Glycerol monolaurate and dodecylglycerol effects on Staphylococcus aureus and toxic shock syndrome toxin-1 in vitro and in vivo

PLoS ONE

Volumn 4, Issue 10, 2009, Pages

  Lin, Ying Chi ^a   Schlievert, Patrick M ^b   Anderson, Michele J ^a   Fair, Christina L ^a   Schaefers, Matthew M ^a   Muthyala, Ramaiah ^a   Peterson, Marnie L ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; EXOTOXIN; GLYCEROL DODECYL ETHER; GLYCEROL MONOLAURATE; TOXIC SHOCK SYNDROME TOXIN 1; TRIACYLGLYCEROL LIPASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BACTERIAL TOXIN; ENTEROTOXIN; ENTEROTOXIN F, STAPHYLOCOCCAL; FATTY ACID; GLYCEROL LAURATE; LAURIC ACID DERIVATIVE; MONOACYLGLYCEROL; SUPERANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM ISOLATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME DEGRADATION; EXPERIMENTAL RABBIT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INOCULATION; MORTALITY; NONHUMAN; PULSED FIELD GEL ELECTROPHORESIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; ANIMAL; CHEMISTRY; DOSE RESPONSE; ENZYMOLOGY; EPITHELIUM CELL; FEMALE; MALE; METABOLISM; MICROBIOLOGY; RABBIT; STAPHYLOCOCCUS;

ORYCTOLAGUS CUNICULUS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-INFECTIVE AGENTS; BACTERIAL TOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROTOXINS; EPITHELIAL CELLS; EXOTOXINS; FATTY ACIDS; FEMALE; HUMANS; LAURATES; LIPASE; MALE; MONOGLYCERIDES; RABBITS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70449441653     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007499     Document Type: Article

References (46)

1. Gordon RJ, Lowy FD (2008) Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis 46 Suppl 5: S350-359.
2. Chuang YY, Huang YC, Lin TY (2005) Toxic shock syndrome in children: epidemiology, pathogenesis, and management. Paediatr Drugs 7: 11-25.
3. Boguniewicz M, Schmid-Grendelmeier P, Leung DY (2006) Atopic dermatitis. J Allergy Clin Immunol 118: 40-43.
4. Jarman A, Duggal A, Korus L, Tredget EE (2007) Toxic shock syndrome in an adult burn patient. Burns 33: 1051-1053.
5. Trop M, Zobel G, Roedl S, Grubbauer HM, Feierl G (2004) Toxic shock syndrome in a scald burn child treated with an occlusive wound dressing. Burns 30: 176-180.
6. Tenover FC, McAllister S, Fosheim G, McDougal LK, Carey RB, et al. (2008) Characterization of Staphylococcus aureus isolates from nasal cultures collected from individuals in the United States in 2001 to 2004. J Clin Microbiol 46: 2837-2841.
7. Limbago B, Fosheim GE, Schoonover V, Crane CE, Nadle J, et al. (2009) Characterization of methicillin-resistant Staphylococcus aureus isolates collected in 2005 and 2006 from patients with invasive disease: a population-based analysis. J Clin Microbiol 47: 1344-1351.
8. Moran GJ, Krishnadasan A, Gorwitz RJ, Fosheim GE, McDougal LK, et al. (2006) Methicillin-resistant S. aureus infections among patients in the emergency department. N Engl J Med 355: 666-674.
9. De Bels D, Garcia-Filoso A, Jeanmaire M, Preseau T, Miendje Deyi VY, et al. (2005) Successful treatment with linezolid of septic shock secondary to methicillin-resistant Staphylococcus aureus arthritis. J Antimicrob Chemother 55: 812-813.
10. Stevens DL, Wallace RJ, Hamilton SM, Bryant AE (2006) Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics. Clin Infect Dis 42: 729-730.
11. Schlievert PM, Kelly JA (1984) Clindamycin-induced suppression of toxic-shock syndrome-associated exotoxin production. J Infect Dis 149: 471.
12. Stevens DL, Ma Y, Salmi DB, McIndoo E, Wallace RJ, et al. (2007) Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus. J Infect Dis 195: 202-211.
13. Ruzin A, Novick RP (2000) Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus. J Bacteriol 182: 2668-2671.
14. Projan SJ, Brown-Skrobot S, Schlievert PM, Vandenesch F, Novick RP (1994) Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction. J Bacteriol 176: 4204-4209.
15. Schlievert PM, Deringer JR, Kim MH, Projan SJ, Novick RP (1992) Effect of glycerol monolaurate on bacterial growth and toxin production. Antimicrob Agents Chemother 36: 626-631.
16. Peterson ML, Schlievert PM (2006) Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells. Biochemistry 45: 2387-2397.
17. Schlievert PM, Strandberg KL, Brosnahan AJ, Peterson ML, Pambuccian SE, et al. (2008) Glycerol Monolaurate Does Not Alter Rhesus Macaque ( Macaca mulatta) Vaginal Lactobacilli and Is Safe for Chronic Use. Antimicrob Agents Chemother 52: 4448-4454.
18. Schlievert PM, Case LC, Strandberg KL, Galask RP, Pack MC, et al. (2007) Vaginal Staphylococcus aureus toxin production is reduced by glycerol monolaurate in tampons. Obstet Gynecol 109: 1S-127S.
19. Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, et al. (2009) Glycerol monolaurate prevents mucosal SIV transmission. Nature 458: 1034-1038.
20. McNamara PJ, Syverson RE, Milligan-Myhre K, Frolova O, Schroeder S, et al. (2009) Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1. Antimicrob Agents Chemother 53: 1898-1906.
21. Brissette JL, Cabacungan EA, Pieringer RA (1986) Studies on the antibacterial activity of dodecylglycerol. Its limited metabolism and inhibition of glycerolipid and lipoteichoic acid biosynthesis in Streptococcus mutans BHT. J Biol Chem 261: 6338-6345.
22. Ved HS, Gustow E, Mahadevan V, Pieringer RA (1984) Dodecylglycerol. A new type of antibacterial agent which stimulates autolysin activity in Streptococcus faecium ATCC 9790. J Biol Chem 259: 8115-8121.
23. Ved HS, Gustow E, Pieringer RA (1984) The involvement of the proteinase of Streptococcus faecium ATCC 9790 in the stimulation of its autolysin activity by dodecylglycerol. J Biol Chem 259: 8122-8124.
24. Ved HS, Gustow E, Pieringer RA (1990) Synergism between penicillin G and the antimicrobial ether lipid, rac-1-dodecylglycerol, acting below its critical micelle concentration. Lipids 25: 119-121.
25. Haynes MP, Buckley HR, Higgins ML, Pieringer RA (1994) Synergism between the antifungal agents amphotericin B and alkyl glycerol ethers. Antimicrob Agents Chemother 38: 1523-1529.
26. Yarwood JM, McCormick JK, Paustian ML, Kapur V, Schlievert PM (2002) Repression of the Staphylococcus aureus accessory gene regulator in serum and in vivo. J Bacteriol 184: 1095-1101.
27. Scott DF, Kling JM, Kirkland JJ, Best GK (1983) Characterization of Staphylococcus aureus isolates from patients with toxic shock syndrome, using polyethylene infection chambers in rabbits. Infect Immun 39: 383-387.
28. McCormick JK, Yarwood JM, Schlievert PM (2001) Toxic shock syndrome and bacterial superantigens: an update. Annu Rev Microbiol 55: 77-104.
29. Kitahara T, Koyama N, Matsuda J, Aoyama Y, Hirakata Y, et al. (2004) Antimicrobial activity of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus. Biol Pharm Bull 27: 1321-1326.
30. Kabara JJ, Swieczkowski DM, Conley AJ, Truant JP (1972) Fatty acids and derivatives as antimicrobial agents. Antimicrob Agents Chemother 2: 23-28.
31. Holland KT, Taylor D, Farrell AM (1994) The effect of glycerol monolaurate on growth of, and production of toxic shock syndrome toxin-1 and lipase by, Staphylococcus aureus. J Antimicrob Chemother 33: 41-55.
32. Preuss HG, Echard B, Enig M, Brook I, Elliott TB (2005) Minimum inhibitory concentrations of herbal essential oils and monolaurin for gram-positive and gram-negative bacteria. Mol Cell Biochem 272: 29-34.
33. Kelsey JA, Bayles KW, Shafii B, McGuire MA (2006) Fatty acids and monoacylglycerols inhibit growth of Staphylococcus aureus. Lipids 41: 951-961.
34. Kenny JG, Ward D, Josefsson E, Jonsson IM, Hinds J, et al. (2009) The Staphylococcus aureus response to unsaturated long chain free fatty acids: survival mechanisms and virulence implications. PLoS One 4: e4344.
35. Johnson W Jr (2004) Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/ Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/ Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/ Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate. Int J Toxicol 23 Suppl 2: 55-94.
36. Weber N (1985) Metabolism of orally administered rac-1-O-[1′-14C]dodecylglycerol and nutritional effects of dietary rac-1-O-dodecylglycerol in mice. J Lipid Res 26: 1412-1420.
37. Yarwood JM, Schlievert PM (2000) Oxygen and carbon dioxide regulation of toxic shock syndrome toxin 1 production by Staphylococcus aureus MN8. J Clin Microbiol 38: 1797-1803.
38. Schlievert PM, Blomster DA (1983) Production of staphylococcal pyrogenic exotoxin type C: influence of physical and chemical factors. J Infect Dis 147: 236-242.
39. Hill DR, Brunner ME, Schmitz DC, Davis CC, Flood JA, et al. (2005) In vivo assessment of human vaginal oxygen and carbon dioxide levels during and post menses. J Appl Physiol 99: 1582-1591.
40. Todd JK, Todd BH, Franco-Buff A, Smith CM, Lawellin DW (1987) Influence of focal growth conditions on the pathogenesis of toxic shock syndrome. J Infect Dis 155: 673-681.
41. Klevens RM, Edwards JR, Tenover FC, McDonald LC, Horan T, et al. (2006) Changes in the epidemiology of methicillin-resistant Staphylococcus aureus in intensive care units in US hospitals, 1992-2003. Clin Infect Dis 42: 389-391.
42. Fey PD, Said-Salim B, Rupp ME, Hinrichs SH, Boxrud DJ, et al. (2003) Comparative molecular analysis of community- or hospital-acquired methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 47: 196-203.
43. Pankey GA, Sabath LD (2004) Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections. Clinical infectious diseases 38: 864-870.
44. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
45. Schlievert PM (1988) Immunochemical assays for toxic shock syndrome toxin-1. Methods Enzymol 165: 339-344.
46. Schlievert PM (2007) Chitosan malate inhibits growth and exotoxin production of toxic shock syndrome-inducing Staphylococcus aureus strains and group A streptococci. Antimicrob Agents Chemother 51: 3056-3062.