The nucleoporin Nup153 maintains nuclear envelope architecture and is required for cell migration in tumor cells

FEBS Letters

Volumn 584, Issue 14, 2010, Pages 3013-3020

  Zhou, Lixin ^a   Panté, Nelly ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cell migration; Cytoskeleton; Nuclear lamina; Nuclear pore complex; Nucleoporin; Nucleoporin 153

Indexed keywords

BINDING PROTEIN; LAMIN; NUCLEOPORIN; NUCLEOPORIN 153; PROTEIN SUN1; UNCLASSIFIED DRUG; CARRIER PROTEIN; INTERMEDIATE FILAMENT PROTEIN; NUCLEAR PROTEIN;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER CELL CULTURE; CARCINOMA CELL; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; CYTOSKELETON; FIBROSARCOMA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; NUCLEAR LAMINA; PRIORITY JOURNAL; PROTEIN DEPLETION; RNA INTERFERENCE; ANIMAL; CELL STRUCTURE; GENETICS; METABOLISM; NUCLEAR PORE; PROTEIN BINDING; XENOPUS LAEVIS;

ANIMALS; CARRIER PROTEINS; CELLULAR STRUCTURES; CYTOSKELETON; HUMANS; INTERMEDIATE FILAMENT PROTEINS; NUCLEAR ENVELOPE; NUCLEAR LAMINA; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; RNA INTERFERENCE; XENOPUS LAEVIS;

EID: 77954176607     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.05.038     Document Type: Article

References (29)

1. Cronshaw J.M., Krutchinsky A.N., Zhang W., Chait B.T., Matunis M.J. Proteomic analysis of the mammalian nuclear pore complex. J. Cell Biol. 2002, 158:915-927.
2. Smythe C., Jenkins H.E., Hutchison C.J. Incorporation of the nuclear pore basket protein nup153 into nuclear pore structures is dependent upon lamina assembly: evidence from cell-free extracts of Xenopus eggs. EMBO J. 2000, 19:3918-3931.
3. Haque F., Lloyd D.J., Smallwood D.T., Dent C.L., Shanahan C.M., Fry A.M., Trembath R.C., Shackleton S. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol. Cell. Biol. 2006, 26:3738-3751.
4. Crisp M., Liu Q., Roux K., Rattner J.B., Shanahan C., Burke B., Stahl P.D., Hodzic D. Coupling of the nucleus and cytoplasm: role of the LINC complex. J. Cell Biol. 2006, 172:41-53.
5. Liu Q., Pante N., Misteli T., Elsagga M., Crisp M., Hodzic D., Burke B., Roux K.J. Functional association of Sun1 with nuclear pore complexes. J. Cell Biol. 2007, 178:785-798.
6. Bodoor K., Shaikh S., Salina D., Raharjo W.H., Bastos R., Lohka M., Burke B. Sequential recruitment of NPC proteins to the nuclear periphery at the end of mitosis. J. Cell Sci. 1999, 112(Pt 13):2253-2264.
7. Harborth J., Elbashir S.M., Bechert K., Tuschl T., Weber K. Identification of essential genes in cultured mammalian cells using small interfering RNAs. J. Cell Sci. 2001, 114:4557-4565.
8. Liu J., Prunuske A.J., Fager A.M., Ullman K.S. The COPI complex functions in nuclear envelope breakdown and is recruited by the nucleoporin Nup153. Dev. Cell 2003, 5:487-498.
9. Prunuske A.J., Liu J., Elgort S., Joseph J., Dasso M., Ullman K.S. Nuclear envelope breakdown is coordinated by both Nup358/RanBP2 and Nup153, two nucleoporins with zinc finger modules. Mol. Biol. Cell 2006, 117:760-769.
10. Mackay D.R., Elgort S.W., Ullman K.S. The Nucleoporin Nup153 Has Separable Roles in Both Early Mitotic Progression and the Resolution of Mitosis. Mol. Biol. Cell 2009, 61:21-22.
11. Roskelley C.D., et al. Inhibition of tumor cell invasion and angiogenesis by motuporamines. Cancer Res. 2001, 61:6788-6794.
12. Walther T.C., Fornerod M., Pickersgill H., Goldberg M., Allen T.D., Mattaj I.W. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J. 2001, 20:5703-5714.
13. Hase M.E., Cordes V.C. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol. Biol. Cell 2003, 14:1923-1940.
14. Bastos R., Lin A., Enarson M., Burke B. Targeting and function in mRNA export of nuclear pore complex protein Nup153. J. Cell Biol. 1996, 134:1141-1156.
15. Shah S., Tugendreich S., Forbes D. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. J. Cell Biol. 1998, 141:31-49.
16. Nakielny S., Shaikh S., Burke B., Dreyfuss G. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J. 1999, 18:1982-1995.
17. Ullman K.S., Shah S., Powers M.A., Forbes D.J. The nucleoporin nup153 plays a critical role in multiple types of nuclear export. Mol. Biol. Cell 1999, 10:649-664.
18. Lussi C.Y., Shumaker D.L., Shimi T., Fahrenkrog B. The nucleoporin Nup153 affects spindle checkpoint activity due to an association wiith Mad1. Nucleus. 2010, 1:71-84.
19. Sabri N., Roth P., Xylourgidis N., Sadeghifar F., Adler J., Samakovlis C. Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. J. Cell Biol. 2007, 178:557-565.
20. Kalverda B., Pickersgill H., Shloma V.V., Fornerod M. Nucleoporins directly stimulate expression of developmental and cell-cycle genes inside the nucleoplasm. Cell. 2010, 140:360-371.
21. Capelson M., Liang Y., Schulte R., Mair W., Wagner U., Hetzer M.W. Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes. Cell. 2010, 140:372-383.
22. Daigle N., Beaudouin J., Hartnell L., Imreh G., Hallberg E., Lippincott-Schwartz J., Ellenberg J. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J. Cell Biol. 2001, 154:71-84.
23. Verstraeten V.L., Broers J.L., Ramaekers F.C., van Steensel M.A. The nuclear envelope, a key structure in cellular integrity and gene expression. Curr. Med. Chem. 2007, 14:1231-1248.
24. Andres V., Gonzalez J.M. Role of A-type lamins in signaling, transcription, and chromatin organization. J. Cell Biol. 2009, 187:945-957.
25. Pekovic V., et al. Nucleoplasmic LAP2alpha-lamin A complexes are required to maintain a proliferative state in human fibroblasts. J. Cell Biol. 2007, 176:163-172.
26. Wilkie G.S., Schirmer E.C. Guilt by association: the nuclear envelope proteome and disease. Mol. Cell. Proteomics 2006, 5:1865-1875.
27. Holaska J.M. Emerin and the nuclear lamina in muscle and cardiac disease. Circ. Res. 2008, 103:16-23.
28. Lee J.S., et al. Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophys. J. 2007, 93:2542-2552.
29. Luke Y., et al. Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. J. Cell Sci. 2008, 121:1887-1898.