Deployment of in silico and in vitro safety assays in early-stage drug discovery

Future Medicinal Chemistry

Volumn 4, Issue 10, 2012, Pages 1211-1213

  Will, Yvonne ^a   Schroeter, Thomas ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

cell based; in silico; in vitro; physiochemical; safety assessment; toxicityty

Indexed keywords

SULFONAMIDE;

CALCIUM CELL LEVEL; CELL TYPE; COMPUTER MODEL; DRUG ABSORPTION; DRUG COST; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG INDUSTRY; DRUG METABOLISM; DRUG SAFETY; DRUG TOXICITY; HUMAN; IN VITRO STUDY; LIPOPHILICITY; LIVER CELL; MOLECULAR WEIGHT; NONHUMAN; NUTRIENT SUPPLY; OXYGEN SUPPLY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW; TOXIC HEPATITIS;

DRUG DISCOVERY; DRUG TOXICITY; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS;

EID: 84863899238     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.71     Document Type: Review

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