R-Ras controls axon branching through afadin in cortical neurons

Molecular Biology of the Cell

Volumn 23, Issue 14, 2012, Pages 2793-2804

  Iwasawa, Nariaki ^a   Negishi, Manabu ^a   Oinuma, Izumi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; F ACTIN; PROTEIN AFADIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ACTIN CYTOSKELETON; ANIMALS; AXONS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CEREBRAL CORTEX; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICROFILAMENT PROTEINS; MICROTUBULES; NERVE TISSUE PROTEINS; NEUROGENESIS; PHOSPHATIDYLINOSITOL 3-KINASE; PROMOTER REGIONS, GENETIC; RAS PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84863890889     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-02-0103     Document Type: Article

References (54)

1. Arimura N, Kaibuchi K (2007). Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci 8, 194-205. (Pubitemid 46294662)
2. Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y (2003). ADIP, a novel afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem 278, 4103-4111. (Pubitemid 36801146)
3. Bradke F, Dotti CG (2000). Establishment of neuronal polarity: lessons from cultured hippocampal neurons. Curr Opin Neurobiol 10, 574-581.
4. Beaudoin GM 3rd, Schofield CM, Nuwal T, Zang K, Ullian EM, Huang B, Reichardt LF (2012). Afadin, a ras/rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci 32, 99-110.
5. Bilimoria PM, Bonni A (2011). Molecular regulation of axon branching. Neuroscientist, doi: 10.1177/1073858411426201.
6. Carmena A, Makarova A, Speicher S (2011). The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation. J Cell Biol 195, 553-562.
7. Cowley S, Paterson H, Kemp P, Marshall CJ (1994). Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77, 841-852. (Pubitemid 24187682)
8. Dail M, Richter M, Godement P, Pasquale EB (2006). Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J Cell Sci 119, 1244-1254.
9. Dent EW, Barnes AM, Tang F, Kalil K (2004). Netrin-1 and semaphorin 3A promote or inhibit cortical axon branching, respectively, by reorganization of the cytoskeleton. J Neurosci 24, 3002-3012. (Pubitemid 38405747)
10. Dent EW, Kalil K (2001). Axon branching requires interactions between dynamic microtubules and actin filaments. J Neurosci 21, 9757-9769. (Pubitemid 34184061)
11. Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE (2010). E3 ligase Nedd4 promotes axon branching by downregulating PTEN. Neuron 65, 341-357.
12. Féréol S, Fodil R, Barnat M, Georget V, Milbreta U, Nothias F (2011). Micropatterned ECM substrates reveal complementary contribution of low and high affinity ligands to neurite outgrowth. Cytoskeleton 68, 373-388.
13. Fournier G et al. (2011). Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth. Oncogene 30, 3862-3874.
14. Hall A, Lalli G (2010). Rho and Ras GTPases in axon growth, guidance, and branching. Cold Spring Harb Perspect Biol 2, a001818.
15. Hiramoto-Yamaki N, Takeuchi S, Ueda S, Harada K, Fujimoto S, Negishi M, Katoh H (2010). Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol 190, 461-477.
16. Ishikawa Y, Katoh H, Negishi M (2003). A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons. J Neurosci 23, 11065-11072. (Pubitemid 37548940)
17. Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (2006). Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse. EMBO Rep 7, 704-709. (Pubitemid 43986267)
18. Ivins JK, Yurchenco PD, Lander AD (2000). Regulation of neurite outgrowth by integrin activation. J Neurosci 20, 6551-6560.
19. Kalil K, Szebenyi G, Dent EW (2000). Common mechanisms underlying growth cone guidance and axon branching. J Neurobiol 44, 145-158.
20. Katoh H, Harada A, Mori K, Negishi M (2002). Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Mol Cell Biol 22, 2952-2964. (Pubitemid 34437454)
21. Keely PJ, Rusyn EV, Cox AD, Parise LV (1999). R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells. J Cell Biol 145, 1077-1088. (Pubitemid 29270064)
22. Kimmelman AC, Nuñez Rodriguez N, Chan AM (2002). R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade. Mol Cell Biol 22, 5946-5961. (Pubitemid 34815842)
23. Kinbara K, Goldfinger LE, Hansen M, Chou FL, Ginsberg MH (2003). Ras GTPases: integrin's friends or foes? Nat Rev Mol Cell Biol 4, 767-776. (Pubitemid 37229373)
24. Komatsu M, Ruoslahti E (2005). R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis. Nat Med 11, 1346-1350. (Pubitemid 41752916)
25. Kurita S, Ogita H, Takai Y (2011). Cooperative role of nectin-nectin and nectin-afadin interactions in formation of nectin-based cell-cell adhesion. J Biol Chem 286, 36297-36303.
26. Liddington RC, Ginsberg MH (2002). Integrin activation takes shape. J Cell Biol 158, 833-839. (Pubitemid 35001074)
27. Lim ST, Lim KC, Giuliano RE, Federoff HJ (2008). Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. J Comp Neurol 507, 1228-1244. (Pubitemid 351288023)
28. Mandai K et al. (1997). Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction. J Cell Biol 139, 517-528. (Pubitemid 27459322)
29. Marler KJ, Becker-Barroso E, Martínez A, Llovera M, Wentzel C, Poopalasundaram S, Hindges R, Soriano E, Comella J, Drescher U (2008). A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis. J Neurosci 28, 12700-12712.
30. Matsumoto K, Asano T, Endo T (1997). Novel small GTPase M-Ras participates in reorganization of actin cytoskeleton. Oncogene 15, 2409-2417. (Pubitemid 27503527)
31. Miyata M et al. (2009). Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor. J Cell Sci 122, 4319-4329.
32. O'Donnell M, Chance RK, Bashaw GJ (2009). Axon growth and guidance: receptor regulation and signal transduction. Annu Rev Neurosci 32, 383-412.
33. Oinuma I, Ishikawa Y, Katoh H, Negishi M (2004a). The semaphorin 4D receptor plexin-B1 is a GTPase activating protein for R-Ras. Science 305, 862-865. (Pubitemid 39038420)
34. Oinuma I, Katoh H, Negishi M (2004b). Molecular dissection of the semaphorin receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons. J Neurosci 24, 11473-11480.
35. Oinuma I, Katoh H, Negishi M (2007). R-Ras controls axon specification upstream of glycogen synthase kinase-3beta through integrin-linked kinase. J Biol Chem 282, 303-318. (Pubitemid 47076649)
36. Pokutta S, Drees F, Takai Y, Nelson WJ, Weis WI (2002). Biochemical and structural definition of the l-afadin- and actin-binding sites of alpha-catenin. J Biol Chem 277, 18868-18874. (Pubitemid 34952446)
37. Prasad KN, Hsie AW (1971). Morphologic differentiation of mouse neuroblastoma cells induced in vitro by dibutyryl adenosine 3′:5′- cyclic monophosphate. Nat New Biol 233, 141-142.
38. Radziwill G, Weiss A, Heinrich J, Baumgartner M, Boisguerin P, Owada K, Moelling K (2007). Regulation of c-Src by binding to the PDZ domain of AF-6. EMBO J 26, 2633-2644. (Pubitemid 46884275)
39. Rodriguez-Viciana P, Sabatier C, McCormick F (2004). Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24, 4943-4954. (Pubitemid 38668058)
40. Saito Y, Oinuma I, Fujimoto S, Negishi M (2009). Plexin-B1 is a GTPase activating protein for M-Ras, remodelling dendrite morphology. EMBO Rep 10, 614-621.
41. Schwamborn JC, Püschel AW (2004). The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat Neurosci 7, 923-929. (Pubitemid 39129500)
42. + homeostasis in the Golgi and disturbs neural polarity. J Neurosci 29, 12174-12182.
43. Shea TB, Fischer I, Sapirstein VS (1985). Effect of retinoic acid on growth and morphological differentiation of mouse NB2a neuroblastoma cells in culture. Brain Res 353, 307-314. (Pubitemid 15228402)
44. Szebenyi G, Callaway JL, Dent EW, Kalil K (1998). Interstitial branches develop from active regions of the axon demarcated by the primary growth cone during pausing behaviors. J Neurosci 18, 7930-7940. (Pubitemid 28441031)
45. Tachibana K, Nakanishi H, Mandai K, Ozaki K, Ikeda W, Yamamoto Y, Nagafuchi A, Tsukita S, Takai Y (2000). Two cell adhesion molecules, nectin and cadherin, interact through their cytoplasmic domain-associated proteins. J Cell Biol 150, 1161-1176.
46. Takahashi K et al. (1999). Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with afadin, a PDZ domain-containing protein. J Cell Biol 145, 539-549. (Pubitemid 29215718)
47. Takai Y, Ikeda W, Ogita H, Rikitake Y (2008). The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. Annu Rev Cell Dev Biol 24, 309-342.
48. Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, Kikutani H (2005). FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci 8, 1712-1719. (Pubitemid 41683199)
49. Uesugi K, Oinuma I, Katoh H, Negishi M (2009). Different requirement for Rnd GTPases of R-Ras GAP activity of plexin-C1 and plexin-D1. J Biol Chem 284, 6743-6751.
50. Xie Z, Huganir RL, Penzes P (2005). Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron 48, 605-618. (Pubitemid 41654682)
51. Yamada A, Uesaka N, Hayano Y, Tabata T, Kano M, Yamamoto N (2010). Role of pre- and postsynaptic activity in thalamocortical axon branching. Proc Natl Acad Sci USA 107, 7562-7567.
52. Yin DM, Huang YH, Zhu YB, Wang Y (2008). Both the establishment and maintenance of neuronal polarity require the activity of protein kinase D in the Golgi apparatus. J Neurosci 28, 8832-8843.
53. Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K (2005). GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120, 137-149. (Pubitemid 40094609)
54. Zhang Z, Vuori K, Wang H, Reed JC, Ruoslahti E (1996). Integrin activation by R-ras. Cell 85, 61-69. (Pubitemid 26116807)