Role of calcium channels in carboxyl-terminal parathyroid hormone receptor signaling

American Journal of Physiology - Cell Physiology

Volumn 291, Issue 1, 2006, Pages

  Selim, A A ^a   Mahon, M ^a   Juppner, H ^a   Bringhurst, F R ^a   Divieti, P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Calcium influx; Osteocytes

Indexed keywords

CALCIUM; CALCIUM CHANNEL; NIFEDIPINE; OMEGA AGATOXIN IVA; OMEGA CONOTOXIN GVIA; PARATHYROID HORMONE RECEPTOR;

ANIMAL CELL; ARTICLE; BONE CELL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CARTILAGE CELL; EXTRACELLULAR CALCIUM; HORMONE RELEASE; MICROFLUOROMETRY; MOUSE; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; TARGET CELL;

CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CELL LINE, TRANSFORMED; CELLS, CULTURED; HUMANS; OSTEOCYTES; PARATHYROID HORMONE; PEPTIDE FRAGMENTS; RECEPTORS, PARATHYROID HORMONE; SIGNAL TRANSDUCTION;

EID: 33745686083     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00566.2005     Document Type: Article

References (29)

1. Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT Jr, Kronenberg HM, and Segre GV. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 89: 2732-2736, 1992.
2. Bringhurst FR, Stern AM, Yotts M, Mizrahi N, Segre GV, and Potts JT Jr. Peripheral metabolism of PTH: fate of biologically active amino terminus in vivo. Am J Physiol Endocrinol Metab 255: E886-E893, 1988.
3. Coirault C, Sauviat MP, Chemla D, Pourny JC, and Lecarpentier Y. The effects of gadolinium, a stretch-sensitive channel blocker, on diaphragm muscle. Eur Respir J 14: 1297-1303, 1999.
4. Divieti P, Lanske B, Kronenberg HM, and Bringhurst FR. Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor. J Bone Miner Res 13: 1835-1845, 1998.
5. Divieti P, Inomata N, Chapin K, Singh R, Juppner H, and Bringhurst FR. Receptors for the carboxyl-terminal region of PTH(1-84) are highly expressed in osteocytic cells. Endocrinology 142: 916-925, 2001.
6. Divieti P, Lotz O, Geller A, Juppner H, and Bringhurst FR. Inhibition of osteoclast formation by human PTH(7-84) involves direct actions on hematopoietic cells (Abstract). J Bone Miner Res 17: S167, 2002.
7. Divieti P, Geller AI, Suliman G, Juppner H, and Bringhurst FR. Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology 146: 1863-1870, 2005.
8. Erdmann S, Muller W, Bahrami S, Vornehm SI, Mayer H, Bruckner P, von der Mark K, and Burkhardt H. Differential effects of parathyroid hormone fragments on collagen gene expression in chondrocytes. J Cell Biol 135: 1179-1191, 1996.
9. Fukayama S, Schipani E, Juppner H, Lanske B, Kronenberg HM, Abou-Samra AB, and Bringhurst FR. Role of protein kinase-A in homologous down-regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in human osteoblast-like SaOS-2 cells. Endocrinology 134: 1851-1858, 1994.
10. Grynkiewicz G, Poenie M, and Tsien RY. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
11. Gu Y, Preston MR, Magnay J, El Haj AJ, and Publicover SJ. Hormonally-regulated expression of voltage-operated Ca(2+) channels in osteocytic (MLO-Y4) cells. Biochem Biophys Res Commun 282: 536-542, 2001.
12. Hescheler J and Schultz G. Nonselective cation channels: physiological and pharmacological modulations of channel activity. EXS 66: 27-43, 1993.
13. Inomata N, Akiyama M, Kubota N, and Jüppner H. Characterization of a novel parathyroid hormone (PTH) receptor with specificity for the carboxyl-terminal region of PTH-(19-84). Endocrinology 136: 4732-4740, 1995.
14. Iqbal J and Zaidi M. Molecular regulation of mechanotransduction. Biochem Biophys Res Commun 328: 751-755, 2005.
15. Jorgensen NR, Teilmann SC, Henriksen Z, Civitelli R, Sorensen OH, and Steinberg TH. Activation of L-type calcium channels is required for gap junction-mediated intercellular calcium signaling in osteoblastic cells. J Biol Chem 278: 4082-4086, 2003.
16. Khosla S, Demay M, Pines M, Hurwitz S, Potts JT Jr, and Kronenberg HM. Nucleotide sequence of cloned cDNAs encoding chicken preproparathyroid hormone. J Bone Miner Res 3: 689-698, 1988.
17. Lacinova L. Voltage-dependent calcium channels. Gen Physiol Biophys 1: 1-78, 2005.
18. Meir A and Dolphin AC. Known calcium channel alpha1 subunits can form low threshold small conductance channels with similarities to native T-type channels. Neuron 20: 341-351, 1998.
19. Meir A, Bell DC, Stephens GJ, Page KM, and Dolphin AC. Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma. Biophys J 79: 731-746, 2000.
20. Murray TM, Rao LG, and Muzaffar SA. Dexamethasone-treated ROS 17/2.8 rat osteosarcoma cells are responsive to human carboxylterminal parathyroid hormone peptide hPTH (53-84): stimulation of alkaline phosphatase. Calcif Tissue Int 49: 120-123, 1991.
21. Murray TM, Rao LG, Divieti P, and Bringhurst FR. Parathyroid hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal ligands. Endocr Rev 26: 78-113, 2005.
22. Nasu M, Sugimoto T, Kaji H, Kano J, and Chihara K. Carboxyl-terminal parathyroid hormone fragments stimulate type-1 procollagen and insulin-like growth factor-binding protein-5 mRNA expression in osteoblastic UMR-106 cells. Endocr J 45: 229-234, 1998.
23. Nguyen-Yamamoto L, Rousseau L, Brossard JH, Lepage R, and D'Amour P. Synthetic carboxyl-terminal fragments of parathyroid hormone (PTH) decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTH-related peptide receptor. Endocrinology 142: 1386-1392, 2001.
24. Peiro C, Vallejo S, Cercas E, Llergo JL, Lafuente N, Matesanz N, Rodriguez-Manas L, and Sanchez-Ferrer CF. Thapsigargin induces apoptosis in cultured human aortic smooth muscle cells. J Cardiovasc Pharmacol 36: 676-680, 2000.
25. Schiller PC, D'Ippolito G, Divieti P, Bringhurst FR, and Howard GA. Specific activation of type I or C-terminal PTH receptors regulate gap-junctional communication among bone-derived cells expressing or lacking PTH1R. J Bone Miner Res 19, Suppl 1: s1-s543, 2004.
26. Sher E, Rosa P, Francolini M, Codignola A, Morlacchi E, Taverna E, Giovannini F, Brioschi A, Clementi F, McEnery MW, and Passafaro M. Metabolism and trafficking of N-type voltage-operated calcium channels in neurosecretory cells. J Bioenerg Biomembr 30: 399-407, 1998.
27. Slatopolsky E, Finch J, Clay P, Martin D, Sicard G, Singer G, Gao P, Cantor T, and Dusso AA. Novel mechanism for skeletal resistance in uremia. Kidney Int 58: 753-761, 2000.
28. Throckmorton D, Kurscheid-Reich D, Rosales OR, Rodriguez-Commes J, Lopez R, Sumpio B, Zhong Q, Ding KH, McCarthy R, Barrett PQ, and Isales CM. Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration. Peptides 23: 79-85, 2002.
29. Yu C, Jia M, Litzinger M, and Nelson PG. Calcium agonist (BayK 8644) augments voltage-sensitive calcium currents but not synaptic transmission in cultured mouse spinal cord neurons. Exp Brain Res 71: 467-474, 1988.