TNFα-mediated apoptosis in human osteoarthritic chondrocytes sensitized by PI3K-NF-κB inhibitor, not mTOR inhibitor

Rheumatology International

Volumn 32, Issue 7, 2012, Pages 2017-2022

  Li, Deling ^a,b   Wu, Zhihong ^a   Duan, Yuanhui ^a   Hao, Dongsheng ^a   Zhang, Xinbo ^c   Luo, Hui ^c   Chen, Baosheng ^c   Qiu, Guixing ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Apoptosis; Chondrocytes; Mammalian target of rapamycin; NF B; Phosphoinositide 3 kinase; Tumor necrosis factor

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; FLICE INHIBITORY PROTEIN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RAPAMYCIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL STIMULATION; CELL VIABILITY; DOWN REGULATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

AGED; APOPTOSIS; BUTADIENES; CAFFEIC ACIDS; CASPASE 3; CELLS, CULTURED; CHONDROCYTES; CHROMONES; FEMALE; HUMANS; MIDDLE AGED; MORPHOLINES; NF-KAPPA B; NITRILES; OSTEOARTHRITIS; PHENYLETHYL ALCOHOL; PHOSPHATIDYLINOSITOL 3-KINASES; POLY(ADP-RIBOSE) POLYMERASES; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863989011     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-011-1929-4     Document Type: Article

References (33)

1. Felson DT (2008) Comparing the prevalence of rheumatic disease in China with the rest of the world. Arthr Res Ther 10(1):1-2
2. Samuels J, Krasnokutsky S, Abramson SB (2008) Osteoarthritis: A tale of three tissues. Bull NYU Hosp Joint Dis 66(3):244-250
3. Carames B, Lopez-Armada MJ, Cillero-Pastor B, Lires-Dean M, Vaamonde C, Galdo F et al (2008) DiVerential eVects of tumor necrosis factor-Alpha and interleukin-1beta on cell death in human articular chondrocytes. Osteoarthr Cartil 16(6):715-722 (Pubitemid 351753713)
4. John T, Muller RD, Oberholzer A, Zreiqat H, Kohl B, Ertel W et al (2007) Interleukin-10 modulates pro-Apoptotic eVects of TNFalpha in human articular chondrocytes in vitro. Cytokine 40(3):226-234 (Pubitemid 350213435)
5. Lee SW, Lee HJ, Chung WT, Choi SM, Rhyu SH, Kim DK et al (2004) TRAIL induces apoptosis of chondrocytes and inXuences the pathogenesis of experimentally induced rat osteoarthritis. Arthritis Rheum 50(2):534-542 (Pubitemid 38198837)
6. Seigio S (2008) Increased levels of apo-A1 and apo B are associated in knee osteoarthritis: Lack of association with VEGF-460 T/C and +405 C/G polymorphisms. Rheumatol Int 29:63-68
7. Mounach A (2008) Risk factors for knee osteoarthritis in Morocco. A case control study. Clin Rheumatol 27:323-326
8. Lalichman K (2007) Age, body composition, and reproductive indices as predictors of radiographic hand osteoarthritis in Chuvashian women. Scand J Rheumatol 36:53-57
9. Dahaghin S (2007) Do metabolic factors add to the eVect of overweight on hand osteoarthritis? The Rotterdam study. Ann Rheum Dis 66:916-920 (Pubitemid 46999793)
10. Nieto-Vazquez I, Fernandez-Veledo S, Kramer DK (2008) Insulin resistance associated to obesity: The link TNF-Alpha. Archives Physiol Biochem 114(3):183-194 (Pubitemid 352009305)
11. Hussein MR, Fathi NA, El-Din AM, Hassan HI, Abdullah F, Al-Hakeem E et al (2008) Alterations of the CD4(+), CD8(+) T cell subsets, interleukins-1beta, IL-10, IL-17, tumor necrosis factor-Alpha and soluble intercellular adhesion molecule-1 in rheumatoid arthritis and osteoarthritis: Preliminary observations. Pathol Oncol Res 14(3):321-328
12. Hulejova H, Baresova V, Klezl Z, Polanska M, Adam M, Senolt L (2007) Increased level of cytokines and matrix metalloproteinases in osteoarthritic subchondral bone. Cytokine 38(3):151-156 (Pubitemid 47248299)
13. Penninx BW, Abbas H, Ambrosius W, Nicklas BJ, Davis C, Messier SP et al (2004) InXammatory markers and physical function among older adults with knee osteoarthritis. J Rheumatol 31(10):2027-2031 (Pubitemid 39336730)
14. Urech DM (2010) Anti-inXammatory and cartilage-protecting eVfects of an intra-Articularly injected anti-TNFa single-chain Fv antibody (ESBA105) designed for local therapeutic use. Ann Rheum Dis 69:443-449
15. Clohisy JC, Roy BC, Biondo C, Frazier E, Willis D, Teitelbaum SL et al (2003) Direct inhibition of NF-kappaB blocks bone erosion associated with inXammatory arthritis. J Immunol 171(10):5547-5553 (Pubitemid 37432845)
16. Lianxu C, Hongti J, Changlong Y (2006) NF-kappaB p65-speciWc siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1beta-induced and TNF-Alpha-induced chondrocytes. Osteoarthr Cartil 14(4):367-376 (Pubitemid 44268926)
17. Chen LX, Lin L, Wang HJ, Wei XL, Fu X, Zhang JY et al (2008) Suppression of early experimental osteoarthritis by in vivo delivery of the adenoviral vector-mediated NF-kappaB p65-speciWc siRNA. Osteoarthr Cartil 16(2):174-184 (Pubitemid 351218179)
18. Yao Z, Xing L, Boyce BF (2009) NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism. J Clin Invest 119(10):3024-3034
19. Yoon HS, Kim HA, Song YW (2006) Inhibition of NF-kappaB renders human juvenile costal chondrocyte cell lines sensitive to TNF-Alpha-mediated cell death. Rheumatol Int 26(3):201-208 (Pubitemid 41830976)
20. Wang L, Du F, Wang X (2008) TNF-Alpha induces two distinct caspase-8 activation pathways. Cell 133(4):693-703 (Pubitemid 351636305)
21. Cejka D, Hayer S, Niederreiter B, Sieghart W, Fuereder T, Zwerina J et al. (2010) mTOR signaling is crucial for joint destruction in TNF-Alpha-driven arthritis. Arthritis Rheum. doi:10.1002/art.27504
22. Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N et al (2002) A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11(5):525-534 (Pubitemid 34257489)
23. Kim HA, Lee YJ, Seong SC, Choe KW, Song YW (2000) Apoptotic chondrocyte death in human osteoarthritis. J Rheumatol 27(2):455-462 (Pubitemid 30095481)
24. Blanco FJ, Guitian R, Vazquez-Martul E, de Toro FJ. Galdo F (1998) Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology. Arthritis Rheum 41(2):284-289 (Pubitemid 28087696)
25. James AF (2007) IAP antagonists target cIAP1 to induce TNFadependent apoptosis. Cell 131:682-693
26. Seguin CA, Bernier SM (2003) TNFalpha suppresses link protein and type II collagen expression in chondrocytes: Role of MEK1/2 and NF-kappaB signaling pathways. J Cell Physiol 197(3):356-369
27. Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124(3):471-484 (Pubitemid 43199434)
28. Sugatani T, Hruska KA (2005) Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast diVerentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors. J Biol Chem 280(5):3583-3589 (Pubitemid 40223824)
29. Phornphutkul C, Lee M, Voigt C, Wu KY, Ehrlich MG, Gruppuso PA et al (2009) The eVect of rapamycin on bone growth in rabbits. J Orthop Res 27(9):1157-1161
30. Janus A, Linke A, Cebula B, Robak T, Smolewski P (2009) Rapamycin, the mTOR kinase inhibitor, sensitizes acute myeloid leukemia cells, HL-60 cells, to the cytotoxic eVect of arabinozide cytarabine. Anticancer Drugs 20(8):693-701
31. Varfolomeev EE, Ashkenazi A (2004) Tumor necrosis factor: An apoptosis JuNKie? Cell 116(4):491-497 (Pubitemid 38264427)
32. Relic B, Bentires-Alj M, Ribbens C, Franchimont N, Guerne PA, Benoit V et al (2002) TNF-Alpha protects human primary articular chondrocytes from nitric oxide-induced apoptosis via nuclear factor-kappaB. Lab Invest 82(12):1661-1672 (Pubitemid 35462979)
33. Xu J, Wu HF, Ang ES, Yip K, Woloszyn M, Zheng MH et al (2009) NF-kappaB modulators in osteolytic bone diseases. Cytokine Growth Factor Rev 20(1):7-17