TGFΒ/Smad3 signal pathway is not required for epidermal langerhans cell development

Journal of Investigative Dermatology

Volumn 132, Issue 8, 2012, Pages 2106-2109

  Xu, Ying Ping ^a,b,c   Shi, Yuling ^a   Cui, Zhi Zhong ^b   Jiang, Hong H ^d   Li, Li ^d   Wang, Xiao Fan ^e   Zhou, Li ^a   Mi, Qing Sheng ^a  

^a HENRY FORD HOSPITAL   (United States)

^b SHANDONG AGRICULTURAL UNIVERSITY   (China)

^c TAISHAN MEDICAL UNIVERSITY   (China)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CD86 ANTIGEN; GAMMA INTERFERON; INHIBITOR OF DIFFERENTIATION 2; LANGERIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR RUNX3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; CELL EXPANSION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC CELL; HOMEOSTASIS; IN VIVO STUDY; INTERFERON PRODUCTION; KERATINOCYTE; LANGERHANS CELL; LETTER; MOUSE; NONHUMAN; ONTOGENY; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WILD TYPE;

EID: 84863984608     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2012.71     Document Type: Letter

References (17)

1. Borkowski TA, Letterio JJ, Farr AG et al. (1996) A role for endogenous transforming growth factor beta 1 in Langerhans cell biology: the skin of transforming growth factor beta 1 null mice is devoid of epidermal Langerhans cells. J Exp Med 184:2417-22
2. Chorro L, Sarde A, Li M et al. (2009) Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network. J Exp Med 206:3089-100
3. Datto MB, Frederick JP, Pan L et al. (1999) Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 19:2495-504
4. Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-84
5. Fainaru O, Woolf E, Lotem J et al. (2004) Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation. EMBO J 23:969-79
6. Hacker C, Kirsch RD, Ju XS et al. (2003) Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 4:380-6
7. Itoh S, Itoh F, Goumans MJ et al. (2000) Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 267:6954-67
8. Kaplan DH, Li MO, Jenison MC et al. (2007) Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med 204:2545-52
9. Kel JM, Girard-Madoux MJ, Reizis B et al. (2010) TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis. J Immunol 185:3248-55
10. Massague J (2000) How cells read TGF-beta signals. Nat Rev Mol Cell Biol 1:169-78
11. Moustakas A, Souchelnytskyi S, Heldin CH (2001) Smad regulation in TGF-beta signal transduction. J Cell Sci 114:4359-69
12. Romani N, Clausen BE, Stoitzner P (2010) Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol Rev 234:120-41
13. Takimoto T, Wakabayashi Y, Sekiya T et al. (2010) Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development. J Immunol 185:842-55
14. Tsukazaki T, Chiang TA, Davison AF et al. (1998) SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell 95:779-91
15. Werner F, Jain MK, Feinberg MW et al. (2000) Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem 275:36653-8
16. Yang X, Letterio JJ, Lechleider RJ et al. (1999) Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J 18:1280-91
17. Zahner SP, Kel JM, Martina CA et al. (2011) Conditional deletion of TGF-betaR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol 187:5069-76