Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans

Diabetic Medicine

Volumn 29, Issue 8, 2012, Pages 986-989

  Wilkinson, D ^a   Chapman, I M ^b   Heilbronn, L K ^b,c  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Adipose tissue hypoxia; Hyperbaric oxygen; Insulin resistance; Obesity

Indexed keywords

ANTIDIABETIC AGENT; HEMOGLOBIN A1C; INSULIN; OXYGEN;

ADULT; AGED; ARTICLE; ATMOSPHERE; BONE NECROSIS; CLINICAL ARTICLE; DIABETIC FOOT; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERBARIC OXYGEN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL INSULIN SENSITIVITY; PROCTITIS; WEIGHT REDUCTION;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPERBARIC OXYGENATION; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY;

EID: 84864004998     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03587.x     Document Type: Article

References (16)

1. Springer R. The importance of glucometer testing of diabetic patients pre and post-dive. Undersea Biomed Res 1991; 18: 1.
2. Ekanayake L, Doolette D. Effects of hyperbaric oxygen treatment on blood sugar levels and insulin levels in diabetics. SPUMS J 2001; 31: 16-20.
3. Karadurmus N, Sahin M, Tasci C, Naharci I, Ozturk C, Ilbasmis S et al. Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot. Endokrynol Pol 2010; 61: 275-279.
4. Al-Waili NS, Butler GJ, Beale J, Abdullah MS, Finkelstein M, Merrow M et al. Influences of hyperbaric oxygen on blood pressure, heart rate and blood glucose levels in patients with diabetes mellitus and hypertension. Arch Med Res 2006; 37: 991-997.
5. Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E et al. Relationship between serum resistin concentrations and insulin resistance in non-obese, obese, and obese diabetic subjects. J Clin Endocrinol Metab 2004; 89: 1844-1848.
6. Albu JB, Heilbronn LK, Kelley DE, Smith SR, Azuma K, Berk ES et al. Metabolic changes following a 1-year diet and exercise intervention in patients with type2 diabetes. Diabetes 2010; 59: 627-633.
7. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of typeII diabetes in the offspring of diabetic parents. Ann Intern Med 1990; 113: 909-915.
8. Heilbronn LK, Campbell LV. Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity. Curr Pharm Des 2008; 14: 1225-1230.
9. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
10. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
11. Yasuda K, Adachi T, Gu N, Matsumoto A, Matsunaga T, Tsujimoto G et al. Effects of hyperbaric exposure with high oxygen concentration on glucose and insulin levels and skeletal muscle-fiber properties in diabetic rats. Muscle Nerve 2007; 35: 337-343.
12. Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in Type2 diabetes. Diabetes 2002; 51: 2944-2950.
13. Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI. Impaired mitochondrial activity in the insulin-resistant offspring of patients with Type2 diabetes. N Engl J Med 2004; 350: 664-671.
14. Mootha VK, Lindgren CM, Eriksson K-F, Subramanian A, Sihag S, Lehar J et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 2003; 34: 267-273.
15. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 2003; 100: 8466-8471.
16. Turner N, Heilbronn LK. Is mitochondrial dysfunction a cause of insulin resistance? Trends Endo Metab 2008; 19: 324-330.