HLA class i antibody-mediated endothelial and smooth muscle cell activation

Current Opinion in Organ Transplantation

Volumn 17, Issue 4, 2012, Pages 446-451

  Zhang, Xiaohai ^a   Valenzuela, Nicole M ^a   Reed, Elaine F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antibody mediated rejection; HLA class I; integrin b4; natural killer cells

Indexed keywords

ACTIN; BETA4 INTEGRIN; HLA ANTIBODY; HLA ANTIGEN CLASS 1; MATRIX METALLOPROTEINASE;

CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CYTOSKELETON; ENDOTHELIUM CELL; LEUKOCYTE; MITOGENESIS; NATURAL KILLER CELL; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ACTINS; ANIMALS; ANTIBODIES; CELL PROLIFERATION; CELL SURVIVAL; CHEMOTAXIS, LEUKOCYTE; CYTOSKELETON; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HLA ANTIGENS; HUMANS; INTEGRIN BETA4; MYOCYTES, SMOOTH MUSCLE; SIGNAL TRANSDUCTION;

EID: 84863843467     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e328355f1c2     Document Type: Review

References (53)

1. Singh N, Pirsch J, Samaniego M. Antibody-mediated rejection: treatment alternatives and outcomes. Transplant Rev (Orlando) 2009; 23:34-46.
2. Zhang Q, Cecka JM, Gjertson DW, et al. HLA and MICA: targets of antibodymediated rejection in heart transplantation. Transplantation 2011; 91:1153-1158.
3. Glanville AR. Antibody-mediated rejection in lung transplantation: myth or reality? J Heart Lung Transplant 2010; 29:395-400.
4. Zhang Q, Liang LW, Gjertson DW, et al. Development of posttransplant antidonor HLA antibodies is associated with acute humoral rejection and early graft dysfunction. Transplantation 2005; 79:591-598.
5. Mitchell RN, Libby P. Vascular remodeling in transplant vasculopathy. Circ Res 2007; 100:967-978.
6. Mehra MR, Crespo-Leiro MG, Dipchand A, et al. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant 2010; 29:717-727.
7. Baldwin WM 3rd, Kasper EK, Zachary AA, et al. Beyond C4d: other complement-related diagnostic approaches to antibody-mediated rejection. Am J Transplant 2004; 4:311-318.
8. Sis B, Campbell PM, Mueller T, et al. Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause. Am J Transplant 2007; 7:1743-1752.
9. Haas M, Mirocha J. Early ultrastructural changes in renal allografts: correlation with antibody-mediated rejection and transplant glomerulopathy. Am J Transplant 2011; 11:2123-2131.
10. Loupy A, Suberbielle-Boissel C, Hill GS, et al. Outcome of subclinical antibody-mediated rejection in kidney transplant recipients with preformed donorspecific antibodies. Am J Transplant 2009; 9:2561-2570.
11. Hirohashi T, Uehara S, Chase CM, et al. Complement independent antibodymediated endarteritis and transplant arteriopathy in mice. Am J Transplant 2010; 10:510-517.
12. Pollard TD. The cytoskeleton, cellular motility and the reductionist agenda. Nature 2003; 422:741-745.
13. Lepin EJ, Jin YP,Barwe SP,et al.HLAclass I signal transduction isdependent on Rho GTPase and ROK. Biochem Biophys Res Commun 2004; 323:213-217.
14. Coupel S, Leboeuf F, Boulday G, et al. RhoA activation mediates phosphatidylinositol 3-kinase-dependent proliferation of human vascular endothelial cells: an alloimmune mechanism of chronic allograft nephropathy. J Am Soc Nephrol 2004; 15:2429-2439.
15. Jin YP, Korin Y, Zhang X, et al. RNA interference elucidates the role of focal adhesion kinase in HLA class I-mediated focal adhesion complex formation and proliferation in human endothelial cells. J Immunol 2007; 178:7911-7922.
16. Jin YP, Singh RP, Du ZY, et al. Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner. J Immunol 2002; 168:5415-5423.
17. Ziegler ME, Souda P, Jin YP, et al. Characterization of the endothelial cell cytoskeleton following HLA class I ligation. PloS one 2012; 7:e29472.
18. Nath N, Bian H, Reed EF, Chellappan SP. HLA class I-mediated induction of cell proliferation involves cyclin E-mediated inactivation of Rb function and induction of E2F activity. J Immunol 1999; 162:5351-5358.
19. Jindra PT, Hsueh A, Hong L, et al. Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts. J Immunol 2008; 180:2214-2224.
20. Zhou L, Pante N. The nucleoporin Nup153 maintains nuclear envelope architecture and is required for cell migration in tumor cells. FEBS Lett 2010; 584:3013-3020.
21. Jindra PT, Jin YP, Rozengurt E, Reed EF. HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway. J Immunol 2008; 180:2357-2366.
22. Lepin EJ, Zhang Q, Zhang X, et al. Phosphorylated S6 ribosomal protein: a novel biomarker of antibody-mediated rejection in heart allografts. Am J Transplant 2006; 6:1560-1571.
23. Jin YP, Fishbein MC, Said JW, et al. Anti-HLA class I antibody-mediated activation of the PI3K/Akt signaling pathway and induction of Bcl-2 and Bcl-xL expression in endothelial cells. Hum Immunol 2004; 65:291-302.
24. Jindra PT, Jin YP, Jacamo R, et al. MHC class I and integrin ligation induce ERK activation via an mTORC2-dependent pathway. Biochem Biophys Res Commun 2008; 369:781-787.
25. Naemi FM, Ali S, Kirby JA. Antibody-mediated allograft rejection: the emerging role of endothelial cell signalling and transcription factors. Transplant immunol 2011; 25:96-103.
26. Li F, Zhang X, Jin YP, et al. Antibody ligation of human leukocyte antigen class I molecules stimulates migration and proliferation of smooth muscle cells in a focal adhesion kinase-dependent manner. Hum Immunol 2011; 72:1150-1159.
27. Galvani S, Auge N, Calise D, et al. HLA class I antibodies provoke graft arteriosclerosis in human arteries transplanted into SCID/beige mice. Am J Transplant 2009; 9:2607-2614.
28. Orth SR, Odoni G, Karkoszka H, et al. Combination treatment with an ET(A)-receptor blocker and an ACE inhibitor is not superior to the respective monotherapies in attenuating chronic transplant vasculopathy in different aorta allotransplantation rat models. Nephrol Dial, Transplant 2003; 18:62-69.
29. Newby AC. Matrix metalloproteinases regulate migration, proliferation, and death of vascular smooth muscle cells by degrading matrix and nonmatrix substrates. Cardiovasc Res 2006; 69:614-624.
30. Galvani S, Trayssac M, Auge N, et al. A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody. Circulation 2011; 124:2725-2734.
31. Abdel-Ghany M, Cheng H-C, Elble RC, Pauli BU. Focal adhesion kinase activated by beta 4 integrin ligation to mCLCA1 Mediates early metastatic growth. J Biol Chem 2002; 277:34391-34400.
32. Giancotti FG. Targeting integrin beta4 for cancer and antiangiogenic therapy. Trends Pharmacol Sci 2007; 28:506-511.
33. Zhang X, Rozengurt E, Reed EF. HLA class I molecules partner with integrin beta4 to stimulate endothelial cell proliferation and migration. Sci Signal 2010; 3:ra85.
34. Sun C, Liu X, Qi L, et al. Modulation of vascular endothelial cell senescence by integrin beta4. J Cell Physiol 2010; 225:673-681.
35. Lachmann N, Terasaki PI, Budde K, et al. Antihuman leukocyte antigen and donor-specific antibodies detected by luminex posttransplant serve as biomarkers for chronic rejection of renal allografts. Transplantation 2009; 87:1505-1513.
36. Narayanan K, Jaramillo A, Phelan DL, Mohanakumar T. Preexposure to subsaturating concentrations of HLA class I antibodies confers resistance to endothelial cells against antibody complement-mediated lysis by regulating Bad through the phosphatidylinositol 3-kinase/Akt pathway. Eur J Immunol 2004; 34:2303-2312.
37. Narayanan K, Jendrisak MD, Phelan DL, Mohanakumar T. HLA class I antibody mediated accommodation of endothelial cells via the activation of PI3K/cAMP dependent PKA pathway. Transplant Immunol 2006; 15:187-197.
38. Iwasaki K, Miwa Y, Ogawa H, et al. Comparative study on signal transduction in endothelial cells after antia/b and human leukocyte antigen antibody reaction: implication of accommodation. Transplantation 2012; 93:390-397.
39. Iwasaki K, Miwa Y, Haneda M, et al. Significance of HLA class I antibodyinduced antioxidant gene expression for endothelial cell protection against complement attack. Biochem Biophys Res Commun 2010; 391:1210-1215.
40. Fukami N, Ramachandran S, Narayanan K, et al. Mechanism of accommodation in a sensitized human leukocyte antigen transgenic murine cardiac transplant model. Transplantation 2012; 93:364-372.
41. Metcalf DJ, Nightingale TD, Zenner HL, et al. Formation and function of Weibel-Palade bodies. J Cell Sci 2008; 121:19-27.
42. Yamakuchi M, Kirkiles-Smith NC, Ferlito M, et al. Antibody to human leukocyte antigen triggers endothelial exocytosis. Proc Natl Acad Sci U S A 2007; 104:1301-1306.
43. Rahimi S, Qian Z, Layton J, et al. Noncomplement-and complement- activating antibodies synergize to cause rejection of cardiac allografts. Am J Transplant 2004; 4:326-334.
44. Saini D, Angaswamy N, Tiriveedhi V, et al. Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantation. J Heart Lung Transplant 2010; 29:1330-1336.
45. Lee CY, Lotfi-Emran S, Erdinc M, et al. The involvement of FcR mechanisms in antibody-mediated rejection. Transplantation 2007; 84:1324-1334.
46. Rocha PN, Plumb TJ, Crowley SD, Coffman TM. Effector mechanisms in transplant rejection. Immunol Rev 2003; 196:51-64.
47. Hirohashi T, Chase CM, Della Pelle P, et al. A novel pathway of chronic allograft rejection mediated by NK cells and alloantibody. Am J Transplant 2012; 12:313-321.
48. Hidalgo LG, Sis B, Sellares J, et al. NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant 2010; 10:1812-1822.
49. Sheikh S, Parhar RS, Bakheet R, et al. Immobilization of rolling NK cells on platelet-borne P-selectin under flow by proinflammatory stimuli, interleukin-12, and leukotriene B4. J Leukoc Biol 2004; 76:603-608.
50. Maurus CF, Schneider MK, Schmidt D, et al. Activation of human microvascular endothelial cells with TNF-alpha and hypoxia/reoxygenation enhances NK-cell adhesion, but not NK-Cytotoxicity. Transplantation 2006; 81:1204-1211.
51. Rajalingam R. Human diversity of killer cell immunoglobulin-like receptors and disease. Korean J Hematol 2011; 46:216-228.
52. Maier S, Tertilt C, Chambron N, et al. Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28-/-mice. Nat Med 2001; 7:557-562.
53. Hiemann NE, Wellnhofer E, Lehmkuhl HB, et al. Everolimus prevents endomyocardial remodeling after heart transplantation. Transplantation 2011; 92:1165-1172.