Inactivation of PKMζ in the NAc shell abolished cocaine-conditioned reward

Journal of Molecular Neuroscience

Volumn 47, Issue 3, 2012, Pages 546-553

  Shabashov, D ^a   Shohami, E ^a   Yaka, R ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Addiction; Cocaine; Conditioned place preference; GluR1; GluR2; Memory; PKM ; ZIP

Indexed keywords

COCAINE; GLUTAMATE RECEPTOR 2; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE M ZETA; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ZETA INHIBITORY PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONED PLACE REFERENCE; CONDITIONING; CONTROLLED STUDY; DISSOCIATION; ENZYME INACTIVATION; INJECTION; LOCOMOTION; MALE; MEDIATOR; NONHUMAN; NUCLEUS ACCUMBENS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RELAPSE; REWARD; WITHDRAWAL SYNDROME;

ANIMALS; COCAINE-RELATED DISORDERS; CONDITIONING (PSYCHOLOGY); MALE; NUCLEUS ACCUMBENS; PEPTIDES; PROTEIN KINASE C; RATS; RATS, INBRED STRAINS; REWARD;

EID: 84863862962     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9671-7     Document Type: Article

References (36)

1. Aberman JE, Salamone JD (1999) Nucleus accumbens dopamine depletions make rats more sensitive to high ratio requirements but do not impair primary food reinforcement. Neuroscience 92:545-552 (Pubitemid 29268042)
2. Aragona BJ, Cleaveland NA, Stuber GD, Day JJ, Carelli RM, Wightman RM (2008) Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. J Neurosci 28:8821-8831
3. Bassareo V, Musio P, Di Chiara G (2011) Reciprocal responsiveness of nucleus accumbens shell and core dopamine to food- and drugconditioned stimuli. Psychopharmacology (Berl) 214:687-697
4. Bossert JM, Poles GC, Wihbey KA, Koya E, Shaham Y (2007) Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. J Neurosci 27:12655-12663 (Pubitemid 350127821)
5. Carlezon WA Jr, Thomas MJ (2009) Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology 56(Suppl 1):122-132
6. Carlezon WA Jr, Devine DP, Wise RA (1995) Habit-forming actions of nomifensine in nucleus accumbens. Psychopharmacology (Berl) 122:194-197 (Pubitemid 26019154)
7. Conrad KL, Tseng KY, Uejima JL, Reimers JM, Heng LJ, Shaham Y, Marinelli M, Wolf ME (2008) Formation of accumbens GluR2- lacking AMPA receptors mediates incubation of cocaine craving. Nature 454:118-121 (Pubitemid 351931970)
8. Corbit LH, Bernard WB (2011) The general and outcome specific forms of pavlovian-instrumental transfer are differentially mediated by the nucleus accumbens core and shell. J Neurosci 31:11786-11794
9. Di Chiara G (2002) Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res 137:75-114
10. Di Chiara G, Tanda G, Bassareo V, Pontieri F, Acquas E, Fenu S, Cadoni C, Carboni E (1999) Drug addiction as a disorder of associative learning. Role of nucleus accumbens shell/extended amygdala dopamine. Ann N Y Acad Sci 877:461-485 (Pubitemid 29351873)
11. Dong Y, Saal D, Thomas M, Faust R, Bonci A, Robinson T, Malenka RC (2004) Cocaine-induced potentiation of synaptic strength in dopamine neurons: behavioral correlates in GluRA(-/-) mice. Proc Natl Acad Sci U S A 101:14282-14287 (Pubitemid 39305066)
12. Ghasemzadeh MB, Vasudevan P, Mueller C, Seubert C, Mantsch JR (2009) Region specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. Brain Res 1267:89-102
13. Goldstein RZ, Craig AD, Bechara A, Garavan H, Childress AR, Paulus MP, Volkow ND (2009) The neurocircuitry of impaired insight in drug addiction. Trends Cogn Sci 13:372-380
14. Harris GC, Aston-Jones G (2003) Enhanced morphine preference following prolonged abstinence: association with increased Fos expression in the extended amygdala. Neuropsychopharmacology 28:292-299
15. He YY, Xue YX, Wang JS, Fang Q, Liu JF, Xue LF, Lu L (2011) PKMzeta maintains drug reward and aversion memory in the basolateral amygdala and extinction memory in the infralimbic cortex. Neuropsychopharmacology 36(10):1972-1981
16. Hyman SE, Malenka RC (2001) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci 2:695-703 (Pubitemid 33674815)
17. Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Brain Res Rev 16:223-244
18. Kelly MT, Crary JF, Sacktor TC (2007) Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation. J Neurosci 27:3439-3444 (Pubitemid 46515119)
19. Kwapis JL, Jarome TJ, Lonergan ME, Helmstetter FJ (2009) Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behav Neurosci 123:844-850
20. Lammel S, Ion DI, Roeper J, Malenka RC (2011) Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron 70:855-862
21. Li YQ, Xue YX, He YY, Li FQ, Xue LF, Xu CM, Sacktor TC, Shaham Y, Lu L (2011) Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci 31:5436-5446
22. Lv XF, Xu Y, Han JS, Cui CL (2011) Expression of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) in the nucleus accumbens is critical for the acquisition, expression and reinstatement of morphine-induced conditioned place preference. Behav Brain Res 223:182-191
23. Malenka RC (2003) Synaptic plasticity and AMPA receptor trafficking. Ann N Y Acad Sci 1003:1-11
24. Migues PV, Hardt O, Wu DC, Gamache K, Sacktor TC, Wang YT, Nader K (2010) PKMzeta maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci 13:630-634
25. Morris RG, Inglis J, Ainge JA, Olverman HJ, Tulloch J, Dudai Y, Kelly PA (2006) Memory reconsolidation: sensitivity of spatial memory to inhibition of protein synthesis in dorsal hippocampus during encoding and retrieval. Neuron 50:479-489
26. Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119-128
27. Parkinson JA, Olmstead MC, Burns LH, Robbins TW, Everitt BJ (1999) Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-amphetamine. J Neurosci 19:2401-2411 (Pubitemid 29133415)
28. Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton AA, Sacktor TC (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313:1141-1144
29. Paxinos G, Watson C (2005) The rat brain in stereotaxic coordinates, Ed 5. Amsterdam: Elseiver Academic
30. Pilotte NS, Sharpe LG, Rountree SD, Kuhar MJ (1996) Cocaine withdrawal reduces dopamine transporter binding in the shell of the nucleus accumbens. Synapse 22:87-92 (Pubitemid 26020420)
31. Sacktor TC (2011) How does PKMzeta maintain long-term memory? Nat Rev Neurosci 12:9-15
32. Sacktor TC, Osten P, Valsamis H, Jiang X, Naik MU, Sublette E (1993) Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation. Proc Natl Acad Sci U S A 90:8342-8346 (Pubitemid 23277664)
33. Sajikumar S, Navakkode S, Sacktor TC, Frey JU (2005) Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depression. J Neurosci 25:5750-5756 (Pubitemid 40847887)
34. Shema R, Sacktor TC, Dudai Y (2007) Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta. Science 317:951-953 (Pubitemid 47301323)
35. Shema R, Haramati S, Ron S, Hazvi S, Chen A, Sacktor TC, Dudai Y (2011) Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex. Science 331:1207-1210
36. Zahm DS (1999) Functional-anatomical implications of the nucleus accumbens core and shell subterritories. Ann N Y Acad Sci 877:113-128