메뉴 건너뛰기




Volumn 18, Issue SUPPL. 6, 2007, Pages

Dasatinib: A new step in molecular target therapy

Author keywords

Bcr abl kinases; Chronic myeloid leukemia; Dasatinib; Target therapy

Indexed keywords

BCR ABL PROTEIN; DASATINIB; IMATINIB; NILOTINIB; PROTEIN TYROSINE KINASE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

EID: 35748952533     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdm223     Document Type: Conference Paper
Times cited : (74)

References (30)
  • 1
    • 0034032012 scopus 로고    scopus 로고
    • BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia
    • Deininger MW, Vieira S, Mendiola R et al. BCR-ABL tyrosine kinase activity regulates the expression of multiple genes implicated in the pathogenesis of chronic myeloid leukemia, Cancer Res 2000; 60: 2049-2055.
    • (2000) Cancer Res , vol.60 , pp. 2049-2055
    • Deininger, M.W.1    Vieira, S.2    Mendiola, R.3
  • 2
    • 0033614446 scopus 로고    scopus 로고
    • Chronic myeloid leukemia
    • Sawyers CL. Chronic myeloid leukemia. N Engl J Med 1999; 340: 1330-1340.
    • (1999) N Engl J Med , vol.340 , pp. 1330-1340
    • Sawyers, C.L.1
  • 3
    • 0029947186 scopus 로고    scopus 로고
    • Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
    • Druker BJ, Tamura S, Buchdunger E et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med 1996; 2: 561-566.
    • (1996) Nat Med , vol.2 , pp. 561-566
    • Druker, B.J.1    Tamura, S.2    Buchdunger, E.3
  • 4
    • 0033816156 scopus 로고    scopus 로고
    • Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
    • Buchdunger E, Cioffi CL, Law N et al. Abl protein-tyrosine kinase inhibitor ST1571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000; 295: 139-145.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 139-145
    • Buchdunger, E.1    Cioffi, C.L.2    Law, N.3
  • 5
    • 0036493872 scopus 로고    scopus 로고
    • The c-KIT mutation causing human mastocytosis is resistant to ST1571 and other KIT kinase inhibitors: Kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
    • Ma Y, Zang S, Metcalfe DO et al. The c-KIT mutation causing human mastocytosis is resistant to ST1571 and other KIT kinase inhibitors: kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 2002; 99: 1741-1744.
    • (2002) Blood , vol.99 , pp. 1741-1744
    • Ma, Y.1    Zang, S.2    Metcalfe, D.O.3
  • 6
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355(23): 2408-2417.
    • (2006) N Engl J Med , vol.355 , Issue.23 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 7
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patents with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ et al. Imatinib induces durable hematologic and cytogenetic responses in patents with accelerated phase chronic myeloid leukemia: Results of a phase 2 study. Blood 2002; 99: 1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 8
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • Copland M, Hamilton A, Brick U et al. Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood 2006; 107(11): 4532-4539.
    • (2006) Blood , vol.107 , Issue.11 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Brick, U.3
  • 9
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Tapaz M, Resta DJ et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001; 344: 1031-1103.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1103
    • Druker, B.J.1    Tapaz, M.2    Resta, D.J.3
  • 11
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia 2002; 16: 2190-2196.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 12
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 2001; 293: 876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 13
    • 10744229080 scopus 로고    scopus 로고
    • Frequency Of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
    • Hughes TP, Kaeda J, Branford S et al. Frequency Of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl J Med 2003; 349: 1423-1432.
    • (2003) N Engl J Med , vol.349 , pp. 1423-1432
    • Hughes, T.P.1    Kaeda, J.2    Branford, S.3
  • 14
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • Shah NP, Tran C, Lee FY et al. Overriding imatinib resistance with a novel ABL kinase inhibitor. Science 2004; 305(5682): 399-401.
    • (2004) Science , vol.305 , Issue.5682 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3
  • 15
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'Hare T, Walters DK, Stoffregen EP et al. In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res 2005; 65(11): 4500-4505.
    • (2005) Cancer Res , vol.65 , Issue.11 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 16
    • 54349090607 scopus 로고    scopus 로고
    • Lombardo LJ, Lee FY, Chen P et al. Discovery of
    • Lombardo LJ, Lee FY, Chen P et al. Discovery of
  • 17
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006; 66(1): 473-481.
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 18
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H et al. Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. New Engl J Med 2006; 354(24): 2531-2541.
    • (2006) New Engl J Med , vol.354 , Issue.24 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 19
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
    • blood-2006-09-046888, doi 10.1 182
    • Cortes J, Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 2006 doi 10.1 182/ blood-2006-09-046888.
    • (2006) Blood
    • Cortes, J.1
  • 20
    • 33644515212 scopus 로고    scopus 로고
    • A phase II study of dasatinib in patients with accelerated phase chronic myeloid leukemia (CML) who are resistant or intolerant to imatinib: First results of the CA180005 'START-A' study
    • Abstr 39
    • Guilhot F, Apperley J, Shah N et al. A phase II study of dasatinib in patients with accelerated phase chronic myeloid leukemia (CML) who are resistant or intolerant to imatinib: First results of the CA180005 'START-A' study. Blood 2005; 106: 16a (Abstr 39).
    • (2005) Blood , vol.106
    • Guilhot, F.1    Apperley, J.2    Shah, N.3
  • 21
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic phase chronic myeloid leukemia after failure of imatinib therapy
    • doi 10.1 182/blood-2006-09-047266
    • Hochhaus A. Dasatinib induces notable hematologic and cytogenetic responses in chronic phase chronic myeloid leukemia after failure of imatinib therapy. Blood 2006 doi 10.1 182/blood-2006-09-047266.
    • (2006) Blood
    • Hochhaus, A.1
  • 22
    • 33846200681 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure
    • Quintas-Cardama A, Kantarjian H, Jones D et al. Dasatinib (BMS-354825) is active in Philadelphia chromosome-positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure. Blood 2007; 109(2): 497-499.
    • (2007) Blood , vol.109 , Issue.2 , pp. 497-499
    • Quintas-Cardama, A.1    Kantarjian, H.2    Jones, D.3
  • 23
    • 34249074686 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukaemia after failure of first-line imatinib: A randomized phase-II trial
    • doi 10. 1182/blood-2006-11-056028
    • Kantarjian H, Pasquini R, Hamerschlak N et al. Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukaemia after failure of first-line imatinib: A randomized phase-II trial. Blood 2007; doi 10. 1182/blood-2006-11-056028.
    • (2007) Blood
    • Kantarjian, H.1    Pasquini, R.2    Hamerschlak, N.3
  • 24
    • 34548825177 scopus 로고    scopus 로고
    • Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia
    • Soverini S, Martinelli G, Colarossi S et al. Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia. J Clin Oncol 2006; 24(33): 51-52.
    • (2006) J Clin Oncol , vol.24 , Issue.33 , pp. 51-52
    • Soverini, S.1    Martinelli, G.2    Colarossi, S.3
  • 25
    • 33645687784 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis
    • Shah NP, Lee FY, Luo R et al. Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis. Blood 2006; 108(1): 286-291.
    • (2006) Blood , vol.108 , Issue.1 , pp. 286-291
    • Shah, N.P.1    Lee, F.Y.2    Luo, R.3
  • 26
    • 33745914717 scopus 로고    scopus 로고
    • Phase I close-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors
    • Evans TRJ, Morgan JA, Van den Abbeele AD. Phase I close-escalation study of the SRC and multi-kinase inhibitor BMS-354825 in patients (pts) with GIST and other solid tumors. J Clin Oncol 2005; 23: 3034.
    • (2005) J Clin Oncol , vol.23 , pp. 3034
    • Evans, T.R.J.1    Morgan, J.A.2    Van den Abbeele, A.D.3
  • 27
    • 1842836011 scopus 로고    scopus 로고
    • Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells
    • Laird AD, Li G, Moss KG et al. Src family kinase activity is required for signal tranducer and activator of transcription 3 and focal adhesion kinase phosphorylation and vascular endothelial growth factor signaling in vivo and for anchorage-dependent and -independent growth of human tumor cells. Mol Cancer Ther 2003; 2: 461-469.
    • (2003) Mol Cancer Ther , vol.2 , pp. 461-469
    • Laird, A.D.1    Li, G.2    Moss, K.G.3
  • 28
    • 33645821453 scopus 로고    scopus 로고
    • Patent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib, Mol Pharmacol 2006; 695, 1527-1533
    • Chen Z, Lee FY, Bhalla KN et al. Patent inhibition of platelet-derived growth factor-induced responses in vascular smooth muscle cells by BMS-354825 (dasatinib). Mol Pharmacol 2006; 69(5): 1527-1533.
    • Chen, Z.1    Lee, F.Y.2    Bhalla, K.N.3
  • 29
    • 85117739388 scopus 로고    scopus 로고
    • Svegliati S, Olivieri A, Campelli N et al. Stimulatory antibodies to PDGF receptor in patients with extensive chronic graft versus host disease. Blood 2007; 0: Blood-2007-01-0710430.
    • Svegliati S, Olivieri A, Campelli N et al. Stimulatory antibodies to PDGF receptor in patients with extensive chronic graft versus host disease. Blood 2007; 0: Blood-2007-01-0710430.
  • 30
    • 33749325184 scopus 로고    scopus 로고
    • Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations
    • Bradeen HA, Eide CA, O'Hare T et al. Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)-based mutagenesis screen: High efficacy of drug combinations. Blood 2006; 108(7): 2332-2338.
    • (2006) Blood , vol.108 , Issue.7 , pp. 2332-2338
    • Bradeen, H.A.1    Eide, C.A.2    O'Hare, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.