A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2)

Journal of Molecular Neuroscience

Volumn 47, Issue 2, 2012, Pages 340-345

  Ru, Wenjuan ^a   Peng, Yanxi ^b   Zhong, Ling ^b   Tang, Shao Jun ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

mTOR; NMDA receptor; Rapamycin; Synaptic activity; TSC2; Tuberous sclerosis complex

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; GLUTAMIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEASOME; RAPAMYCIN; TUBERIN;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; EVOKED CORTICAL RESPONSE; MEDIATOR; NEGATIVE FEEDBACK; NERVE CELL; NERVE CELL CULTURE; NERVE STIMULATION; NEUROTRANSMISSION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION;

ANIMALS; CEREBRAL CORTEX; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMIC ACID; MICE; MICE, INBRED C57BL; NEURAL PATHWAYS; NEURONS; PRIMARY CELL CULTURE; PROTEASOME ENDOPEPTIDASE COMPLEX; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 84863882700     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9753-1     Document Type: Article

References (22)

1. Bliss TV, Collingridge GL (1993) A synaptic model of memory: longterm potentiation in the hippocampus. Nature 361:31-39 (Pubitemid 23020772)
2. Campbell DS, Holt CE (2001) Chemotropic responses of retinal growth cones mediated by rapid local protein synthesis and degradation. Neuron 32:1013-1026 (Pubitemid 34075393)
3. Choi YJ, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski DJ, Sahin M, He X (2008) Tuberous sclerosis complex proteins control axon formation. Genes Dev 22:2485-2495
4. Choo AY, Roux PP, Blenis J (2006) Mind the GAP: Wnt steps onto the mTORC1 train. Cell 126:834-836 (Pubitemid 44310790)
5. Dotti CG, Sullivan CA, Banker GA (1988) The establishment of polarity by hippocampal neurons in culture. J Neurosci 8:1454-1468
6. Dufner A, Thomas G (1999) Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 253:100-109
7. Fingar DC, Blenis J (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171 (Pubitemid 38638827)
8. Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G (2003) Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11:1457-1466 (Pubitemid 36776533)
9. Gong R, Park CS, Abbassi NR, Tang SJ (2006) Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J Biol Chem 281:18802-18815 (Pubitemid 44043076)
10. Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926-1945 (Pubitemid 39071573)
11. Jaworski J, Spangler S, Seeburg DP, Hoogenraad CC, Sheng M (2005) Control of dendritic arborization by the phosphoinositide-3′-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci 25:11300-11312 (Pubitemid 43083704)
12. Kumar V, Zhang MX, Swank MW, Kunz J, Wu GY (2005) Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways. J Neurosci 25:11288-11299 (Pubitemid 43083703)
13. Kwiatkowski DJ (2003) Tuberous sclerosis: from tubers to mTOR. Ann Hum Genet 67:87-96
14. Ouyang Y, Rosenstein A, Kreiman G, Schuman EM, Kennedy MB (1999) Tetanic stimulation leads to increased accumulation of Ca (2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J Neurosci 19:7823-7833 (Pubitemid 30225781)
15. Parsons RG, Gafford GM, Helmstetter FJ (2006) Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. J Neurosci 26:12977-12983 (Pubitemid 44954616)
16. Pullen N, Thomas G (1997) The modular phosphorylation and activation of p70s6k. FEBS Lett 410:78-82
17. Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253-262
18. Steward O, Halpain S (1999) Lamina-specific synaptic activation causes domain-specific alterations in dendritic immunostaining for MAP2 and CAM kinase II. J Neurosci 19:7834-7845 (Pubitemid 30225782)
19. Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N, Schuman EM (2002) A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A 99:467-472 (Pubitemid 34060384)
20. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ (1999) Genetic enhancement of learning and memory in mice. Nature 401:63-69
21. Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL (2005) Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci 8:1727-1734 (Pubitemid 41683201)
22. Tischmeyer W, Schicknick H, Kraus M, Seidenbecher CI, Staak S, Scheich H, Gundelfinger ED (2003) Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. Eur J Neurosci 18:942-950 (Pubitemid 37059704)