Polymorphisms in the multidrug resistance gene MDR1 (ABCB1) predict for molecular resistance in patients with newly diagnosed chronic myeloid leukemia receiving high-dose imatinib

Blood

Volumn 116, Issue 26, 2010, Pages 6144-6145

  Deenik, Wendy ^a   Van Der Holt, Bronno ^b   Janssen, Jeroen J W M ^c   Chu, Isabel W T ^a   Valk, Peter J M ^a   Ossenkoppele, Gert J ^c   Van Der Heiden, Ilse P ^a   Sonneveld, Pieter ^a   Van Schaik, Ron H N ^a   Cornelissen, Jan J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB;

CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; DRUG MEGADOSE; GENE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LETTER; MOLECULAR RESISTANCE; MULTIDRUG RESISTANCE; MULTIVARIATE ANALYSIS; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; UNIVARIATE ANALYSIS;

EID: 78650630752     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-07-296954     Document Type: Letter

References (6)

1. Dulucq S, Bouchet S, Turcq B, et al. Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood. 2008;112(5):2024-2027.
2. Deenik W, van der Holt B, Verhoef GEG, et al. Dose-finding study of imatinib in combination with intravenous cytarabine: feasibility in newly diagnosed patients with chronic myeloid leukemia. Blood. 2008;111(5):2581-2588.
3. Deenik W, Janssen JJWM, van der Holt B, et al. Efficacy of escalated imatinib combined with cytarabine in newly diagnosed patients with chronic myeloid leukemia. Haematologica. 2010;95(6):914-921.
4. Kim RB, Leake BF, Choo EF, et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther. 2001;70(2):189-199.
5. Gurney H, Wong M, Balleine RL, et al. Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype. Clin Pharmacol Ther. 2007;82(1):33-40.
6. Ni LN, Li JY, Miao KR, et al. Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemia [published online ahead of print March 4, 2010]. Med Oncol. doi:10.1007/s12032- 010-9456-9.