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Volumn 10, Issue 7, 2012, Pages 979-991

Human ESC self-renewal promoting microRNAs induce epithelial - Mesenchymal transition in hepatocytes by controlling the PTEN and TGFβ tumor suppressor signaling pathways

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; KLF11 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 84864009582     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0421     Document Type: Article
Times cited : (20)

References (46)
  • 1
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7. (Pubitemid 28516247)
    • (1998) Science , vol.282 , Issue.5391 , pp. 1145-1147
    • Thomson, J.A.1
  • 2
    • 57349112286 scopus 로고    scopus 로고
    • Generation and regeneration of cells of the liver and pancreas
    • Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008;322:1490-4.
    • (2008) Science , vol.322 , pp. 1490-1494
    • Zaret, K.S.1    Grompe, M.2
  • 3
    • 49249091550 scopus 로고    scopus 로고
    • Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo
    • Hay DC, Zhao D, Fletcher J, Hewitt ZA, McLean D, Urruticoechea- Uriguen A, et al. Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo. Stem Cells 2008;26:894-902.
    • (2008) Stem Cells , vol.26 , pp. 894-902
    • Hay, D.C.1    Zhao, D.2    Fletcher, J.3    Hewitt, Z.A.4    McLean, D.5    Urruticoechea- Uriguen, A.6
  • 4
    • 47949092668 scopus 로고    scopus 로고
    • Efficient differentiation of functional hepatocytes from human embryonic stem cells
    • Agarwal S, Holton KL, Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 2008;26:1117-27.
    • (2008) Stem Cells , vol.26 , pp. 1117-1127
    • Agarwal, S.1    Holton, K.L.2    Lanza, R.3
  • 5
    • 33750728409 scopus 로고    scopus 로고
    • Stem cells: The good, bad and barely in control
    • DOI 10.1038/nm1106-1237, PII NM11061237
    • Carson CT, Aigner S, Gage FH. Stem cells: the good, bad and barely in control. Nat Med 2006;12:1237-8. (Pubitemid 44706920)
    • (2006) Nature Medicine , vol.12 , Issue.11 , pp. 1237-1238
    • Carson, C.T.1    Aigner, S.2    Gage, F.H.3
  • 6
    • 4043056464 scopus 로고    scopus 로고
    • Nuclear transplantation, embryonic stem cells and the potential for cell therapy
    • DOI 10.1038/sj.thj.6200435
    • Hochedlinger K, Rideout WM, Kyba M, Daley GQ, Blelloch R, Jaenisch R. Nuclear transplantation, embryonic stem cells and the potential for cell therapy. Hematol J 2004;5 Suppl 3:S114-7. (Pubitemid 39077287)
    • (2004) Hematology Journal , vol.5 , Issue.SUPPL. 3
    • Hochedlinger, K.1    Rideout, W.M.2    Kyba, M.3    Daley, G.Q.4    Blelloch, R.5    Jaenisch, R.6
  • 7
    • 41449118521 scopus 로고    scopus 로고
    • Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells
    • DOI 10.1016/j.stem.2008.02.009, PII S1934590908000738
    • Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008;2:333-44. (Pubitemid 351455242)
    • (2008) Cell Stem Cell , vol.2 , Issue.4 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3    Cassarino, D.4    Segal, E.5    Chang, H.Y.6
  • 8
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • DOI 10.1038/nature03100
    • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-31. (Pubitemid 39551660)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 9
    • 33646045010 scopus 로고    scopus 로고
    • Stem cells and cancer: Two faces of eve
    • Clarke MF, Fuller M. Stem cells and cancer: two faces of eve. Cell 2006;124:1111-5.
    • (2006) Cell , vol.124 , pp. 1111-1115
    • Clarke, M.F.1    Fuller, M.2
  • 10
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11. (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 11
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • DOI 10.1038/ng.127, PII NG127
    • Ben-Porath I, Thomson MW, Carey VJ, Ge R, Bell GW, Regev A, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507. (Pubitemid 351601215)
    • (2008) Nature Genetics , vol.40 , Issue.5 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3    Ge, R.4    Bell, G.W.5    Regev, A.6    Weinberg, R.A.7
  • 12
    • 0345059767 scopus 로고    scopus 로고
    • Applying the principles of stem-cell biology to cancer
    • Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902. (Pubitemid 37500174)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.12 , pp. 895-902
    • Pardal, R.1    Clarke, M.F.2    Morrison, S.J.3
  • 14
    • 0033935425 scopus 로고    scopus 로고
    • Control of developmental timing in Caenorhabditis elegans
    • DOI 10.1016/S0959-437X(00)00108-8
    • Ambros V. Control of developmental timing in Caenorhabditis elegans. Curr Opin Genet Dev 2000;10:428-33. (Pubitemid 30450048)
    • (2000) Current Opinion in Genetics and Development , vol.10 , Issue.4 , pp. 428-433
    • Ambros, V.1
  • 16
    • 56749091922 scopus 로고    scopus 로고
    • Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation
    • Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R. Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet 2008;40:1478-83.
    • (2008) Nat Genet , vol.40 , pp. 1478-1483
    • Wang, Y.1    Baskerville, S.2    Shenoy, A.3    Babiarz, J.E.4    Baehner, L.5    Blelloch, R.6
  • 17
    • 77957664647 scopus 로고    scopus 로고
    • MicroRNAs as regulators of differentiation and cell fate decisions
    • Ivey KN, Srivastava D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell 2010;7:36-41.
    • (2010) Cell Stem Cell , vol.7 , pp. 36-41
    • Ivey, K.N.1    Srivastava, D.2
  • 18
    • 79951979718 scopus 로고    scopus 로고
    • MicroRNAs: Master regulators as potential therapeutics in cancer
    • Garofalo M, Croce CM. microRNAs: master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol 2011;51:25-43.
    • (2011) Annu Rev Pharmacol Toxicol , vol.51 , pp. 25-43
    • Garofalo, M.1    Croce, C.M.2
  • 19
    • 33747195353 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
    • DOI 10.1016/j.cell.2006.07.024, PII S0092867406009767
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76. (Pubitemid 44233629)
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 20
    • 39149086020 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from fibroblast cultures
    • Takahashi K, Okita K, Nakagawa M, Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat Protoc 2007;2:3081-9.
    • (2007) Nat Protoc , vol.2 , pp. 3081-3089
    • Takahashi, K.1    Okita, K.2    Nakagawa, M.3    Yamanaka, S.4
  • 21
    • 67349149082 scopus 로고    scopus 로고
    • Micro-RNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
    • Xu N, Papagiannakopoulos T, Pan G, Thomson JA, Kosik KS. Micro-RNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009;137:647-58.
    • (2009) Cell , vol.137 , pp. 647-658
    • Xu, N.1    Papagiannakopoulos, T.2    Pan, G.3    Thomson, J.A.4    Kosik, K.S.5
  • 23
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary microRNA processing
    • DOI 10.1101/gad.1262504
    • Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev 2004;18:3016-27. (Pubitemid 39658171)
    • (2004) Genes and Development , vol.18 , Issue.24 , pp. 3016-3027
    • Han, J.1    Lee, Y.2    Yeom, K.-H.3    Kim, Y.-K.4    Jin, H.5    Kim, V.N.6
  • 24
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • DOI 10.1016/j.cell.2004.12.035, PII S0092867404012607
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are micro-RNA targets. Cell 2005;120:15-20. (Pubitemid 40094598)
    • (2005) Cell , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 26
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 2006;12:410-6.
    • (2006) Nat Med , vol.12 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3    Chu, I.S.4    Kaposi-Novak, P.5    Calvisi, D.F.6
  • 29
    • 77956627711 scopus 로고    scopus 로고
    • The role of signaling pathways in the development and treatment of hepatocellular carcinoma
    • Whittaker S, Marais R, Zhu AX. The role of signaling pathways in the development and treatment of hepatocellular carcinoma. Oncogene 2009;29:4989-5005.
    • (2009) Oncogene , vol.29 , pp. 4989-5005
    • Whittaker, S.1    Marais, R.2    Zhu, A.X.3
  • 30
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 31
    • 4143069155 scopus 로고    scopus 로고
    • KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by ERK-MAPK in pancreatic cancer cells
    • DOI 10.1053/j.gastro.2004.05.018, PII S0016508504008649
    • Ellenrieder V, Buck A, Harth A, Jungert K, Buchholz M, Adler G, et al. KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. Gastroenterology 2004;127:607-20. (Pubitemid 39091908)
    • (2004) Gastroenterology , vol.127 , Issue.2 , pp. 607-620
    • Ellenrieder, V.1    Buck, A.2    Harth, A.3    Jungert, K.4    Buchholz, M.5    Adler, G.6    Urrutia, R.7    Gress, T.M.8
  • 32
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009;119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 33
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 30 kinase/AKT pathways
    • DOI 10.1038/sj.onc.1209091, PII 1209091
    • Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 30 kinase/AKT pathways. Oncogene 2005;24:7443-54. (Pubitemid 41637984)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 35
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, et al. Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 1995;268:1336-8.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3    Parsons, R.4    Sun, L.5    Lutterbaugh, J.6
  • 36
    • 0141625268 scopus 로고    scopus 로고
    • An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation
    • DOI 10.1093/emboj/cdg470
    • Fernandez-Zapico ME, Mladek A, Ellenrieder V, Folch-Puy E, Miller L, Urrutia R. An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J 2003;22:4748-58. (Pubitemid 37162911)
    • (2003) EMBO Journal , vol.22 , Issue.18 , pp. 4748-4758
    • Fernandez-Zapico, M.E.1    Mladek, A.2    Ellenrieder, V.3    Folch-Puy, E.4    Miller, L.5    Urrutia, R.6
  • 38
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • DOI 10.1126/science.275.5300.665
    • Franke TF, Kaplan DR, Cantley LC, Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 1997;275:665-8. (Pubitemid 27061333)
    • (1997) Science , vol.275 , Issue.5300 , pp. 665-668
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 39
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN Tumor Suppression
    • DOI 10.1016/j.cell.2008.04.013, PII S0092867408005047
    • Salmena L, Carracedo A, Pandolfi PP. Tenets of PTEN tumor suppression. Cell 2008;133:403-14. (Pubitemid 351622014)
    • (2008) Cell , vol.133 , Issue.3 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 40
    • 34047270440 scopus 로고    scopus 로고
    • Characterization of microRNA expression levels and their biological correlates in human cancer cell lines
    • DOI 10.1158/0008-5472.CAN-06-2698
    • Gaur A, Jewell DA, Liang Y, Ridzon D, Moore JH, Chen C, et al. Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res 2007;67:2456-68. (Pubitemid 46548930)
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2456-2468
    • Gaur, A.1    Jewell, D.A.2    Liang, Y.3    Ridzon, D.4    Moore, J.H.5    Chen, C.6    Ambros, V.R.7    Israel, M.A.8
  • 42
    • 79961124478 scopus 로고    scopus 로고
    • MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma
    • Cai K, Wang Y, Bao X. MiR-106b promotes cell proliferation via targeting RB in laryngeal carcinoma. J Exp Clin Cancer Res 2011;30:73.
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 73
    • Cai, K.1    Wang, Y.2    Bao, X.3
  • 43
    • 77953948708 scopus 로고    scopus 로고
    • Identification of the miR-106b ∼ 25 microRNA cluster as a protooncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation
    • Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, Hobbs RM, et al. Identification of the miR-106b ∼ 25 microRNA cluster as a protooncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal 2010;3:ra29.
    • (2010) Sci Signal , vol.3
    • Poliseno, L.1    Salmena, L.2    Riccardi, L.3    Fornari, A.4    Song, M.S.5    Hobbs, R.M.6
  • 44
    • 78650858038 scopus 로고    scopus 로고
    • miR-301a as an NFkappaB activator in pancreatic cancer cells
    • Lu Z, Li Y, Takwi A, Li B, Zhang J, Conklin DJ, et al. miR-301a as an NFkappaB activator in pancreatic cancer cells. EMBO J 2011;30:57-67.
    • (2011) EMBO J , vol.30 , pp. 57-67
    • Lu, Z.1    Li, Y.2    Takwi, A.3    Li, B.4    Zhang, J.5    Conklin, D.J.6
  • 45
    • 78649681554 scopus 로고    scopus 로고
    • miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • MaS, Tang KH, ChanYP, Lee TK, Kwan PS, Castilho A, et al. miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010;7:694-707.
    • (2010) Cell Stem Cell , vol.7 , pp. 694-707
    • Ma, S.1    Tang, K.H.2    Chan, Y.P.3    Lee, T.K.4    Kwan, P.S.5    Castilho, A.6


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