Acute regulation of circulating parathyroid hormone (PTH) molecular forms by calcium: Utility of PTH fragments/PTH(1-84) ratios derived from three generations of PTH assays

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 1, 2006, Pages 283-289

  D'Amour, Pierre ^a,b   Räkel, Agnès ^a,b   Brossard, Jean Hugúes ^a,b   Rousseau, Louise ^a,b   Albert, Caroline ^a,b   Cantor, Tom ^c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c Scantibodies Laboratory Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHLORIDE; CITRATE SODIUM; PARATHYROID HORMONE;

ADULT; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; HYPERCALCEMIA; HYPOCALCEMIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

ADULT; ALGORITHMS; CALCIUM; CALCIUM CHLORIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRATES; FEMALE; HUMANS; HYPERCALCEMIA; HYPOCALCEMIA; MALE; PARATHYROID GLANDS; PARATHYROID HORMONE; PEPTIDE FRAGMENTS;

EID: 30344487569     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1628     Document Type: Article

References (16)

1. D'Amour P, Labelle F, Lecavalier L, Plourde V, Harvey D 1986 Influence of serum Ca concentration on circulating molecular forms of PTH in three species. Am J Physiol 251:E680-E687
2. D'Amour P, Palardy J, Bashali G, Malette LE, DeLean A, Lepage R 1992 Modulation of circulating parathyroid hormone immunoheterogeneity in man by ionized calcium concentration. J Clin Endocrinol Metab 75:525-532
3. Brossard JH, Cloutier M, Roy L, Lepage R, Gascon-Barre M, D'Amour P 1996 Accumulation of non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values. J Clin Endocrinol Metab 81:3923-3929
4. D'Amour P, Brossard JH, Räkel A, Rousseau L, Albert C, Cantor T 2005 Evidence that the amino-terminal composition of non-(1-84) parathyroid hormone fragments starts before position 19. Clin Chem 51:169-176
5. D'Amour P, Brossard JH, Rousseau L, Lazure C, Lavigne JR, Zahradnik RJ 2005 Structure of non-(1-84) PTH fragments secreted by parathyroid glands in primary and secondary hyperparathyroidism. Kidney Int 68:997-1007
6. Brossard JH, Cardinal H, Roy L, Lepage R, Rousseau L, Dorais C, D'Amour P 2000 Influence of glomerular filtration rate on intact parathyroid hormone levels in renal failure patients: role of non-(1-84) PTH detected by intact PTH assays. Clin Chem 46:697-703
7. Nguyen-Yamamoto L, Rousseau L, Brossard JH, Lepage R, Gao P, Cantor T, D'Amour P 2002 Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays. Eur J Endocrinol 147:123-131
8. D'Amour P, Brossard JH, Rousseau L, Roy L, Gao P, Cantor T 2003 Amino-terminal form of parathyroid hormone (PTH) with immunologic similarities to hPTH(1-84) is overproduced in primary and secondary hyperparathyroidism. Clin Chem 49:2037-2044
9. John MR, Coolman WG, Gao P, Cantor TL, Saluski IB, Juppner H 1999 A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure. J Clin Endocrinol Metab 84:4287-4290
10. Gao P, Scheibel S, D'Amour P, John MR, Rao SD, Schmidt-Gayk H, Cantor TL 2001 Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res 16:605-614
11. Bennett HPJ, Solomon S, Goltzman D 1981 Isolation and analysis of human parathyrin in parathyroid tissue and plasma. Use of reversed-phase liquid chromatography. Biochem J 197:391-400
12. Slatopolsky E, Finch J, Clay P, Martin D, Sicard G, Singera G, Gao P, Cantor T, Dusso A 2000 A novel mechanism for skeletal resistance in uremia. Kidney Int 58:753-761
13. Nguyen-Yamamoto L, Rousseau L, Brossard JH, Lepage R, D'Amour P 2001 Synthetic carboxyl-terminal fragments of PTH decrease ionized calcium concentration in rats by acting on a receptor different from the PTH/PTHrP receptor. Endocrinology 142:1386-1392
14. Langub MC, Monier-Faugere MC, Wang G, Williams JP, Koszewski NJ, Malluche HH 2003 Administration of PTH-(7-84) antagonizes the effects of PTH-(1-84) on bone in rats with moderate renal failure. Endocrinology 144:1135-1138
15. Divieti P, John MR, Jüppner H, Bringhurst FR 2002 Human PTH-(7-84) inhibits bone resorption in vitro via actions independent of the type 1 PTH/ PTHrP receptor. Endocrinology 143:171-176
16. Divieti P, Geller AI, Suliman G, Jüppner H, Bringhurst FR 2005 Receptors specific for the carboxyl-terminal region of parathyroid hormone on bone-derived cells: determinants of ligand binding and bioactivity. Endocrinology 146:1863-1870