Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients

Journal of Molecular Neuroscience

Volumn 47, Issue 2, 2012, Pages 207-218

  Kong, Ying ^a   Bai, Pei Song ^a   Sun, Hong ^a   Nan, Ke Jun ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Apoptosis; CAC1; Cell cycle

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; CAC1 PROTEIN; CYCLIN E; PROTEIN; PROTEIN P53; TAU PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; FEMALE; GENE SILENCING; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MALE; OXIDATIVE STRESS; PROTEIN EXPRESSION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOPTOSIS; CELL LINE, TUMOR; CULLIN PROTEINS; FEMALE; HELA CELLS; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS;

EID: 84863876685     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9717-5     Document Type: Article

References (27)

1. Arendt T (2002) Dysregulation of neuronal differentiation and cell cycle control in Alzheimer's disease. J Neural Transm Suppl 62:77-85
2. Arendt T, Bruckner MK (2007) Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity. Biochim Biophys Acta 1772(4):413-421 (Pubitemid 46400388)
3. Ashford JW, Mortimer JA (2002) Non-familial Alzheimer's disease is mainly due to genetic factors. J Alzheimers Dis 4(3):169-177 (Pubitemid 35006049)
4. Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827 (Pubitemid 24187680)
5. Bertram L (2009) Alzheimer's disease genetics current status and future perspectives. Int Rev Neurobiol 84:167-184
6. Bertram L, Tanzi RE (2004) Alzheimer's disease: one disorder, too many genes? Hum Mol Genet 13(Spec No 1):R135-R141 (Pubitemid 38443807)
7. Bettens K, Sleegers K, Van Broeckhoven C (2010) Current status on Alzheimer disease molecular genetics: from past, to present, to future. Hum Mol Genet 19(R1):R4-R11
8. Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic VP, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG (2009) Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging 1(4):382-388
9. Bonda DJ, Bajić VP, Spremo-Potparevic B, Casadesus G, Zhu X, Smith MA, Lee HG (2010) Cell cycle aberrations and neurodegeneration. Neuropathol Appl Neurobiol 36(2):157-163
10. Bowser R, Smith MA (2002) Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. J Alzheimers Dis 4(3):249-254 (Pubitemid 35006056)
11. Browne SE, Ferrante RJ, Beal MF (1999) Oxidative stress in Huntington's disease. Brain Pathol 9:147-163 (Pubitemid 29056525)
12. Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA, Terstappen GC, Nicoletti F (2003) The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease? Trends Pharmacol Sci 24(5):233-238 (Pubitemid 36588871)
13. Chen Y, Zhang YZ, Zhou ZG, Wang G, Yi ZN (2006) Identification of differently expressed genes in human colorectal adenocarcinoma. World J Gastroenterol 12(7):1025-1032
14. Copani A, Caraci F, Hoozemans JJ, Calafiore M, Sortino MA, Nicoletti F (2007) The nature of the cell cycle in neurons: focus on a "non- canonical" pathway of DNA replication causally related to death. Biochim Biophys Acta 1772(4):409-412 (Pubitemid 46400384)
15. Crews L, Masliah E (2010) Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19(R1):R12-R20
16. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O'brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P (2007) Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 6(8):734-746 (Pubitemid 47058377)
17. Erol A (2010) Are paradoxical cell cycle activities in neurons and glia related to the metabolic theory of Alzheimer's disease? J Alzheimers Dis 19(1):129-135
18. Harris PL, Zhu X, Pamies C, Rottkamp CA, Ghanbari HA, McShea A, Feng Y, Ferris DK, Smith MA (2000) Neuronal polo-like kinase in Alzheimer disease indicates cell cycle changes. Neurobiol Aging 21(6):837-841
19. Herrup K, Yang Y (2001) Pictures in molecular medicine: contemplating Alzheimer's disease as cancer: a loss of cell-cycle control. Trends Mol Med 7(11):527 (Pubitemid 33021684)
20. Hornsby PJ (2007) Senescence as an anticancer mechanism. J Clin Oncol 25(14):1852-1857
21. Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI (1999) The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 38:7609-7616 (Pubitemid 29289332)
22. Kamboh MI (2004) Molecular genetics of late-onset Alzheimer's disease. Ann Hum Genet 68:381-404
23. Kong Y, Nan K, Yin Y (2009) Identification and characterization of CAC1 as a novel CDK2-associated cullin. Cell Cycle 8(21):3544-3553
24. Lendon C, Craddock N (2001) Susceptibility gene(s) for Alzheimer's disease on chromosome 10. Trends Neurosci 24:557-559 (Pubitemid 32913378)
25. McShea A, Wahl AF, Smith MA (1999) Re-entry into the cell cycle: a mechanism for neurodegeneration in Alzheimer disease. Med Hypotheses 52(6):525-527 (Pubitemid 29322571)
26. Sultana R, Perluigi M, Butterfield DA (2009) Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis. Acta Neuropathol 118(1):131-150
27. Waring SC, Rosenberg RN (2008) Genome-wide association studies in Alzheimer disease. Arch Neurol 65(3):329-334 (Pubitemid 351409357)