Hepatitis B virus e antigen physically associates with receptor-interacting serine/threonine protein kinase 2 and regulates IL-6 gene expression

Journal of Infectious Diseases

Volumn 206, Issue 3, 2012, Pages 415-420

  Wu, Shuang ^a   Kanda, Tatsuo ^a   Imazeki, Fumio ^a   Nakamoto, Shingo ^a   Tanaka, Takeshi ^a   Arai, Makoto ^a   Roger, Thierry ^b   Shirasawa, Hiroshi ^a   Nomura, Fumio ^a   Yokosuka, Osamu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 4; HEPATITIS B(E) ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 2;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANTIGEN FUNCTION; ARTICLE; CELL MIGRATION; CELL STRAIN HEPG2; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; HEPATITIS B; HUMAN; INNATE IMMUNITY; INTERLEUKIN 6 GENE; INTRACELLULAR SIGNALING; MOLECULAR INTERACTION; MOLECULAR PATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; WOUND HEALING;

ANIMALS; CELL LINE; DOWN-REGULATION; GENE EXPRESSION REGULATION; HEPATITIS B E ANTIGENS; HEPATITIS B VIRUS; HUMANS; INTERLEUKIN-6; NF-KAPPA B; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2;

EID: 84863923963     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis363     Document Type: Article

References (15)

1. Ait-Goughoulte M, Lucifora J, Zoulim F, Durantel D. Innate antiviral immune responses to hepatitis B virus. Viruses 2010; 2:1394-410.
2. Chen M, Sallberg M, Hughes J, et al. Immune tolerance split between hepatitis B virus precore and core proteins. J Virol 2005; 79:3016-27.
3. Ou JH, Laub O, Rutter WJ. Hepatitis B virus gene function: the precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc Natl Acad Sci USA 1986; 83:1578-82.
4. Wu S, Kanda T, Imazeki F, et al. Hepatitis B virus e antigen downregulates cytokine production in human hepatoma cell lines. Viral Immunol 2010; 23:467-76.
5. Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A. The hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway. J Hepatol 2011; 55:762-9.
6. Hasegawa M, Fujimoto Y, Lucas PC, et al. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 2008; 27:373-83.
7. Kobayashi K, Inohara N, Hernandez LD, et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002; 416:194-9.
8. Krieg A, Correa RG, Garrison JB, et al. XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci USA 2009; 106:14524-9.
9. Scott MJ, Chen C, Sun Q, Billiar TR. Hepatocytes express functional NOD1 and NOD2 receptors: a role for NOD1 in hepatocyte CC and CXC chemokine production. J Hepatol 2010; 53:693-701.
10. Adams S, Valchanova RS, Munz B. RIP2: a novel player in the regulation of keratinocyte proliferation and cutaneous wound repair? Exp Cell Res 2010; 316:728-36.
11. Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996; 274:1379-83.
12. Moura-Neto V, Kryszke MH, Li Z, Vicart P, Lilienbaum A, Paulin D. A 28-bp negative element with multiple factor-binding activity controls expression of the vimentin-encoding gene. Gene 1996; 168:261-6.
13. Meylan E, Tschopp J. The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 2005; 30:151-9.
14. Chin AI, Dempsey PW, Bruhn K, Miller JF, Xu Y, Cheng G. Involvement of receptor-interacting protein 2 in innate and adaptive immune responses. Nature 2002; 416:190-4.
15. Garcia PD, Ou JH, Rutter WJ, Walter P. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol 1988; 106:1093-104.