Different effects of short- and long-term recombinant hGH administration on ghrelin and adiponectin levels in GH-deficient adults

Clinical Endocrinology

Volumn 61, Issue 1, 2004, Pages 81-87

  Giavoli, Claudia ^a   Cappiello, Vincenzo ^a   Corbetta, Sabrina ^a   Ronchi, Cristina L ^a   Morpurgo, Paola S ^a   Ferrante, Emanuele ^a   Beck Peccoz, Paolo ^a   Spada, Anna ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; GHRELIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HUMAN GROWTH HORMONE; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SOMATOMEDIN C; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY FAT; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; INSULIN BLOOD LEVEL; LONG TERM CARE; MALE; ONSET AGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHORT COURSE THERAPY; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; ADULT; CASE-CONTROL STUDIES; CHOLESTEROL; CHOLESTEROL, LDL; DRUG ADMINISTRATION SCHEDULE; FEMALE; GROWTH HORMONE; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; MIDDLE AGED; PEPTIDE HORMONES; PROTEINS; RECOMBINANT PROTEINS;

EID: 3242719361     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2004.02067.x     Document Type: Article

References (37)

1. Adamczak, M., Wiecek, A., Funahashi, T., Chudek, J., Kokot, F. & Matsuzawa, Y. (2003) Decreased plasma adiponectin concentration in patients with essential hypertension. American Journal of Hypertension, 16, 72-75.
2. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T. & Matsuzawa, Y. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications, 257, 79-83.
3. Arvat, E., Di Vito, L., Broglio, F., Capotti, M., Muccioli, G., Dieguez, C., Casanueva, F.F., Deghenghi, R., Camanni, F. & Ghigo, E. (2000) Preliminary evidence that ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. Journal of Endocrinological Investigation, 23, 493-495.
4. Aryiasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., Shirakami, G., Usui, T., Shimatsu, A., Doi, K., Hosoda, H., Kojima, M., Kangawa, K. & Nakao, K. (2001) Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. Journal of Clinical Endocrinology and Metabolism, 86, 4753-4758.
5. Barkan, A.L., Dimoraki, E.V., Jessup, S.K., Symons, K.V., Ermolenko, M. & Jaffe, C.A. (2003) Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. Journal of Clinical Endocrinology and Metabolism, 88, 2180-2184.
6. Beaumont, N.J., Skinner, V.O., Tan, M.M., Ramesh, B.S., Byrne, D.J., MacColl, G.S., Keen, J.N., Bouloux, P.M., Mikhailidis, D.P., Bruckdorfer, K.R., Vanderpump, M.P. & Srai, K.S. (2003) Ghrelin can bind to a species of high-density lipoprotein associated with paraoxonase. Journal of Biological Chemistry, 278, 8877-8880.
7. Buckway, C.K., Guevara-Aguirre, J., Pratt, K.L., Burren, C.P. & Rosenfeld, R.G. (2001) The IGF-I generation test revisited: a marker of GH sensitivity. Journal of Clinical Endocrinology and Metabolism, 86, 5176-5183.
8. Cappiello, V., Ronchi, C., Morpurgo, P.S., Epaminonda, P., Arosio, M., Beck-Peccoz, P. & Spada, A. (2002) Circulating ghrelin levels in basal conditions and during glucose tolerance test in acromegalic patients. European Journal of Endocrinology, 147, 189-194.
9. Cummings, D.E., Purnell, J.Q., Frayo, R.S., Schmidova, K., Wisse, B.E. & Weigle, D.S. (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes, 50, 1714-1719.
10. Dall, R., Kanaley, J., Hansen, T.K., Møller, N., Christiansen, J.S., Hosoda, H., Kangawa, K. & Jørgensen, J.O.L. (2002) Plasma ghrelin levels during exercise in healthy subjects and in growth hormone-deficient patients. European Journal of Endocrinology, 147, 65-70.
11. Engström, B.E., Burman, P., Holdstock, C. & Karlsson, F.A. (2003) Effects of growth hormone (GH) on ghrelin, leptin and adiponectin in GH-deficient patients. Journal of Clinical Endocrinology and Metabolism, 88, 5193-5198.
12. Freda, P.U., Reyes, C.M., Conwell, I.M., Sindeen, R.E. & Wardlaw, S.L. (2003) Serum ghrelin levels in acromegaly: effects of surgical and long-acting octreotide therapy. Journal of Clinical Endocrinology and Metabolism, 88, 2037-2044.
13. Fruebis, J., Tsao, T.S., Javorschi, S., Ebbets-Reed, D., Erickson, M.R., Yen, F.T., Bihain, B.E. & Lodish, H.F. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proceeding of the National Academy of Sciences, 98, 2005-2010.
14. Ghigo, E., Aimaretti, G., Giannotti, L., Bellone, J., Arvat, E. & Camanni, F. (1996) New approach to the diagnosis of growth hormone deficiency in adults. European Journal of Endocrinology, 134, 352-356.
15. Hansen, T., Dall, R., Hosoda, H., Kojima, M., Kangawa, K., Christiansen, J.S. & Jørgensen, J.O. (2002) Weight loss increases circulating levels of ghrelin in human obesity. Clinical Endocrinology, 56, 203-206.
16. Haque, W.A., Shimomura, I., Matsuzawa, Y. & Garg, A. (2002) Serum adiponectin and leptin levels in patients with lipodystrophies. Journal of Clinical Endocrinology and Metabolism, 87, 2395.
17. Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., Nishida, M., Kihara, S., Sakai, N., Nakajima, T., Hasegawa, K., Muraguchi, M., Ohmoto, Y., Nakamura, T., Yamashita, S., Hanafusa, T. & Matsuzawa, Y. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis and Vascular Biology, 20, 1595-1599.
18. Janssen, J.A.M.J.L., van der Toorn, F.M., Hofland, L.J., van Koetsveld, P., Broglio, F., Ghigo, E., Lamberts, S.W. & Van der Lely, J.A. (2001) Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by 1 year of growth hormone replacement therapy. European Journal of Endocrinology, 145, 711-716.
19. Katz, A., Nambi, S.S., Mather, K., Baron, A.D., Follmann, D.A., Sullivan, G. & Quon, M.J. (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. Journal of Clinical Endocrinology and Metabolism, 85, 2402-2410.
20. Kishida, K., Nagaretani, H., Kondo, H., Kobayashi, H., Tanaka, S., Maeda, N., Nagasawa, A., Hibuse, T., Ohashi, K., Kumada, M., Nishizawa, H., Okamoto, Y., Ouchi, N., Maeda, K., Kihara, S., Funahashi, T. & Matsuzawa, Y. (2003) Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochemical and Biophysical Research Communications, 306, 286-292.
21. Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H. & Kangawa, K. (1999) Ghrelin is a growth hormone-releasing acylated peptide released from the stomach. Nature, 402, 656-660.
22. Kojima, M., Hosoda, H., Matsuo, H. & Kangawa, K. (2001) Ghrelin, discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends in Endocrinology and Metabolism, 12, 118-122.
23. Kumada, M., Kihara, S., Sumitsuji, S., Kawamoto, T., Matsumoto, S., Ouchi, N., Arita, Y., Okamoto, Y., Shimomura, I., Hiraoka, H., Nakamura, T., Funahashi, T. & Matsuzawa, Y. (2003) Osaka CAD Study Group. Coronary artery disease. Association of hypoadiponectinemia with coronary artery disease in men. Arteriosclerosis, Thrombosis and Vascular Biology, 23, 85-89.
24. Malik, I.A., English, P.J., Ghatei, M.A., Bloom, S.R., MacFarlane, I.A. & Wilding, J.P.H. (2004) The relationship of ghrelin to biochemical and anthropometric markers of adult growth hormone deficiency. Clinical Endocrinology, 60, 137-141.
25. Matsubara, M., Maruoka, S. & Katayose, S. (2002) Decreased plasma adiponectin concentrations in women with dyslipidemia. Journal of Clinical Endocrinology and Metabolism, 87, 2764-2769.
26. Matthews, D., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. & Turner, R.C. (1985) Homeostasis model assessment, insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
27. Otto, B., Cuntz, U., Fruehauf, E., Wawarta, R., Folwaczny, C., Riepl, R.L., Heiman, M.L., Lehnert, P., Fichter, M. & Tschöp, M. (2001) Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. European Journal of Endocrinology, 145, 669-673.
28. Purnell, J.Q., Weigle, D.S., Breen, P. & Cummings, D.E. (2003) Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status or cortisol levels in humans. Journal of Clinical Endocrinology and Metabolism, 88, 5747-5752.
29. Ronchi, C.L., Corbetta, S., Cappiello, V., Morpurgo, P.S., Giavoli, C., Beck-Peccoz, P., Arosio, M. & Spada, A. (2004) Circulating adiponectin levels and cardiovascular risk factors in acromegalic patients. European Journal of Endocrinology, 150, 663-669.
30. Saad, M.F., Bernaba, B., Hwu, C.M., Jinagouda, S., Fahmi, S., Kogosov, E. & Boyadjian, R. (2002) Insulin regulates plasma ghrelin concentration. Journal of Clinical Endocrinology and Metabolism, 87, 3997-4000.
31. Segal, K.R., Van Loan, M., Fitzgerald, P.I., Hodgdon, J.A. & Van Itallie, T.B. (1988) Lean body mass estimation by bioelectrical impedance analysis: a four-site cross validation study. American Journal of Clinical Nutrition, 47, 7-14.
32. Shiiya, T., Nakazato, M., Mizuta, M., Date, Y., Mondal, M.S., Tanaka, M., Nozoe, S., Hosoda, H., Kangawa, K. & Matsukura, S. (2002) Plasma ghrelin levels in lean and obese human and the effect of glucose on ghrelin secretion. Journal of Clinical Endocrinology and Metabolism, 87, 240-244.
33. Silha, J.V., Krsek, M., Hana, V., Marek, J., Jezkova, J., Weiss, V. & Murphy, L.J. (2003a) Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance. Clinical Endocrinology, 58, 736-742.
34. Silha, J.V., Krsek, M., Skrha, J.V., Sucharda, P., Nyomba, B.L. & Murphy, L.J. (2003b) Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. European Journal of Endocrinology, 149, 331-335.
35. Tschöp, M., Weyer, C., Tataranni, P.A., Devanarayan, V., Ravussin, E. & Heiman, M.L. (2001) Circulating ghrelin levels are decreased in human obesity. Diabetes, 50, 707-709.
36. Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R.E. & Tataranni, P.A. (2001) Hypoadiponectinemia in obesity and type 2 diabetes, close association with insulin resistance and hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism, 86, 1930-1935.
37. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M.L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P. & Kadowaki, T. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine, 7, 941-946.