Cerebrospinal fluid neopterin as marker of the meningo-encephalitic stage of trypanosoma brucei gambiense sleeping sickness

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Tiberti, Natalia ^a   Hainard, Alexandre ^a   Lejon, Veerle ^b   Courtioux, Bertrand ^c   Matovu, Enock ^d   Enyaru, John Charles ^d   Robin, Xavier ^a   Turck, Natacha ^a   Kristensson, Krister ^e   Ngoyi, Dieudonné Mumba ^f   Vatunga, Gedeão M L ^g   Krishna, Sanjeev ^h   Büscher, Philippe ^b   Bisser, Sylvie ^c   Ndung'u, Joseph Mathu ⁱ   Sanchez, Jean Charles ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^c UNIVERSITÉ DE LIMOGES   (France)

^d MAKERERE UNIVERSITY   (Uganda)

^e KAROLINSKA INSTITUTE   (Sweden)

^f Institut National de Recherche Biomedicale   (Congo)

^g Instituto de Combate e Controlo das Tripanossomiases   (Angola)

^h ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

ⁱ FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL13 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; IMMUNOGLOBULIN M; INTERCELLULAR ADHESION MOLECULE 1; NEOPTERIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AFRICAN TRYPANOSOMIASIS; ANGOLA; AREA UNDER THE CURVE; ARTICLE; BABINSKI REFLEX; CEREBROSPINAL FLUID ANALYSIS; CHAD; CONTROLLED STUDY; DAYTIME SOMNOLENCE; DEMOCRATIC REPUBLIC CONGO; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FEMALE; GAIT DISORDER; HUMAN; IMMUNOASSAY; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MENINGOENCEPHALITIS; NEUROLOGIC DISEASE; PARASITE IDENTIFICATION; SENSORY DYSFUNCTION; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA GAMBIENSE;

ADULT; BIOLOGICAL MARKERS; COHORT STUDIES; FEMALE; HUMANS; IMMUNOGLOBULIN M; LEUKOCYTE COUNT; MALE; MENINGOENCEPHALITIS; NEOPTERIN; REPRODUCIBILITY OF RESULTS; TRYPANOSOMA BRUCEI GAMBIENSE; TRYPANOSOMIASIS, AFRICAN;

PROTOZOA; TRYPANOSOMA BRUCEI GAMBIENSE;

EID: 84863995553     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040909     Document Type: Article

References (38)

1. Brun R, Blum J, Chappuis F, Burri C, (2009) Human African trypanosomiasis. Lancet 375: 148-159.
2. Malvy D, Chappuis F, (2011) Sleeping sickness. Clin Microbiol Infect 17: 986-995.
3. Chappuis F, Loutan L, Simarro P, Lejon V, Buscher P, (2005) Options for field diagnosis of human african trypanosomiasis. Clin Microbiol Rev 18: 133-146.
4. Burri C, (2010) Chemotherapy against human African trypanosomiasis: is there a road to success? Parasitology 137: 1987-1994.
5. Moore AC, (2005) Prospects for improving African trypanosomiasis chemotherapy. J Infect Dis 191: 1793-1795.
6. WHO (2009) Model list of essential medicines (EML).
7. Priotto G, Kasparian S, Mutombo W, Ngouama D, Ghorashian S, et al. (2009) Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet 374: 56-64.
8. Simarro PP, Franco J, Diarra A, Postigo JA, Jannin J, (2012) Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis. Parasitology pp. 1-5.
9. Simarro PP, Diarra A, Ruiz Postigo JA, Franco JR, Jannin JG, (2011) The human African trypanosomiasis control and surveillance programme of the World Health Organization 2000-2009: the way forward. PLoS Negl Trop Dis 5: e1007.
10. Mugasa CM, Adams ER, Boer KR, Dyserinck HC, Buscher P, et al. (2012) Diagnostic accuracy of molecular amplification tests for human African trypanosomiasis-systematic review. PLoS Negl Trop Dis 6: e1438.
11. WHO (1998) Control and surveillance of African trypanosomiasis. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 881: I-VI, 1-114.
12. Kennedy PG, (2008) Diagnosing central nervous system trypanosomiasis: two stage or not to stage? Trans R Soc Trop Med Hyg 102: 306-307.
13. Kennedy PG, (2011) Difficulties in diagnostic staging of human African trypanosomiasis. J Neuroparasitol 2.
14. Doua F, Miezan TW, Sanon SingaroJR, Boa Yapo F, Baltz T, (1996) The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis. Am J Trop Med Hyg 55: 586-588.
15. Lejon V, Reiber H, Legros D, Dje N, Magnus E, et al. (2003) Intrathecal immune response pattern for improved diagnosis of central nervous system involvement in trypanosomiasis. J Infect Dis 187: 1475-1483.
16. Deborggraeve S, Lejon V, Ekangu RA, Mumba Ngoyi D, Pati Pyana P, et al. (2011) Diagnostic accuracy of PCR in gambiense sleeping sickness diagnosis, staging and post-treatment follow-up: a 2-year longitudinal study. PLoS Negl Trop Dis 5: e972.
17. Truc P, Jamonneau V, Cuny G, Frezil JL, (1999) Use of polymerase chain reaction in human African trypanosomiasis stage determination and follow-up. Bull World Health Organ 77: 745-748.
18. Lejon V, Legros D, Richer M, Ruiz JA, Jamonneau V, et al. (2002) IgM quantification in the cerebrospinal fluid of sleeping sickness patients by a latex card agglutination test. Trop Med Int Health 7: 685-692.
19. Bisser S, Lejon V, Preux PM, Bouteille B, Stanghellini A, et al. (2002) Blood-cerebrospinal fluid barrier and intrathecal immunoglobulins compared to field diagnosis of central nervous system involvement in sleeping sickness. J Neurol Sci 193: 127-135.
20. Lejon V, Buscher P, Sema NH, Magnus E, Van Meirvenne N, (1998) Human African trypanosomiasis: a latex agglutination field test for quantifying IgM in cerebrospinal fluid. Bull World Health Organ 76: 553-558.
21. Kristensson K, Nygard M, Bertini G, Bentivoglio M, (2010) African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions. Prog Neurobiol 91: 152-171.
22. Amin DN, Rottenberg ME, Thomsen AR, Mumba D, Fenger C, et al. (2009) Expression and role of CXCL10 during the encephalitic stage of experimental and clinical African trypanosomiasis. J Infect Dis 200: 1556-1565.
23. Amin DN, Ngoyi DM, Nhkwachi GM, Palomba M, Rottenberg M, et al. (2010) Identification of stage biomarkers for human African trypanosomiasis. Am J Trop Med Hyg 82: 983-990.
24. Hainard A, Tiberti N, Robin X, Lejon V, Ngoyi DM, et al. (2009) A combined CXCL10, CXCL8 and H-FABP panel for the staging of human African trypanosomiasis patients. PLoS Negl Trop Dis 3: e459.
25. Courtioux B, Pervieux L, Vatunga G, Marin B, Josenando T, et al. (2009) Increased CXCL-13 levels in human African trypanosomiasis meningo-encephalitis. Trop Med Int Health 14: 529-534.
26. Hainard A, Tiberti N, Robin X, Ngoyi DM, Matovu E, et al. (2011) Matrix metalloproteinase-9 and intercellular adhesion molecule 1 are powerful staging markers for human African trypanosomiasis. Trop Med Int Health 16: 119-126.
27. Tiberti N, Hainard A, Lejon V, Robin X, Ngoyi DM, et al. (2010) Discovery and verification of osteopontin and Beta-2-microglobulin as promising markers for staging human African trypanosomiasis. Mol Cell Proteomics 9: 2783-2795.
28. Hoffmann G, Wirleitner B, Fuchs D, (2003) Potential role of immune system activation-associated production of neopterin derivatives in humans. Inflamm Res 52: 313-321.
29. Maclean L, Odiit M, Sternberg JM, (2006) Intrathecal cytokine responses in Trypanosoma brucei rhodesiense sleeping sickness patients. Trans R Soc Trop Med Hyg 100: 270-275.
30. Mumba Ngoyi D, Lejon V, Pyana P, Boelaert M, Ilunga M, et al. (2010) How to shorten patient follow-up after treatment for Trypanosoma brucei gambiense sleeping sickness. J Infect Dis 201: 453-463.
31. Miezan TW, Meda HA, Doua F, Dje NN, Lejon V, et al. (2000) Single centrifugation of cerebrospinal fluid in a sealed pasteur pipette for simple, rapid and sensitive detection of trypanosomes. Trans R Soc Trop Med Hyg 94: 293.
32. Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, et al. (2011) pROC: an open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics 12: 77.
33. Kennedy PG, (2010) Novel biomarkers for late-stage human African trypanosomiasis-the search goes on. Am J Trop Med Hyg 82: 981-982.
34. Lejon V, Legros D, Savignoni A, Etchegorry MG, Mbulamberi D, et al. (2003) Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with pentamidine. J Neuroimmunol 144: 132-138.
35. Sucher R, Schroecksnadel K, Weiss G, Margreiter R, Fuchs D, et al. (2010) Neopterin, a prognostic marker in human malignancies. Cancer Lett 287: 13-22.
36. Hagberg L, Cinque P, Gisslen M, Brew BJ, Spudich S, et al. (2010) Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection. AIDS Res Ther 7: 15.
37. Agranoff D, Fernandez-Reyes D, Papadopoulos MC, Rojas SA, Herbster M, et al. (2006) Identification of diagnostic markers for tuberculosis by proteomic fingerprinting of serum. Lancet 368: 1012-1021.
38. Buhrer-Sekula S, Hamerlinck FF, Out TA, Bordewijk LG, Klatser PR, (2000) Simple dipstick assay for semi-quantitative detection of neopterin in sera. J Immunol Methods 238: 55-58.