Regulation of c-Src by binding to the PDZ domain of AF-6

EMBO Journal

Volumn 26, Issue 11, 2007, Pages 2633-2644

  Radziwill, Gerald ^a   Weiss, Andreas ^a   Heinrich, Jochen ^a   Baumgartner, Martin ^a   Boisguerin, Prisca ^b   Owada, Koji ^c   Moelling, Karin ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b Institute of Medical Immunology   (Germany)

^c KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cell junction; PDZ domain; Signal transduction; Src protein kinase

Indexed keywords

PDZ PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AF 6; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; EMBRYO; HUMAN; HUMAN CELL; ONCOGENE SRC; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING;

AMINO ACID SEQUENCE; ENZYME ACTIVATION; GENE COMPONENTS; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KINESIN; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MYOSINS; PDZ DOMAINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 34249990373     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601706     Document Type: Article

References (33)

1. Behrens J, Vakaet L, Friis R, Winterhager E, Van Roy F, Mareel MM, Birchmeier W (1993) Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol 120: 757-766
2. Bjorge JD, Jakymiw A, Fujita DJ (2000) Selected glimpses into the activation and function of Src kinase. Oncogene 19: 5620-5635
3. Boettner B, Govek EE, Cross J, Van Aelst L (2000) The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proc Natl Acad Sci USA 97: 9064-9069
4. Boisguerin P, Leben R, Ay B, Radziwill G, Moelling K, Dong L, Volkmer-Engert R (2004) An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. Chem Biol 11: 449-459
5. Buchert M, Schneider S, Meskenaite V, Adams MT, Canaani E, Baechi T, Moelling K, Hovens CM (1999) The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J Cell Biol 144: 361-371
6. Cao TT, Deacon HW, Reczek D, Bretscher A, von Zastrow M (1999) A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor. Nature 401: 286-290
7. Chen YH, Lu Q, Goodenough DA, Jeansonne B (2002) Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol Biol Cell 13: 1227-1237
8. Chong YP, Ia KK, Mulhern TD, Cheng HC (2005) Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases. Biochim Biophys Acta 1754: 210-220
9. Cowan-Jacob SW, Fendrich G, Manley PW, Jahnke W, Fabbro D, Liebetanz J, Meyer T (2005) The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation. Structure 13: 861-871
10. Frame MC (2002) Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta 1602: 114-130
11. Heinrich J, Bosse M, Eickhoff H, Nietfeld W, Reinhardt R, Lehrach H, Moelling K (2000) Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization. J Mol Med 78: 380-388
12. Hock B, Bohme B, Karn T, Yamamoto T, Kaibuchi K, Holtrich U, Holland S, Pawson T, Rubsamen-Waigmann H, Strebhardt K (1998) PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci USA 95: 9779-9784
13. Irby RB, Yeatman TJ (2000) Role of Src expression and activation in human cancer. Oncogene 19: 5636-5642
14. Jaffrey SR, Snowman AM, Eliasson MJ, Cohen NA, Snyder SH (1998) CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 20: 115-124
15. Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P (1999) Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18: 2459-2471
16. Kuhne C, Gardiol D, Guarnaccia C, Amenitsch H, Banks L (2000) Differential regulation of human papillomavirus E6 by protein kinase A: conditional degradation of human discs large protein by oncogenic E6. Oncogene 19: 5884-5891
17. Lorger M, Moelling K (2006) Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton. J Cell Sci 119: 3385-3398
18. Lua BL, Low BC (2005) Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control. FEBS Lett 579: 577-585
19. Martin GS (2001) The hunting of the Src. Nat Rev Mol Cell Biol 2: 467-475
20. Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS (2004) Erk/Src phosphorylation of cortactin acts as a switch onswitch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol 24: 5269-5280
21. Nourry C, Grant SG, Borg JP (2003) PDZ domain proteins: plug and play!. Sci STKE 2003: RE7
22. Otte L, Wiedemann U, Schlegel B, Pires JR, Beyermann M, Schmieder P, Krause G, Volkmer-Engert R, Schneider-Mergener J, Oschkinat H (2003) WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains. Protein Sci 12: 491-500
23. Radziwill G, Erdmann RA, Margelisch U, Moelling K (2003) The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Mol Cell Biol 23: 4663-4672
24. Ress A, Moelling K (2006) Interaction partners of the PDZ domain of Erbin. Protein Pept Lett 13: 877-881
25. Roskoski Jr R (2004) Src protein-tyrosine kinase structure and regulation. Biochem Biophys Res Commun 324: 1155-1164
26. Schneider S, Buchert M, Georgiev O, Catimel B, Halford M, Stacker SA, Baechi T, Moelling K, Hovens CM (1999) Mutagenesis and selection of PDZ domains that bind new protein targets. Nat Biotechnol 17: 170-175
27. Songyang Z, Fanning AS, Fu C, Xu J, Marfatia SM, Chishti AH, Crompton A, Chan AC, Anderson JM, Cantley LC (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science 275: 73-77
28. Soriano P, Montgomery C, Geske R, Bradley A (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693-702
29. Sun G, Sharma AK, Budde RJ (1998) Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. Oncogene 17: 1587-1595
30. Takai Y, Nakanishi H (2003) Nectin and afadin: novel organizers of intercellular junctions. J Cell Sci 116: 17-27
31. Wiedemann U, Boisguerin P, Leben R, Leitner D, Krause G, Moelling K, Volkmer-Engert R, Oschkinat H, Ay B, Radziwill G, Dong L (2004) Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides. An improved method for the synthesis of cellulose membrane-bound peptides with free C termini is useful for PDZ domain binding studies. J Mol Biol 343: 703-718
32. Yeatman TJ, Roskoski Jr R (2004) A renaissance for SRC. Src protein-tyrosine kinase structure and regulation. Nat Rev Cancer 4: 470-480
33. Ziogas A, Moelling K, Radziwill G (2005) CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. J Biol Chem 280: 24205-24211