-
1
-
-
27244445489
-
Molecular pathogenesis and a consequent classification of multiple myeloma
-
Bergsagel P.L., Kuehl W.M. Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 2005, 23:6333-6338.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6333-6338
-
-
Bergsagel, P.L.1
Kuehl, W.M.2
-
2
-
-
74049162897
-
International myeloma working group molecular classification of multiple myeloma: spotlight review
-
Fonseca R., Bergsagel P.L., Drach J., Shaughnessy J., Gutierrez N., Stewart A.K., et al. International myeloma working group molecular classification of multiple myeloma: spotlight review. Leukemia 2009, 23:2210-2221.
-
(2009)
Leukemia
, vol.23
, pp. 2210-2221
-
-
Fonseca, R.1
Bergsagel, P.L.2
Drach, J.3
Shaughnessy, J.4
Gutierrez, N.5
Stewart, A.K.6
-
3
-
-
34547106018
-
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
-
Hideshima T., Mitsiades C., Tonon G., Richardson P.G., Anderson K.C. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007, 7:585-598.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 585-598
-
-
Hideshima, T.1
Mitsiades, C.2
Tonon, G.3
Richardson, P.G.4
Anderson, K.C.5
-
5
-
-
11144225205
-
Integrin-linked kinase: a cancer therapeutic target unique among its ILK
-
Hannigan G., Troussard A.A., Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005, 5:51-63.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 51-63
-
-
Hannigan, G.1
Troussard, A.A.2
Dedhar, S.3
-
6
-
-
33845329178
-
Signalling via integrins: implications for cell survival and anticancer strategies
-
Hehlgans S., Haase M., Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 2007, 1775:163-180.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 163-180
-
-
Hehlgans, S.1
Haase, M.2
Cordes, N.3
-
7
-
-
0037115611
-
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites
-
Zhang Y., Chen K., Tu Y., Velyvis A., Yang Y., Qin J., et al. Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci 2002, 115:4777-4786.
-
(2002)
J Cell Sci
, vol.115
, pp. 4777-4786
-
-
Zhang, Y.1
Chen, K.2
Tu, Y.3
Velyvis, A.4
Yang, Y.5
Qin, J.6
-
8
-
-
80055062698
-
Integrin-linked kinase: not so 'pseudo' after all
-
Hannigan G.E., McDonald P.C., Walsh M.P., Dedhar S. Integrin-linked kinase: not so 'pseudo' after all. Oncogene 2011, 30:4375-4385.
-
(2011)
Oncogene
, vol.30
, pp. 4375-4385
-
-
Hannigan, G.E.1
McDonald, P.C.2
Walsh, M.P.3
Dedhar, S.4
-
9
-
-
79957552048
-
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK)
-
Fukuda K., Knight J.D.R., Piszczek G., Kothary R., Qin J. Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK). J Biol Chem 2011, 286:21886-21895.
-
(2011)
J Biol Chem
, vol.286
, pp. 21886-21895
-
-
Fukuda, K.1
Knight, J.D.R.2
Piszczek, G.3
Kothary, R.4
Qin, J.5
-
10
-
-
47749087950
-
Integrin-linked kinase - essential roles in physiology and cancer biology
-
McDonald P.C., Fielding A.B., Dedhar S. Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 2008, 121:3121-3132.
-
(2008)
J Cell Sci
, vol.121
, pp. 3121-3132
-
-
McDonald, P.C.1
Fielding, A.B.2
Dedhar, S.3
-
11
-
-
33744911160
-
Integrin-linked kinase activity is associated with interleukin-1α-induced progressive behavior of pancreatic cancer and poor patient survival
-
Sawai H., Okada Y., Funahashi H., Matsuo Y., Takahashi H., Takeyama H., et al. Integrin-linked kinase activity is associated with interleukin-1α-induced progressive behavior of pancreatic cancer and poor patient survival. Oncogene 2006, 25:3237-3246.
-
(2006)
Oncogene
, vol.25
, pp. 3237-3246
-
-
Sawai, H.1
Okada, Y.2
Funahashi, H.3
Matsuo, Y.4
Takahashi, H.5
Takeyama, H.6
-
12
-
-
34250192581
-
Prognostic value of integrin β1-ILK-pAkt signaling pathway in non-small cell lung cancer
-
Okamura M., Yamaji S., Nagashima Y., Yoshimoto N., Kido Y., Iemoto Y., et al. Prognostic value of integrin β1-ILK-pAkt signaling pathway in non-small cell lung cancer. Hum Pathol 2007, 38:1081-1091.
-
(2007)
Hum Pathol
, vol.38
, pp. 1081-1091
-
-
Okamura, M.1
Yamaji, S.2
Nagashima, Y.3
Yoshimoto, N.4
Kido, Y.5
Iemoto, Y.6
-
13
-
-
33847382879
-
Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells
-
Hess F., Estrugo D., Fischer A., Belka C., Cordes N. Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells. Oncogene 2006, 26:1372-1384.
-
(2006)
Oncogene
, vol.26
, pp. 1372-1384
-
-
Hess, F.1
Estrugo, D.2
Fischer, A.3
Belka, C.4
Cordes, N.5
-
14
-
-
4143113653
-
Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase
-
Chen P., Shen W.-Z., Karnik P. Suppression of malignant growth of human breast cancer cells by ectopic expression of integrin-linked kinase. Int J Cancer 2004, 111:881-891.
-
(2004)
Int J Cancer
, vol.111
, pp. 881-891
-
-
Chen, P.1
Shen, W.-Z.2
Karnik, P.3
-
15
-
-
67651006358
-
JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma
-
Durbin A.D., Somers G.R., Forrester M., Pienkowska M., Hannigan G.E., Malkin D. JNK1 determines the oncogenic or tumor-suppressive activity of the integrin-linked kinase in human rhabdomyosarcoma. J Clin Invest 2009, 119:1558-1570.
-
(2009)
J Clin Invest
, vol.119
, pp. 1558-1570
-
-
Durbin, A.D.1
Somers, G.R.2
Forrester, M.3
Pienkowska, M.4
Hannigan, G.E.5
Malkin, D.6
-
16
-
-
34447292863
-
Multiple myeloma. A prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment
-
Mitsiades C.S., Mitsiades N.S., Richardson P.G., Munshi N.C., Anderson K.C. Multiple myeloma. A prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment. J Cell Biochem 2007, 101:950-968.
-
(2007)
J Cell Biochem
, vol.101
, pp. 950-968
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
Richardson, P.G.3
Munshi, N.C.4
Anderson, K.C.5
-
17
-
-
77951692928
-
Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585
-
Stühmer T., Arts J., Chatterjee M., Borawski J., Wolff A., King P., et al. Preclinical anti-myeloma activity of the novel HDAC-inhibitor JNJ-26481585. Br J Haematol 2010, 149:529-536.
-
(2010)
Br J Haematol
, vol.149
, pp. 529-536
-
-
Stühmer, T.1
Arts, J.2
Chatterjee, M.3
Borawski, J.4
Wolff, A.5
King, P.6
-
18
-
-
31544439674
-
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival
-
Troussard A.A., McDonald P.C., Wederell E.D., Mawji N.M., Filipenko N.R., Gelmon K.A., et al. Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Res 2006, 66:393-403.
-
(2006)
Cancer Res
, vol.66
, pp. 393-403
-
-
Troussard, A.A.1
McDonald, P.C.2
Wederell, E.D.3
Mawji, N.M.4
Filipenko, N.R.5
Gelmon, K.A.6
-
19
-
-
33947427988
-
Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells
-
Janz M., Stühmer T., Vassilev L.T., Bargou R.C. Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells. Leukemia 2007, 21:772-779.
-
(2007)
Leukemia
, vol.21
, pp. 772-779
-
-
Janz, M.1
Stühmer, T.2
Vassilev, L.T.3
Bargou, R.C.4
-
20
-
-
79951507143
-
Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival
-
Steinbrunn T., Stühmer T., Gattenlöhner S., Rosenwald A., Mottok A., Unzicker C., et al. Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival. Blood 2011, 117:1998-2004.
-
(2011)
Blood
, vol.117
, pp. 1998-2004
-
-
Steinbrunn, T.1
Stühmer, T.2
Gattenlöhner, S.3
Rosenwald, A.4
Mottok, A.5
Unzicker, C.6
-
21
-
-
0037666792
-
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
-
Troussard A.A., Mawji N.M., Ong C., Mui A., St.-Arnaud R., Dedhar S. Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. J Biol Chem 2003, 278:22374-22378.
-
(2003)
J Biol Chem
, vol.278
, pp. 22374-22378
-
-
Troussard, A.A.1
Mawji, N.M.2
Ong, C.3
Mui, A.4
St.-Arnaud, R.5
Dedhar, S.6
-
22
-
-
33746886979
-
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
-
Fulda S., Debatin K.-M. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 2006, 25:4798-4811.
-
(2006)
Oncogene
, vol.25
, pp. 4798-4811
-
-
Fulda, S.1
Debatin, K.-M.2
-
23
-
-
0035192884
-
FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis
-
Krueger A., Baumann S., Krammer P.H., Kirchhoff S. FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol Cell Biol 2001, 21:8247-8254.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 8247-8254
-
-
Krueger, A.1
Baumann, S.2
Krammer, P.H.3
Kirchhoff, S.4
-
24
-
-
0034699353
-
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
-
Engels I.H., Stepczynska A., Stroh C., Lauber K., Berg C., Schwenzer R., et al. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 2000, 19:4563-4573.
-
(2000)
Oncogene
, vol.19
, pp. 4563-4573
-
-
Engels, I.H.1
Stepczynska, A.2
Stroh, C.3
Lauber, K.4
Berg, C.5
Schwenzer, R.6
-
25
-
-
84655170274
-
Targeting integrin-linked kinase increases apoptosis and decreases invasion of myeloma cell lines and inhibits IL-6 and VEGF secretion from BMSCs
-
Wang X., Zhang Z., Yao C. Targeting integrin-linked kinase increases apoptosis and decreases invasion of myeloma cell lines and inhibits IL-6 and VEGF secretion from BMSCs. Med Oncol 2011, 28:1596-1600.
-
(2011)
Med Oncol
, vol.28
, pp. 1596-1600
-
-
Wang, X.1
Zhang, Z.2
Yao, C.3
-
26
-
-
9444273447
-
Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells
-
Chatterjee M., Stühmer T., Herrmann P., Bommert K., Dörken B., Bargou R.C. Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood 2004, 104:3712-3721.
-
(2004)
Blood
, vol.104
, pp. 3712-3721
-
-
Chatterjee, M.1
Stühmer, T.2
Herrmann, P.3
Bommert, K.4
Dörken, B.5
Bargou, R.C.6
-
27
-
-
62149130798
-
Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells
-
Muranyi A.L., Dedhar S., Hogge D.E. Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells. Exp Hematol 2009, 37:450-460.
-
(2009)
Exp Hematol
, vol.37
, pp. 450-460
-
-
Muranyi, A.L.1
Dedhar, S.2
Hogge, D.E.3
-
28
-
-
68149092724
-
The small molecule inhibitor QLT0267 radiosensitizes squamous cell carcinoma cells of the head and neck
-
Eke I., Leonhardt F., Storch K., Hehlgans S., Cordes N. The small molecule inhibitor QLT0267 radiosensitizes squamous cell carcinoma cells of the head and neck. PLoS One 2009, 4:e6434.
-
(2009)
PLoS One
, vol.4
-
-
Eke, I.1
Leonhardt, F.2
Storch, K.3
Hehlgans, S.4
Cordes, N.5
|