Dynamics of salivary proteins and metabolites during extreme endurance sports - a case study

Proteomics

Volumn 12, Issue 13, 2012, Pages 2221-2235

  Zauber, Henrik ^a   Mosler, Stephan ^a,b   Heßberg, Andreas von ^a,c   Schulze, Waltraud X ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PLANT PHYSIOLOGY   (Germany)

^b NONE   (Germany)

^c NONE   (Germany)

Author keywords

Biomedicine; Diurnal rhythm; Endurance sports; Metabolomics; Saliva

Indexed keywords

AMYLASE; CREATININE; GLUCOSE; IMMUNOGLOBULIN; LYSOZYME; SALIVA PROTEIN;

ADULT; ARTICLE; CYCLING; ENDURANCE SPORT; ENDURANCE TRAINING; ENERGY CONSUMPTION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; METABOLOMICS; MOLECULAR DYNAMICS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SALIVA ANALYSIS;

EID: 84863992311     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201100228     Document Type: Article

References (65)

1. Huq, N., Cross, K., Ung, M., Myroforidis, H. et al., A review of the salivary proteome and peptidome and saliva-derived peptide therapeutics. Int. J. Peptide Res. Ther. 2007, 13, 547-564.
2. Loo, J. A., Yan, W., Ramachandran, P., Wong, D. T., Comparative human salivary and plasma proteomes. J. Dental Res. 2010, 89, 1016-1023.
3. Humphrey, S., Williamson, R., A review of saliva: normal composition, flow and function. J. Prosthet. Dent. 2001, 2, 162-169.
4. Schipper, R., Silletti, E., Vingerhoeds, M., Saliva as research material: biochemical, physicochemical and practical aspects. Arch. Oral Biol. 2007, 52, 1114-1135.
5. Tirumalai, R., Chan, K., Prieto, D., Issaq, H., Characterization of the low molecular weight human serum proteome. Mol. Cell. Proteomics 2003, 2, 1096-1103.
6. Hu, S., Loo, J., Wong, D., Human body fluid proteome analysis. Proteomics 2006, 6, 6326-6353.
7. Robinson, S., Niles, R. K., Witkowska, H. E., Rittenbach, K. J. et al., A mass spectrometry-based strategy for detecting and characterizing endogenous proteinase activities in complex biological samples. Proteomics 2008, 8, 435-445.
8. Vitorino, R., Barros, A., Caseiro, A., Domingues, P., Towards defining the whole salivar peptidome. Proteomics Clin. Appl. 2009, 3, 528-540.
9. Actis, A., Perovic, N., Defago, D., Beccacecce, C., Fatty acid profile of human saliva: a possible indicator of dietary fat intake. Archives Oral Biol. 2005, 50, 1-6.
10. Chiappin, S., Antonelli, G., Gatti, R., Palo, E. D., Saliva specimen: a new laboratory tool for diagnostic and basic investigation. Clin. Chim. Acta 2007, 383, 30-40.
11. Guan, Y., Chu, Q., Ye, J., Determination of uric acid in human saliva by capillary electrophoresis with electrochemical detection: potential application in fast diagnosis of gout. Anal. Bioanal. Chem. 2004, 308, 813-917.
12. Lloyd, J., Broughton, A., Selby, C., Salivary creatinine assays as potential screen for renal diesease. Ann. Clin. Biochem. 1996, 33, 428-431.
13. Nagler, R., Hershkovich, O., Lischinsky, S., Diamond, E., Saliva analysis in the clinical setting: revisiting an underused diagnostic tool. J. Invest. Med. 2002, 50, 214-225.
14. Walsh, M., Brennan, L., Malthouse, J., Roche, H., Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. Am. J. Clin. Nutr. 2006, 84, 531-539.
15. Beato, M., Chavez, S., Truss, M., Transcriptional regulation by steroid hormones. Steroids 1996, 61, 240-251.
16. Pratt, W., Toft, D., Steroid receptor interactions with heat shock protein and immuniphilin chaperones 1. Endocr Rev. 1997, 18, 306-360.
17. Vining, R., McGinley, R., Symons, R., Hormones in saliva: mode of entry and consequent implications for clinical interpretations. Clin. Chem. 1983, 29, 1752-1756.
18. Hofman, L., Human saliva as a diagnostic specimen 1. J. Nutr. 2001, 131, 1621S-1625S.
19. Nater, U., Marca, R. L., Florin, L., Moses, A., Stress-induced changes in human salivary alpha-amylase activity - associations with adrenergic activity. Psychoneuroendocrinology 2006, 31, 49-58.
20. Gröschl, M., Current status of salivary hormone analysis. Clin. Chem. 2008, 54, 1759-1769.
21. Denny, P., Hagen, F. K., Hardt, M., Liao, L. et al., The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions. J. Proteome Res. 2008, 7, 1994-2006.
22. Castagnola, M., Inzitari, R., Fanali, C., Iavarone, F. et al., The surprising composition of the salivary proteome of preterm human newborn. Mol. Cell Proteomics 2011, 10, M110.003467.
23. Salih, E., Siqueira, W. L., Helmerhorst, E. J., Oppenheim, F. G., Large-scale phosphoproteome of human whole saliva using disulfide-thiol interchange covalent chromatography and mass spectrometry. Anal. Biochem. 2010, 407, 19-33.
24. Bandhakavi, S., Stone, M. D., Onsongo, G., van Riper, S. K. et al., A dynamic range compression and three-dimensional peptide fractionation analysis platform expands proteome coverage and the diagnostic potential of whole saliva. J. Proteome Res. 2009, 8, 5590-6000.
25. Haigh, B. J., Stewart, K. W., Whelan, J. R., Barnett, M. P. et al., Alterations in the salivary proteome associated with periodontitis. J. Clin. Periodontol. 2010, 37, 241-247.
26. Rao, P. V., Reddy, A. P., Lu, X., Dasari, S. et al., Proteomic identification of salivary biomarkers of type-2 diabetes. J. Proteome Res. 2009, 8, 239-245.
27. Hu, S., Arellano, M., Boontheung, P., Wang, J. et al., Salivary proteomics for oral cancer biomarker discovery. Clin. Cancer Res. 2008, 14, 6246-6252.
28. Lippi, G., De Vita, F., Salvagno, G. L., Gelati, M. et al., Measurement of morning saliva cortisol in athletes. Clin. Biochem. 2009, 42, 904-906.
29. Kon, M., Iizuka, T., Maegawa, T., Hashimoto, E. et al., Salivary secretory immunoglobulin A response of elite speed skaters during a competition period. J. Strength Cond. Res. 2010, 24, 2249-2254.
30. Moreira, A., Arsati, F., Cury, P. R., Franciscon, C., et al., Salivary immunoglobulin a response to a match in top-level brazilian soccer players. J. Strength Cond. Res. 2009, 23, 1968-1973.
31. Weckwerth, W., Wenzel, K., Fiehn, O., Process for the integrated extraction, identification and quantification of metabolites, proteins and RNA to reveal their co-regulation in biochemical networks. Proteomics 2004, 4, 78-83.
32. Ishihama, Y., Rappsilber, J., Mann, M., Modular stop and go extraction tips with stacked disks for parallel and multidimensional peptide fractionation in proteomics. J. Proteome Res. 2006, 5, 988-994.
33. Erban, A., Schauer, N., Fernie, A. R., Kopka, J., in: Weckwerth, W. (Ed.), Metabolomics: Methods and Protocols, Humana Press, Totowa 2006, pp. 19-39.
34. Ishihama, Y., Oda, Y., Tabata, T., Sato, T. et al., Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol. Cell Proteomics 2005, 4, 1265-1272.
35. Andersen, J. S., Wilkinson, C. J., Myoru, T., Mortensen, P. et al., Proteomic characterization of the human centrosome by protein correlation profiling. Nature 2003, 426, 570-574.
36. Schulze, W., Usadel, B., Quantitation in mass-spectrometry-based proteomics. Annu. Rev. Plant Biol. 2010, 61, 491-516.
37. Kopka, J., Schauer, N., Krüger, S., Birkemeyer, C. et al., GMD@CSBDB: the Golm Metabolome database. Bioinformatics 2005, 21, 1635-1638.
38. Schauer, N., Steinhauser, D., Strelkov, S., Schomburg, D. et al., GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett. 2005, 579, 1332-1337.
39. Lüdemann, A., Strassburger, K., Erban, A., Kopka, J., TagFinder for the quantitative analysis of gras chromatography-mass spectrometry (GC-MS)-based metabolite profiling experiments. Bioinformatics 2008, 24, 732-737.
40. Team, R. D. C., R: A languange and Environment for Statistical Computing, R Foundation for Statistical Computing, Vienna 2009.
41. Thomas, P. D., Campbell, M. J., Kejariwal, A., Mi, H. et al., PANTHER: a library of protein families and subfamilies indexed by function. Genome Res. 2003, 13, 2129-2141.
42. Quintana, M., Palicki, O., Lucchi, G., Ducoroy, P. et al., Inter-individual variability of protein patterns in saliva of healthy adults. J. Proteomics 2009, 72, 822-830.
43. Nagaraj, N., Mann, M., Quantitative analysis of the intra- and inter-individual variability of the normal urinary proteome. J. Proteome Res. 2011, 10, 637-645.
44. Wilmore, J. H., Costill, D. L., Kenney, W. L., Physiology of Sports and Exercise, Human Kinetics, Champaign, IL, USA 2008.
45. Nater, U. M., Rohleder, N., Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research. Psychoneuroendocrinology 2009, 34, 486-496.
46. Antharaman, V., Aravind, L., Novel conserved domains in protiens with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability. BMC Genomics 2004, 5, 1-12.
47. Gandini, R., Dossena, S., Vezzoli, V., Tamplenizza, M. et al., LSM4 associates with the plasma membrane and acts as a co-factor in cell volume regulation. Cell Physiol. Biochem. 2008, 22, 579-590.
48. der Voorn, L. V., Ploegh, H., The WD-40 repeat. FEBS Lett. 1992, 307, 131-134.
49. Robinovitch, M. R., Ashley, R. L., Iversen, J. M., Vigoren, E. M. et al., Parotid salivary basic proline-rich proteins inhibit HIV-I infectivity. Oral Dis. 2001, 7, 86-93.
50. Malamud, D., Wahl, S. M., The mouth: a gateway or a trap for HIV? AIDS 2010, 24, 5-16.
51. Kanagawa, M., Satoh, T., Ikeda, A., Nakano, Y. et al., Crystal structures of human secretory proteins ZG16p and ZG16b reveal a Jacalin-related β-prism fold. Biochem. Biophys. Res. Commun. 2011, 404, 201-205.
52. Nozaki, S., Tanaka, M., Mizuno, K., Ataka, S. et al., Mental and physical fatigue-related biochemical alterations. Nutrition 2009, 25, 51-57.
53. Suh, S. H., Paik, I. Y., Jacobs, K. J., Regulation of blood glucose homeostasis during prolonged exercise. Mol. Cell 2007, 23, 272-279.
54. Mastorakos, G., Pavlatou, M., Diamanti-Kandarakis, E., Chrousos, G. P., Exercise and the stress system. Hormones 2005, 4, 73-89.
55. Hechter, O., Grossman, A., Chatterton, R. T., Relationship of dehydroenpiandrosterone and cortisol in disease. Med. Hypotheses 1997, 49, 85-91.
56. Tremblay, M. S., Copeland, J. L., van Helder, W., Influence of exercise duration on post-exercise steroid responses in trained males. Eur. J. Appl. Physiol. 2005, 94, 505-513.
57. Hill, E. E., Zack, E., Battaglini, C., Viru, M. et al., Exercise and circulating cortisol levels: the intensity threshold effect. J. Endocrinol. Invest. 2008, 31, 587-591.
58. Opstad, K., Circadian rhythm of hormones is extinguished during prolonged physical stress, sleep and energy deficiency in young men. Eur. J. Endocrinol. 1994, 131, 56-66.
59. Neubauer, O., König, D., Wagner, K. H., Recovery after an Ironman triathlon: sustained inflammatory responses and muscular stress. Eur. J. Appl. Physiol. 2008, 104, 417-426.
60. Bobbert, T., Brechtel, L., Mai, K., Otto, B. et al., Adaptation of the hypothalamic-pituitary hormones during intensive endurance training. Clin. Endocrinol. 2005, 63, 530-536.
61. Gundersen, Y., Opstad, P. K., Reistad, T., Thrane, I. et al., Seven days' around the clock exhaustive physical exertion combined with energy depletion and sleep deprivation primes circulating leukocytes. Eur. J. Appl. Physiol. 2006, 97, 151-157.
62. Van Westerloo, D. J., Choi, G., Löwenberg, E. C., Truijen, J. et al., Acute stress elicited by bungee jumping suppresses human innate immunity. Mol. Med. 2010, 17, 180-188.
63. Fisher-Wellman, K., Bloomer, R. J., Acute exercise and oxidative stress: a 30 year history. Dynamic Med. 2009, 8, 1-25.
64. Paterson, J. R., Baxter, G., Dreyer, J. S., Halket, J. M. et al., Salicylic acid sans aspirin in animals and man: persistence in fasting and biosynthesis from benzoic acid. J. Agric. Food Chem. 2008, 56, 11648-11652.
65. Jauniaux, E., Hempstock, J., Teng, C., Battaglia, F. C. et al., Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: Maintenance of redox potential in a low oxygen environment. J. Clin. Endocrinol. Metab. 2005, 90, 1171-1175.