Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 12, 2008, Pages 4448-4454

  Schlievert, Patrick M ^a   Strandberg, Kristi L ^a   Brosnahan, Amanda J ^a   Peterson, Marnie L ^b   Pambuccian, Stefan E ^a   Nephew, Karla R ^c   Brunner, Kevin G ^c   Schultz Darken, Nancy J ^c   Haase, Ashley T ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL MONOLUARIC ACID; INTERLEUKIN 8; LACTIC ACID; LAURIC ACID DERIVATIVE; MICROBICIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL VIABILITY; BACTERICIDAL ACTIVITY; BETA HEMOLYTIC STREPTOCOCCUS; BIOPSY; CELL POPULATION; COAGULASE NEGATIVE STAPHYLOCOCCUS; COLPOSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG SAFETY; DRUG SCREENING; EPITHELIUM CELL; FEMALE; FOOD AND DRUG ADMINISTRATION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LACTOBACILLUS; MACACA; NONHUMAN; PRIORITY JOURNAL; RHESUS MACAQUE; SIMIAN IMMUNODEFICIENCY VIRUS; STAPHYLOCOCCUS AUREUS; VAGINA FLORA; VIRUS TRANSMISSION; YEAST;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; FEMALE; HUMANS; LACTOBACILLUS; LAURATES; MACACA MULATTA; MODELS, ANIMAL; MONOGLYCERIDES; SURFACE-ACTIVE AGENTS; VAGINA; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 57049134824     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00989-08     Document Type: Article

References (37)

1. Antonio, M. A., S. E. Hawes, and S. L. Hillier. 1999. The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species. J. Infect. Dis. 180:1950-1956.
2. Blomster-Hautamaa, D. A., and P. M. Schlievert. 1988. Preparation of toxic shock syndrome toxin-1. Methods Enzymol. 165:37-43.
3. Boris, S., and C. Barbes. 2000. Role played by lactobacilli in controlling the population of vaginal pathogens. Microbes Infect. 2:543-546.
4. Eckert, L. O. 2006. Clinical practice. Acute vulvovaginitis. N. Engl. J. Med. 355:1244-1252.
5. Eschenbach, D. A., S. Hillier, C. Critchlow, C. Stevens, T. DeRouen, and K. K. Holmes. 1988. Diagnosis and clinical manifestations of bacterial vaginosis. Am. J. Obstet. Gynecol. 158:819-828.
6. Fichorova, R. N., P. J. Desai, F. C. Gibson III, and C. A. Genco. 2001. Distinct proinflammatory host responses to Neisseria gonorrhoeae infection in immortalized human cervical and vaginal epithelial cells. Infect. Immun. 69:5840-5848.
7. Fichorova, R. N., L. D. Tucker, and D. J. Anderson. 2001. The molecular basis of nonoxynol-9-induced vaginal inflammation and its possible relevance to human immunodeficiency virus type 1 transmission. J. Infect. Dis. 184: 418-428.
8. Fidel, P. L., Jr. 2004. History and new insights into host defense against vaginal candidiasis. Trends Microbiol. 12:220-227.
9. Galvin, S. R., and M. S. Cohen. 2004. The role of sexually transmitted diseases in HIV transmission. Nat. Rev. Microbiol. 2:33-42.
10. Geisler, W. M., S. Yu, M. Venglarik, and J. R. Schwebke. 2004. Vaginal leucocyte counts in women with bacterial vaginosis: relation to vaginal and cervical infections. Sex. Transm. Infect. 80:401-405.
11. Hawes, S. E., S. L. Hillier, J. Benedetti, C. E. Stevens, L. A. Koutsky, P. Wolner-Hanssen, and K. K. Holmes. 1996. Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections. J. Infect. Dis. 174:1058-1063.
12. Kabara, J. J. 1984. Cosmetic and drug preservation, p.1-14. Marcel Dekker, New York, NY.
13. Kabara, J. J. 1981. Food-grade chemicals for use in designing food preservatives. J. Food Prot. 44:633-647.
14. Kabara, J. J. 1980. GRAS antimicrobial agents for cosmetic products. J. Soc. Cosmet. Chem. 31:1-10.
15. Laga, M., A. Manoka, M. Kivuvu, B. Malele, M. Tuliza, N. Nzila, J. Goeman, F. Behets, V. Batter, M. Alary, et al. 1993. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS 7:95-102.
16. Onderdonk, A. B., M. L. Delaney, G. R. Zamarchi, M. L. Hirsch, A. Munoz, and E. H. Kass. 1989. Normal vaginal microflora during use of various forms of catamenial protection. Rev. Infect. Dis. 11(Suppl. 1):S61-S67.
17. Onderdonk, A. B., G. R. Zamarchi, M. L. Rodriguez, M. L. Hirsch, A. Munoz, and E. H. Kass. 1987. Quantitative assessment of vaginal microflora during use of tampons of various compositions. Appl. Environ. Microbiol. 53:2774-2778.
18. Patton, D. L., G. G. Kidder, Y. C. Sweeney, L. K. Rabe, and S. L. Hillier. 1999. Effects of multiple applications of benzalkonium chloride and nonoxynol 9 on the vaginal epithelium in the pigtailed macaque (Macaca nemestrina). Am. J. Obstet. Gynecol. 180:1080-1087.
19. Patton, D. L., Y. C. Sweeney, L. K. Rabe, and S. L. Hillier. 1996. The vaginal microflora of pig-tailed macaques and the effects of chlorhexidine and benzalkonium on this ecosystem. Sex. Transm. Dis. 23:489-493.
20. Peterson, M., K. Ault, M. J. Kremer, A. J. Klingelhutz, C. C. Davis, C. A. Squier, and P. M. Schlievert. 2005. Innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin-1. Infect. Immun. 73:2164-2174.
21. Peterson, M. L., P. M. Schlievert, K. L. Strandberg, L. C. Case, Y. C. Lin, M. C. Pack, and D. J. Chase. 2007. Staphylococcus aureus exotoxin production in vivo is reduced by glycerol monolaurate (GML) tampons, abstr. E450B. Abstr. 47th Intersci. Conf. Antimicrob. Agents Chemother. American Society for Microbiology, Washington, DC.
22. Peterson, M. L., and P. M. Schlievert. 2006. Glycerol monolaurate inhibits the effects of gram-positive select agents on eukaryotic cells. Biochemistry 45:2387-2397.
23. Plummer, F. A. 1998. Heterosexual transmission of human immunodeficiency virus type 1 (HIV): interactions of conventional sexually transmitted diseases, hormonal contraception and HIV-1. AIDS Res. Hum. Retrovir. 14(Suppl. 1):S5-S10.
24. Pollack, M., W. G. Weinberg, W. J. Hoskins, W. F. O'Brien, P. B. Iannini, S. E. Anderson, and P. M. Schlievert. 1983. Toxinogenic vaginal infections due to Staphylococcus aureus in menstruating rhesus monkeys without toxic-shock syndrome. J. Infect. Dis. 147:963-964.
25. Projan, S. J., S. Brown-Skrobot, P. M. Schlievert, F. Vandenesch, and R. P. Novick. 1994. Glycerol monolaurate inhibits the production of beta-lactamase, toxic shock toxin-1, and other staphylococcal exoproteins by interfering with signal transduction. J. Bacteriol. 176:4204-4209.
26. Reinhardt, V. 2008. Taking better care of monkeys and apes: refinement of housing and handling practices for caged nonhuman primates. Animal Welfare Institute, Washington, DC.
27. Sands, J., D. Auperin, and W. Snipes. 1979. Extreme sensitivity of enveloped viruses, including herpes simplex, to long-chain unsaturated monoglycerides and alcohols. Antimicrob. Agents Chemother. 15:67-73.
28. Schlievert, P. M. 1982. Enhancement of host susceptibility to lethal endotoxin shock by staphylococcal pyrogenic exotoxin type C. Infect. Immun. 36:123-128.
29. Schlievert, P. M., J. R. Deringer, M. H. Kim, S. J. Projan, and R. P. Novick. 1992. Effect of glycerol monolaurate on bacterial growth and toxin production. Antimicrob. Agents Chemother. 36:626-631.
30. Schlievert, P. M., K. N. Shands, B. B. Dan, G. P. Schmid, and R. D. Nishimura. 1981. Identification and characterization of an exotoxin from Staphylococcus aureus associated with toxic-shock syndrome. J. Infect. Dis. 143:509-516.
31. Sobel, J. D., S. Faro, R. W. Force, B. Foxman, W. J. Ledger, P. R. Nyirjesy, B. D. Reed, and P. R. Summers. 1998. Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. Am. J. Obstet. Gynecol. 178:203-211.
32. Spence, D. 2004. Candidiasis (vulvovaginal). Clin. Evid. 2:493-511.
33. Stone, R. L., and P. M. Schlievert. 1987. Evidence for the involvement of endotoxin in toxic shock syndrome. J. Infect. Dis. 155:682-689.
34. Thormar, H., C. E. Isaacs, H. R. Brown, M. R. Barshatzky, and T. Pessolano. 1987. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 31:27-31.
35. Thormar, H., C. E. Isaacs, K. S. Kim, and H. R. Brown. 1994. Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann. N. Y. Acad. Sci. 724:465-471.
36. Vetter, S., T. J. Tripp, and P. M. Schlievert. 2005. Glycerol monolaurate inhibits virulence factor production in Bacillus anthracis. Antimicrob. Agents Chemother. 49:1302-1305.
37. Witcher, K. J., R. P. Novick, and P. M. Schlievert. 1996. Modulation of immune cell proliferation by glycerol monolaurate. Clin. Diagn. Lab. Immunol. 3:10-13.