The complexity of allergic patients' IgE repertoire correlates with serum concentration of allergen-specific IgE

Clinical and Experimental Allergy

Volumn 42, Issue 8, 2012, Pages 1227-1236

  Willumsen, N ^a   Holm, J ^a   Christensen, L H ^a   Wurtzen P A ^a   Lund, K ^a  

^a ALK ABELLÓ   (Denmark)

Author keywords

Allergic march; Allergy; Antibody clonality; Antibody binding affinity; Facilitated antigen presentation; IgE titre; IgE repertoire complexity; Recombinant IgE; Serum IgE repertoire; T cell activation

Indexed keywords

CD23 ANTIGEN; EPITOPE; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY;

ALLERGIC DISEASE; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CLINICAL ARTICLE; CLONAL VARIATION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; PRIORITY JOURNAL;

ALLERGENS; ANIMALS; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN-ANTIBODY COMPLEX; ANTIGENS, DERMATOPHAGOIDES; ARTHROPOD PROTEINS; B-LYMPHOCYTES; EPITOPES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; PROTEIN BINDING; PYROGLYPHIDAE; RECEPTORS, IGE; RECOMBINANT PROTEINS;

EID: 84864002906     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2012.04009.x     Document Type: Article

References (46)

1. Prussin C, Metcalfe DD. 5 IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2006; 117:S450-6.
2. Mudde GC, van Reijsen FC, Boland GJ, de Gast GC, Bruijnzeel PL, Bruijnzeel-Koomen CA. Allergen presentation by epidermal Langerhans' cells from patients with atopic dermatitis is mediated by IgE. Immunology 1990; 69:335-41.
3. Maurer D, Ebner C, Reininger B et al. The high affinity IgE receptor (Fc epsilon RI) mediates IgE-dependent allergen presentation. J Immunol 1995; 154:6285-90.
4. Lundberg K, Lindstedt M, Larsson K et al. Augmented Phl p 5-specific Th2 response after exposure of dendritic cells to allergen in complex with specific IgE compared to IgG1 and IgG4. Clin Immunol 2008; 128:358-65.
5. van der Heijden FL, Joost van Neerven RJ, van Katwijk M, Bos JD, Kapsenberg ML. Serum-IgE-facilitated allergen presentation in atopic disease. J Immunol 1993; 150:3643-50.
6. van der Heijden FL, van Neerven RJ, Kapsenberg ML. Relationship between facilitated allergen presentation and the presence of allergen-specific IgE in serum of atopic patients. Clin Exp Immunol 1995; 99:289-93.
7. van Neerven RJ, Wikborg T, Lund G et al. Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J Immunol 1999; 163:2944-52.
8. van Neerven RJ, van Roomen CP, Thomas WR, de Boer M, Knol EF, Davis FM. Humanized anti-IgE mAb Hu-901 prevents the activation of allergen-specific T cells. Int Arch Allergy Immunol 2001; 124:400-2.
9. Wachholz PA, Soni NK, Till SJ, Durham SR. Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy. J Allergy Clin Immunol 2003; 112:915-22.
10. Shamji MH, Wilcock LK, Wachholz PA et al. The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses. J Immunol Methods 2006; 317:71-9.
11. Wurtzen PA, Lund G, Lund K, Arvidsson M, Rak S, Ipsen H. A double-blind placebo-controlled birch allergy vaccination study II: correlation between inhibition of IgE binding, histamine release and facilitated allergen presentation. Clin Exp Allergy 2008; 38:1290-301.
12. Getahun A, Hjelm F, Heyman B. IgE enhances antibody and T cell responses in vivo via CD23+ B cells. J Immunol 2005; 175:1473-82.
13. van Neerven RJ, Knol EF, Ejrnaes A, Wurtzen PA. IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy. Int Arch Allergy Immunol 2006; 141:119-29.
14. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001; 107:891-6.
15. Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol 2005; 116:744-9.
16. Soderstrom L, Kober A, Ahlstedt S et al. A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases. Allergy 2003; 58:921-8.
17. Maloney JM, Rudengren M, Ahlstedt S, Bock SA, Sampson HA. The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. J Allergy Clin Immunol 2008; 122:145-51.
18. Nickelsen JA, Georgitis JW, Reisman RE. Lack of correlation between titers of serum allergen-specific IgE and symptoms in untreated patients with seasonal allergic rhinitis. J Allergy Clin Immunol 1986; 77:43-8.
19. Kerkhof M, Schouten JP, De Monchy JGR. The association of sensitization to inhalant allergens with allergy symptoms: the influence of bronchial hyperresponsiveness and blood eosinophil count. Clin Exp Allergy 2000; 30:1387-94.
20. Hamilton RG, Adkinson NF Jr. 23. Clinical laboratory assessment of IgE-dependent hypersensitivity. J Allergy Clin Immunol 2003; 111:S687-701.
21. Chen ST, Sun HL, Lu KH, Lue KH, Chou MC. Correlation of immunoglobulin E, eosinophil cationic protein, and eosinophil count with the severity of childhood perennial allergic rhinitis. J Microbiol Immunol Infect 2006; 39:212-8.
22. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol 2001; 108:S147-334.
23. Matricardi PM, Bockelbrink A, Keil T et al. Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort. Clin Exp Allergy 2009; 39:1551-7.
24. Christensen LH, Holm J, Lund G, Riise E, Lund K. Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge. J Allergy Clin Immunol 2008; 122:298-304.
25. Holm J, Willumsen N, Wurtzen PA, Christensen LH, Lund K. Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity. J Allergy Clin Immunol 2011; 127:1029-37.
26. Petersen AB, Gudmann P, Milvang-Gronager P et al. Performance evaluation of a specific IgE assay developed for the ADVIA centaur immunoassay system. Clin Biochem 2004; 37:882-92.
27. Christensen LH, Riise E, Bang L, Zhang C, Lund K. Isoallergen variations contribute to the overall complexity of effector cell degranulation: effect mediated through differentiated IgE affinity. J Immunol 2010; 184:4966-72.
28. Pierson-Mullany LK, Jackola DR, Blumenthal MN, Rosenberg A. Characterization of polyclonal allergen-specific IgE responses by affinity distributions. Mol Immunol 2000; 37:613-20.
29. Mueller GA, Smith AM, Chapman MD, Rule GS, Benjamin DC. Hydrogen exchange nuclear magnetic resonance spectroscopy mapping of antibody epitopes on the house dust mite allergen Der p 2. J Biol Chem 2001; 276:9359-65.
30. Mirza O, Henriksen A, Ipsen H et al. Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1. J Immunol 2000; 165:331-8.
31. Vanderlugt CL, Begolka WS, Neville KL et al. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunol Rev 1998; 164:63-72.
32. Powell AM, Black MM. Epitope spreading: protection from pathogens, but propagation of autoimmunity? Clin Exp Dermatol 2001; 26:427-33.
33. Neuberger MS, Ehrenstein MR, Rada C et al. Memory in the B-cell compartment: antibody affinity maturation. Philos Trans R Soc Lond B Biol Sci 2000; 355:357-60.
34. Mudde GC, Bheekha R, Bruijnzeel-Koomen CA. Consequences of IgE/CD23-mediated antigen presentation in allergy. Immunol Today 1995; 16:380-3.
35. Gould HJ, Sutton BJ. IgE in allergy and asthma today. Nat Rev Immunol 2008; 8:205-17.
36. Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol 2004; 113:776-82.
37. Flinterman AE, Knol EF, Lencer DA et al. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol 2008; 121:737-43.
38. Jarvinen KM, Beyer K, Vila L, Chatchatee P, Busse PJ, Sampson HA. B-cell epitopes as a screening instrument for persistent cow's milk allergy. J Allergy Clin Immunol 2002; 110:293-7.
39. Beyer K, Ellman-Grunther L, Jarvinen KM, Wood RA, Hourihane J, Sampson HA. Measurement of peptide-specific IgE as an additional tool in identifying patientswith clinical reactivity to peanuts. J Allergy Clin Immunol 2003; 112:202-7.
40. Lee MF, Tsai JJ, Hwang GY, Lin SJ, Chen YH. Identification of immunoglobulin E (IgE)-binding epitopes and recombinant IgE reactivities of a latex cross-reacting Indian jujube Ziz m 1 allergen. Clin Exp Immunol 2008; 152:464-71.
41. Kim KE, Rosenberg A, Roberts S, Blumenthal MN. The affinity of allergen specific IgE and the competition between IgE and IgG for the allergen in Amb a V sensitive individuals. Mol Immunol 1996; 33:873-80.
42. Hantusch B, Scholl I, Harwanegg C et al. Affinity determinations of purified IgE and IgG antibodies against the major pollen allergens Phl p 5a and Bet v 1a: discrepancy between IgE and IgG binding strength. Immunol Lett 2005; 97:81-9.
43. Jackola DR, Pierson-Mullany LK, Liebeler CL, Blumenthal MN, Rosenberg A. Variable binding affinities for allergen suggest a 'selective competition' among immunoglobulins in atopic and non-atopic humans. Mol Immunol 2002; 39:367-77.
44. Pierson-Mullany LK, Jackola DR, Blumenthal MN, Rosenberg A. Evidence of an affinity threshold for IgE-allergen binding in the percutaneous skin test reaction. Clin Exp Allergy 2002; 32:107-16.
45. Pastorello EA, Incorvaia C, Ortolani C et al. Studies on the relationship between the level of specific IgE antibodies and the clinical expression of allergy: I. Definition of levels distinguishing patients with symptomatic from patients with asymptomatic allergy to common aeroallergens. J Allergy Clin Immunol 1995; 96:580-7.
46. Asarnoj A, Ostblom E, Kull I et al. Sensitization to inhalant allergens between 4 and 8 years of age is a dynamic process: results from the BAMSE birth cohort. Clin Exp Allergy 2008; 38:1507-13.