Neuro-inflammatory risk factors for treatment failure in "early second stage" sleeping sickness patients treated with Pentamidine

Journal of Neuroimmunology

Volumn 144, Issue 1-2, 2003, Pages 132-138

  Lejon, Veerle ^a   Legros, Dominique ^b   Savignoni, Alexia ^b   Etchegorry, Marc Gastellu ^c   Mbulamberi, Dawson ^d   Büscher, Philippe ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b EPICENTRE   (France)

^c MÉDECINS SANS FRONTIÈRES   (Switzerland)

^d Natl Sleeping Sickness Contr Prog   (Uganda)

Author keywords

Card agglutination; Cerebrospinal fluid; IgM; Intrathecal humoral immune response; Pentamidine; Treatment failure; Trypanosoma brucei gambiense

Indexed keywords

IMMUNOGLOBULIN M; PENTAMIDINE;

ADOLESCENT; ADULT; AFRICAN TRYPANOSOMIASIS; AGGLUTINATION TEST; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BRAIN INFECTION; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; MAJOR CLINICAL STUDY; MEDICAL DECISION MAKING; PRIORITY JOURNAL; PROTEIN DETERMINATION; RISK FACTOR; TREATMENT FAILURE; TREATMENT OUTCOME; TRYPANOSOMA BRUCEI;

EID: 0142195838     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2003.08.033     Document Type: Article

References (32)

1. Andersson M., Alvarez-Cermeno J., Bernardi G., Cogato I., Fredman P., Frederiksen J.L., Frederikson S., Gallo P., Grimaldi L.M., Gronning M., Keir G., Lamers K., Link H., Magalhães A., Massaro A.R., Öhman S., Reiber H., Rönnbäck L., Schluep M., Schuller E., Sindic C.J.M., Thompson E.J., Trojano M., Wurster U. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J. Neurol. Neurosurg. Psychiatry. 57:1994;897-902.
2. Bisser S., Bouteille B., Sarda J., Stanghellini A., Ricard D., Jauberteau M.O., Marchan F., Dumas M., Breton J.C. Apport des examens biochimiques dans le diagnostic de la phase nerveuse de la trypanosomose humaine. Bull. Soc. Pathol. Exot. Fil. 90:1997;321-326.
3. Bisser S., Lejon V., Preux P.M., Bouteille B., Stanghellini A., Jauberteau M.O., Büscher P., Dumas M. Blood-cerebrospinal fluid barrier and intrathecal immunoglobulins compared to field diagnosis of central nervous system involvement in sleeping sickness. J. Neurol. Sci. 193:2002;127-135.
4. Bronner U., Doua F., Ericsson O., Gustafsson L.L., Miézan T.W., Rais M., Rombo L. Pentamidine concentrations in plasma, whole blood and cerebrospinal fluid during treatment of Trypanosoma gambiense infection in Côte d'Ivoire. Trans. R. Soc. Trop. Med. Hyg. 85:1991;608-611.
5. Büscher P., Lejon V., Magnus E., Van Meirvenne N. Improved latex agglutination test for detection of antibodies in serum and cerebrospinal fluid of Trypanosoma brucei gambiense infected patients. Acta Trop. 73:1999;11-20.
6. Cattand P., Miezan B.T., de Raadt P. Human African trypanosomiasis: use of double centrifugation of cerebrospinal fluid to detect trypanosomes. Bull. World Health Organ. 66:1988;83-86.
7. Doua F., Miezan T.W., Sanon S.R., Boa Y.F., Baltz T. The efficacy of pentamidine in the treatment of early-late stage Trypanosoma brucei gambiense trypanosomiasis. Am. J. Trop. Med. Hyg. 55:1996;586-588.
8. Felgenhauer K., Reiber H. The diagnostic significance of antibody specificity indices in multiple sclerosis and herpes virus induced diseases of the nervous system. Clin. Investig. 70:1992;28-37.
9. Greenwood B.M., Whittle H.C. Cerebrospinal-fluid IgM in patients with sleeping-sickness. Lancet. 2:1973;525-527.
10. Knobloch J., Tischendorf F., König J., Mehlitz D. Evaluation of immunoassays for diagnosis and management of sleeping sickness in Liberia. Tropenmed. Parasitol. 35:1984;137-140.
11. Lambert P.H., Berney M., Kazyumba G. Immune complexes in serum and in cerebrospinal fluid in African trypanosomiasis. Correlation with polyclonal B cell activation and with intracerebral immunoglobulin synthesis. J. Clin. Invest. 67:1981;77-85.
12. Lejon V., Büscher P., Magnus E., Moons A., Wouters I., Van Meirvenne N. A semi-quantitative ELISA for detection of Trypanosoma brucei gambiense specific antibodies in serum and cerebrospinal fluid of sleeping sickness patients. Acta Trop. 69:1998;151-164.
13. Lejon V., Legros D., Richer M., Ruiz J.A., Jamonneau V., Doua F., Djé N., N'Siesi F.X., Bisser S., Magnus E., Wouters I., Konings J., Vervoort T., Sultan F., Büscher P. IgM quantification in the cerebrospinal fluid of sleeping sickness patients by a latex card agglutination test. Trop. Med. Int. Health. 7:2002;685-692.
14. Lejon V., Reiber H., Legros D., Djé N., Magnus E., Wouters I., Sindic C., Büscher P. Intrathecal immune response pattern for improved diagnosis of central nervous system involvement in trypanosomiasis. J. Infect. Dis. 187:2003;1475-1483.
15. Lourie E.M. Treatment of sleeping sickness in Sierra Leone. Trop. Med. Parasitol. 36:1942;113-131.
16. Lucasse C. Fluorescent antibody test as applied to cerebrospinal fluid in human sleeping sickness. Bull. Soc. Pathol. Exot. Fil. 57:1964;283-292.
17. Matovu E., Enyaru J.C.K., Legros D., Schmid C., Seebeck T., Kaminsky R. Melarsoprol refractory T.b. gambiense from Omugo, north-western Uganda. Trop. Med. Int. Health. 6:2001;407-411.
18. Matovu E., Geiser F., Schneider V., Mäser P., Enyaru J.C.K., Kaminsky R., Gallati S., Seebeck T. Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy. Mol. Biochem. Parasitol. 117:2001;73-81.
19. Mattern P. Etat actuel et résultats des techniques immunologiques utilisées à l'Institut Pasteur de Dakar pour le diagnostic et l'étude de la trypanosomiase humaine africaine. Bull. World Health Organ. 38:1968;1-8.
20. Miézan T.W., Meda H.A., Doua F., Yapo F.B., Baltz T. Assessment of central nervous system involvement in gambiense trypanosomiasis: value of the cerebro-spinal white cell count. Trop. Med. Int. Health. 3:1998;571-575.
21. Nantulya V.M., Doua F., Molisho D. Diagnosis of Trypanosoma brucei gambiense sleeping sickness using an antigen detection enzyme-linked immunosorbent assay. Trans. R. Soc. Trop. Med. Hyg. 86:1992;42-45.
22. Pépin J., Milord F. The treatment of human African trypanosomiasis. Adv. Parasitol. 33:1994;2-49.
23. Reiber H., Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin. Chem. 37:1991;1153-1160.
24. Reiber H., Peter J.B. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J. Neurol. Sci. 184:2001;101-122.
25. Ruiz J.A., Simarro P.P., Josenando T. Control of human African trypanosomiasis in the Quiçama focus, Angola. Bull. World Health Organ. 80:2002;738-745.
26. Schultzberg M., Ambatsis M., Samuelsson E.-B., Kristensson K., Van Meirvenne N. Spread of Trypanosoma brucei to the nervous system: early attack on circumventricular organs and sensory ganglia. J. Neurosci. Res. 21:1988;56-61.
27. Stanghellini A., Josenando T. The situation of sleeping sickness in Angola: a calamity. Trop. Med. Int. Health. 6:2001;330-334.
28. Truc P., Jamonneau V., Cuny G., Frézil J.L. Use of polymerase chain reaction in human African trypanosomiasis stage determination and follow-up. Bull. World Health Organ. 77:1999;745-748.
29. Tumani H., Nölker G., Reiber H. Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis. Neurology. 45:1995;1663-1670.
30. Van Nieuwenhove S. Present strategies in the treatment of human African trypanosomiasis. Dumas M., Bouteille B., Buguet A. Progress in Human African Trypanosomiasis, Sleeping Sickness. 1999;253-281 Springer, Paris.
31. Whittle H.C., Greenwood B.M., Bidwell D.E., Bartlett A., Voller A. IgM and antibody measurement in the diagnosis and management of Gambian trypanosomiasis. Am. J. Trop. Med. Hyg. 26:1977;1129-1135.
32. WHO, 1998. Control and surveillance of African trypanosomiasis. WHO Technical Report Series 881, 1-113.