A prospective randomized study to compare pelvic floor rehabilitation and dapoxetine for treatment of lifelong premature ejaculation

International Journal of Andrology

Volumn 35, Issue 4, 2012, Pages 528-533

  Pastore, A L ^a,b,d   Palleschi, G ^a,b   Leto, A ^b   Pacini, L ^a   Iori, F ^c   Leonardo, C ^c   Carbone, A ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Uroresearch Association   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NONE   (Italy)

Author keywords

Biofeedback; Dapoxetine; Electrostimulation; Intra vaginal ejaculatory latency time; Premature ejaculation

Indexed keywords

DAPOXETINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DISEASE DURATION; EJACULATION; HUMAN; INTERMETHOD COMPARISON; LATENT PERIOD; MALE; OUTCOME ASSESSMENT; PELVIC FLOOR MUSCLE TRAINING; PREMATURE EJACULATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION; TREATMENT RESPONSE;

ADULT; BENZYLAMINES; EJACULATION; EXERCISE; HUMANS; MALE; MIDDLE AGED; NAPHTHALENES; PELVIC FLOOR; PREMATURE EJACULATION; PROSPECTIVE STUDIES; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84863871913     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2011.01243.x     Document Type: Article

References (26)

1. Althof SE. (2006) Prevalence, characteristics and implications of premature ejaculation/rapid ejaculation. J Urol 175, 842-848.
2. Buvat J, Tesfaye F, Rothman M, Rivas DA & Giuliano F. (2009) Dapoxetine for the treatment of premature ejaculation: results from a randomized, double blind, placebo-controlled phase three trial in 22 countries. Eur Urol 55, 957-968.
3. Carson C & Gunn K. (2006) Premature ejaculation: definition and prevalence. Int J Impot Res 18, S5-S13.
4. Colpi GM, Negri L, Nappi RE & Chinea B. (1999) Perineal floor efficiency in sexually potent and impotent men. Int J Impot Res 11, 154-157.
5. Gengo PJ, Giuliano F & McKenna K. (2005) Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation [abstract]. J Urol; 173, 239.
6. Giuliano F & Clement P. (2006) Serotonin and premature ejaculation: from physiology to patient management. Eur Urol 50, 454-466.
7. Giuliano F & Clément P. (2005) Physiology of Ejaculation: Emphasis on Serotonergic Control. Eur Urol 46, 408-417.
8. Hay-Smith J, Herbison P & Mørkved S. (2007) Physical therapies for prevention of urinary and faecal incontinence in adults. Cochrane Database Syst Rev CD003191.
9. Hiemke C & Hartter S. (2000) Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol Ther 85, 11-28.
10. de Jong TR, Veening JG, Waldinger MD, Cools AR & Olivier B. (2006) Serotonin and the neurobiology of the ejaculatory threshold. Neurosci Biobehav Rev 30, 893-907.
11. Kaplan HS. (1974) The New Sex Therapy. Brunner Mazel, New York 1974.
12. Kim SW & Paick JS. (2004) Peripheral effects of serotonin on the contractile responses of rat seminal vesicles and vasa deferentia. J Androl 25, 893-896.
13. Kinsey AC. (1948) Sexual Behaviour in the Human Male. WB Saunders Co., Philadelphia 1948.
14. La Pera G & Nicastro A. (1996) A new treatment for premature ejaculation. The rehabilitation of the pelvic floor. J Sex Marital Ther 22, 22-26.
15. McKenna K. (1999) Ejaculation. In: Encyclopedia of Reproduction vol. 1 (eds) E Knobil & J Neil ), pp. 1002-1008. Academic Press, New York, 1999.
16. McMahon CG, Althof SE, Waldinger MD, Porst H, Dean J, Sharlip ID, et al. (2008) An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) Ad Hoc Committee for the Definition of Premature Ejaculation. J Sex Med 5, 1590-1606.
17. Modi NB, Dresser MJ, Simon M, Lin D, Desai D & Gupta S. (2006) Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation. J Clin Pharmacol 46, 301-309.
18. Montejo AL, Llorca G, Izquierdo JA & Rico-Villademoros F. (2001) Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. J Clin Psychiatry 62, 10-21.
19. Montejo-González AL, Llorca G, Izquierdo JA, Ledesma A, Bousoño M, Calcedo A et al. (1997) SSRI-induced sexual dysfunction: fluoxetine, paroxetine, sertraline, and fl uvoxamine in a prospective, multicenter, and descriptive clinical study of 344 patients. J Sex Marital Ther 23, 176-194.
20. Piediferro G, Colpi EM, Castiglioni F & Scroppo FI. (2004) Premature ejaculation. Arch Ital Urol Androl 76, 192-198.
21. Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S & Alexander J. (2007) The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking. Eur Urol 51, 816-824.
22. Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Miloslavsky M & Kell S. (2006) Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomized-controlled trials. Lancet 368, 929-937.
23. Shabsigh R, Patrick DL, Rowland DL, Bull SA, Tesfaye F & Rothman M. (2008) Perceived control over ejaculation is central to treatment benefit in men with premature ejaculation: results from phase III trials with dapoxetine. BJU Int 102, 824-828.
24. Shafik A. (2000) The role of the levator ani muscle in evacuation, sexual performance and pelvic floor disorders. Int Urogynecol J Pelvic Floor Dysfunct 11, 361-376.
25. Waldinger MD. (2002) The neurobiological approach to premature ejaculation. J Urol 168, 2359.
26. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH & Boolell M. (2005) A multinational population survey of intravaginal ejaculation latency time. J Sex Med 2, 492-497.