The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in polish children

Journal of Physiology and Pharmacology

Volumn 63, Issue 3, 2012, Pages 241-248

  Luczynski, Wlodzimierz ^a   Zalewski, G ^a   Bossowski, A ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Blood pressure; Body mass; Cardiovascular risk factors; Fat mass and obesity associated gene polymorphism; Glucose level; Insulin resistance; Obesity; Overweight; Triglycerides

Indexed keywords

GLUCOSE; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ANTHROPOMETRIC PARAMETERS; ANTHROPOMETRY; ARM CIRCUMFERENCE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY HEIGHT; BODY MASS; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; CHILD; CONTROLLED STUDY; FEMALE; FTO GENE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HETEROZYGOSITY; HIP CIRCUMFERENCE; HOMOZYGOSITY; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; OBESITY; POLAND; PRESCHOOL CHILD; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADOLESCENT; ANTHROPOMETRY; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INSULIN RESISTANCE; MALE; OBESITY; POLAND; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84864000253     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Power C, Thomas C. Changes in BMI, duration of overweight and obesity, and glucose metabolism: 45 years of follow-up a birth cohort. Diabetes Care 2011; 34: 1986-1991.
2. Morrison JA, Friedman LA, Gray McGuire C. Metabolicsyndrome in childhood predicts adult cardiovascular disease 25 years late. The Princeton Lipid Research Clinics Followup Study. Pediatrics 2007; 120: 340-345.
3. Friedenberg FK, Tang DM, Vanar V, Mendonca T. Predictive value of body mass index at age 18 on adulthood obesity: results of a prospective survey of an urban population. Am J Med Sci 2011; 342: 371-382.
4. Bac A, Wozniacka R, Matusik S, Golec J, Golec E. Prevalence of overweight and obesity in children aged 6-13 years-alarming increase in obesity in Cracow, Poland. Eur J Pediatr 2012; 171: 245-251.
5. Kulaga Z, Litwin M, Tkaczyk M, et al. Polish 2010 growth references for school-aged children and adolescents. Eur J Pediatr 2011; 170: 599-609.
6. Wardle J, Carnell S, Haworth CM. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr 2008; 87: 398.
7. Zhao J, Grant SF. Genetics of childhood obesity. J Obesity 2011; 2011: 845148.
8. Hinney A, Vogel CI, Hebebrand J. From monogenic to polygenic obesity: recent advances. Eur Child Adolesc Psychiatry 2010; 19: 297-310.
9. Hetherington MM, Cecil JE. Gene-environment interactions in obesity. Forum Nutr 2010; 63: 195-203.
10. Day FR, Loos RJ. Developments in obesity genetics in the era of genome-wide association studies. J Nutrigenet Nutrigenomics 2011; 4: 222-238.
11. Peng S, Zhu Y, Xu F, Ren X, Li X, Lai M. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med 2011; 9: 71.
12. Frayling TM, Timpson NJ, Weedon MN, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894.
13. Kulaga Z, Litwin M, Zajaczkowska MM, et al. Comparison of waist and hip circumferences ranges in children and adolescents in Poland 7-18 y of age with cardiovascular risk thresholds initial results of OLAF project (PL0080). Standardy Medyczne 2008; 5: 473-485.
14. National Cholesterol Education Program (NCEP): highlights of the report of the expert panel on blood cholesterol levels in children and adolescents. Pediatrics 1992; 89: 495-501.
15. Tresaco B, Bueno G, Pineda I, Moreno LA, Garagorri JM, Bueno M. Homeostatic model assessment (HOMA) index cut-off values to identify the metabolic syndrome in children. J Physiol Biochem 2005; 61: 381-388.
16. Kulaga Z, Litwin M, Grajda A, et al. Distribution of blood pressure in school-aged children and adolescents reference population. Standardy Medyczne Pediatria 2010; 7: 100-111.
17. Loos RJ, Bouchard C. FTO: the first gene contributing to common forms of human obesity. Obes Rev 2008; 9: 246-250.
18. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000; 320: 1240.
19. Rolland-Cachera MF. Childhood obesity: current definitions and recommendations for their use. Int J Pediatr Obes 2011; 6: 325-331.
20. Bialokoz-Kalinowska I, Abramowicz P, Konstantynowicz JPiotrowska-Jastrzebska J. Assessment of the nutritional status in 7-10 years old children from Podlasie region. Pediatria Wspolczesna, Gastroenterologia, Hepatologia i Zywienie Dziecka 2007; 9: 127-129.
21. Poplawska H, Dmitruk A, Czeczuk A. Overweight and obesity incidence in rural girls and boys depending on their parents' education level. Zdr Publ 2007; 117: 54-58.
22. Chrzanowska M, Suder A. Changes in central fatness and abdominal obesity in children and adolescents from Cracow, Poland 1983-2000. Ann Hum Biol 2010; 37: 242-252.
23. Olds T, Maher C, Zumin S, et al. Evidence that the prevalence of childhood overweight is plateauing: data from nine countries. Int J Pediatr Obes 2011; 6: 342-360.
24. Plonka M, Toton-Morys A, Adamski P, et al. Association of the physical activity with leptin blood serum level, body mass indices and obesity in schoolgirls. J Physiol Pharmacol 2011; 62: 647-656.
25. Jacobsson JA, Danielsson P, Svensson V, et al. Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun 2008; 368: 476-482.
26. Yajnik CS, Janipalli CS, Bhaskar S, Kulkarni SR. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 2009; 52: 247-252.
27. Shimaoka I, Kamide K, Ohishi M, et al. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. Hypertens Res 2010; 33: 214-218.
28. Liu Y, Liu Z, Song Y, et al. Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. Obesity 2010; 18: 16191624.
29. Chang YC, Liu PH, Lee WJ, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes 2008; 57: 2245-2252.
30. Hardy R, Wills AK, Wong A, et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 2010; 19: 545-552.
31. Mei H, Chen W, Srinivasan SR, et al. FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI. Hum Genet 2010; 128: 589-596.
32. Hakanen M, Raitakari OT, Lehtimaki T, et al. FTO genotype is associated with body mass index after age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab 2009; 94: 1281-1287.
33. Pausova Z, Syme C, Abrahamowicz M, et al. A common variant of the FTO gene is associated not only with increased adiposity but also elevated blood pressure in French Canadians. Circ Cardiovasc Genet 2009; 2: 260-269.
34. Melka MG, Bernard M, Mahoubi A, et al. Genome-wide scan for loci of adolescent obesity and their relationship with blood pressure. J Clin Endocrinol Metab 2012; 97: 45-50.
35. Baik I, Shin C. Interactions between the FTO rs9939609 polymorphism, body mass index, and lifestyle-related factors on metabolic syndrome risk. Nutr Res Pract 2012; 6: 78-85.
36. Liu G, Zhu H, Dong Y, Podolsky RH, Treiber FA, Snieder H. Influence of common variant in FTO and near INSIG2 and MC4R on growth curves for adiposity in Africanand European-American youth. Eur J Epidemiol 2011; 26: 463-373.
37. Riffo B, Asenjo S, Saez K, et al. FTO gene is related to obesity in Chilean Amerindian children and impairs HOMAIR in prepubertal girls. Pediatr Diabetes 2011; Dec 5. Doi: 10.1111/j.1399-5448.2011.00834.x. (Epub ahead of print).
38. Attanoua R, Ait El Mkadem S, Lautier C, et al. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. Diabet Metab 2009; 35: 476-483.
39. Doney AS, Dannfald J, Kimber CH, et al. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (GoDARTS) study. Circ Cardiovasc Genet 2009; 2: 255-259.
40. Zimmermann E, Kring SII, Berentzen TL, et al. Fatnessassociated FTO gene variant increases mortality independent of fatness in cohorts of Danish Men. PLoS One 2009; 4: e4428.
41. Fang H, Li Y, Du S, et al. Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children. BMC Med Genet 2010; 11: 136.
42. Timpson NJ, Emmett PM, Frayling TM, et al. The fat massand obesity-associated locus and dietary intake in children. Am J Clin Nutr 2008; 88: 971-978.
43. Cecil JE, Tavendale R, Watt P, Hetherington MM, Palmer CN. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med 2008; 359: 2558-2566.
44. Hasselbalch AL, Angquist L, Christiansen L, Heitmann BL, Kyvik KO, Sorensen TI. A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. J Nutr 2010; 140: 831-834.
45. Tanofsky-Kraff M, Han JC, Anandalingam K, et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr 2009; 90: 1483-1488.
46. Wardle J, Carnell S, Haworth CM, Farooqi IS, O'Rahilly SPlomin R. Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab 2008; 93: 3640-3643.
47. Szczepanska-Sadowska E, Cudnoch-Jedrzejewska A, Ufnal MZera T. Brain and cardiovascular diseases:common neurogenic background of cardiovascular, metabolic and inflammatory diseases. J Physiol Pharmacol 2010; 61: 509-521.
48. Willer CJ, Speliotes EK, Loos RJF, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
49. Rendo T, Moleres A, del Moral AM. Effects of the FTO gene on lifestyle interwention studies in children. Obes Facts 2009; 2: 393-399.
50. Razquin C, Martinez JA, Martinez-Gonzalez MA, BesRastrollo M, Fernandez-Crehuet J, Marti A. A 3-year intervention with a Mediterranean diet modified the associoation between the rs9939609 gene variant in FTO and body weight changes. Int J Obes (Lond) 2010; 34: 266-272.
51. Reinehr T, Hinney A, Toschke AM, Hebebrand J. Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. Arch Dis Child 2009; 94: 965-967.
52. Muller TD, Hinney A, Scherag A, et al. Fat mass and obesity associated gene (FTO): no significant association of variant rs9939609 with weight loss in lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Med Genet 2008; 9: 85.
53. Tan S, Scherag A, Janssen OE, et al. Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variations in patients with polycystic ovary syndrome (PCOS). BMC Med Genet 2010; 11: 12.
54. Ma S, Frick KD. A simulation of affordability and effectiveness of childhood obesity interventions. Acad Pediatr 2011; 11: 342-350.