Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals

Journal of the American Chemical Society

Volumn 131, Issue 40, 2009, Pages 14473-14479

  Lowery, Colin A ^a   Park, Junguk ^a   Gloeckner, Christian ^a   Meijler, Michael M ^a,e   Mueller, Ryan S ^b   Boshoff, Helena I ^c   Ulrich, Ricky L ^d,f   Barry III, Clifton E ^c   Bartlett, Douglas H ^b   Kravchenko, Vladimir V ^a   Kaufmann, Gunnar F ^a   Janda, Kim D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^e BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^f Hagerstown Community College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTIBACTERIALS; CELLULAR STRESS; COMPETITIVE ENVIRONMENT; COMPREHENSIVE STUDIES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIUM; HOMOSERINE LACTONES; HOST ORGANISM; HUMAN CELLS; HUMAN PATHOGENS; MECHANISM OF ACTION; MEMBRANE POTENTIALS; MODE OF ACTION; P.AERUGINOSA; PARENT MOLECULES; PH GRADIENTS; PSEUDOMONAS AERUGINOSA; PYRROLIDINES; QUORUM-SENSING; TETRAMIC ACIDS;

BACTERIOLOGY; CELL DEATH; CELL MEMBRANES; COMPETITION; LEAD COMPOUNDS; MACHINERY; ORGANIC ACIDS; PATHOGENS;

BACTERIA;

3 (1 HYDROXYDECYLIDENE) 5 (2 HYDROXYETHYL)PYRROLIDINE 2,4 DIONE; PYRROLIDINE DERIVATIVE; TETRAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL DEATH; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SIGNAL TRANSDUCTION;

4-BUTYROLACTONE; ANTI-BACTERIAL AGENTS; GRAM-POSITIVE BACTERIA; HUMANS; MEMBRANE POTENTIALS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; PYRROLIDINES; PYRROLIDINONES; QUORUM SENSING;

EID: 70349929820     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9056079     Document Type: Article

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