메뉴 건너뛰기




Volumn 41, Issue 6, 2012, Pages 904-909

SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma

Author keywords

pancreatic cancer; SLC5A8; survival; tissue microarray; tumor suppressor gene

Indexed keywords

SODIUM CHANNEL; SODIUM CHANNEL SLC5A8; UNCLASSIFIED DRUG;

EID: 84863958857     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31823f429f     Document Type: Article
Times cited : (12)

References (36)
  • 2
    • 51249118120 scopus 로고    scopus 로고
    • Sodium-coupled monocarboxylate transporters in normal tissues and in cancer
    • Ganapathy V, Thangaraju M, Gopal E, et al. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 2008;10:193Y199.
    • (2008) AAPS J. , vol.10 , pp. 193-199
    • Ganapathy, V.1    Thangaraju, M.2    Gopal, E.3
  • 3
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: Relevance to warburg hypothesis and beyond
    • Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther. 2009;121:29Y40.
    • (2009) Pharmacol. Ther. , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 4
    • 33847164080 scopus 로고    scopus 로고
    • Transport of nicotinate and structurally related compounds by human SMCT1 SLC5A8 and its relevance to drug transport in the mammalian intestinal tract
    • Gopal E, Miyauchi S, Martin PM, et al. Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharm Res. 2007;24:575Y584.
    • (2007) Pharm. Res. , vol.24 , pp. 575-584
    • Gopal, E.1    Miyauchi, S.2    Martin, P.M.3
  • 5
    • 33745081830 scopus 로고    scopus 로고
    • Identity of SMCT1 SLC5A8 as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain
    • Martin PM, Gopal E, Ananth S, et al. Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain. J Neurochem. 2006;98:279Y288.
    • (2006) J. Neurochem. , vol.98 , pp. 279-288
    • Martin, P.M.1    Gopal, E.2    Ananth, S.3
  • 6
    • 33645969256 scopus 로고    scopus 로고
    • SLC5A8 SMCT1-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
    • Gupta N, Martin PM, Prasad PD, et al. SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sci. 2006;78:2419Y2425.
    • (2006) Life Sci. , vol.78 , pp. 2419-2425
    • Gupta, N.1    Martin, P.M.2    Prasad, P.D.3
  • 7
    • 33846232686 scopus 로고    scopus 로고
    • SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases
    • Thangaraju M, Gopal E, Martin PM, et al. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer Res. 2006;66:11560Y11564.
    • (2006) Cancer Res. , vol.66 , pp. 11560-11564
    • Thangaraju, M.1    Gopal, E.2    Martin, P.M.3
  • 8
    • 0038153876 scopus 로고    scopus 로고
    • SLC5A8 a sodium transporter is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
    • U S A.
    • Li H, Myeroff L, Smiraglia D, et al. SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers. Proc Natl Acad Sci U S A. 2003;100:8412Y8417.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 8412-8417
    • Li, H.1    Myeroff, L.2    Smiraglia, D.3
  • 9
    • 18144402837 scopus 로고    scopus 로고
    • Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8
    • Hong C, Maunakea A, Jun P, et al. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005;65:3617Y3623.
    • (2005) Cancer Res. , vol.65 , pp. 3617-3623
    • Hong, C.1    Maunakea, A.2    Jun, P.3
  • 10
    • 13244264729 scopus 로고    scopus 로고
    • Progressive methylation during the serrated neoplasia pathway of the colorectum
    • Dong SM, Lee EJ, Jeon ES, et al. Progressive methylation during the serrated neoplasia pathway of the colorectum. Mod Pathol. 2005;18:170Y178.
    • (2005) Mod. Pathol. , vol.18 , pp. 170-178
    • Dong, S.M.1    Lee, E.J.2    Jeon, E.S.3
  • 11
    • 33646561826 scopus 로고    scopus 로고
    • Na+ monocarboxylate transport SMCT protein expression correlates with survival in coloncancer: Molecular characterization of SMCT
    • U S A.
    • Paroder V, Spencer SR, Paroder M, et al. Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in coloncancer: molecular characterization of SMCT. Proc Natl Acad Sci U S A. 2006;103:7270Y7275.
    • (2006) Proc. Natl. Acad. Sci. , vol.103 , pp. 7270-7275
    • Paroder, V.1    Spencer, S.R.2    Paroder, M.3
  • 12
    • 52549103966 scopus 로고    scopus 로고
    • Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer
    • discussion 1781Y1782
    • Thangaraju M, Cresci G, Itagaki S, et al. Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. J Gastrointest Surg. 2008;12:1773Y1781; discussion 1781Y1782.
    • (2008) J. Gastrointest. Surg. , vol.12 , pp. 1773-1781
    • Thangaraju, M.1    Cresci, G.2    Itagaki, S.3
  • 13
    • 21044448948 scopus 로고    scopus 로고
    • Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas
    • Porra V, Ferraro-Peyret C, Durand C, et al. Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas. J Clin Endocrinol Metab. 2005;90:3028Y3035.
    • (2005) J. Clin. Endocrinol. Metab. , vol.90 , pp. 3028-3035
    • Porra, V.1    Ferraro-Peyret, C.2    Durand, C.3
  • 14
    • 33749599164 scopus 로고    scopus 로고
    • Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer
    • Hu S, Liu D, Tufano RP, et al. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006;119:2322Y2329.
    • (2006) Int. J. Cancer , vol.119 , pp. 2322-2329
    • Hu, S.1    Liu, D.2    Tufano, R.P.3
  • 15
    • 33747367221 scopus 로고    scopus 로고
    • CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma
    • Schagdarsurengin U, Gimm O, Dralle H, et al. CpG island methylation of tumor-related promoters occurs preferentially in undifferentiated carcinoma. Thyroid. 2006;16:633Y642.
    • (2006) Thyroid , vol.16 , pp. 633-642
    • Schagdarsurengin, U.1    Gimm, O.2    Dralle, H.3
  • 16
    • 33847073463 scopus 로고    scopus 로고
    • Gene methylation in thyroid tumorigenesis
    • Xing M. Gene methylation in thyroid tumorigenesis. Endocrinology. 2007;148:948Y953.
    • (2007) Endocrinology , vol.148 , pp. 948-953
    • Xing, M.1
  • 17
    • 4644308877 scopus 로고    scopus 로고
    • Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer
    • Ueno M, Toyota M, Akino K, et al. Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer. Tumour Biol. 2004;25:134Y140.
    • (2004) Tumour. Biol. , vol.25 , pp. 134-140
    • Ueno, M.1    Toyota, M.2    Akino, K.3
  • 18
    • 34347405530 scopus 로고    scopus 로고
    • CpG island hypermethylation profiling of lung cancer using restriction landmark genomic scanning RLGS analysis
    • Park J, Brena RM, Gruidl M, et al. CpG island hypermethylation profiling of lung cancer using restriction landmark genomic scanning (RLGS) analysis. Cancer Biomark. 2005;1:193Y200.
    • (2005) Cancer Biomark. , vol.1 , pp. 193-200
    • Park, J.1    Brena, R.M.2    Gruidl, M.3
  • 19
    • 36448948627 scopus 로고    scopus 로고
    • Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor
    • Park JY, Zheng W, Kim D, et al. Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor. Cancer Detect Prev. 2007;31:359Y365.
    • (2007) Cancer Detect Prev. , vol.31 , pp. 359-365
    • Park, J.Y.1    Zheng, W.2    Kim, D.3
  • 20
    • 49649128474 scopus 로고    scopus 로고
    • Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma
    • Bennett KL, Karpenko M, Lin MT, et al. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res. 2008;68:4494Y4499.
    • (2008) Cancer Res. , vol.68 , pp. 4494-4499
    • Bennett, K.L.1    Karpenko, M.2    Lin, M.T.3
  • 21
    • 52649089060 scopus 로고    scopus 로고
    • DNA hypermethylation and epigenetic silencing of the tumor suppressor gene SLC5A8 in acute myeloid leukemia with the MLL partial tandem duplication
    • Whitman SP, Hackanson B, Liyanarachchi S, et al. DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication. Blood. 2008;112:2013Y2016.
    • (2008) Blood , vol.112 , pp. 2013-2016
    • Whitman, S.P.1    Hackanson, B.2    Liyanarachchi, S.3
  • 22
    • 42549172744 scopus 로고    scopus 로고
    • Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 SLC5A8 in human pancreatic cancer
    • Park JY, Helm JF, Zheng W, et al. Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. Pancreas. 2008;36:e32Ye39.
    • (2008) Pancreas , vol.36
    • Park, J.Y.1    Helm, J.F.2    Zheng, W.3
  • 23
    • 55249115120 scopus 로고    scopus 로고
    • Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution
    • Helm JF, Centeno BA, Coppola D, et al. Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution. Cancer Control. 2008;15:288Y294.
    • (2008) Cancer Control. , vol.15 , pp. 288-294
    • Helm, J.F.1    Centeno, B.A.2    Coppola, D.3
  • 24
    • 70149091056 scopus 로고    scopus 로고
    • Histologic characteristics enhance predictive value of american joint committee on cancer staging in resectable pancreas cancer
    • Helm J, Centeno BA, Coppola D, et al. Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer. Cancer. 2009;115:4080Y4089.
    • (2009) Cancer , vol.115 , pp. 4080-4089
    • Helm, J.1    Centeno, B.A.2    Coppola, D.3
  • 25
    • 1642405321 scopus 로고    scopus 로고
    • Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer
    • Wong SC, Lo ES, Lee KC, et al. Prognostic and diagnostic significance of beta-catenin nuclear immunostaining in colorectal cancer. Clin Cancer Res. 2004;10:1401Y1408.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1401-1408
    • Wong, S.C.1    Lo, E.S.2    Lee, K.C.3
  • 26
    • 79952282179 scopus 로고    scopus 로고
    • Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma
    • Li XH, Kikuchi K, Zheng Y, et al. Downregulation and translocation of nuclear ING4 is correlated with tumorigenesis and progression of head and neck squamous cell carcinoma. Oral Oncol. 2011;47:217Y223.
    • (2011) Oral. Oncol. , vol.47 , pp. 217-223
    • Li, X.H.1    Kikuchi, K.2    Zheng, Y.3
  • 27
    • 77954654427 scopus 로고    scopus 로고
    • Deletion mapping of chromosome region 12q13-24 in colorectal cancer
    • Aytekin T, Ozaslan M, Cengiz B. Deletion mapping of chromosome region 12q13-24 in colorectal cancer. Cancer Genet Cytogenet. 2010;201:32Y38.
    • (2010) Cancer Genet. Cytogenet. , vol.201 , pp. 32-38
    • Aytekin, T.1    Ozaslan, M.2    Cengiz, B.3
  • 28
    • 0030593038 scopus 로고    scopus 로고
    • DPC4 a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996;271:350Y353.
    • (1996) Science , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 29
    • 46049102782 scopus 로고    scopus 로고
    • Expression of smad2 and smad4 in cervical cancer: Absent nuclear smad4 expression correlates with poor survival
    • Kloth JN, Kenter GG, Spijker HS, et al. Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival. Mod Pathol. 2008;21:866Y875.
    • (2008) Mod. Pathol. , vol.21 , pp. 866-875
    • Kloth, J.N.1    Kenter, G.G.2    Spijker, H.S.3
  • 30
    • 0034896633 scopus 로고    scopus 로고
    • Expression of the tumor suppressor gene maspin in human pancreatic cancers
    • Maass N, Hojo T, Ueding M, et al. Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res. 2001;7:812Y817.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 812-817
    • Maass, N.1    Hojo, T.2    Ueding, M.3
  • 31
    • 0036180148 scopus 로고    scopus 로고
    • Expression of maspin in pancreatic neoplasms: Application of maspin immunohistochemistry to the differential diagnosis
    • Oh YL, Song SY, Ahn G. Expression of maspin in pancreatic neoplasms: application of maspin immunohistochemistry to the differential diagnosis. Appl Immunohistochem Mol Morphol. 2002;10:62Y66.
    • (2002) Appl. Immunohistochem. Mol. Morphol. , vol.10 , pp. 62-66
    • Oh, Y.L.1    Song, S.Y.2    Ahn, G.3
  • 32
    • 34247382565 scopus 로고    scopus 로고
    • Prognostic significance of maspin in pancreatic ductal adenocarcinoma: Tissue microarray analysis of 223 surgically resected cases
    • Cao D, Zhang Q, Wu LS, et al. Prognostic significance of maspin in pancreatic ductal adenocarcinoma: tissue microarray analysis of 223 surgically resected cases. Mod Pathol. 2007;20:570Y578.
    • (2007) Mod. Pathol. , vol.20 , pp. 570-578
    • Cao, D.1    Zhang, Q.2    Wu, L.S.3
  • 33
    • 14644408093 scopus 로고    scopus 로고
    • Biological functions of SLC5A8 a candidate tumour suppressor
    • Ganapathy V, Gopal E, Miyauchi S, et al. Biological functions of SLC5A8, a candidate tumour suppressor. Biochem Soc Trans. 2005;33:237Y240.
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 237-240
    • Ganapathy, V.1    Gopal, E.2    Miyauchi, S.3
  • 34
    • 70350101307 scopus 로고    scopus 로고
    • Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 HDAC1 and HDAC3 underlies the antitumor activity of 3-bromopyruvate
    • Thangaraju M, Karunakaran SK, Itagaki S, et al. Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. Cancer. 2009;115:4655Y4666.
    • (2009) Cancer , vol.115 , pp. 4655-4666
    • Thangaraju, M.1    Karunakaran, S.K.2    Itagaki, S.3
  • 35
    • 71649114637 scopus 로고    scopus 로고
    • Identification and characterization of the human SLC5A8 gene promoter
    • Zhang Y, Bao YL, Wu Y, et al. Identification and characterization of the human SLC5A8 gene promoter. Cancer Genet Cytogenet. 2010;196:124Y132.
    • (2010) Cancer Genet. Cytogenet. , vol.196 , pp. 124-132
    • Zhang, Y.1    Bao, Y.L.2    Wu, Y.3
  • 36
    • 78149253777 scopus 로고    scopus 로고
    • Activin a induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells
    • Zhang Y, Bao YL, Yang MT, et al. Activin A induces SLC5A8 expression through the Smad3 signaling pathway in human colon cancer RKO cells. Int J Biochem Cell Biol. 2010;42:1964Y1972.
    • (2010) Int. J. Biochem. Cell. Biol. , vol.42 , pp. 1964-1972
    • Zhang, Y.1    Bao, Y.L.2    Yang, M.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.