Acute and chronic regulation of circulating PTH: Significance in health and in disease

Clinical Biochemistry

Volumn 45, Issue 12, 2012, Pages 964-969

  D'Amour, Pierre ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Calcium; Parathyroid hormone; Primary and secondary hyperparathyroidism; Renal failure

Indexed keywords

1,25 DIHYDROXYERGOCALCIFEROL; CALCIUM; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PHOSPHATE; SERINE; VITAMIN D RECEPTOR;

CALCIUM BLOOD LEVEL; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE METABOLISM; HUMAN; HYPERCALCEMIA; HYPOCALCEMIA; KIDNEY FAILURE; LIVER METABOLISM; NONHUMAN; PARATHYROID GLAND; PARATHYROID HORMONE RELEASE; PHOSPHORYLATION; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; RADIOIMMUNOASSAY; REVIEW; SECONDARY HYPERPARATHYROIDISM; VITAMIN D DEFICIENCY;

ANIMALS; CALCIUM; HUMANS; HYPERPARATHYROIDISM; KIDNEY; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; RECEPTORS, PARATHYROID HORMONE; RENAL INSUFFICIENCY;

EID: 84863880484     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.04.029     Document Type: Review

References (71)

1. Habener J.F., Amherdt M., Ravazzola M., Orci L. Parathyroid hormone biosynthesis. Correlation of conversion of biosynthetic precursors with intracellular protein migration as determined by electron microscope autoradiography. J Cell Biol 1979, 80:715-731.
2. Tregear G.W., Van Rietschoten J., Greene E., Keutmann H.T., Niall H.D., Reit B., et al. Bovine parathyroid hormone: minimum chain length of synthetic peptide required for biological activity. Endocrinology 1973, 93:1349-1353.
3. Jüppner H., Abou-Samra A.B., Freeman M., Kong X.F., Schipani E., Richards J., et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991, 254:1024-1026.
4. Abou-Samra A.B., Jüppner H., Force T., Freeman M.W., Kong X.F., Schipani E., et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A 1992, 89:2732-2736.
5. Berson S.A., Yalow R.S. Immunochemical heterogeneity of parathyroid hormone in plasma. J Clin Endocrinol Metab 1968, 28:1037-1047.
6. Segre G.V., Habener J.F., Powell D., Tregear G.W., Potts J.T. Parathyroid hormone in human plasma: immunochemical characterization and biological implications. J Clin Invest 1972, 51:3163-3172.
7. Rosenblatt M., Segre G.V., Tregear G.W., Shepard G.L., Tyler G.A., Potts J.T. Human parathyroid hormone: synthesis and chemical, biological, and immunological evaluation of the carboxyl-terminal region. Endocrinology 1978, 103:978-984.
8. Pines M., Adams A.E., Stueckle S., Bessalle R., Rashti-Behar V., Chorev M., et al. Generation and characterization of human kidney cell lines stably expressing recombinant human PTH/PTHrP receptor: lack of interaction with a C-terminal human PTH peptide. Endocrinology 1994, 135:1713-1716.
9. Murray T.M., Rao L.G., Divieti P., Bringhurst F.R. Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands. Endocr Rev 2005, 26:78-113.
10. Berson S.A., Yalow R.S., Aurbach G.D., Potts J.T. Immunoassay of bovine and human parathyroid hormone. Proc Natl Acad Sci U S A 1963, 49:613-617.
11. Segre G.V., Tregear G., Potts J.T. Development and application of sequence-specific radioimmunoassay for analysis of the metabolism of parathyroid hormone. Methods in Enzymology 1975, vol. 37:38-66. Academic Press, New York. B.W. O'Malley, J.G. Hardman (Eds.).
12. D'Amour P., Labelle F., Lazure C. Comparison of four carboxylterminal tracers in a radioimmunoassay specific to the 68-84 region of human parathyroid hormone. J Immunoassay 1984, 5:183-204.
13. D'Amour P., Labelle F., Lecavalier L., Plourde V., Harvey D. Influence of serum Ca concentration on circulating molecular forms of PTH in three species. Am J Physiol 1986, 251:E680-E687.
14. Segre G.V., D'Amour P., Potts J.T. Metabolism of radioiodinated bovine parathyroid hormone in the rat. Endocrinology 1976, 99:1645-1652.
15. Zhang C.X., Weber B.V., Thammavong J., Grover T.A., Wells D.S. Identification of carboxyl-terminal peptide fragments of parathyroid hormone in human plasma at low-picomolar levels by mass spectrometry. Anal Chem 2006, 78:1636-1643.
16. Nussbaum S.R., Zahradnik R.J., Lavigne J.R., Brennan G.L., Nozawa-Ung K., Kim L.Y., et al. Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 1987, 33:1364-1367.
17. Brossard J.H., Cloutier M., Roy L., Lepage R., Gascon-Barré M., D'Amour P. Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values. J Clin Endocrinol Metab 1996, 81:3923-3929.
18. D'Amour P., Brossard J.H., Rousseau L., Nguyen-Yamamoto L., Nassif E., Lazure C., et al. Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism. Kidney Int 2005, 68:998-1007.
19. D'Amour P., Räkel A., Brossard J.H., Rousseau L., Albert C., Cantor T. Acute regulation of circulating parathyroid hormone (PTH) molecular forms by calcium: utility of PTH fragments/PTH(1-84) ratios derived from three generations of PTH assays. J Clin Endocrinol Metab 2006, 91:283-289.
20. D'Amour P., Brossard J.H., Rousseau L., Roy L., Gao P., Cantor T. Amino-terminal form of parathyroid hormone (PTH) with immunologic similarities to hPTH(1-84) is overproduced in primary and secondary hyperparathyroidism. Clin Chem 2003, 49:2037-2044.
21. Rabbani S.A., Kremer R., Bennett H.P., Goltzman D. Phosphorylation of parathyroid hormone by human and bovine parathyroid glands. J Biol Chem 1984, 259:2949-2955.
22. Nguyen-Yamamoto L., Rousseau L., Brossard J.H., Lepage R., Gao P., Cantor T., et al. Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays. Eur J Endocrinol 2002, 147(147):123-131.
23. D'Amour P., Segre G.V., Potts J.T. Analysis of parathyroid hormone and its fragments in rat tissues: chemical identification and microscopical localization. J Clin Invest 1979, 63:89-98.
24. Habener J.F., Rosenblatt M., Potts J.T. Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev 1984, 64:985-1053.
25. Silver J., Russell J., Sherwood L.M. Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci U S A 1985, 82:4270-4273.
26. Kilav R., Silver J., Naveh-Many T. A conserved cis-acting element in the parathyroid hormone 3'-untranslated region is sufficient for regulation of RNA stability by calcium and phosphate. J Biol Chem 2001, 276:8727-8733.
27. 3 cytoplasmic receptors from human and chick parathyroid glands. Arch Biochem Biophys 1980, 201:95-103.
28. Setoguti T., Inoue Y., Shin M. Electron-microscopic studies on the threshold value of calcium concentration for the release of storage granules and the acceleration of their degradation in the parathyroid gland. Cell Tissue Res 1988, 251:531-539.
29. Hashizume Y., Waguri S., Watanabe T., Kominami E., Uchiyama Y. Cysteine proteinases in rat parathyroid cells with special reference to their correlation with parathyroid hormone (PTH) in storage granules. J Histochem Cytochem 1993, 41:273-282.
30. Bringhurst F.R., Stern A.M., Yotts M., Mizrahi N., Segre G.V., Potts J.T. Peripheral metabolism of [35S]parathyroid hormone in vivo: influence of alterations in calcium availability and parathyroid status. J Endocrinol 1989, 122:237-245.
31. Segre G.V., D'Amour P., Haltman A., Potts J.T. Effects of hepatectomy, nephrectomy and nephrectomy/uremia on the metabolism of parathyroid hormone in the rat. J Clin Invest 1981, 67:439-448.
32. Mayer G.P., Keaton J.A., Hurst J.G., Habener J.F. Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood. Endocrinology 1979, 104:1778-1784.
33. Mayer G.P., Hurst J.G. Sigmoidal relationship between parathyroid hormone secretion rate and plasma calcium concentration in calves. Endocrinology 1978, 102:1036-1042.
34. Mayer G.P., Habener J.F., Potts J.T. Parathyroid hormone secretion in vivo. Demonstration of a calcium-independent nonsuppressible component of secretion. J Clin Invest 1976, 57:678-683.
35. Cloutier M., D'Amour P., Gascon-Barré M., Hamel L. Low calcium diet in dogs causes a greater increase in parathyroid hormone measures with an intact hormone than with a carboxylterminal assay. Bone Miner 1990, 9:179-188.
36. Cloutier M., Brossard J.H., Gascon-Barré M., D'Amour P. Lack of involution of hyperplastic parathyroid glands in dogs: adaptation via a decrease in the calcium stimulation set point and a change in secretion profile. J Bone Miner Res 1994, 9:621-629.
37. 3 or partial parathyroidectomy in normal dogs. J Endocrinol 1997, 155:133-141.
38. Brossard J.H., Whittom S., Lepage R., D'Amour P. Carboxyl-terminal fragments of parathyroid hormone are not secreted preferentially in primary hyperparathyroidism as they are in other hypercalcemic conditions. J Clin Endocrinol Metab 1993, 77:413-419.
39. Benson R.C., Riggs G.L., Pickard B.M., Arnaud C. Radioimmunoassay of parathyroid hormone in hypercalcemic patients with malignant disease. Am J Med 1974, 56:821-826.
40. Lufkin E.G., Kao P.C., Heath H. Parathyroid hormone radioimmunoassays in the differential diagnosis of hypercalcemia due to primary hyperparathyroidism or malignancy. Ann Int Med 1987, 106:559-560.
41. D'Amour P., Weisnagel J., Brossard J.H., Ste-Marie L.G., Rousseau L., Lepage R. Functional evidence for two types of parathyroid adenoma. Clin Endocrinol 1998, 48:593-601.
42. Räkel A., Brossard J.H., Patenaude J.V., Albert C., Nassif E., Cantor T., et al. Overproduction of an amino-terminal form of PTH distinct from human PTH(1-84) in a case of severe primary hyperparathyroidism: influence of medical treatment and surgery. Clin Endocrinol 2005, 62:721-727.
43. Arakawa T., D'Amour P., Rousseau L., Brossard J.H., Sakai M., Kasumoto H., et al. Overproduction and secretion of a novel amino-terminal form of parathyroid hormone from a severe type of parathyroid hyperplasia in uremia. Clin J Am Soc Nephrol 2006, 1:525-531.
44. Rubin M.R., Silverberg S.J., D'Amour P., Brossard J.H., Rousseau L., Sliney J., et al. An N-terminal molecular form of parathyroid hormone (PTH) distinct from hPTH(1 84) is overproduced in parathyroid carcinoma. Clin Chem 2007, 53:1470-1476.
45. Souberbielle J.C., Boudou P., Cormier C. Lessons from second- and third generation parathyroid hormone assays in primary hyperparathyroidism. J Endocrinol Invest 2008, 32:463-469.
46. Brossard J.H., Lepage R., Cardinal H., Roy L., Rousseau L., Dorais C., et al. Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays. Clin Chem 2000, 46:697-703.
47. Monier-Faugère M.C., Geng Z., Mawad H., Friedler R.M., Gao P., Cantor T.L., et al. Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients. Kidney Int 2001, 60:1460-1468.
48. Salusky I.B., Goodman W.G., Kuizon B.D., Lavigne J.R., Zahranik R.J., Gales B., et al. Similar predictive value of bone turnover using first- and second-generation immunometric PTH assays in pediatric patients treated with peritoneal dialysis. Kidney Int 2003, 63:1801-1808.
49. Koller H., Zitt E., Staudacher G., Neyer U., Mayer G., Rosenkranz A.R. Variable parathyroid hormone (1-84)/carboxyl-terminal PTH ratios detected by 4 novel parathyroid hormone assays. Clin Nephrol 2004, 61:337-343.
50. Slatopolsky E., Finch J., Clay P., Martin D., Sicard G., Singer G., et al. A novel mechanism for skeletal resistance in uremia. Kidney Int 2000, 58:753-761.
51. D'Amour P. Lessons from second and third generation PTH assays in patient with renal failure. J Endocrinol Invest 2008, 31:459-462.
52. Inomata N., Akiyama M., Kubota N., Jüppner H. Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(1-84). Endocrinology 1995, 136:4732-4740.
53. Divieti P., Inomata N., Chapin K., Singh R., Jüppner H., Bringhurst F.R. Receptors for the carboxyl-terminal region of PTH(1-84) are highly expressed in osteocytic cells. Endocrinology 2001, 142:916-925.
54. Divieti P., Geller A.I., Suliman G., Jüppner H., Bringhurst F.R. Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology 2005, 146:1863-1870.
55. Erdmann S., Burkhardt H., von der Mark K., Müller W. Mapping of a carboxyl-terminal active site of parathyroid hormone by calcium-imaging. Cell Calcium 1998, 23(6):413-421.
56. Selim A.A., Mahon M., Juppner H., Bringhurst F.R., Divieti P. Role of calcium channels in carboxyl-terminal parathyroid hormone receptor signaling. Am J Physiol 2006, 291:C114-C121.
57. Nguyen-Yamamoto L., Rousseau L., Brossard J.H., Lepage R., D'Amour P. Synthetic carboxyl-terminal fragments of parathyroid hormone (PTH) decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTH-related peptide receptor. Endocrinology 2001, 142:1386-1392.
58. Takasu H., Baba H., Inomata N., Uchiyama Y., Kubota N., Kumaki K., et al. The 69-84 amino acid region of the parathyroid hormone molecule is essential for the interaction of the hormone with the binding sites with carboxyl-terminal specificity. Endocrinology 1996, 137:5537-5543.
59. Gao P., D'Amour P. Evolution of the parathyroid (PTH) assay: importance of circulating PTH immunoheterogeneity and of its regulation. Clin Lab 2005, 51:21-29.
60. Langub M.C., Monier-Faugere M.C., Wang G., Williams J.P., Koszewski N.J., Malluche H.H. Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure. Endocrinology 2003, 144:1135-1138.
61. 2D synthesis. Kidney Int 2007, 72:1330-1335.
62. Nakamoto C., Baba H., Fukase M., Nakajima K., Kimura T., Sakakibara S., et al. Individual and combined effects of intact PTH, amino-terminal, and a series of truncated carboxyl-terminal PTH fragments on alkaline phosphatase activity in dexamethasone-treated rat osteoblastic osteosarcoma cells, ROS 17/2.8. Acta Endocrinol 1993, 128:367-372.
63. Sutherland M.K., Rao L.G., Wylie J.N., Gupta A., Ly H., Sodek J., et al. Carboxyl-terminal parathyroid hormone peptide (53-84) elevates alkaline phosphatase and osteocalcin mRNA levels in SaOS-2 cells. J Bone Miner Res 1994, 9:453-458.
64. Kaji H., Sugimoto T., Kanatani M., Miyauchi A., Kimura T., Sakakibara S., et al. Carboxyl-terminal parathyroid hormone fragments stimulate osteoclast-like cell formation and osteoclastic activity. Endocrinology 1994, 13:1897-1904.
65. Tsuboi T., Togari A. Comparison of the effects of carboxyl-terminal parathyroid hormone peptide[53-84] and aminoterminal peptide[1-34] on mouse tooth germ in vitro. Arch Oral Biol 1998, 43:335-339.
66. Erdmann S., Müller W., Bahrami S., Vornehm S.I., Mayer H., Bruckner P., et al. Differential effects of parathyroid hormone fragments on collagen gene expression in chondrocytes. J Cell Biol 1996, 135:1179-1191.
67. Divieti P., John M.R., Jüppner H., Bringhurst F.R. Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/PTHrP receptor. Endocrinology 2002, 143:171-176.
68. Segre G.V., Rosenblatt M., Reiner B.L., Mahaffey J.E., Potts J.T. Characterization of parathyroid hormone receptors in canine renal cortical plasma membranes using a radioiodinated sulfur-free hormone analogue. Correlation of binding with adenylate cyclase activity. J Biol Chem 1979, 254:6980-6986.
69. Sneddon W.B., Magyar C.E., Willick G.E., Syme C.A., Galbiati F., Bisello A., et al. Ligand-selective dissociation of activation and internalization of the parathyroid hormone (PTH) receptor: conditional efficacy of PTH peptide fragments. Endocrinology 2004, 145:2815-2823.
70. Sneddon W.B., Syme C.A., Bisello A., Magyar C.E., Rochdi M.D., Parent J.L., et al. Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem 2003, 278:43787-43796.
71. Russell J., Lettieri D., Sherwood L.M. Suppression by 1,25(OH)2D3 of transcription of the pre-proparathyroid hormone gene. Endocrinology 1986, 119:2864-2866.