Intracellular retention of ABL kinase inhibitors determines commitment to apoptosis in CML cells

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Lipka, Daniel B ^a,b   Wagner, Marie Christine ^a   Dziadosz, Marek ^a   Schnöder, Tina ^a   Heidel, Florian ^a   Schemionek, Mirle ^c,d   Melo, Junia V ^e,f   Kindler, Thomas ^g   Müller Tidow, Carsten ^c   Koschmieder, Steffen ^c,d   Fischer, Thomas ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY OF AACHEN MEDICAL CENTER   (Germany)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BCR ABL PROTEIN; DASATINIB; IMATINIB; PROTEIN TYROSINE KINASE; STAT5 PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; CELL POPULATION; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG RETENTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN TARGETING;

ANNEXIN A5; APOPTOSIS; ATP-BINDING CASSETTE TRANSPORTERS; CASPASE 3; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTRACELLULAR SPACE; KINETICS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84863994296     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040853     Document Type: Article

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