOXETINE; IBUPROFEN; KETOPROFEN; NAPROXEN; SERTRALINE; SOTALOL; SURFACE WATER; VENLAFAXINE;

BIOAVAILABILITY; BIOMARKER; DOSE-RESPONSE RELATIONSHIP; DRUG; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MUNICIPAL SOLID WASTE; POLLUTION EXPOSURE; SALMONID; SAMPLER; SURFACE WATER; WASTE DISPOSAL; WASTE TREATMENT; WASTEWATER; WATER POLLUTION;

ANIMAL TISSUE; ARTICLE; BILE; BLOOD ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAINBOW TROUT; WASTE WATER MANAGEMENT; WASTE WATER TREATMENT PLANT; WATER ANALYSIS; WATER POLLUTION; WATER POLLUTION INDICATOR;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BILE; BIOLOGICAL AVAILABILITY; CARBAMAZEPINE; CHROMATOGRAPHY, LIQUID; CITALOPRAM; CYCLOHEXANOLS; DICLOFENAC; FINLAND; IBUPROFEN; LIVER; MALE; NAPROXEN; ONCORHYNCHUS MYKISS; PLASMA; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

FINLAND;

ANIMALIA; ONCORHYNCHUS MYKISS; SALMONIDAE;

EID: 84864020951     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.1879     Document Type: Article

References (42)

1. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: A national reconnaissance. Environ Sci Technol 36: 1202-1211.
2. Vieno N. 2007. Occurrence of pharmaceuticals in Finnish sewage treatment plants, surface waters, and their elimination in drinking water treatment processes. PhD Thesis, Tampere University of Technology, Tampere, Finland.
3. Daneshvar A, Svanfelt J, Kronberg L, Weyhenmeyer GA. 2010. Winter accumulation of acidic pharmaceuticals in a Swedish river. Environ Sci Pollut Res 17: 908-916.
4. Daneshvar A, Svanfelt J, Kronberg L, Prévost M, Weyhenmeyer GA. 2010. Seasonal variations in the occurrence and fate of basic and neutral pharmaceuticals in a Swedish river-lake system. Chemosphere 80: 301-309.
5. Larsson DGJ, Adolfsson-Erici M, Parkkonen J, Pettersson M, Berg AH, Olsson P-E, Förlin L. 1999. Ethinylestradiol-An undesired fish contraceptive? Aquat Toxicol 45: 91-97.
6. Brooks BW, Chambliss CK, Stanley JK, Ramirez A, Banks KE, Johnson RD, Lewis RJ. 2005. Determination of select antidepressants in fish from an effluent-dominated stream. Environ Toxicol Chem 24: 464-469.
7. Brown JN, Paxéus N, Förlin L, Larsson DG. 2007. Variations in bioconcentration of human pharmaceuticals from sewage effluents into fish blood plasma. Environ Toxicol Pharmacol 24: 267-274.
8. Ramirez AJ, Brain RA, Usenko S, Mottaleb MA, O'Donnell JG, Stahl LL, Wathen JB, Snyder BD, Pitt JL, Perez-Hurtado P, Dobbins LL, Brooks BW, Chambliss CK. 2009. Occurrence of pharmaceuticals and personal care products in fish: Results of a national pilot study in the United States. Environ Toxicol Chem 28: 2587-2597.
9. Fick J, Lindberg RH, Parkkonen J, Arvidsson B, Tysklind M, Larsson DGJ. 2010. Therapeutic levels of levonorgestrel detected in blood plasma of fish: Results from screening rainbow trout exposed to treated sewage effluents. Environ Sci Technol 44: 2661-2666.
10. Lajeunesse A, Gagnon C, Gagné F, Louis S, Čejka P, Sauvé S. 2011. Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment-Evidence of biological effects. Chemosphere 83: 564-571.
11. Nakamura Y, Yamamoto H, Sekizawa J, Kondo T, Hirai N, Tatarazako N. 2008. The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes): Acute toxicity in fish larvae and bioaccumulation in juvenile fish. Chemosphere 70: 865-873.
12. Fu W, Franco A, Trapp S. 2009. Methods for estimating the bioconcentration factor of ionizable organic chemicals. Environ Toxicol Chem 28: 1372-1379.
13. Górecki T, Namieśnik J. 2002. Passive sampling. Trends Anal Chem 21: 276-291.
14. Gibson R, Smith MD, Spary CJ, Tyler CR, Hill EM. 2005. Mixtures of estrogenic contaminants in bile of fish exposed to wastewater treatment works effluents. Environ Sci Technol 39: 2461-2471.
15. Vermeirssen ELM, Körner O, Schönenberger R, Suter MJ-F, Burkhardt-Holm P. 2005. Characterization of environmental estrogens in river water using a three-pronged approach: Active and passive water sampling and the analysis of accumulated estrogens in the bile of caged fish. Environ Sci Technol 39: 8191-8198.
16. Lahti M, Brozinski J-M, Jylhä A, Kronberg L, Oikari A. 2011. Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout. Environ Toxicol Chem 30: 1403-1411.
17. Oikari A, Kukkonen JVK, Vuorikari P. 1999. Can biliary chlorophenolics represent their tissue residues in fish. Toxicol Environ Chem 69: 49-60.
18. Alvarez DA, Petty JD, Huckins JN, Jones-Lepp TL, Getting DT, Goddard JP, Manahan SE. 2004. Development of a passive, in situ, integrative sampler for hydrophilic organic contaminants in aquatic environments. Environ Toxicol Chem 23: 1640-1648.
19. Togola A, Budzinski H. 2007. Development of polar organic integrative samplers for analysis of pharmaceuticals in aquatic systems. Anal Chem 79: 6734-6741.
20. MacLeod SL, McClure EL, Wong CS. 2007. Laboratory calibration and field deployment of the polar organic chemical integrative sampler for pharmaceuticals and personal care products in wastewater and surface water. Environ Toxicol Chem 26: 2517-2529.
21. Purdom CE, Hardiman PA, Bye VJ, Eno NC, Tyler CR, Sumpter JP. 1994. Estrogenic effects of effluent from sewage treatment works. Chem Ecol 8: 275-285.
22. Desbrow C, Routledge EJ, Brighty GC, Sumpter JP, Waldock M. 1998. Identification of estrogenic chemicals in STW effluents. I. Chemical fractionation and in vitro biological screening. Environ Sci Technol 32: 1549-1558.
23. Sumpter JP, Jobling S. 1995. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment. Environ Health Perspect 103: 173-178.
24. Hodson PV, Efler S, Wilson JY, El-Shaarawi A, Maj M, Williams TG. 1996. Measuring the potency of pulp mill effluents for induction of hepatic mixed-function oxygenase activity in fish. J Toxicol Environ Health 49: 83-110.
25. Vehniäinen E-R, Schultz E, Lehtivuori H, Ihalainen JA, Oikari AOJ. 2012. More accuracy to the EROD measurements-The resorufin fluorescence differs between species and individuals. Aquat Toxicol 116-117C: 102-108.
26. Oikari A. 2006. Caging techniques for field exposures of fish to chemical contaminants. Aquat Toxicol 78: 370-381.
27. Kallio J-M, Lahti M, Oikari A, Kronberg L. 2010. Metabolites of the aquatic pollutant diclofenac in fish bile. Environ Sci Technol 44: 7213-7219.
28. Castiglioni S, Zuggato E, Crisci E, Chiabrando C, Fanelli R, Bagnati R. 2006. Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry. Anal Chem 79: 8421-8429.
29. Wenger M, Sattler U, Goldschmidt-Clermont E, Segner H. 2011. 17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection. Fish Shellfish Immunol 31: 90-97.
30. Mehinto AC, Hill EM, Tyler CR. 2010. Uptake and biological effects of environmentally relevant concentrations of the nonsteroidal anti-inflammatory pharmaceutical diclofenac in rainbow trout (Oncorhynchus mykiss). Environ Sci Technol 44: 2176-2182.
31. Metcalfe CD, Chu S, Judt C, Li H, Oakes KD, Servos MR, Andrews DM. 2010. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed. Environ Toxicol Chem 29: 79-89.
32. Schultz MM, Furlong ET, Kolpin DW, Werner SL, Schoenfuss HL, Barber LB, Blazer VS, Norris DO, Vajda AM. 2010. Antidepressant pharmaceuticals in two U.S. effluent impacted streams: Occurrence and fate in water and sediment, and selective uptake in fish neural tissue. Environ Sci Technol 44: 1918-1925.
33. Statham CN, Melancon MJ Jr, Lech JJ. 1976. Bioconcentration of xenobiotics in trout bile: A proposed monitoring aid for some waterborne chemicals. Science 193: 680-681.
34. Wachtmeister CA, Förlin L, Arnoldsson KC, Larsson J. 1991. Fish bile as a tool for monitoring aquatic pollutants: Studies with radioactively labelled 4, 5, 6-trichloroguaiacol. Chemosphere 22: 39-46.
35. Brozinski J-M, Lahti M, Oikari A, Kronberg L. 2011. Detection of naproxen and its metabolites in fish bile following intraperitoneal and aqueous exposure. Environ Sci Pollut Res 18: 811-818.
36. Kallio J-M, Lahti M, Oikari A, Kronberg L. 2010. Identification of ibuprofen and carbamazepine metabolites in fish bile. Proceedings, 20th SETAC Europe Annual Meeting, Seville, Spain, May 23-27, p 323.
37. Talbot C, Higgins PJ. 1982. Observations on the gall bladder of juvenile Atlantic salmon Salmo salar L., in relation to feeding. J Fish Biol 21: 663-669.
38. Brumley CM, Haritos VS, Ahokas JT, Holdway DA. 1998. The effects of exposure duration and feeding status on fish bile metabolites: Implications for biomonitoring. Ecotoxicol Environ Saf 39: 147-153.
39. Sturm A, Segner H. 2005. P-glycoproteins and xenobiotics efflux transport in fish. In Mommsten TP, Moon TW, eds, Biochemistry and Molecular Biology of Fishes. Elsevier, Amsterdam, The Netherlands, pp 495-533.
40. Thomas-Jones E, Thorpe K, Harrison N, Thomas G, Morris C, Hutchinson T, Woodhead S, Tyler C. 2003. Dynamics of estrogen biomarker responses in rainbow trout exposed to 17β-estradiol and 17α-ethinylestradiol. Environ Toxicol Chem 22: 3001-3008.
41. Arukwe A, Förlin L, Goksøyr A. 1997. Xenobiotic and steroid biotransformation enzymes in Atlantic salmon (Salmo salar) liver treated with an estrogenic compound, 4-nonylphenol. Environ Toxicol Chem 16: 2576-2583.
42. Olsvik PA, Lie KK, Sturve J, Hasselberg L, Andersen OK. 2009. Transcriptional effects of nonylphenol, bisphenol-A and PBDE-47 in liver of juvenile Atlantic cod (Gadus morhua). Chemosphere 75: 360-367.