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Volumn 6, Issue , 2012, Pages 243-252

Vandetanib for the treatment of metastatic Medullary thyroid cancer

Author keywords

Medullary thyroid cancer; RET; Vandetanib

Indexed keywords

BEVACIZUMAB; CAPECITABINE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IMATINIB; IRINOTECAN; OXALIPLATIN; PEMETREXED; PLACEBO; PROTEIN RET; SUNITINIB; TRANSFORMING GROWTH FACTOR ALPHA; VANDETANIB; VASCULOTROPIN RECEPTOR;

EID: 84863924901     PISSN: 11795549     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S7999     Document Type: Review
Times cited : (29)

References (64)
  • 2
    • 14444272505 scopus 로고    scopus 로고
    • Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: Results in 899 patients. The GETC Study Group. Groupe d'étude des tumeurs à calcitonine
    • Modigliani E, Cohen R, Crampos JM, et al. Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: results in 899 patients. The GETC Study Group. Groupe d'étude des tumeurs à calcitonine. Clinical Endocrinology. 1998;48(3):265-73.
    • (1998) Clinical Endocrinology , vol.48 , Issue.3 , pp. 265-273
    • Modigliani, E.1    Cohen, R.2    Crampos, J.M.3
  • 3
    • 0029916917 scopus 로고    scopus 로고
    • Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathological variables
    • Dottorini ME, Assi A, Sironi M, Sangalli G, Spreafico G, Colombo L. Multivariate analysis of patients with medullary thyroid carcinoma. Prognostic significance and impact on treatment of clinical and pathological variables. Cancer. 1996;77(8):1556-65.
    • (1996) Cancer , vol.77 , Issue.8 , pp. 1556-1565
    • Dottorini, M.E.1    Assi, A.2    Sironi, M.3    Sangalli, G.4    Spreafico, G.5    Colombo, L.6
  • 4
    • 33750509391 scopus 로고    scopus 로고
    • Prognosis of medullary thyroid carcinoma: Demographic, clinical, and pathologic predictors of survival in 1252 cases
    • Roman S, Lin R, Sosa JA. Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer. 2006;107(9):2134-42.
    • (2006) Cancer , vol.107 , Issue.9 , pp. 2134-2142
    • Roman, S.1    Lin, R.2    Sosa, J.A.3
  • 5
    • 43249107532 scopus 로고    scopus 로고
    • Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium
    • Matuszczyk A, Petersenn S, Bockisch A, et al. Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium. Horm Metab Res. 2008;40(3):210-3.
    • (2008) Horm Metab Res , vol.40 , Issue.3 , pp. 210-213
    • Matuszczyk, A.1    Petersenn, S.2    Bockisch, A.3
  • 6
    • 0033817180 scopus 로고    scopus 로고
    • Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU dacarbazine
    • Nocera M, Baudin E, Pellegriti G, Cailleux AF, Mechelany-Corone C, Schlumberger M. Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU dacarbazine. British Journal of Cancer. 2000;83(6):715-71.
    • (2000) British Journal of Cancer , vol.83 , Issue.6 , pp. 715-771
    • Nocera, M.1    Baudin, E.2    Pellegriti, G.3    Cailleux, A.F.4    Mechelany-Corone, C.5    Schlumberger, M.6
  • 7
    • 0035679630 scopus 로고    scopus 로고
    • The role of radiotherapy in the management of elevated calcitonin after surgery for medullary thyroid cancer
    • Fersht N, Vini L, A'Hern R, Harmer C. The role of radiotherapy in the management of elevated calcitonin after surgery for medullary thyroid cancer. Thyroid. 2001;11(12):1161-8.
    • (2001) Thyroid , vol.11 , Issue.12 , pp. 1161-1168
    • Fersht, N.1    Vini, L.2    A'Hern, R.3    Harmer, C.4
  • 8
    • 77952877804 scopus 로고    scopus 로고
    • Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC
    • Raue KF, Rondot S, Raue F. Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC. Molecular and Cellular Endocrinology. 2010;332:2-7.
    • (2010) Molecular and Cellular Endocrinology , vol.332 , pp. 2-7
    • Raue, K.F.1    Rondot, S.2    Raue, F.3
  • 9
    • 54549114194 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer
    • Pitt SC, Chen H. The phosphatidylinositol 3-kinase/akt signaling pathway in medullary thyroid cancer. Surgery. 2008;144(5):721-4.
    • (2008) Surgery , vol.144 , Issue.5 , pp. 721-724
    • Pitt, S.C.1    Chen, H.2
  • 10
    • 36448947662 scopus 로고    scopus 로고
    • Neurotrophic factor receptor RET: Structure, cell biology, and inherited diseases
    • Runeberg-Roos P, Saarma M. Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases. Annals of Medicine. 2007;39(8):572-80.
    • (2007) Annals of Medicine , vol.39 , Issue.8 , pp. 572-580
    • Runeberg-Roos, P.1    Saarma, M.2
  • 11
    • 0026565264 scopus 로고
    • Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC
    • Pierotti MA, Santoro M, Jenkins RB, et al. Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC. Proc Natl Acad Sci U S A. 1992;89(5):1616-20.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.5 , pp. 1616-1620
    • Pierotti, M.A.1    Santoro, M.2    Jenkins, R.B.3
  • 12
    • 43049161065 scopus 로고    scopus 로고
    • RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer
    • Lodish MB, Stratakis CA. RET oncogene in MEN2, MEN2B, MTC and other forms of thyroid cancer. Expert Rev Anticancer Ther. 2008;4: 625-32.
    • (2008) Expert Rev Anticancer Ther , vol.4 , pp. 625-632
    • Lodish, M.B.1    Stratakis, C.A.2
  • 13
    • 80053139912 scopus 로고    scopus 로고
    • Gimenez-Roqueplo AP. Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma
    • Burnichon N, Vescovo L, Amar L, et al. Gimenez-Roqueplo AP. Integrative genomic analysis reveals somatic mutations in pheochromocytoma and paraganglioma. Hum Mol Genet. 2011;20(20):3974-85.
    • (2011) Hum Mol Genet , vol.20 , Issue.20 , pp. 3974-3985
    • Burnichon, N.1    Vescovo, L.2    Amar, L.3
  • 14
    • 0030292383 scopus 로고    scopus 로고
    • Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient
    • Angrist M, Bolk S, Halushka M, Lapchak PA, Chakravarti A. Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. Nat Genet. 1996;14(3):341-4.
    • (1996) Nat Genet , vol.14 , Issue.3 , pp. 341-344
    • Angrist, M.1    Bolk, S.2    Halushka, M.3    Lapchak, P.A.4    Chakravarti, A.5
  • 15
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 16
    • 77955298957 scopus 로고    scopus 로고
    • Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma
    • Capp C, Wajner SM, Siqueira DR, Brasil BA, Meurer L, Maia AL. Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma. Thyroid. 2010;20(8):863-71.
    • (2010) Thyroid , vol.20 , Issue.8 , pp. 863-871
    • Capp, C.1    Wajner, S.M.2    Siqueira, D.R.3    Brasil, B.A.4    Meurer, L.5    Maia, A.L.6
  • 17
    • 77449155462 scopus 로고    scopus 로고
    • Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis
    • Rodríguez-Antona C, Pallares J, Montero-Conde C, et al. Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis. Endocr Relat Cancer. 2010;17(1):7-16.
    • (2010) Endocr Relat Cancer , vol.17 , Issue.1 , pp. 7-16
    • Rodríguez-Antona, C.1    Pallares, J.2    Montero-Conde, C.3
  • 18
    • 0034754136 scopus 로고    scopus 로고
    • Epidermal growth factor receptor biology
    • Kim ES, Khuri FR, Herbst RS. Epidermal growth factor receptor biology. Curr Opin Oncol. 2001;13(6):506-13.
    • (2001) Curr Opin Oncol , vol.13 , Issue.6 , pp. 506-513
    • Kim, E.S.1    Khuri, F.R.2    Herbst, R.S.3
  • 19
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma SV, Bell DW, Settleman J, Haber DA. Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007;7(3):169-81.
    • (2007) Nat Rev Cancer , vol.7 , Issue.3 , pp. 169-181
    • Sharma, S.V.1    Bell, D.W.2    Settleman, J.3    Haber, D.A.4
  • 20
    • 16444368462 scopus 로고    scopus 로고
    • Genetic pathways to glioblastomas
    • Ohgaki H. Genetic pathways to glioblastomas. Neuropathology. 2005; 25(1):1-7.
    • (2005) Neuropathology , vol.25 , Issue.1 , pp. 1-7
    • Ohgaki, H.1
  • 21
    • 34547776916 scopus 로고    scopus 로고
    • Epidermal growth factor receptor status in anaplastic thyroid carcinoma
    • Lee DH, Lee GK, Kong SY, et al. Epidermal growth factor receptor status in anaplastic thyroid carcinoma. J Clin Pathol. 2007;60(8):881-4.
    • (2007) J Clin Pathol , vol.60 , Issue.8 , pp. 881-884
    • Lee, D.H.1    Lee, G.K.2    Kong, S.Y.3
  • 22
    • 0033227225 scopus 로고    scopus 로고
    • Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage
    • Chen BK, Ohtsuki Y, Furihata M, et al. Co-overexpression of p53 protein and epidermal growth factor receptor in human papillary thyroid carcinomas correlated with lymph node metastasis, tumor size and clinicopathologic stage. Int J Oncol. 1999;15(5):893-8.
    • (1999) Int J Oncol , vol.15 , Issue.5 , pp. 893-898
    • Chen, B.K.1    Ohtsuki, Y.2    Furihata, M.3
  • 23
    • 0037115405 scopus 로고    scopus 로고
    • ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
    • Carlomagno F, Vitagliano D, Guida T, et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res. 2002;62(24):7284-90.
    • (2002) Cancer Res , vol.62 , Issue.24 , pp. 7284-7290
    • Carlomagno, F.1    Vitagliano, D.2    Guida, T.3
  • 24
    • 79251531655 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells
    • Vitagliano D, De Falco V, Tamburrino A, et al. The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells. Endocr Relat Cancer. 2010;18(1):1-11.
    • (2010) Endocr Relat Cancer , vol.18 , Issue.1 , pp. 1-11
    • Vitagliano, D.1    de Falco, V.2    Tamburrino, A.3
  • 25
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V, et al. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res. 2003;9(4):1546-56.
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 26
    • 23844544081 scopus 로고    scopus 로고
    • Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors
    • Holden SN, Eckhardt SG, Basser R, et al. Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumors. Ann Oncol. 2005;16(8):1391-7.
    • (2005) Ann Oncol , vol.16 , Issue.8 , pp. 1391-1397
    • Holden, S.N.1    Eckhardt, S.G.2    Basser, R.3
  • 27
    • 33846844387 scopus 로고    scopus 로고
    • A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors
    • Tamura T, Minami H, Yamada Y, et al. A phase I dose-escalation study of ZD6474 in Japanese patients with solid, malignant tumors. J Thorac Oncol. 2006;1(9):1002-9.
    • (2006) J Thorac Oncol , vol.1 , Issue.9 , pp. 1002-1009
    • Tamura, T.1    Minami, H.2    Yamada, Y.3
  • 28
    • 84863393782 scopus 로고    scopus 로고
    • Pharmacokinetics of vandetanib: Three phase I studies in healthy subjects
    • Martin P, Oliver S, Kennedy SJ, et al. Pharmacokinetics of vandetanib: three phase I studies in healthy subjects. Clin Ther. 2012;34(1):221-37.
    • (2012) Clin Ther , vol.34 , Issue.1 , pp. 221-237
    • Martin, P.1    Oliver, S.2    Kennedy, S.J.3
  • 29
    • 79953156602 scopus 로고    scopus 로고
    • Pharmacokinetic drug interactions with vandetanib during coadministration with rifampicin or itraconazole
    • Martin P, Oliver S, Robertson J, Kennedy SJ, Read J, Duvauchelle T. Pharmacokinetic drug interactions with vandetanib during coadministration with rifampicin or itraconazole. Drugs R D. 2011;11(1):37-51.
    • (2011) Drugs R D , vol.11 , Issue.1 , pp. 37-51
    • Martin, P.1    Oliver, S.2    Robertson, J.3    Kennedy, S.J.4    Read, J.5    Duvauchelle, T.6
  • 30
    • 77955454200 scopus 로고    scopus 로고
    • Pharmacokinetics of vandetanib in subjects with renal or hepatic impairment
    • Weil A, Martin P, Smith R, et al. Pharmacokinetics of vandetanib in subjects with renal or hepatic impairment. Clin Pharmacokinet. 2010;49(9):607-18.
    • (2010) Clin Pharmacokinet , vol.49 , Issue.9 , pp. 607-618
    • Weil, A.1    Martin, P.2    Smith, R.3
  • 31
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 2002;62(16):4645-55.
    • (2002) Cancer Res , vol.62 , Issue.16 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 32
    • 79956029711 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of vandetanib in Chinese patients with solid, malignant tumors: An open-label, phase I, rising multiple-dose study
    • Zhang L, Li S, Zhang Y, et al. Pharmacokinetics and tolerability of vandetanib in Chinese patients with solid, malignant tumors: an open-label, phase I, rising multiple-dose study. Clin Ther. 2011;33(3):315-27.
    • (2011) Clin Ther , vol.33 , Issue.3 , pp. 315-327
    • Zhang, L.1    Li, S.2    Zhang, Y.3
  • 33
    • 77649214078 scopus 로고    scopus 로고
    • Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Wells SA Jr, Gosnell JE, Gagel RF, et al. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Oncol. 2010;28(5):767-72.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 767-772
    • Wells Jr., S.A.1    Gosnell, J.E.2    Gagel, R.F.3
  • 34
    • 77954478933 scopus 로고    scopus 로고
    • Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer
    • Jun
    • Robinson BG, Paz-Ares L, Krebs A, Vasselli J, Haddad R. Vandetanib (100 mg) in patients with locally advanced or metastatic hereditary medullary thyroid cancer. J Clin Endocrinol Metab. Jun 2010;95(6):2664-71.
    • (2010) J Clin Endocrinol Metab , vol.95 , Issue.6 , pp. 2664-2671
    • Robinson, B.G.1    Paz-Ares, L.2    Krebs, A.3    Vasselli, J.4    Haddad, R.5
  • 35
    • 84655175698 scopus 로고    scopus 로고
    • Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: A randomized, double-blind phase III trial
    • Wells SA Jr, Robinson BG, Gagel RF, et al. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol. 2012;30(2):134-41.
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 134-141
    • Wells Jr., S.A.1    Robinson, B.G.2    Gagel, R.F.3
  • 36
    • 84898702283 scopus 로고    scopus 로고
    • News and Events
    • FDA, FDA [Apr 6, 2011]. Web [Feb 27, 2012]
    • FDA. "News and Events. " FDA Approves New Treatment for Rare Form of Thyroid Cancer. FDA [Apr 6, 2011]. Web [Feb 27, 2012]. http://www.fda. gov/NewsEvents/Newsroom/PressAnnouncements/ucm250168.htm.
    • FDA Approves New Treatment for Rare Form of Thyroid Cancer
  • 37
    • 84857158314 scopus 로고    scopus 로고
    • Incidence and risk of QTc interval prolongation among cancer patients treated with vandetanib: A systematic review and meta-analysis
    • Zang J, Wu S, Tang L, et al. Incidence and risk of QTc interval prolongation among cancer patients treated with vandetanib: a systematic review and meta-analysis. PLoS One. 2012;7(2):e30353.
    • (2012) PLoS One , vol.7 , Issue.2
    • Zang, J.1    Wu, S.2    Tang, L.3
  • 38
    • 84859551607 scopus 로고    scopus 로고
    • Risk of rash in cancer patients treated with vandetanib: Systematic review and meta-analysis
    • Feb 29
    • Rosen AC, Wu S, Damse A, Sherman E, Lacouture ME. Risk of rash in cancer patients treated with vandetanib: systematic review and meta-analysis. J Clin Endocrinol Metab. Feb 29, 2012.
    • (2012) J Clin Endocrinol Metab
    • Rosen, A.C.1    Wu, S.2    Damse, A.3    Sherman, E.4    Lacouture, M.E.5
  • 39
    • 84863123228 scopus 로고    scopus 로고
    • Stevens-johnson syndrome induced by vandetanib
    • Yoon J, Oh CW, Kim CY. Stevens-johnson syndrome induced by vandetanib. Ann Dermatol. 2011;23(Suppl 3):S343-5.
    • (2011) Ann Dermatol , vol.23 , Issue.SUPPL 3
    • Yoon, J.1    Oh, C.W.2    Kim, C.Y.3
  • 40
    • 84855590684 scopus 로고    scopus 로고
    • Unusual adverse event with vandetanib in metastatic medullary thyroid cancer
    • Duplomb S, Benoit A, Mechtouff-Cimarelli L, et al. Unusual adverse event with vandetanib in metastatic medullary thyroid cancer. J Clin Oncol. 2012; 30(2):e21-3.
    • (2012) J Clin Oncol , vol.30 , Issue.2
    • Duplomb, S.1    Benoit, A.2    Mechtouff-Cimarelli, L.3
  • 41
    • 84855823712 scopus 로고    scopus 로고
    • Risk evaluation and mitigation strategies (REMS): Educating the prescriber
    • Nicholson SC, Peterson J, Yektashenas B. Risk evaluation and mitigation strategies (REMS): educating the prescriber. Drug Saf. 2012;35(2): 91-104.
    • (2012) Drug Saf , vol.35 , Issue.2 , pp. 91-104
    • Nicholson, S.C.1    Peterson, J.2    Yektashenas, B.3
  • 42
    • 79953076105 scopus 로고    scopus 로고
    • FDA, FDA [Jun 22, 2011]. Web [Apr 5, 2012]
    • FDA. Approved Risk Evaluation and Mitigation Strategies (REMS). FDA [Jun 22, 2011]. Web [Apr 5, 2012]. http://www.fda.gov/downloads/Drugs/ DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ UCM253441.pdf.
    • Approved Risk Evaluation and Mitigation Strategies (REMS)
  • 44
    • 78650065559 scopus 로고    scopus 로고
    • Cost effectiveness of tyrosine kinase inhibitor therapy in metastatic gastrointestinal stromal tumors
    • Blanke CD, Huse D. Cost effectiveness of tyrosine kinase inhibitor therapy in metastatic gastrointestinal stromal tumors. Journal of Medical Economics. 2010;13(4):681-90.
    • (2010) Journal of Medical Economics , vol.13 , Issue.4 , pp. 681-690
    • Blanke, C.D.1    Huse, D.2
  • 45
    • 79956290905 scopus 로고    scopus 로고
    • The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells
    • Verbeek HH, Alves MM, de Groot JW, et al. The effects of four different tyrosine kinase inhibitors on medullary and papillary thyroid cancer cells. J Clin Endocrinol Metab. 2011;96(6):E991-5.
    • (2011) J Clin Endocrinol Metab , vol.96 , Issue.6
    • Verbeek, H.H.1    Alves, M.M.2    de Groot, J.W.3
  • 46
    • 79955006847 scopus 로고    scopus 로고
    • Vandetanib in locally advanced or metastatic differentiated thyroid cancer: A randomized, double-blind phase II trial
    • (abstr 1008PD)
    • Leboulleux S, Bastholt L, Krause TM, et al. Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomized, double-blind phase II trial. Ann Oncol. 2010;21(Suppl 8):viii 315 (abstr 1008PD).
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL 8
    • Leboulleux, S.1    Bastholt, L.2    Krause, T.M.3
  • 47
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
    • Ciardiello F, Bianco R, Caputo R, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res. 2004;10(2):784-93.
    • (2004) Clin Cancer Res , vol.10 , Issue.2 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3
  • 48
    • 66149163097 scopus 로고    scopus 로고
    • Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance
    • Naumov GN, Nilsson MB, Cascone T, et al. Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance. Clin Cancer Res. 2009;15(10):3484-94.
    • (2009) Clin Cancer Res , vol.15 , Issue.10 , pp. 3484-3494
    • Naumov, G.N.1    Nilsson, M.B.2    Cascone, T.3
  • 49
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: Results from a twopart, double-blind, randomized phase II study
    • Natale RB, Bodkin D, Govindan R, et al. Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a twopart, double-blind, randomized phase II study. J Clin Oncol. 2009;27(15): 2523-9.
    • (2009) J Clin Oncol , vol.27 , Issue.15 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 50
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced nonsmall-cell lung cancer
    • Natale RB, Thongprasert S, Greco FA, et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced nonsmall-cell lung cancer. J Clin Oncol. 2011;29(8):1059-66.
    • (2011) J Clin Oncol , vol.29 , Issue.8 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 51
    • 84861720010 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: A randomized, double-blind phase III trial (ZEPHYR)
    • Lee JS, Hirsh V, Park K, et al. Vandetanib versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol. 2012;30(10): 1114-21.
    • (2012) J Clin Oncol , vol.30 , Issue.10 , pp. 1114-1121
    • Lee, J.S.1    Hirsh, V.2    Park, K.3
  • 52
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-smallcell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-smallcell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol. 2010;11(7):619-26.
    • (2010) Lancet Oncol , vol.11 , Issue.7 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.3
  • 53
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial
    • De Boer RH, Arrieta Ó, Yang CH, et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. J Clin Oncol. 2011;29(8):1067-74.
    • (2011) J Clin Oncol , vol.29 , Issue.8 , pp. 1067-1074
    • de Boer, R.H.1    Arrieta, O.2    Yang, C.H.3
  • 54
    • 0141725532 scopus 로고    scopus 로고
    • Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer
    • Atalay G, Cardoso F, Awada A, Piccart MJ. Novel therapeutic strategies targeting the epidermal growth factor receptor (EGFR) family and its downstream effectors in breast cancer. Ann Oncol. 2003;14(9):1346-63.
    • (2003) Ann Oncol , vol.14 , Issue.9 , pp. 1346-1363
    • Atalay, G.1    Cardoso, F.2    Awada, A.3    Piccart, M.J.4
  • 55
    • 18244387980 scopus 로고    scopus 로고
    • A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer
    • May 1
    • Miller KD, Trigo JM, Wheeler C, et al. A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer. Clin Cancer Res. May 1, 2005;11(9): 3369-76.
    • (2005) Clin Cancer Res , vol.11 , Issue.9 , pp. 3369-3376
    • Miller, K.D.1    Trigo, J.M.2    Wheeler, C.3
  • 56
    • 78649651308 scopus 로고    scopus 로고
    • ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells
    • Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M. ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells. J Cell Physiol. 2011;226(2):375-84.
    • (2011) J Cell Physiol , vol.226 , Issue.2 , pp. 375-384
    • Sarkar, S.1    Mazumdar, A.2    Dash, R.3    Sarkar, D.4    Fisher, P.B.5    Mandal, M.6
  • 57
    • 84861040218 scopus 로고    scopus 로고
    • Vandetanib with docetaxel as secondline treatment for advanced breast cancer: A double-blind, placebo-controlled, randomized phase II study
    • Boér K, Láng I, Llombart-Cussac A, et al. Vandetanib with docetaxel as secondline treatment for advanced breast cancer: a double-blind, placebo-controlled, randomized phase II study. Invest New Drugs. 2012;30(2):681-7.
    • (2012) Invest New Drugs , vol.30 , Issue.2 , pp. 681-687
    • Boér, K.1    Láng, I.2    Llombart-Cussac, A.3
  • 58
    • 84864335912 scopus 로고    scopus 로고
    • A phase I trial of vandetanib combined with capecitabine, oxaliplatin and bevacizumab for the first-line treatment of metastatic colorectal cancer
    • Mar 15
    • Cabebe EC, Fisher GA, Sikic BI. A phase I trial of vandetanib combined with capecitabine, oxaliplatin and bevacizumab for the first-line treatment of metastatic colorectal cancer. Invest New Drugs. Mar 15, 2011.
    • (2011) Invest New Drugs
    • Cabebe, E.C.1    Fisher, G.A.2    Sikic, B.I.3
  • 59
    • 68149172828 scopus 로고    scopus 로고
    • Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: Results from an open-label, multicentre phase I study
    • Saunders MP, Wilson R, Peeters M, et al. Vandetanib with FOLFIRI in patients with advanced colorectal adenocarcinoma: results from an open-label, multicentre phase I study. Cancer Chemother Pharmacol. 2009;64(4):665-72.
    • (2009) Cancer Chemother Pharmacol , vol.64 , Issue.4 , pp. 665-672
    • Saunders, M.P.1    Wilson, R.2    Peeters, M.3
  • 60
    • 64649096230 scopus 로고    scopus 로고
    • Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer
    • Michael M, Gibbs P, Smith R, Godwood A, Oliver S, Tebbutt N. Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer. Invest New Drugs. 2009;27(3):253-61.
    • (2009) Invest New Drugs , vol.27 , Issue.3 , pp. 253-261
    • Michael, M.1    Gibbs, P.2    Smith, R.3    Godwood, A.4    Oliver, S.5    Tebbutt, N.6
  • 61
    • 84862832278 scopus 로고    scopus 로고
    • Vandetanib in patients with inoperable hepatocellular carcinoma: A phase II, randomized, double-blind, placebocontrolled study
    • Jan 13
    • Hsu C, Yang TS, Huo TI, et al. Vandetanib in patients with inoperable hepatocellular carcinoma: A phase II, randomized, double-blind, placebocontrolled study. J Hepatol. Jan 13, 2012.
    • (2012) J Hepatol
    • Hsu, C.1    Yang, T.S.2    Huo, T.I.3
  • 62
    • 66249113517 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer
    • Horti J, Widmark A, Stenzl A, et al. A randomized, double-blind, placebo-controlled phase II study of vandetanib plus docetaxel/prednisolone in patients with hormone-refractory prostate cancer. Cancer Biother Radiopharm. 2009;24(2):175-80.
    • (2009) Cancer Biother Radiopharm , vol.24 , Issue.2 , pp. 175-180
    • Horti, J.1    Widmark, A.2    Stenzl, A.3
  • 63
    • 84856851592 scopus 로고    scopus 로고
    • Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinumpretreated metastatic urothelial cancer
    • Choueiri TK, Ross RW, Jacobus S, et al. Double-blind, randomized trial of docetaxel plus vandetanib versus docetaxel plus placebo in platinumpretreated metastatic urothelial cancer. J Clin Oncol. 2012;30(5):507-12.
    • (2012) J Clin Oncol , vol.30 , Issue.5 , pp. 507-512
    • Choueiri, T.K.1    Ross, R.W.2    Jacobus, S.3
  • 64
    • 80052690695 scopus 로고    scopus 로고
    • Phase I dose-finding study of vandetanib in combination with gemcitabine in locally advanced unresectable or metastatic pancreatic adenocarcinoma
    • Saletti P, Sessa C, De Dosso S, Cerny T, Renggli V, Koeberle D. Phase I dose-finding study of vandetanib in combination with gemcitabine in locally advanced unresectable or metastatic pancreatic adenocarcinoma. Oncology. 2011;81(1):50-4.
    • (2011) Oncology , vol.81 , Issue.1 , pp. 50-54
    • Saletti, P.1    Sessa, C.2    de Dosso, S.3    Cerny, T.4    Renggli, V.5    Koeberle, D.6


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