Effect of Arginine Infusion on Ghrelin Secretion in Growth Hormone-Sufficient and GH-Deficient Children

International Journal of Endocrinology and Metabolism

Volumn 10, Issue 2, 2012, Pages 470-474

  Prodam, Flavia ^a   Genoni, Giulia ^a   Bellone, Simonetta ^a   Longhi, Silvia ^b   Agarla, Valentina ^a   Bona, Gianni ^a   Radetti, Giorgio ^b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b CENTRAL HOSPITAL OF BOLZANO   (Italy)

Author keywords

Acylated ghrelin; Growth hormone; Growth hormone deficiency

Indexed keywords

ACYLATED GHRELIN; ARGININE; GHRELIN; GROWTH HORMONE; SOMATOMEDIN C; SOMATOSTATIN; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; CHEMICAL INTERACTION; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; INFUSION; MALE; NEGATIVE FEEDBACK; PREPUBERTY; PROVOCATION TEST; SCHOOL CHILD; SHORT STATURE;

EID: 84864010067     PISSN: 1726913X     EISSN: 17269148     Source Type: Journal    
DOI: 10.5812/ijem.3826     Document Type: Article

References (44)

1. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab. 2002;87(6):2988.
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-60.
3. Muccioli G, Tschop M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol. 2002;440(2-3):235-54.
4. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-7.
5. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85(2):495-522.
6. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004;25(3):426-57.
7. Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, et al. Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab. 2004;89(6):3062-5.
8. Gauna C, Delhanty PJ, Hofland LJ, Janssen JA, Broglio F, Ross RJ, et al. Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab. 2005;90(2):1055-60.
9. Gil-Campos M, Aguilera CM, Canete R, Gil A. Ghrelin. a hormone regulating food intake and energy homeostasis. Br J Nutr. 2006;96(2):201-26.
10. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, et al. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab. 2001;86(10):4753-8.
11. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50(8):1714-9.
12. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab. 2002;87(1):240-4.
13. Hartman ML, Faria AC, Vance ML, Johnson ML, Thorner MO, Veldhuis JD. Temporal structure of in vivo growth hormone secretory events in humans. Am J Physiol. 1991;260(1 Pt 1):E101-10.
14. Thorner MO, Chapman IM, Gaylinn BD, Pezzoli SS, Hartman ML. Growth hormone-releasing hormone and growth hormonereleasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging. Recent Prog Horm Res. 1997;52:215-44; discussion 44-6.
15. Muller EE, Locatelli V, Cocchi D. Neuroendocrine control of growth hormone secretion. Physiol Rev. 1999;79(2):511-607.
16. Arvat E, Maccario M, Di Vito L, Broglio F, Benso A, Gottero C, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone. J Clin Endocrinol Metab. 2001;86(3):1169-74.
17. Hataya Y, Akamizu T, Takaya K, Kanamoto N, Ariyasu H, Saijo M, et al. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab. 2001;86(9):4552.
18. Maghnie M, Pennati MC, Civardi E, Di Iorgi N, Aimaretti G, Foschini ML, et al. GH response to ghrelin in subjects with congenital GH deficiency: evidence that ghrelin action requires hypothalamicpituitary connections. Eur J Endocrinol. 2007;156(4):449-54.
19. Popovic V, Miljic D, Micic D, Damjanovic S, Arvat E, Ghigo E, et al. Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level. J Clin Endocrinol Metab. 2003;88(7):3450-3.
20. Tannenbaum GS, Epelbaum J, Bowers CY. Interrelationship between the novel peptide ghrelin and somatostatin/growth hormone-releasing hormone in regulation of pulsatile growth hormone secretion. Endocrinology. 2003;144(3):967-74.
21. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, et al. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab. 2000;85(12):4908-11.
22. Tolle V, Bassant MH, Zizzari P, Poindessous-Jazat F, Tomasetto C, Epelbaum J, et al. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology. 2002;143(4):1353-61.
23. Koutkia P, Canavan B, Breu J, Johnson ML, Grinspoon SK. Nocturnal ghrelin pulsatility and response to growth hormone secretagogues in healthy men. Am J Physiol Endocrinol Metab. 2004;287(3):E506-12.
24. Avram AM, Jaffe CA, Symons KV, Barkan AL. Endogenous circulating ghrelin does not mediate growth hormone rhythmicity or response to fasting. J Clin Endocrinol Metab. 2005;90(5):2982-7.
25. Muller AF, Lamberts SW, Janssen JA, Hofland LJ, Koetsveld PV, Bidlingmaier M, et al. Ghrelin drives GH secretion during fasting in man. Eur J Endocrinol. 2002;146(2):203-7.
26. Hirsh D, Heinrichs C, Leenders B, Wong AC, Cummings DE, Chanoine JP. Ghrelin is suppressed by glucagon and does not mediate glucagon-related growth hormone release. Horm Res. 2005;63(3):111-8.
27. Matsuoka H, Hosoda H, Sugawara H, Iwama S, Kim HS, Kangawa K, et al. Short-term secretory regulation of ghrelin during growth hormone provocative tests in prepubertal children with various growth hormone secretory capacities. Horm Res. 2005;64(6):274-9.
28. Radetti G, Prodam F, Lauriola S, Di Dio G, D'Addato G, Corneli G, et al. Acute ghrelin response to intravenous dexamethasone administration in idiopathic short stature or isolated idiopathic growth hormone-deficient children. J Endocrinol Invest. 2008;31(3):224-8.
29. Stylianou C, Galli-Tsinopoulou A, Grammatikopoulou MG, Koliakos G, Varlamis G. Ghrelin and growth hormone serum levels during the clonidine test in children with short stature and variable growth hormone status. Hormones (Athens). 2011;10(1):39-45.
30. Tarantini B, Ciuoli C, Checchi S, Montanaro A, Bonato V, Theodoropoulou A, et al. Serum ghrelin levels in growth hormone-sufficient and growth hormone-deficient patients during growth hormone-releasing hormone plus arginine test. J Endocrinol Invest. 2009;32(4):335-7.
31. Cacciari E, Milani S, Balsamo A, Spada E, Bona G, Cavallo L, et al. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr). J Endocrinol Invest. 2006;29(7):581-93.
32. Richmond EJ, Rogol AD. Growth hormone deficiency in children. Pituitary. 2008;11(2):115-20.
33. Groschl M, Wagner R, Dotsch J, Rascher W, Rauh M. Preanalytical influences on the measurement of ghrelin. Clin Chem. 2002;48(7):1114-6.
34. Holistic Numerical Methods. Transforming Numerical Methods Education for the STEM Undergraduate. 2012 [updated 2011 Jan]; Available from: http://numericalmethods.eng.usf.edu/topics/ trapezoidal_rule.htm.
35. Broglio F, Gottero C, Prodam F, Destefanis S, Gauna C, Me E, et al. Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans. Clin Endocrinol (Oxf). 2004;61(4):503-9.
36. Prodam F, Me E, Riganti F, Gramaglia E, Bellone S, Baldelli R, et al. The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition. Eur J Nutr. 2006;45(7):399-405.
37. Ramkumar D, Schulze KS. Gastroduodenal motility. Curr Opin Gastroenterol. 2003;19(6):540-5.
38. Janssen JA, van der Toorn FM, Hofland LJ, van Koetsveld P, Broglio F, Ghigo E, et al. Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy. Eur J Endocrinol. 2001;145(6):711-6.
39. Eden Engstrom B, Burman P, Holdstock C, Karlsson FA. Effects of growth hormone (GH) on ghrelin, leptin, and adiponectin in GH-deficient patients. J Clin Endocrinol Metab. 2003;88(11):5193-8.
40. Giavoli C, Cappiello V, Corbetta S, Ronchi CL, Morpurgo PS, Ferrante E, et al. Different effects of short- and long-term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adults. Clin Endocrinol (Oxf). 2004;61(1):81-7.
41. Jarkovska Z, Rosicka M, Marek J, Hana V, Weiss V, Justova V, et al. Plasma levels of total and active ghrelin in acromegaly and growth hormone deficiency. Physiol Res. 2006;55(2):175-81.
42. Jung CH, Lee WY, Rhee EJ, Kim SY, Oh KW, Yun EJ, et al. Serum ghrelin and leptin levels in adult growth hormone deficiency syndrome. Arch Med Res. 2006;37(5):612-8.
43. Ryber L, Obrink K, Houe N, Frystyk J, Jorgensen JO. Serum ghrelin levels are suppressed in hypopituitary patients following insulin-induced hypoglycaemia irrespective of GH status. Clin Endocrinol (Oxf). 2006;65(2):210-4.
44. Kim SW, Kim KW, Shin CS, Park do J, Park KS, Cho BY, et al. Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans. Horm Res. 2007;67(5):211-9.