메뉴 건너뛰기




Volumn 6, Issue , 2012, Pages 205-217

Acute myeloid leukemia: Focus on novel therapeutic strategies

Author keywords

Acute myeloid leukemia; Cancer stem cells; Clofarabine; FLT3; Gemtuzumab ozogamicin

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTHRACYCLINE; ANTILEUKEMIC AGENT; AZACITIDINE; CELATOR; CLOFARABINE; CPX 351; CYCLOPHOSPHAMIDE; CYTARABINE; DASATINIB; ELACYTARABINE; ETOPOSIDE; FLAVOPIRIDOL; FLUCYTOSINE DEOXYRIBOSIDE; GEMTUZUMAB OZOGAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; IDARUBICIN; IMATINIB; LENALIDOMIDE; LOMUSTINE; MITOXANTRONE; PANOBINOSTAT; PLERIXAFOR; QUIZARTINIB; ROMIDEPSIN; SAPACITABINE; TIGECYCLINE; TIOGUANINE; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

EID: 84863911468     PISSN: 11795549     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S7244     Document Type: Review
Times cited : (29)

References (85)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Jul-Aug
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin. Jul-Aug 2011;61(4):212-36.
    • (2011) CA Cancer J Clin , vol.61 , Issue.4 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 79952079063 scopus 로고    scopus 로고
    • Modern approaches to treating acute promyelocytic leukemia
    • Feb
    • Sanz MA, Lo-Coco F. Modern approaches to treating acute promyelocytic leukemia. J Clin Oncol. Feb 2011;29(5):495-503.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 495-503
    • Sanz, M.A.1    Lo-Coco, F.2
  • 3
    • 0019812609 scopus 로고
    • Treatment of acute myelocytic leukemia: A study by cancer and leukemia group B
    • Dec
    • Rai KR, Holland JF, Glidewell OJ, et al. Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Blood. Dec 1981;58(6): 1203-12.
    • (1981) Blood , vol.58 , Issue.6 , pp. 1203-1212
    • Rai, K.R.1    Holland, J.F.2    Glidewell, O.J.3
  • 4
    • 0015721940 scopus 로고
    • Cytosine arabinoside (NSC-63878) and daunorubicin (NSC-83142) therapy in acute nonlymphocytic leukemia
    • Nov-Dec
    • Yates JW, Wallace HJ, Ellison RR, Holland JF. Cytosine arabinoside (NSC-63878) and daunorubicin (NSC-83142) therapy in acute nonlymphocytic leukemia. Cancer Chemother Rep. Nov-Dec 1973;57(4):485-8.
    • (1973) Cancer Chemother Rep , vol.57 , Issue.4 , pp. 485-488
    • Yates, J.W.1    Wallace, H.J.2    Ellison, R.R.3    Holland, J.F.4
  • 5
    • 0027941369 scopus 로고
    • Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B
    • Oct
    • Mayer RJ, Davis RB, Schiffer CA, et al. Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. N Engl J Med. Oct 1994;331(14):896-903.
    • (1994) N Engl J Med , vol.331 , Issue.14 , pp. 896-903
    • Mayer, R.J.1    Davis, R.B.2    Schiffer, C.A.3
  • 6
    • 33745191374 scopus 로고    scopus 로고
    • Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: Results from Cancer and Leukemia Group B 8461
    • Jul
    • Farag SS, Archer KJ, Mrózek K, et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood. Jul 2006;108(1): 63-73.
    • (2006) Blood , vol.108 , Issue.1 , pp. 63-73
    • Farag, S.S.1    Archer, K.J.2    Mrózek, K.3
  • 7
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Oct
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. Oct 1998;92(7):2322-33.
    • (1998) Blood , vol.92 , Issue.7 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 8
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: A Southwest Oncology Group/Eastern Cooperative Oncology Group Study
    • Dec
    • Slovak M, Kopecky K, Cassileth P, et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. Dec 2000;96(13):4075-83.
    • (2000) Blood , vol.96 , Issue.13 , pp. 4075-4083
    • Slovak, M.1    Kopecky, K.2    Cassileth, P.3
  • 9
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Dec
    • Byrd J, Mrózek K, Dodge R, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood. Dec 2002; 100(13):4325-36.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.1    Mrózek, K.2    Dodge, R.3
  • 10
    • 84898689404 scopus 로고    scopus 로고
    • NCCN Practice Guidelines in Oncology v.2.2010
    • Accessed Jul 5, 2010
    • Members NAMLP. NCCN Practice Guidelines in Oncology v.2.2010. Acute Myeloid Leukemia. 2010; http://www.nccn.org/professionals/physician_ gls/PDF/aml.pdf. Accessed Jul 5, 2010.
    • (2010) Acute Myeloid Leukemia
    • Members, N.A.M.L.P.1
  • 11
    • 0038170400 scopus 로고    scopus 로고
    • Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
    • Jun
    • Care RS, Valk PJ, Goodeve AC, et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol. Jun 2003;121(5):775-7.
    • (2003) Br J Haematol , vol.121 , Issue.5 , pp. 775-777
    • Care, R.S.1    Valk, P.J.2    Goodeve, A.C.3
  • 12
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): A Cancer and Leukemia Group B Study
    • Aug
    • Paschka P, Marcucci G, Ruppert AS, et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. J Clin Oncol. Aug 2006;24(24): 3904-11.
    • (2006) J Clin Oncol , vol.24 , Issue.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 13
    • 14644438570 scopus 로고    scopus 로고
    • Risk assessment in patients with acute myeloid leukemia and a normal karyotype
    • Feb
    • Bienz M, Ludwig M, Leibundgut E, et al. Risk assessment in patients with acute myeloid leukemia and a normal karyotype. Clin Cancer Res. Feb 2005; 11(4):1416-24.
    • (2005) Clin Cancer Res , vol.11 , Issue.4 , pp. 1416-1424
    • Bienz, M.1    Ludwig, M.2    Leibundgut, E.3
  • 14
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: Are we ready for a prognostically prioritized molecular classification?
    • Jan
    • Mrózek K, Marcucci G, Paschka P, Whitman S, Bloomfield C. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood. Jan 2007;109(2):431-48.
    • (2007) Blood , vol.109 , Issue.2 , pp. 431-448
    • Mrózek, K.1    Marcucci, G.2    Paschka, P.3    Whitman, S.4    Bloomfield, C.5
  • 15
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • May
    • Schlenk R, Döhner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med. May 2008;358(18):1909-18.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1909-1918
    • Schlenk, R.1    Döhner, K.2    Krauter, J.3
  • 16
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: Recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Jan
    • Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. Jan 2010;115(3): 453-474.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3
  • 17
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Jan
    • Falini B, Mecucci C, Tiacci E, et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med. Jan 2005; 352(3):254-66.
    • (2005) N Engl J Med , vol.352 , Issue.3 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 18
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: A study of the AML Study Group Ulm
    • Dec
    • Fröhling S, Schlenk R, Breitruck J, et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood. Dec 2002;100(13):4372-80.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4372-4380
    • Fröhling, S.1    Schlenk, R.2    Breitruck, J.3
  • 19
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: Prognostic relevance and analysis of cooperating mutations
    • Feb
    • Fröhling S, Schlenk R, Stolze I, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol. Feb 2004;22(4): 624-33.
    • (2004) J Clin Oncol , vol.22 , Issue.4 , pp. 624-633
    • Fröhling, S.1    Schlenk, R.2    Stolze, I.3
  • 20
    • 70349467775 scopus 로고    scopus 로고
    • Anthracycline dose intensification in acute myeloid leukemia
    • Sep
    • Fernandez HF, Sun Z, Yao X, et al. Anthracycline dose intensification in acute myeloid leukemia. N Engl J Med. Sep 2009;361(13):1249-59.
    • (2009) N Engl J Med , vol.361 , Issue.13 , pp. 1249-1259
    • Fernandez, H.F.1    Sun, Z.2    Yao, X.3
  • 21
    • 77649202987 scopus 로고    scopus 로고
    • Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: Results of the ALFA-9801 study
    • Feb
    • Pautas C, Merabet F, Thomas X, et al. Randomized study of intensified anthracycline doses for induction and recombinant interleukin-2 for maintenance in patients with acute myeloid leukemia age 50 to 70 years: results of the ALFA-9801 study. J Clin Oncol. Feb 2010;28(5):808-14.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 808-814
    • Pautas, C.1    Merabet, F.2    Thomas, X.3
  • 22
    • 70349451999 scopus 로고    scopus 로고
    • High-dose daunorubicin in older patients with acute myeloid leukemia
    • Sep
    • Löwenberg B, Ossenkoppele GJ, van Putten W, et al. High-dose daunorubicin in older patients with acute myeloid leukemia. N Engl J Med. Sep 2009;361(13):1235-48.
    • (2009) N Engl J Med , vol.361 , Issue.13 , pp. 1235-1248
    • Löwenberg, B.1    Ossenkoppele, G.J.2    van Putten, W.3
  • 23
    • 84898690338 scopus 로고    scopus 로고
    • Accessed Mar 1, 2012
    • http://www.clinicaltrials.gov. Accessed Mar 1, 2012.
  • 24
    • 77955280642 scopus 로고    scopus 로고
    • Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:Daunorubicin formulation, in bone marrow xenografts
    • Sep
    • Lim WS, Tardi PG, Dos Santos N, et al. Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:daunorubicin formulation, in bone marrow xenografts. Leuk Res. Sep 2010;34(9): 1214-23.
    • (2010) Leuk Res , vol.34 , Issue.9 , pp. 1214-1223
    • Lim, W.S.1    Tardi, P.G.2    Dos Santos, N.3
  • 25
    • 84863968369 scopus 로고    scopus 로고
    • CPX-351: A Randomized Phase 2b Study of CPX-351 v. Intensive Salvage Therapy in #65 Yo First Relapse AML Patients: Initial Efficacy and Safety Report
    • Cortes J, Feldman E, Goldberg S, et al. CPX-351: A Randomized Phase 2b Study of CPX-351 v. Intensive Salvage Therapy in #65 Yo First Relapse AML Patients: Initial Efficacy and Safety Report. Blood ASH Annual Meeting Abstracts. 2011;118:254.
    • (2011) Blood ASH Annual Meeting Abstracts , vol.118 , pp. 254
    • Cortes, J.1    Feldman, E.2    Goldberg, S.3
  • 26
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: Results of the MRC AML15 trial
    • Feb
    • Burnett AK, Hills RK, Milligan D, et al. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J Clin Oncol. Feb 2011;29(4): 369-77.
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3
  • 27
    • 84860121680 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to intensive chemotherapy in older patients with AML produces a significant improvement in overall survival: Results of UK NCRI AML16 randomized trial
    • Burnett A, Hills R, Hunter A, et al. The addition of gemtuzumab ozogamicin to intensive chemotherapy in older patients with AML produces a significant improvement in overall survival: results of UK NCRI AML16 randomized trial. Blood ASH Annual Meeting Abstracts. 2011; 118:582.
    • (2011) Blood ASH Annual Meeting Abstracts , vol.118 , pp. 582
    • Burnett, A.1    Hills, R.2    Hunter, A.3
  • 28
    • 84860176499 scopus 로고    scopus 로고
    • Fractionated Doses of Gemtuzumab Ozogamicin (GO) Combined to Standard Chemotherapy (CT) Improve Event-Free and Overall Survival in Newly-Diagnosed De Novo AML Patients Aged 50-70 Years Old: A Prospective Randomized Phase 3 Trial From the Acute Leukemia French Association (ALFA)
    • Castaigne S, Pautas C, Terre C, Raffoux E, Bordessoule D. Fractionated Doses of Gemtuzumab Ozogamicin (GO) Combined to Standard Chemotherapy (CT) Improve Event-Free and Overall Survival in Newly-Diagnosed De Novo AML Patients Aged 50-70 Years Old: A Prospective Randomized Phase 3 Trial From the Acute Leukemia French Association (ALFA). Blood ASH Annual Meeting Abstracts. 2011;118:6.
    • (2011) Blood ASH Annual Meeting Abstracts , vol.118 , pp. 6
    • Castaigne, S.1    Pautas, C.2    Terre, C.3    Raffoux, E.4    Bordessoule, D.5
  • 29
    • 84861733011 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to chemotherapy improves event-free survival but not overall survival of AML patients wtih intermediate cytogenetics not eligible for allogeneic transplantation. Resuilts of the GOELAMS AML 2006 IR study
    • Delauney J, Recher C, Pigneux A, et al. Addition of gemtuzumab ozogamicin to chemotherapy improves event-free survival but not overall survival of AML patients wtih intermediate cytogenetics not eligible for allogeneic transplantation. Resuilts of the GOELAMS AML 2006 IR study. Blood ASH Annual Meeting Abstracts. 2011;118:615.
    • (2011) Blood ASH Annual Meeting Abstracts , vol.118 , pp. 615
    • Delauney, J.1    Recher, C.2    Pigneux, A.3
  • 30
    • 80051604949 scopus 로고    scopus 로고
    • Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
    • Aug
    • Scandura JM, Roboz GJ, Moh M, et al. Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. Blood. Aug 2011;118(6):1472-80.
    • (2011) Blood , vol.118 , Issue.6 , pp. 1472-1480
    • Scandura, J.M.1    Roboz, G.J.2    Moh, M.3
  • 31
    • 28544443503 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias
    • Dec
    • Karp JE, Passaniti A, Gojo I, et al. Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias. Clin Cancer Res. Dec 2005;11(23):8403-12.
    • (2005) Clin Cancer Res , vol.11 , Issue.23 , pp. 8403-8412
    • Karp, J.E.1    Passaniti, A.2    Gojo, I.3
  • 32
    • 77952902915 scopus 로고    scopus 로고
    • Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia
    • Jul
    • Karp JE, Blackford A, Smith BD, et al. Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. Leuk Res. Jul 2010; 34(7):877-82.
    • (2010) Leuk Res , vol.34 , Issue.7 , pp. 877-882
    • Karp, J.E.1    Blackford, A.2    Smith, B.D.3
  • 33
    • 84898693613 scopus 로고    scopus 로고
    • Final report of a phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS)
    • Garcia-Manero G, Tambaro F, Bekele N, Yang H. Final report of a phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS). Blood ASH Annual Meeting Abstracts. 2011;118:763.
    • (2011) Blood ASH Annual Meeting Abstracts , vol.118 , pp. 763
    • Garcia-Manero, G.1    Tambaro, F.2    Bekele, N.3    Yang, H.4
  • 34
    • 0037158110 scopus 로고    scopus 로고
    • The outcomes and costs of acute myeloid leukemia among the elderly
    • Jul
    • Menzin J, Lang K, Earle CC, Kerney D, Mallick R. The outcomes and costs of acute myeloid leukemia among the elderly. Arch Intern Med. Jul 2002;162(14):1597-603.
    • (2002) Arch Intern Med , vol.162 , Issue.14 , pp. 1597-1603
    • Menzin, J.1    Lang, K.2    Earle, C.C.3    Kerney, D.4    Mallick, R.5
  • 35
    • 33646404606 scopus 로고    scopus 로고
    • Age and acute myeloid leukemia
    • May
    • Appelbaum FR, Gundacker H, Head DR, et al. Age and acute myeloid leukemia. Blood. May 2006;107(9):3481-5.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3481-3485
    • Appelbaum, F.R.1    Gundacker, H.2    Head, D.R.3
  • 36
    • 81255175041 scopus 로고    scopus 로고
    • Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: A novel paradigm for treatment assignment
    • Nov
    • Walter RB, Othus M, Borthakur G, et al. Prediction of early death after induction therapy for newly diagnosed acute myeloid leukemia with pretreatment risk scores: a novel paradigm for treatment assignment. J Clin Oncol. Nov 2011;29(33):4417-23.
    • (2011) J Clin Oncol , vol.29 , Issue.33 , pp. 4417-4423
    • Walter, R.B.1    Othus, M.2    Borthakur, G.3
  • 37
    • 77449121200 scopus 로고    scopus 로고
    • "I am older, not elderly, " said the patient with acute myeloid leukemia
    • Feb
    • Schiffer CA. "I am older, not elderly, " said the patient with acute myeloid leukemia. J Clin Oncol. Feb 2010;28(4):521-3.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 521-523
    • Schiffer, C.A.1
  • 38
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Feb
    • Fenaux P, Mufti GJ, Hellström-Lindberg E, et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol. Feb 2010;28(4):562-9.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3
  • 39
    • 77449149374 scopus 로고    scopus 로고
    • Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia
    • Feb
    • Cashen AF, Schiller GJ, O'Donnell MR, DiPersio JF. Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia. J Clin Oncol. Feb 2010;28(4):556-61.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 556-561
    • Cashen, A.F.1    Schiller, G.J.2    O'Donnell, M.R.3    DiPersio, J.F.4
  • 40
    • 73149099172 scopus 로고    scopus 로고
    • Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities
    • Dec
    • Ravandi F, Issa JP, Garcia-Manero G, et al. Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities. Cancer. Dec 2009;115(24):5746-51.
    • (2009) Cancer , vol.115 , Issue.24 , pp. 5746-5751
    • Ravandi, F.1    Issa, J.P.2    Garcia-Manero, G.3
  • 41
    • 79951908984 scopus 로고    scopus 로고
    • Dose escalation of lenalidomide in relapsed or refractory acute leukemias
    • Nov
    • Blum W, Klisovic RB, Becker H, et al. Dose escalation of lenalidomide in relapsed or refractory acute leukemias. J Clin Oncol. Nov 2010;28(33): 4919-25.
    • (2010) J Clin Oncol , vol.28 , Issue.33 , pp. 4919-4925
    • Blum, W.1    Klisovic, R.B.2    Becker, H.3
  • 42
    • 79960687125 scopus 로고    scopus 로고
    • A phase 2 study of lenalidomide monotherapy in patients with deletion 5q acute myeloid leukemia: Southwest Oncology Group Study S0605
    • Jul
    • Sekeres MA, Gundacker H, Lancet J, et al. A phase 2 study of lenalidomide monotherapy in patients with deletion 5q acute myeloid leukemia: Southwest Oncology Group Study S0605. Blood. Jul 2011;118(3):523-8.
    • (2011) Blood , vol.118 , Issue.3 , pp. 523-528
    • Sekeres, M.A.1    Gundacker, H.2    Lancet, J.3
  • 43
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • Feb
    • Kantarjian HM, Erba HP, Claxton D, et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol. Feb 2010;28(4): 549-55.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 549-555
    • Kantarjian, H.M.1    Erba, H.P.2    Claxton, D.3
  • 44
    • 77952491723 scopus 로고    scopus 로고
    • European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
    • May
    • Burnett AK, Russell NH, Kell J, et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol. May 2010;28(14): 2389-95.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2389-2395
    • Burnett, A.K.1    Russell, N.H.2    Kell, J.3
  • 45
    • 33745586575 scopus 로고    scopus 로고
    • Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older
    • Jul
    • Faderl S, Verstovsek S, Cortes J, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older. Blood. Jul 2006;108(1):45-51.
    • (2006) Blood , vol.108 , Issue.1 , pp. 45-51
    • Faderl, S.1    Verstovsek, S.2    Cortes, J.3
  • 46
    • 52649154001 scopus 로고    scopus 로고
    • A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
    • Sep
    • Faderl S, Ravandi F, Huang X, et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood. Sep 2008;112(5):1638-45.
    • (2008) Blood , vol.112 , Issue.5 , pp. 1638-1645
    • Faderl, S.1    Ravandi, F.2    Huang, X.3
  • 47
    • 67651102574 scopus 로고    scopus 로고
    • Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG
    • Jul
    • Martin MG, Uy GL, Procknow E, et al. Allo-SCT conditioning for myelodysplastic syndrome and acute myeloid leukemia with clofarabine, cytarabine and ATG. Bone Marrow Transplant. Jul 2009;44(1):13-7.
    • (2009) Bone Marrow Transplant , vol.44 , Issue.1 , pp. 13-17
    • Martin, M.G.1    Uy, G.L.2    Procknow, E.3
  • 48
    • 80054107916 scopus 로고    scopus 로고
    • Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies
    • Oct
    • Magenau J, Tobai H, Pawarode A, et al. Clofarabine and busulfan conditioning facilitates engraftment and provides significant antitumor activity in nonremission hematologic malignancies. Blood. Oct 2011; 118(15):4258-64.
    • (2011) Blood , vol.118 , Issue.15 , pp. 4258-4264
    • Magenau, J.1    Tobai, H.2    Pawarode, A.3
  • 49
    • 79956017109 scopus 로고    scopus 로고
    • Clofarabine-fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS
    • Jun
    • Andersson BS, Valdez BC, de Lima M, et al. Clofarabine-fludarabine with once daily i.v. busulfan as pretransplant conditioning therapy for advanced myeloid leukemia and MDS. Biol Blood Marrow Transplant. Jun 2011;17(6):893-900.
    • (2011) Biol Blood Marrow Transplant , vol.17 , Issue.6 , pp. 893-900
    • Andersson, B.S.1    Valdez, B.C.2    de Lima, M.3
  • 50
    • 83655184694 scopus 로고    scopus 로고
    • Cytoreductive treatment with clofarabine/ ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome
    • Jan
    • Buchholz S, Dammann E, Stadler M, et al. Cytoreductive treatment with clofarabine/ ara-C combined with reduced-intensity conditioning and allogeneic stem cell transplantation in patients with high-risk, relapsed, or refractory acute myeloid leukemia and advanced myelodysplastic syndrome. Eur J Haematol. Jan 2012;88(1):52-60.
    • (2012) Eur J Haematol , vol.88 , Issue.1 , pp. 52-60
    • Buchholz, S.1    Dammann, E.2    Stadler, M.3
  • 51
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Feb
    • Lapidot T, Sirard C, Vormoor J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. Feb 1994; 367(6464):645-8.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 52
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Jul
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. Jul 1997;3(7):730-7.
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 53
    • 38349018710 scopus 로고    scopus 로고
    • Maintenance for acute myeloid leukemia revisited
    • Aug
    • Büchner T, Krug U, Berdel WE, et al. Maintenance for acute myeloid leukemia revisited. Curr Treat Options Oncol. Aug 2007;8(4):296-304.
    • (2007) Curr Treat Options Oncol , vol.8 , Issue.4 , pp. 296-304
    • Büchner, T.1    Krug, U.2    Berdel, W.E.3
  • 54
    • 0026668478 scopus 로고
    • Varying intensity of postremission therapy in acute myeloid leukemia
    • Apr
    • Cassileth PA, Lynch E, Hines JD, et al. Varying intensity of postremission therapy in acute myeloid leukemia. Blood. Apr 1992;79(8):1924-30.
    • (1992) Blood , vol.79 , Issue.8 , pp. 1924-1930
    • Cassileth, P.A.1    Lynch, E.2    Hines, J.D.3
  • 55
    • 0035469856 scopus 로고    scopus 로고
    • Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: The results of the United Kingdom Medical Research Council AML11 trial
    • Sep
    • Goldstone AH, Burnett AK, Wheatley K, et al. Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial. Blood. Sep 2001;98(5):1302-11.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1302-1311
    • Goldstone, A.H.1    Burnett, A.K.2    Wheatley, K.3
  • 56
    • 1542753653 scopus 로고    scopus 로고
    • 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): A randomized trial of the German AML Cooperative Group
    • Dec
    • Büchner T, Hiddemann W, Berdel WE, et al. 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TAD-HAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group. J Clin Oncol. Dec 2003;21(24):4496-504.
    • (2003) J Clin Oncol , vol.21 , Issue.24 , pp. 4496-4504
    • Büchner, T.1    Hiddemann, W.2    Berdel, W.E.3
  • 57
    • 79959845267 scopus 로고    scopus 로고
    • Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia
    • Jun
    • Buyse M, Squifflet P, Lange BJ, et al. Individual patient data meta-analysis of randomized trials evaluating IL-2 monotherapy as remission maintenance therapy in acute myeloid leukemia. Blood. Jun 2011;117(26):7007-13.
    • (2011) Blood , vol.117 , Issue.26 , pp. 7007-7013
    • Buyse, M.1    Squifflet, P.2    Lange, B.J.3
  • 58
    • 54449095992 scopus 로고    scopus 로고
    • Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: Cancer and Leukemia Group B Study 9720
    • Oct
    • Baer MR, George SL, Caligiuri MA, et al. Low-dose interleukin-2 immunotherapy does not improve outcome of patients age 60 years and older with acute myeloid leukemia in first complete remission: Cancer and Leukemia Group B Study 9720. J Clin Oncol. Oct 2008;26(30):4934-9.
    • (2008) J Clin Oncol , vol.26 , Issue.30 , pp. 4934-4939
    • Baer, M.R.1    George, S.L.2    Caligiuri, M.A.3
  • 59
    • 49649116897 scopus 로고    scopus 로고
    • Phase II trial of tipifarnib as maintenance therapy in first complete remission in adults with acute myelogenous leukemia and poor-risk features
    • May
    • Karp JE, Smith BD, Gojo I, et al. Phase II trial of tipifarnib as maintenance therapy in first complete remission in adults with acute myelogenous leukemia and poor-risk features. Clin Cancer Res. May 2008;14(10): 3077-82.
    • (2008) Clin Cancer Res , vol.14 , Issue.10 , pp. 3077-3082
    • Karp, J.E.1    Smith, B.D.2    Gojo, I.3
  • 60
    • 69549118237 scopus 로고    scopus 로고
    • Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia
    • Sep
    • Chowdhury S, Seropian S, Marks PW. Decitabine combined with fractionated gemtuzumab ozogamicin therapy in patients with relapsed or refractory acute myeloid leukemia. Am J Hematol. Sep 2009;84(9):599-600.
    • (2009) Am J Hematol , vol.84 , Issue.9 , pp. 599-600
    • Chowdhury, S.1    Seropian, S.2    Marks, P.W.3
  • 61
    • 33845216261 scopus 로고    scopus 로고
    • Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine
    • Feb
    • Graef T, Kuendgen A, Fenk R, Zohren F, Haas R, Kobbe G. Successful treatment of relapsed AML after allogeneic stem cell transplantation with azacitidine. Leuk Res. Feb 2007;31(2):257-9.
    • (2007) Leuk Res , vol.31 , Issue.2 , pp. 257-259
    • Graef, T.1    Kuendgen, A.2    Fenk, R.3    Zohren, F.4    Haas, R.5    Kobbe, G.6
  • 62
    • 84858002418 scopus 로고    scopus 로고
    • Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: Results of the RELAZA trial
    • Sep
    • Platzbecker U, Wermke M, Radke J, et al. Azacitidine for treatment of imminent relapse in MDS or AML patients after allogeneic HSCT: results of the RELAZA trial. Leukemia. Sep 2011.
    • (2011) Leukemia
    • Platzbecker, U.1    Wermke, M.2    Radke, J.3
  • 63
    • 84898693997 scopus 로고    scopus 로고
    • Azacitidine in combination with the mTOR inhibitor everolimus in relapsed and refractory AML
    • Wei A, Tan P, Catalano J, Walker P. Azacitidine in combination with the mTOR inhibitor everolimus in relapsed and refractory AML. Blood ASH Annual Meeting Abstracts. 2011;118:2599.
    • (2011) Blood ASH Annual Meeting Abstracts , vol.118 , pp. 2599
    • Wei, A.1    Tan, P.2    Catalano, J.3    Walker, P.4
  • 64
    • 0141482004 scopus 로고    scopus 로고
    • Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia
    • Oct
    • Kantarjian H, Gandhi V, Cortes J, et al. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood. Oct 2003;102(7):2379-86.
    • (2003) Blood , vol.102 , Issue.7 , pp. 2379-2386
    • Kantarjian, H.1    Gandhi, V.2    Cortes, J.3
  • 65
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Feb
    • Faderl S, Gandhi V, O'Brien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood. Feb 2005;105(3):940-7.
    • (2005) Blood , vol.105 , Issue.3 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 66
    • 80053572350 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared to cytarabine alone in older patients with relapsed or refractory (R/R) acute myelogenous leukemia (AML): Results from the phase III CLASSIC 1 trial
    • Abstr 6503
    • Faderl S, Wetzler M, Rizzieri D, Schiller G, Jagasia M. Clofarabine plus cytarabine compared to cytarabine alone in older patients with relapsed or refractory (R/R) acute myelogenous leukemia (AML): Results from the phase III CLASSIC 1 trial. J Clin Oncol. 2011;29(Suppl);Abstr 6503.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3    Schiller, G.4    Jagasia, M.5
  • 67
    • 80052231301 scopus 로고    scopus 로고
    • FLT3 inhibition as therapy in acute myeloid leukemia: A record of trials and tribulations
    • Fathi AT, Chabner BA. FLT3 inhibition as therapy in acute myeloid leukemia: a record of trials and tribulations. Oncologist. 2011;16(8):1162-74.
    • (2011) Oncologist , vol.16 , Issue.8 , pp. 1162-1174
    • Fathi, A.T.1    Chabner, B.A.2
  • 68
    • 78650073854 scopus 로고    scopus 로고
    • FLT3 as a therapeutic target in AML: Still challenging after all these years
    • Dec
    • Kindler T, Lipka DB, Fischer T. FLT3 as a therapeutic target in AML: still challenging after all these years. Blood. Dec 2010;116(24):5089-102.
    • (2010) Blood , vol.116 , Issue.24 , pp. 5089-5102
    • Kindler, T.1    Lipka, D.B.2    Fischer, T.3
  • 69
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Sep
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. Sep 2001;98(6): 1752-9.
    • (2001) Blood , vol.98 , Issue.6 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 70
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes
    • Jul
    • Vardiman J, Thiele J, Arber D, et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood. Jul 2009;114(5):937-51.
    • (2009) Blood , vol.114 , Issue.5 , pp. 937-951
    • Vardiman, J.1    Thiele, J.2    Arber, D.3
  • 71
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • Mar
    • Levis M, Ravandi F, Wang ES, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood. Mar 2011;117(12):3294-301.
    • (2011) Blood , vol.117 , Issue.12 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 72
    • 20244361887 scopus 로고    scopus 로고
    • Prognostic index for adult patients with acute myeloid leukemia in first relapse
    • Mar
    • Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol. Mar 2005; 23(9):1969-78.
    • (2005) J Clin Oncol , vol.23 , Issue.9 , pp. 1969-1978
    • Breems, D.A.1    van Putten, W.L.2    Huijgens, P.C.3
  • 73
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Nov
    • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. Nov 2004;432(7015):324-31.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 74
    • 0035902140 scopus 로고    scopus 로고
    • The Hedgehog and Wnt signalling pathways in cancer
    • May
    • Taipale J, Beachy P. The Hedgehog and Wnt signalling pathways in cancer. Nature. May 2001;411(6835):349-54.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 349-354
    • Taipale, J.1    Beachy, P.2
  • 75
    • 64749091867 scopus 로고    scopus 로고
    • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
    • Apr
    • Zhao C, Chen A, Jamieson CH, et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. Apr 2009;458(7239):776-9.
    • (2009) Nature , vol.458 , Issue.7239 , pp. 776-779
    • Zhao, C.1    Chen, A.2    Jamieson, C.H.3
  • 76
    • 78650827256 scopus 로고    scopus 로고
    • Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926
    • Lin TL, Wang QH, Brown P, et al. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One. 2010;5(12):e15262.
    • (2010) PLoS One , vol.5 , Issue.12
    • Lin, T.L.1    Wang, Q.H.2    Brown, P.3
  • 77
    • 34247192972 scopus 로고    scopus 로고
    • Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma
    • Mar
    • Peacock CD, Wang Q, Gesell GS, et al. Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A. Mar 2007;104(10):4048-53.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.10 , pp. 4048-4053
    • Peacock, C.D.1    Wang, Q.2    Gesell, G.S.3
  • 78
    • 34547683699 scopus 로고    scopus 로고
    • Essential role of stromally induced hedgehog signaling in B-cell malignancies
    • Dierks C, Grbic J, Zirlik K, et al. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nature Medicine. 2007;13(8): 944-51.
    • (2007) Nature Medicine , vol.13 , Issue.8 , pp. 944-951
    • Dierks, C.1    Grbic, J.2    Zirlik, K.3
  • 79
    • 77952420404 scopus 로고    scopus 로고
    • Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation
    • Mar
    • Singh R, Kim J, Davuluri Y, et al. Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia. Mar 2010.
    • (2010) Leukemia
    • Singh, R.1    Kim, J.2    Davuluri, Y.3
  • 80
    • 84861403258 scopus 로고    scopus 로고
    • Phase 1 Dose-Escalation Study of PF-04449913, An Oral Hedgehog (Hh) Inhibitor, in Patients with Select Hematologic Malignancies
    • Jamieson C, Cortes JE, Oehler V, et al. Phase 1 Dose-Escalation Study of PF-04449913, An Oral Hedgehog (Hh) Inhibitor, in Patients with Select Hematologic Malignancies. Blood. 2011;118:424.
    • (2011) Blood , vol.118 , pp. 424
    • Jamieson, C.1    Cortes, J.E.2    Oehler, V.3
  • 81
    • 84155180788 scopus 로고    scopus 로고
    • Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: Results of a phase II GIMEMA study (AML-1107)
    • Jan
    • Amadori S, Stasi R, Martelli AM, et al. Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107). Br J Haematol. Jan 2012;156(2):205-12.
    • (2012) Br J Haematol , vol.156 , Issue.2 , pp. 205-212
    • Amadori, S.1    Stasi, R.2    Martelli, A.M.3
  • 82
    • 84860349448 scopus 로고    scopus 로고
    • A phase I/II study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Feb
    • Uy GL, Rettig MP, Motabi IH, et al. A phase I/II study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood. Feb 2012.
    • (2012) Blood
    • Uy, G.L.1    Rettig, M.P.2    Motabi, I.H.3
  • 83
    • 81255192118 scopus 로고    scopus 로고
    • Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia
    • Nov
    • Skrtić M, Sriskanthadevan S, Jhas B, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. Nov 2011;20(5):674-88.
    • (2011) Cancer Cell , vol.20 , Issue.5 , pp. 674-688
    • Skrtić, M.1    Sriskanthadevan, S.2    Jhas, B.3
  • 84
    • 33847417644 scopus 로고    scopus 로고
    • Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML
    • Mar; Author reply 2265
    • Bornhäuser M, Illmer T, Schaich M, et al. Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML. Blood. Mar 2007; 109(5):2264-5; Author reply 2265.
    • (2007) Blood , vol.109 , Issue.5 , pp. 2264-2265
    • Bornhäuser, M.1    Illmer, T.2    Schaich, M.3
  • 85
    • 80051670412 scopus 로고    scopus 로고
    • Role of allogeneic transplantation for FLT3/ITD acute myeloid leukemia: Outcomes from 133 consecutive newly diagnosed patients from a single institution
    • Sep
    • DeZern AE, Sung A, Kim S, et al. Role of allogeneic transplantation for FLT3/ITD acute myeloid leukemia: outcomes from 133 consecutive newly diagnosed patients from a single institution. Biol Blood Marrow Transplant. Sep 2011;17(9):1404-9.
    • (2011) Biol Blood Marrow Transplant , vol.17 , Issue.9 , pp. 1404-1409
    • DeZern, A.E.1    Sung, A.2    Kim, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.