Glycerol monolaurate antibacterial activity in broth and biofilm cultures

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Schlievert, Patrick M ^a   Peterson, Marnie L ^b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; EDETIC ACID; GLYCEROL DERIVATIVE; GLYCEROL MONOLAURATE; LAURIC ACID DERIVATIVE; SUPERANTIGEN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS ANTHRACIS; BACILLUS CEREUS; BACTERIUM ISOLATION; BACTEROIDES FRAGILIS; BIOFILM; BORDETELLA BRONCHISEPTICA; BROTH DILUTION; BURKHOLDERIA CENOCEPACIA; CAMPYLOBACTER JEJUNI; CLOSTRIDIUM PERFRINGENS; COLONY FORMING UNIT; COMPARATIVE EFFECTIVENESS; CONCENTRATION (PARAMETERS); ENTEROBACTER AEROGENES; ENTEROBACTERIACEAE; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; ESCHERICHIA COLI; FEMALE; FUSOBACTERIUM; GARDNERELLA VAGINALIS; GROWTH INHIBITION; HAEMOPHILUS INFLUENZAE; HUMAN; KLEBSIELLA PNEUMONIAE; LISTERIA MONOCYTOGENES; MYCOBACTERIUM PHLEI; MYCOBACTERIUM TUBERCULOSIS; MYCOPLASMA HOMINIS; NEISSERIA GONORRHOEAE; NONHUMAN; PASTEURELLA MULTOCIDA; PEPTOSTREPTOCOCCUS; PH; PREVOTELLA MELANINOGENICA; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; SALMONELLA MINNESOTA; SHIGELLA SONNEI; SPECIES DIFFERENTIATION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS GROUP C; STREPTOCOCCUS GROUP F; STREPTOCOCCUS GROUP G; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STREPTOCOCCUS SANGUINIS; STREPTOCOCCUS SUIS;

ANTI-BACTERIAL AGENTS; BACTERIA; BIOFILMS; COMMUNITY-ACQUIRED INFECTIONS; GLYCEROL; HUMANS; HYDROGEN-ION CONCENTRATION; LAURATES; LAURIC ACIDS; MICROBIAL SENSITIVITY TESTS; MONOGLYCERIDES; SUPERANTIGENS;

ANIMALIA; BACTERIA (MICROORGANISMS); ENTEROBACTERIACEAE; HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

EID: 84863814767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040350     Document Type: Article

References (33)

1. Hall-Stoodley L, Costerton JW, Stoodley P, (2004) Bacterial biofilms: from the natural environment to infectious diseases. Nat Rev Microbiol 2: 95-108.
2. Schlievert PM, Deringer JR, Kim MH, Projan SJ, Novick RP, (1992) Effect of glycerol monolaurate on bacterial growth and toxin production. Antimicrob Agents Chemother 36: 626-631.
3. Vetter S, Tripp TJ, Schlievert PM, (2005) Glycerol monolaurate inhibits virulence factor production in Bacillus anthracis. Antimicrob Agents Chemother 49: 1302-1305.
4. Projan SJ, Brown-Skrobot S, Schlievert PM, Vandenesch F, Novick RP, (1994) Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction. J Bacteriol 176: 4204-4209.
5. Schlievert PM, Kelly JA, (1984) Clindamycin-induced suppression of toxic-shock syndrome-associated exotoxin production. J Infect Dis 149: 471.
6. Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, et al. (2009) Glycerol monolaurate prevents mucosal SIV transmission. Nature 458: 1034-1038.
7. Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T, (1987) Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob Agents Chemother 31: 27-31.
8. Thormar H, Isaacs CE, Kim KS, Brown HR, (1994) Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann N Y Acad Sci 724: 465-471.
9. Ruzin A, Novick RP, (2000) Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus. J Bacteriol 182: 2668-2671.
10. Lin YC, Schlievert PM, Anderson MJ, Fair CL, Schaefers MM, et al. (2009) Glycerol monolaurate and dodecylglycerol effects on Staphylococcus aureus and toxic shock syndrome toxin-1 in vitro and in vivo. PLoS One 4: e7499.
11. Strandberg KL, Peterson ML, Lin YC, Pack MC, Chase DJ, et al. (2010) Glycerol monolaurate inhibits Candida and Gardnerella vaginalis in vitro and in vivo but not Lactobacillus. Antimicrob Agents Chemother 54: 597-601.
12. Reiser RF, Hinzman SJ, Bergdoll MS, (1987) Production of toxic shock syndrome toxin 1 by Staphylococcus aureus restricted to endogenous air in tampons. J Clin Microbiol 25: 1450-1452.
13. Deleo FR, Kennedy AD, Chen L, Bubeck Wardenburg J, Kobayashi SD, et al. (2011) Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proc Natl Acad Sci U S A 108: 18091-18096.
14. Giantonio BJ, Alpaugh RK, Schultz J, McAleer C, Newton DW, et al. (1997) Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer. J Clin Oncol 15: 1994-2007.
15. Djordjevic D, Wiedmann M, McLandsborough LA, (2002) Microtiter plate assay for assessment of Listeria monocytogenes biofilm formation. Appl Environ Microbiol 68: 2950-2958.
16. Minnikin DE, Kremer L, Dover LG, Besra GS, (2002) The methyl-branched fortifications of Mycobacterium tuberculosis. Chem Biol 9: 545-553.
17. Schlievert PM, Strandberg KL, Brosnahan AJ, Peterson ML, Pambuccian SE, et al. (2008) Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use. Antimicrob Agents Chemother 52: 4448-4454.
18. Pechous R, Ledala N, Wilkinson BJ, Jayaswal RK, (2004) Regulation of the expression of cell wall stress stimulon member gene msrA1 in methicillin-susceptible or-resistant Staphylococcus aureus. Antimicrob Agents Chemother 48: 3057-3063.
19. Delaune A, Poupel O, Mallet A, Coic YM, Msadek T, et al. (2011) Peptidoglycan crosslinking relaxation plays an important role in Staphylococcus aureus WalKR-dependent cell viability. PLoS One 6: e17054.
20. Kaufmann GF, Sartorio R, Lee SH, Rogers CJ, Meijler MM, et al. (2005) Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A 102: 309-314.
21. Lowery CA, Park J, Gloeckner C, Meijler MM, Mueller RS, et al. (2009) Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals. J Am Chem Soc 131: 14473-14479.
22. Ganzle MG, Vogel RF, (2003) Studies on the mode of action of reutericyclin. Appl Environ Microbiol 69: 1305-1307.
23. Strandberg KL, Peterson ML, Schaefers MM, Case LC, Pack MC, et al. (2009) Reduction in Staphylococcus aureus growth and exotoxin production and in vaginal interleukin 8 levels due to glycerol monolaurate in tampons. Clin Infect Dis 49: 1711-1717.
24. Schlievert PM, Shands KN, Dan BB, Schmid GP, Nishimura RD, (1981) Identification and characterization of an exotoxin from Staphylococcus aureus associated with toxic-shock syndrome. J Infect Dis 143: 509-516.
25. Bergdoll MS, Crass BA, Reiser RF, Robbins RN, Davis JP, (1981) A new staphylococcal enterotoxin, enterotoxin F, associated with toxic- shock-syndrome Staphylococcus aureus isolates. Lancet 1: 1017-1021.
26. Recsei P, Kreiswirth B, O'Reilly M, Schlievert P, Gruss A, et al. (1986) Regulation of exoprotein gene expression in Staphylococcus aureus by agar. Mol Gen Genet 202: 58-61.
27. Schlievert PM, Nemeth KA, Davis CC, Peterson ML, Jones BE, (2010) Staphylococcus aureus exotoxins are present in vivo in tampons. Clin Vaccine Immunol 17: 722-727.
28. Kabara JJ, (1980) GRAS antimicrobial agents for cosmetic products. J Soc Cosmet Chem 31: 1-10.
29. Kabara JJ, (1981) Food-grade chemicals for use in designing food preservatives. J Food Prot 44: 633-647.
30. Peterson ML, Schlievert PM, (2006) Glycerol monolaurate inhibits the effects of gram-positive select agents on eukaryotic cells. Biochemistry 45: 2387-2397.
31. Zabriskie JB, (1964) The role of temperate bacteriophage in the production of erythrogenic toxin by group A streptococci. J Exp Med 119: 761-780.
32. Nauciel C, Blass J, Mangalo R, Raynaud M, (1969) Evidence for two molecular forms of streptococcal erythrogenic toxin. Conversion to a single form by 2-mercaptoethanol. Eur J Biochem 11: 160-164.
33. Schlievert PM, Case LC, Nemeth KA, Davis CC, Sun Y, et al. (2007) Alpha and beta chains of hemoglobin inhibit production of Staphylococcus aureus exotoxins. Biochemistry 46: 14349-14358.