Antidiabetic II drug metformin in plants: Uptake and translocation to edible parts of cereals, oily seeds, beans, tomato, squash, carrots, and potatoes

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 28, 2012, Pages 6929-6935

  Eggen, Trine ^a   Lillo, Cathrine ^b  

^a NORWEGIAN INSTITUTE OF BIOECONOMY RESEARCH   (Norway)

^b UNIVERSITY OF STAVANGER   (Norway)

Author keywords

bioconcentration factor (BCF); Brassica; metformin; OCTs; pharmaceuticals; seeds

Indexed keywords

ACTIVATED SLUDGE; ADVERSE EFFECT; AGRICULTURAL SOILS; ANTIDIABETIC; BEAN PODS; BIOCONCENTRATION FACTOR; BRASSICA; BRASSICA NAPUS; BRASSICA RAPA; DEGRADATION PRODUCTS; DRY WEIGHT; EDIBLE PLANTS; FOOD CHAIN; GREENHOUSE EXPERIMENTS; GUANYLUREA; INITIAL CONCENTRATION; METFORMINS; NON-TARGETED; OCTS; ORGANIC CATION TRANSPORTERS;

DEGRADATION; DRUG PRODUCTS; FRUITS; GRAIN (AGRICULTURAL PRODUCT); SEWAGE SLUDGE;

SEED;

ANTIDIABETIC AGENT; METFORMIN;

ARTICLE; BRASSICA; CARROT; CEREAL; CHEMISTRY; FABACEAE; FRUIT; METABOLISM; PLANT; PLANT ROOT; PLANT SEED; POTATO; TOMATO; TRANSPORT AT THE CELLULAR LEVEL;

BIOLOGICAL TRANSPORT; BRASSICA; CEREALS; DAUCUS CAROTA; FABACEAE; FRUIT; HYPOGLYCEMIC AGENTS; LYCOPERSICON ESCULENTUM; METFORMIN; PLANT ROOTS; PLANTS, EDIBLE; SEEDS; SOLANUM TUBEROSUM;

BRASSICA; BRASSICA NAPUS; BRASSICA RAPA; DAUCUS CAROTA; HORDEUM; LYCOPERSICON ESCULENTUM; MAMMALIA; SOLANUM TUBEROSUM; TRITICUM AESTIVUM;

EID: 84863918026     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf301267c     Document Type: Article

References (48)

1. Heberer, T.; Schmidt-Bäumler, R.; Stan, H.-J. Occurrence and distribution of organic contaminants in the aquatic system in Berlin. Part I. Drug residues and other polar contaminants in Berlin surface and groundwater Acta Hydrochim. Hydrobiol. 1998, 26, 272-278
2. Daughton, C. G.; Ternes, T. A. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. 1999, 107, 907-937
3. Henschel, K.-P.; Wenzel, A.; Diedrich, M.; Fliedner, A. Environmental hazard assessment of pharmaceuticals Regul. Toxicol. Pharmacol. 1997, 25, 220-225
4. Zhao, L.; Dong, Y. H.; Wang, H. Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China Sci. Total Environ. 2010, 408, 1069-1075
5. Campagnolol, E. R.; Johnson, K. R.; Karpati, A.; Rubin, C. S.; Kolpin, D. W.; Meyer, M. T.; Esteban, J. E.; Currier, R. W.; Smith, K.; Thu, K. M.; McGeehin, M. Antimicrobial residues in animal waste and water resouces proximal to large-scale swine and poultry feeding operations Sci. Total Environ. 2002, 299, 89-95
6. Onesios, K. M.; Yu, J. T.; Bouwer, E. J. Biodegradation and removal of pharmaceuticals and personal care products in treatment systems: a review Biodegradation 2009, 20, 441-466
7. McClellan, K.; Halden, R. U. Pharmaceuticals and personal care products in archived U.S. biosolids from the 2001 EPA national sewage sludge survey Water Res. 2010, 44, 658-668
8. Wu, C.; Spongberg, A. L.; Witter, J. D.; Fang, M.; Czajkowski, K. P. Uptake of pharmaceutical and personal care products by soybean plants from soils applied with biosolids and irrigated with contaminated water Environ. Sci. Technol. 2010, 44, 6157-6161
9. Pedersen, J. A.; Soliman, M.; Suffet, I.H. Human pharmaceuticals, hormones, and personal care product ingredients in runoff from agricultural fields irrigated with treated wastewater J. Agric. Food Chem. 2005, 53, 1625-1632
10. Sebastine, I. M.; Wakeman, R. J. Consumption and environmental hazards of pharmaceutical substances in the UK Process Saf. Environ. 2003, 81, 229-235
11. Huschek, G.; Hansen, P. D.; Maurer, H. H.; Krengel, D.; Kayser, A. Environmental risk assessment of medicinal products for human use according to European commission recommendation Environ. Toxicol. 2004, 19, 226-240
12. Pentikainen, P. J. Eur. J. Clin. Pharmacol. 1979, 16, 195-202
13. Kolpin, D. W.; Furlong, E. T.; Meyer, M. T.; Thurman, E. M.; Zaugg, S. D.; Barber, L. B.; Buxton, H. T. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance Environ. Sci. Technol. 2002, 36, 1202-1211
14. Scheurer, M.; Sacher, F.; Brauch, H.-J. Occurrence of the antidiabetic drug metformin in sewage and surface waters in Germany J. Environ. Monitor. 2009, 11, 1608-1613
15. U.S. EPA. Targeted National Sewage Sludge Survey; Sampling and Analysis Technical Report; Washington, DC, 2008.
16. Trautwein, C.; Kümmer, K. Incomplete aerobic degradation of the antidiabetic drug Metformin and identification of the bacterial dead-end transformation product guanylurea Chemosphere 2011, 85, 765-773
17. Eggen, T.; Asp, T. N.; Grave, K.; Hormazabal, V. Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants Chemosphere 2011, 85, 26-33
18. Bailey, C. J.; Day, C. Metformin: its botanical background Pract. Diabetes Int. 2004, 21, 115-117
19. Hormazabal, V.; østensvik, ø. Determination of metformin in cultivated plant species and soil by liquid chromatography-mass spectrometry J. Liq. Chromatogr. Relat. Technol. 2010, 33, 1630-1639
20. 15N-labelling-based simulation model of N partitioning between vegetative and reproductive tissues Ann. Bot. 2005, 95, 1187-1198
21. Rossato, L.; Lainé, P.; Ourry, A. Nitrogen storage and remobilization in Brassica napus L. during growth cycle: nitrogen fluxes within the plant and changes in soluble protein patterns J. Exp. Bot. 2001, 52, 1655-1663
22. Malagoli, P.; Laine, P.; Rossato, L.; Ourry, A. Dynamics of nitrogen uptake and mobilization in field-grown winter oilseed rape (Brassica napus) from stem extension to harvest. I. Global N flows between vegetative and reproductive tissues in relation to leaf fall and their residual N Ann. Bot. 2005, 95, 853-861
23. Schjoerring, J. K.; Bock, J. G. H.; Gammelvind, L; Jensen, C. R.; Mogensen, V. O. Nitrogen incorporation and remobilization in different shoot components of field-grown winter oilseed rape (Brassica napus L.) as affected by rate of nitrogen application and irrigation Plant Soil 1995, 177, 255-264
24. Zohair, A.; Salim, A.-B.; Soyibo, A. A.; Beck, A. J. Residues of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides in organically-farmed vegetables Chemosphere 2006, 63, 541-553
25. Boxall, A. B. A.; Johnson, P.; Smith, E. J.; Sinclair, C. J.; Stutt, E.; Levy, L. S. Uptake of veterinary medicines from soils into plants J. Agric. Food Chem. 2006, 54, 2288-2297
26. Beevers, L. Nitrogen Metabolism in Plants; Elsevier: New York, 1976; ISBN: 0444195025.
27. Rosenthal, G. A. l -Canavanine metabolism in Jack bean, Canavalia ensiformis (L.) DC. (Leguminosae) Plant Physiol. 1982, 69, 1066-1069
28. Nies, A. T.; Hofmann, U.; Resch, C.; Schaeffeler, E.; Rius, M.; Schwab, M. Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs) PLoS One 2011, 6, e22163
29. Jonker, J. W.; Schinkel, A. H. Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2 and 3 (SLC22A1-3) J. Pharmacol. Exp. Ther. 2004, 308, 2-9
30. Lelandais-Brière, C.; Javanovic, M.; Torres, G. A. M.; Perrin, Y.; Lemoine, R.; Corre-Menguy, F.; Hartmann, C. Disruption of AtOCT1, an organic cation transporter gene, affects root development and carnitine-related responses in Arabidopsis Plant J. 2007, 51, 154-164
31. Küfner, I.; Koch, W. Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane. BMC Res. Notes I 2008, 43, DOI: 10.1186/1756-0500-1-43.
32. Herklotz, P. A.; Gurung, P.; Heuvel, B. V.; Kinney, C. A. Uptake of human pharmaceuticals by plants grown under hydroponic conditions Chemosphere 2010, 78, 1416-1421
33. Bartha, B.; Huber, C.; Harpaintner; Schröder, P. Effects of acetaminophen in Brassica juncea L. Czern.: investigation of uptake, translocation, detoxificiation, and the induced defense pathways Environ. Sci. Pollut. Res. 2010, 17, 1553-1562
34. Kumar, K.; Gupta, S. C.; Baidoo, S. K.; Chander, Y.; Rosen, C. J. Antibiotic uptake by plants from soil fertilized with animal manure J. Environ. Qual. 2005, 34, 2082-2085
35. Bromilow, R. H.; Chamberlain, K. Principles Governing Uptake and Transport of Chemicals; Lewis Publishers: London, U.K., 1995; pp 37-68.
36. Trapp, S. Model for uptake of xenobiotics into plants. In Plant Contamination. Modeling and Simulation of Organic Chemical Processes; Trapp, S.; McFarlane, J. C., Eds.; Lewis Publishers: Boca Raton, FL, 1995.
37. Trapp, S.; Matthies, M. Generic one-compartment model for uptake of organic chemicals by foliar vegetation Environ. Sci. Technol. 1995, 29, 2333-2338
38. Briggs, G. G.; Bromilow, R. H.; Evans, A. A.; Williams, M. Relationships between lipophilicity and the distribution of non-ionised chemicals in barley shoots following uptake by the roots Pestic. Sci. 1983, 14, 492-500
39. Ryan, J. A.; Bell, R. M.; Davidson, J. M.; O'Connor, G. A. Plant uptake of non-ionic organic chemicals from soils Chemosphere 1988, 17, 2299-2323
40. Chiou, C. T.; Sheng, G.; Manes, M. A partition-limited model for the plant uptake of organic contaminants from soil and water Environ. Sci. Technol. 2001, 35, 1437-1444
41. McFarlane, J. C. Anatomy and physiology of plant conductive systems. In Plant Contaminantion. Modeling and Simulation of Organic Chemical Processes; Trapp, S.; McFarlane, J. C., Eds.; Lewis Publishers: Boca Raton, FL, 1995.
42. Dettenmaier, E. M.; Doucette, W. J.; Bugbee, B. Chemical hydrophobicity and uptake by plant roots Environ. Sci. Technol. 2009, 43, 324-329
43. Kleier, D. A. Phloem mobility of xenobiotics. V. Structural requirements for phloem-systemic pesticides Pestic. Sci. 1994, 42, 1-11
44. Kleier, D. A. Phloem mobility of xenobiotics Plant Physiol. 1988, 86, 803-810
45. Wink, M. Quinolizidine alkaloids: Biochemistry, metabolism, and function in plants and cell suspension cultures Planta Med. 1987, 509-514
46. Wink, M.; Hartmann, T.; Witte, L.; Rheinheimer, J. Interrelationship between quinolizidine alkaloid producing legumes and infesting insects: exploitation of the alkaloid-containing phloem sap of Cytisus scoparius by the Brrom Aphid Aphis cytisorum Z. Naturforsch. 1982, 37c, 1081-1086
47. Wink, M.; Witte, L. Turnover and transport of quinolizidine alkaloids. Diurnal fluctuations of lupanine in the phloem sap, leaves and fruits of Lupinus albus L Planta Med. 1984, 161, 519-523
48. Rentsch, D.; Schmidt, S.; Tegeder, M. Transporters for uptake and allocation of organic nitrogen compounds in plants. Minireview FEBS Lett. 2007, 581, 2281-2289