메뉴 건너뛰기




Volumn 88, Issue , 2012, Pages 133-152

Treatment with Aβ42 binding d-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic mice

Author keywords

Alzheimer's disease; Amyloid; Limbic system; Mouse; Plaques; Treatment

Indexed keywords


EID: 84863960017     PISSN: 18761623     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398314-5.00005-2     Document Type: Chapter
Times cited : (21)

References (52)
  • 3
    • 36849078628 scopus 로고    scopus 로고
    • Insight into the kinetic of amyloid β (1-42) peptide self-aggregation: Elucidation of inhibitors' mechanism of action
    • DOI 10.1002/cbic.200700427
    • M. Bartolini, C. Bertucci, M.L. Bolognesi, A. Cavalli, C. Melchiorre, and V. Andrisano Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: Elucidation of inhibitors' mechanism of action Chembiochem 8 2007 2152 2161 (Pubitemid 350220767)
    • (2007) ChemBioChem , vol.8 , Issue.17 , pp. 2152-2161
    • Bartolini, M.1    Bertucci, C.2    Bolognesi, M.L.3    Cavalli, A.4    Melchiorre, C.5    Andrisano, V.6
  • 5
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • H. Braak, and E. Braak Neuropathological stageing of Alzheimer-related changes Acta Neuropathologica 82 1991 239 259
    • (1991) Acta Neuropathologica , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 6
    • 0031596284 scopus 로고    scopus 로고
    • Evolution of neuronal changes in the course of alzheimer's disease
    • H. Braak, and E. Braak Evolution of neuronal changes in the course of Alzheimer's disease Journal of Neural Transmission 53 1998 127 140 (Pubitemid 28361774)
    • (1998) Journal of Neural Transmission, Supplement , Issue.53 , pp. 127-140
    • Braak, H.1    Braak, E.2
  • 8
    • 0035898257 scopus 로고    scopus 로고
    • The morphological phenotype of β-amyloid plaques and associated neuritic changes in Alzheimer's disease
    • DOI 10.1016/S0306-4522(01)00169-5, PII S0306452201001695
    • T.C. Dickson, and J.C. Vickers The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease Neuroscience 105 2001 99 107 (Pubitemid 32722097)
    • (2001) Neuroscience , vol.105 , Issue.1 , pp. 99-107
    • Dickson, T.C.1    Vickers, J.C.2
  • 9
    • 0042232110 scopus 로고    scopus 로고
    • Studies on the internalization mechanism of cationic cell-penetrating peptides
    • DOI 10.1074/jbc.M303938200
    • G. Drin, S. Cottin, E. Blanc, A.R. Rees, and J. Temsamani Studies on the internalization mechanism of cationic cell-penetrating peptides Journal of Biological Chemistry 278 2003 31192 31201 (Pubitemid 36994635)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.33 , pp. 31192-31201
    • Drin, G.1    Cottin, S.2    Blanc, E.3    Rees, A.R.4    Temsamani, J.5
  • 11
    • 77956686266 scopus 로고    scopus 로고
    • Oral treatment with the D-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's disease transgenic mice
    • S.A. Funke, T. van Groen, I. Kadish, D. Bartnik, L. Nagel-Steger, and O. Brener Oral treatment with the D-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's disease transgenic mice ACS Chemical Neuroscience 1 2010 639 648
    • (2010) ACS Chemical Neuroscience , vol.1 , pp. 639-648
    • Funke, S.A.1    Van Groen, T.2    Kadish, I.3    Bartnik, D.4    Nagel-Steger, L.5    Brener, O.6
  • 12
    • 8844285984 scopus 로고    scopus 로고
    • Mouse models of Alzheimer's disease: Insight into treatment
    • D.C. German, and A.J. Eisch Mouse models of Alzheimer's disease: Insight into treatment Reviews in the Neurosciences 15 2004 353 369 (Pubitemid 39536384)
    • (2004) Reviews in the Neurosciences , vol.15 , Issue.5 , pp. 353-369
    • German, D.C.1    Eisch, A.J.2
  • 13
    • 0033615580 scopus 로고    scopus 로고
    • The presenilins in Alzheimer's disease - Proteolysis holds the key
    • C. Haass, and B. De Strooper The presenilins in Alzheimer's disease - Proteolysis holds the key Science 286 1999 916 919
    • (1999) Science , vol.286 , pp. 916-919
    • Haass, C.1    De Strooper, B.2
  • 14
    • 0026546599 scopus 로고
    • An 'anatomical cascade hypothesis' for Alzheimer's disease
    • J. Hardy An 'anatomical cascade hypothesis' for Alzheimer's disease Trends in Neurosciences 15 6 1992 200 201
    • (1992) Trends in Neurosciences , vol.15 , Issue.6 , pp. 200-201
    • Hardy, J.1
  • 15
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: Prevalence estimates using the 2000 census
    • DOI 10.1001/archneur.60.8.1119
    • L.E. Hebert, P.A. Scherr, J.L. Bienias, D.A. Bennett, and D.A. Evans Alzheimer disease in the US population: Prevalence estimates using the 2000 census Archives of Neurology 60 2003 1119 1122 (Pubitemid 36975801)
    • (2003) Archives of Neurology , vol.60 , Issue.8 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3    Bennett, D.A.4    Evans, D.A.5
  • 16
    • 33846604242 scopus 로고    scopus 로고
    • How common are the "common" neurologic disorders?
    • DOI 10.1212/01.wnl.0000252807.38124.a3, PII 0000611420070130000006
    • D. Hirtz, D.J. Thurman, K. Gwinn-Hardy, M. Mohamed, A.R. Chaudhuri, and R. Zalutsky How common are the "common" neurologic disorders? Neurology 68 2007 326 337 (Pubitemid 46188246)
    • (2007) Neurology , vol.68 , Issue.5 , pp. 326-337
    • Hirtz, D.1    Thurman, D.J.2    Gwinn-Hardy, K.3    Mohamed, M.4    Chaudhuri, A.R.5    Zalutsky, R.6
  • 17
    • 0031255112 scopus 로고    scopus 로고
    • Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease
    • B.T. Hyman, and J.Q. Trojanowski Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease Journal of Neuropathology and Experimental Neurology 56 1997 1095 1097
    • (1997) Journal of Neuropathology and Experimental Neurology , vol.56 , pp. 1095-1097
    • Hyman, B.T.1    Trojanowski, J.Q.2
  • 20
    • 0035049961 scopus 로고    scopus 로고
    • Co-expression of multiple transgenes in mouse CNS: A comparison of strategies
    • DOI 10.1016/S1389-0344(01)00067-3, PII S1389034401000673
    • J.L. Jankowsky, H.H. Slunt, T. Ratovitski, N.A. Jenkins, N.G. Copeland, and D.R. Borchelt Co-expression of multiple transgenes in mouse CNS: A comparison of strategies Biomolecular Engineering 17 2001 157 165 (Pubitemid 32409891)
    • (2001) Biomolecular Engineering , vol.17 , Issue.6 , pp. 157-165
    • Jankowsky, J.L.1    Slunt, H.H.2    Ratovitski, T.3    Jenkins, N.A.4    Copeland, N.G.5    Borchelt, D.R.6
  • 21
    • 0035082722 scopus 로고    scopus 로고
    • Amyloid β40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice
    • Y. Ji, B. Permanne, E.M. Sigurdsson, D.M. Holtzman, and T. Wisniewski Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice Journal of Alzheimer's Disease 3 2001 23 30 (Pubitemid 32238247)
    • (2001) Journal of Alzheimer's Disease , vol.3 , Issue.1 , pp. 23-30
    • Ji, Y.1    Permanne, B.2    Sigurdsson, E.M.3    Holtzman, D.M.4    Wisniewski, T.5
  • 22
    • 0037095722 scopus 로고    scopus 로고
    • Low Levels of Estrogen Significantly Diminish Axonal Sprouting after Entorhinal Cortex Lesions in the Mouse
    • I. Kadish, and T. van Groen Low levels of estrogen significantly diminish axonal sprouting after entorhinal cortex lesions in the mouse Journal of Neuroscience 22 10 2002 May 15 4095 4102 (Pubitemid 37465717)
    • (2002) Journal of Neuroscience , vol.22 , Issue.10 , pp. 4095-4102
    • Kadish, I.1    Van Groen, T.2
  • 23
    • 37749036105 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: Pathogenetic mechanisms and link to dense amyloid plaques
    • S. Kumar-Singh Cerebral amyloid angiopathy: Pathogenetic mechanisms and link to dense amyloid plaques Genes, Brain, and Behavior 7 Suppl. 1 2008 67 82
    • (2008) Genes, Brain, and Behavior , vol.7 , Issue.SUPPL. 1 , pp. 67-82
    • Kumar-Singh, S.1
  • 25
    • 77952413110 scopus 로고    scopus 로고
    • Transport of Alzheimer disease amyloid-beta-binding d-amino acid peptides across an in vitro blood-brain barrier model
    • H. Liu, S.A. Funke, and D. Willbold Transport of Alzheimer disease amyloid-beta-binding d-amino acid peptides across an in vitro blood-brain barrier model Rejuvenation Research 13 2010 210 213
    • (2010) Rejuvenation Research , vol.13 , pp. 210-213
    • Liu, H.1    Funke, S.A.2    Willbold, D.3
  • 26
    • 0037151296 scopus 로고    scopus 로고
    • Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice
    • DOI 10.1016/S0166-4328(02)00058-X, PII S016643280200058X
    • L. Liu, S. Ikonen, T. Heikkinen, M. Heikkilä, J. Puoliväli, and T. van Groen Effects of fimbria-fornix lesion and amyloid pathology on spatial learning and memory in transgenic APP+PS1 mice Behavioural Brain Research 134 2002 433 445 (Pubitemid 34912723)
    • (2002) Behavioural Brain Research , vol.134 , Issue.1-2 , pp. 433-445
    • Liu, L.1    Ikonen, S.2    Heikkinen, T.3    Heikkila, M.4    Puolivali, J.5    Van Groen, T.6    Tanila, H.7
  • 28
    • 33750603844 scopus 로고    scopus 로고
    • Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the Aβ amyloid pathway
    • DOI 10.1093/brain/awl251
    • C.L. Masters, and K. Beyreuther Alzheimer's centennial legacy: Prospects for rational therapeutic intervention targeting the Aβ amyloid pathway Brain 29 2006 2823 2839 (Pubitemid 44684506)
    • (2006) Brain , vol.129 , Issue.11 , pp. 2823-2839
    • Masters, C.L.1    Beyreuther, K.2
  • 31
    • 0036615884 scopus 로고    scopus 로고
    • Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide
    • B. Permanne, C. Adessi, G.P. Saborio, S. Fraga, M.J. Frossard, and J. Van Dorpe Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide The FASEB Journal 16 2002 860 862
    • (2002) The FASEB Journal , vol.16 , pp. 860-862
    • Permanne, B.1    Adessi, C.2    Saborio, G.P.3    Fraga, S.4    Frossard, M.J.5    Van Dorpe, J.6
  • 33
    • 0034814056 scopus 로고    scopus 로고
    • Microglial chemotaxis, activation, and phagocytosis of amyloid β-peptide as linked phenomena in Alzheimer's disease
    • DOI 10.1016/S0197-0186(01)00040-7, PII S0197018601000407
    • J. Rogers, and L.F. Lue Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease Neurochemistry International 39 2001 333 340 (Pubitemid 32907397)
    • (2001) Neurochemistry International , vol.39 , Issue.5-6 , pp. 333-340
    • Rogers, J.1    Lue, L.-F.2
  • 34
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • D.J. Selkoe Alzheimer's disease: Genes, proteins, and therapy Physiological Reviews 81 2001 741 766 (Pubitemid 32267077)
    • (2001) Physiological Reviews , vol.81 , Issue.2 , pp. 741-766
    • Selkoe, D.J.1
  • 35
    • 35348860241 scopus 로고    scopus 로고
    • Presenilin: Running with Scissors in the Membrane
    • DOI 10.1016/j.cell.2007.10.012, PII S0092867407012822
    • D.J. Selkoe, and M.S. Wolfe Presenilin: Running with scissors in the membrane Cell 131 2007 215 221 (Pubitemid 47576152)
    • (2007) Cell , vol.131 , Issue.2 , pp. 215-221
    • Selkoe, D.J.1    Wolfe, M.S.2
  • 36
    • 0037111838 scopus 로고    scopus 로고
    • Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Aβ amyloidosis
    • J.G. Sheng, D.L. Price, and V.E. Koliatsos Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis Journal of Neuroscience 22 2002 9794 9799 (Pubitemid 35332863)
    • (2002) Journal of Neuroscience , vol.22 , Issue.22 , pp. 9794-9799
    • Sheng, J.G.1    Price, D.L.2    Koliatsos, V.E.3
  • 37
    • 0030600371 scopus 로고    scopus 로고
    • Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation
    • DOI 10.1006/bbrc.1996.1413
    • C. Soto, M.S. Kindy, M. Baumann, and B. Frangione Inhibition of Alzheimer's amyloidosis by peptides that prevent beta-sheet conformation Biochemical and Biophysical Research Communications 226 1996 672 680 (Pubitemid 26348532)
    • (1996) Biochemical and Biophysical Research Communications , vol.226 , Issue.3 , pp. 672-680
    • Soto, C.1    Kindy, M.S.2    Baumann, M.3    Frangione, B.4
  • 38
    • 0034992123 scopus 로고    scopus 로고
    • 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: No evidence of intracellular amyloid
    • DOI 10.1016/S0197-4580(01)00209-3, PII S0197458001002093
    • M. Stalder, T. Deller, M. Staufenbiel, and M. Jucker 3D-Reconstruction of microglia and amyloid in APP23 transgenic mice: No evidence of intracellular amyloid Neurobiology of Aging 22 2001 427 434 (Pubitemid 32510915)
    • (2001) Neurobiology of Aging , vol.22 , Issue.3 , pp. 427-434
    • Stalder, M.1    Deller, T.2    Staufenbiel, M.3    Jucker, M.4
  • 39
    • 13944276825 scopus 로고    scopus 로고
    • Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective
    • DOI 10.1016/j.cell.2005.02.008
    • R.E. Tanzi, and L. Bertram Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective Cell 120 4 2005 545 555 (Pubitemid 40269768)
    • (2005) Cell , vol.120 , Issue.4 , pp. 545-555
    • Tanzi, R.E.1    Bertram, L.2
  • 40
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Aβ peptide: The many roads to perdition
    • DOI 10.1016/j.neuron.2004.08.024, PII S0896627304005331
    • R.E. Tanzi, R.D. Moir, and S.L. Wagner Clearance of Alzheimer's Abeta peptide: The many roads to perdition Neuron 43 2004 605 608 (Pubitemid 39179722)
    • (2004) Neuron , vol.43 , Issue.5 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 41
    • 34547173081 scopus 로고    scopus 로고
    • Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches
    • DOI 10.1159/000105156
    • B. Van Broeck, C. Van Broeckhoven, and S. Kumar-Singh Current insights into molecular mechanisms of Alzheimer disease and their implications for therapeutic approaches Neurodegenerative Diseases 4 2007 349 365 (Pubitemid 47123462)
    • (2007) Neurodegenerative Diseases , vol.4 , Issue.5 , pp. 349-365
    • Van Broeck, B.1    Van Broeckhoven, C.2    Kumar-Singh, S.3
  • 42
    • 17844377296 scopus 로고    scopus 로고
    • Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology
    • DOI 10.1016/j.brainresrev.2004.12.026, Glial-Neuron Crosstalk in Neuroinflamation, Neurodegeneration and Neuroprotection
    • T. van Groen, and I. Kadish Transgenic AD model mice, effects of potential anti-AD treatments on inflammation and pathology Brain Research Reviews 48 2005 370 378 (Pubitemid 40585768)
    • (2005) Brain Research Reviews , vol.48 , Issue.2 , pp. 370-378
    • Van Groen, T.1    Kadish, I.2
  • 43
    • 60849108336 scopus 로고    scopus 로고
    • In vitro and in vivo staining characteristics of small, fluorescent, Abeta42-binding D-enantiomeric peptides in transgenic AD mouse models
    • T. van Groen, I. Kadish, K. Wiesehan, S.A. Funke, and D. Willbold In vitro and in vivo staining characteristics of small, fluorescent, Abeta42-binding D-enantiomeric peptides in transgenic AD mouse models ChemMedChem 4 2009 276 282
    • (2009) ChemMedChem , vol.4 , pp. 276-282
    • Van Groen, T.1    Kadish, I.2    Wiesehan, K.3    Funke, S.A.4    Willbold, D.5
  • 44
    • 33747153860 scopus 로고    scopus 로고
    • Deposition of mouse amyloid β in human APP/PS1 double and single AD model transgenic mice
    • DOI 10.1016/j.nbd.2006.05.010, PII S0969996106001240
    • T. van Groen, A.J. Kiliaan, and I. Kadish Deposition of mouse amyloid beta in human APP/PS1 double and single AD model transgenic mice Neurobiology of Disease 23 2006 653 662 (Pubitemid 44234102)
    • (2006) Neurobiology of Disease , vol.23 , Issue.3 , pp. 653-662
    • Van Groen, T.1    Kiliaan, A.J.2    Kadish, I.3
  • 45
    • 0037756809 scopus 로고    scopus 로고
    • Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions
    • DOI 10.1016/S0306-4522(03)00215-X
    • T. van Groen, L. Liu, S. Ikonen, and I. Kadish Diffuse amyloid deposition, but not plaque number, is reduced in amyloid precursor protein/presenilin 1 double-transgenic mice by pathway lesions Neuroscience 119 2003 1185 1197 (Pubitemid 36776463)
    • (2003) Neuroscience , vol.119 , Issue.4 , pp. 1185-1197
    • Van Groen, T.1    Liu, L.2    Ikonen, S.3    Kadish, I.4
  • 46
    • 79955631935 scopus 로고    scopus 로고
    • Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology
    • T. van Groen, P. Miettinen, and I. Kadish Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology Journal of Alzheimer's Disease 24 2011 301 313
    • (2011) Journal of Alzheimer's Disease , vol.24 , pp. 301-313
    • Van Groen, T.1    Miettinen, P.2    Kadish, I.3
  • 47
    • 0346848902 scopus 로고    scopus 로고
    • Gender differences in the amount and deposition of amyloidβ in APPswe and PS1 double transgenic mice
    • DOI 10.1016/j.nbd.2003.08.009
    • J. Wang, H. Tanila, J. Puolivali, I. Kadish, and T. van Groen Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice Neurobiology of Disease 14 2003 318 327 (Pubitemid 37543511)
    • (2003) Neurobiology of Disease , vol.14 , Issue.3 , pp. 318-327
    • Wang, J.1    Tanila, H.2    Puolivali, J.3    Kadish, I.4    Van Groen, T.5
  • 48
    • 33748753481 scopus 로고    scopus 로고
    • Clearance of amyloid-beta in Alzheimer's disease: Progress, problems and perspectives
    • Y.J. Wang, H.D. Zhou, and X.F. Zhou Clearance of amyloid-beta in Alzheimer's disease: Progress, problems and perspectives Drug Discovery Today 11 2006 931 938
    • (2006) Drug Discovery Today , vol.11 , pp. 931-938
    • Wang, Y.J.1    Zhou, H.D.2    Zhou, X.F.3
  • 50
    • 41149162218 scopus 로고    scopus 로고
    • Inhibition of cytotoxicity and amyloid fibril formation by a D-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide
    • DOI 10.1093/protein/gzm054
    • K. Wiesehan, J. Stöhr, L. Nagel-Steger, T. van Groen, D. Riesner, and D. Willbold Inhibition of cytotoxicity and amyloid fibril formation by a d-amino acid peptide that specifically binds to Alzheimer's disease amyloid peptide Protein Engineering, Design & Selection 21 2008 241 246 (Pubitemid 351431052)
    • (2008) Protein Engineering, Design and Selection , vol.21 , Issue.4 , pp. 241-246
    • Wiesehan, K.1    Stohr, J.2    Nagel-Steger, L.3    Van Groen, T.4    Riesner, D.5    Willbold, D.6
  • 51
    • 0141683549 scopus 로고    scopus 로고
    • Mirror-image phage display: Aiming at the mirror
    • DOI 10.1002/cbic.200300570
    • K. Wiesehan, and D. Willbold Mirror-image phage display: Aiming at the mirror Chembiochem 4 2003 811 815 (Pubitemid 37185690)
    • (2003) ChemBioChem , vol.4 , Issue.9 , pp. 811-815
    • Wiesehan, K.1    Willbold, D.2
  • 52
    • 0037931149 scopus 로고    scopus 로고
    • Specific compositions of amyloid-β peptides as the determinant of toxic β-aggregation
    • DOI 10.1074/jbc.M212785200
    • Y. Yoshiike, D.H. Chui, T. Akagi, N. Tanakama, and A. Takashima Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation Journal of Biological Chemistry 278 2003 23648 23655 (Pubitemid 36830187)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.26 , pp. 23648-23655
    • Yoshiike, Y.1    Chui, D.-H.2    Akagi, T.3    Tanaka, N.4    Takashima, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.