The immune reconstitution inflammatory syndrome related to HIV co-infections: A review

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 31, Issue 6, 2012, Pages 919-927

  Huis in 't Veld, D ^a,b   Sun, H Y ^d   Hung, C C ^d   Colebunders, R ^a,c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b RESEARCH FOUNDATION FLANDERS FWO   (Belgium)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CORTICOSTEROID; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE; THALIDOMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT;

ATYPICAL MYCOBACTERIOSIS; ATYPICAL MYCOBACTERIUM; CD4 LYMPHOCYTE COUNT; CLINICAL FEATURE; CRYPTOCOCCOSIS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS RETINITIS; DISEASE ACTIVITY; DISEASE ASSOCIATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; GENITAL HERPES; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME; INFECTION RISK; KAPOSI SARCOMA; LEISHMANIASIS; MENINGOENCEPHALITIS; MIXED INFECTION; MOLECULAR PATHOLOGY; MOLLUSCUM CONTAGIOSUM; NONHUMAN; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; REVIEW; RISK ASSESSMENT; RISK FACTOR; SCHISTOSOMIASIS; STRONGYLOIDES STERCORALIS; SYNDROME DELINEATION; TOXOPLASMOSIS; TUBERCULOSIS; VERRUCA VULGARIS; IMMUNOLOGY; PATHOLOGY;

ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; ANTI-INFLAMMATORY AGENTS; CD4 LYMPHOCYTE COUNT; COINFECTION; HIV INFECTIONS; HUMANS; IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME;

EID: 84863813775     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-011-1413-9     Document Type: Review

References (98)

1. French MA (2009) HIV/AIDS: immune reconstitution inflammatory syndrome: a reappraisal. Clin Infect Dis 48(1):101-107
2. Meintjes G, Lawn SD, Scano F, Maartens G, French MA, Worodria W, Elliott JH, Murdoch D, Wilkinson RJ, Seyler C, John L, van der Loeff MS, Reiss P, Lynen L, Janoff EN, Gilks C, Colebunders R; International Network for the Study of HIVassociated IRIS (2008) Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings. Lancet Infect Dis 8(8):516-523 (Pubitemid 352005824)
3. Costello DJ, Gonzalez RG, Frosch MP (2011) Case records of the Massachusetts General Hospital. Case 18-2011. A 35-year-old HIV-positive woman with headache and altered mental status. N Engl J Med 364(24):2343-2352
4. Huyst V, Lynen L, Bottieau E, Zolfo M, Kestens L, Colebunders R (2007) Immune reconstitution inflammatory syndrome in an HIV/TB co-infected patient four years after starting antiretroviral therapy. Acta Clin Belg 62(2):126-129 (Pubitemid 46724411)
5. Müller M, Wandel S, Colebunders R, Attia S, Furrer H, Egger M; IeDEA Southern and Central Africa (2010) Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis. Lancet Infect Dis 10(4):251-261
6. Knysz B, Bolanowski M, Klimczak M, Gladysz A, Zwolinska K (2006) Graves' disease as an immune reconstitution syndrome in an HIV-1-positive patient commencing effective antiretroviral therapy: case report and literature review. Viral immunol 19 (1):102-107
7. Martí N, Martin JM, Mayordomo E, Calduch L, Jordá E (2011) Cutaneous and pulmonary sarcoidosis in a patient with human immunodeficiency virus: a late feature of immune restoration syndrome. Clin Exp Dermatol 36:306-307
8. Haddow LJ, Colebunders R, Meintjes G, Lawn SD, Elliott JH, Manabe YC, Bohjanen PR, Sungkanuparph S, Easterbrook PJ, French MA, Boulware DR; International Network for the Study of HIV-associated IRIS (INSHI) (2010) Cryptococcal immune reconstitution inflammatory syndrome in HIV-1-infected individuals: proposed clinical case definitions. Lancet Infect Dis 10 (11):791-802
9. Bourgarit A, Carcelain G, Martinez V, Lascoux C, Delcey V, Gicquel B, Vicaut E, Lagrange PH, Sereni D, Autran B (2006) Explosion of tuberculin-specific Th1-responses induces immune restoration syndrome in tuberculosis and HIV co-infected patients. AIDS 20(2):F1-F7
10. Lawn SD, Wainwright H, Orrell C (2009) Fatal unmasking tuberculosis immune reconstitution disease with bronchiolitis obliterans organizing pneumonia: the role of macrophages. AIDS 23(1):143-145
11. Van den Bergh R, Vanham G, Raes G, De Baetselier P, Colebunders R (2006) Mycobacterium-associated immune reconstitution disease: macrophages running wild? Lancet Infect Dis 6 (1):2-3
12. Conradie F, Foulkes AS, Ive P, Yin X, Roussos K, Glencross DK, Lawrie D, Stevens W, Montaner LJ, Sanne I, Azzoni L (2011) Natural killer cell activation distinguishes M. tuberculosis-mediated immune reconstitution inflammatory syndrome (IRIS) from chronic HIV and HIV-MTB co-infection. J Acquir Immune Defic Syndr. Epub ahead of print. doi:10.1097/QAI.0b013e31822e0d15
13. French MA, Price P, Stone SF (2004) Immune restoration disease after antiretroviral therapy. AIDS 18(12):1615-1627 (Pubitemid 39095778)
14. Seddiki N, Sasson SC, Santner-Nanan B, Munier M, van Bockel D, Ip S, Marriott D, Pett S, Nanan R, Cooper DA, Zaunders JJ, Kelleher AD (2009) Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease. Eur J Immunol 39(2):391-403
15. Burman W, Weis S, Vernon A, Khan A, Benator D, Jones B, Silva C, King B, LaHart C, Mangura B, Weiner M, El-Sadr W (2007) Frequency, severity and duration of immune reconstitution events in HIV-related tuberculosis. Int J Tuberc Lung Dis 11(12):1282- 1289
16. Pepper DJ, Marais S, Maartens G, Rebe K, Morroni C, Rangaka MX, Oni T, Wilkinson RJ, Meintjes G (2009) Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series. Clin Infect Dis 48(11):e96-e107
17. Laureillard D, Marcy O, Madec Y, Chan S, Borand L, Prak N, Kim C, Lak KK, Hak C, Dim B, Nerrienet E, Sok T, Goldfeld AE, Blanc FX (2011) Incidence and risk factors of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in HIV-infected adults enrolled in the CAMELIA clinical trial. In: 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, July 2011
18. Karim SSA, Naidoo K, Grobler A, Padayatchi N, Baxter C, Gray AL, Gengiah T, Gengiah S, Naidoo A, Jithoo N, Nair G, El-Sadr WM, Friedland G, Abdool Karim Q (2011) Optimal timing of antiretroviral therapy during tuberculosis treatment: The SAPiT trial. In: 17th Conference of Retroviruses and Opportunistic Infections, Boston, MA, 28 February 2011
19. Havlir D, Ive P, Kendall M, Luetkemeyer A, Swindells S, Kumwenda J, Qasba S, Hogg E, Anderson J, Sanne I and A5221 Team (2011) International randomized trial of immediate vs early ART in HIV+ patients treated for TB: ACTG 5221 STRIDE Study. In: 18th Conference on Retroviruses and Opportunistic Infections (CROI), Boston, MA, February/March 2011, abstract 38
20. Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, O'Brien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA; American Thoracic Society, Centers for Disease Control and Prevention and the Infectious Diseases Society (2003) American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med 167(4):603-662
21. Breen RA, Smith CJ, Bettinson H, Dart S, Bannister B, Johnson MA, Lipman MC (2004) Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection. Thorax 59(8):704-707 (Pubitemid 39061536)
22. Meintjes G, Wilkinson RJ, Morroni C, Pepper DJ, Rebe K, Rangaka MX, Oni T, Maartens G (2010) Randomized placebocontrolled trial of prednisone for paradoxical tuberculosisassociated immune reconstitution inflammatory syndrome. AIDS 24(15):2381-2390
23. Phillips P, Bonner S, Gataric N, Bai T, Wilcox P, Hogg R, O'Shaughnessy M, Montaner J (2005) Nontuberculous mycobacterial immune reconstitution syndrome in HIV-infected patients: spectrum of disease and long-term follow-up. Clin Infect Dis 41 (10):1483-1497 (Pubitemid 41579994)
24. Lawn SD, Lipman MC, Easterbrook PJ (2008) Immune reconstitution disease associated with mycobacterial infections. Curr Opin HIV AIDS 3(4):425-431
25. Lawn SD, Bekker LG, Miller RF (2005) Immune reconstitution disease associated with mycobacterial infections in HIV-infected individuals receiving antiretrovirals. Lancet Infect Dis 5(6):361- 373 (Pubitemid 40779257)
26. Boulware DR, Bonham SC, Meya DB, Wiesner DL, Park GS, Kambugu A, Janoff EN, Bohjanen PR (2010) Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome. J Infect Dis 202(6):962-970
27. Ratnam I, Chiu C, Kandala NB, Easterbrook PJ (2006) Incidence and risk factors for immune reconstitution inflammatory syndrome in an ethnically diverse HIV type 1-infected cohort. Clin Infect Dis 42(3):418-427 (Pubitemid 43122323)
28. Torok ME, Kambugu A, Wright E (2008) Immune reconstitution disease of the central nervous system. Curr Opin HIV AIDS 3 (4):438-445
29. Puthanakit T, Oberdorfer P, Akarathum N, Wannarit P, Sirisanthana T, Sirisanthana V (2006) Immune reconstitution syndrome after highly active antiretroviral therapy in human immunodeficiency virus-infected Thai children. Pediatr Infect Dis J 25(1):53-58 (Pubitemid 43361477)
30. Jabs DA, Ahuja A, van Natta M, Lyon A, Srivastava S, Gangaputra S; Studies of the Ocular Complications of AIDS Research Group (2010) Course of cytomegalovirus retinitis in the era of highly active antiretroviral therapy: five-year outcomes. Ophthalmology 117(11):2152-2161
31. Karavellas MP, Azen SP, MacDonald JC, Shufelt CL, Lowder CY, Plummer DJ, Glasgow B, Torriani FJ, Freeman WR (2001) Immune recovery vitritis and uveitis in AIDS: clinical predictors, sequelae, and treatment outcomes. Retina 21(1):1-9 (Pubitemid 32151755)
32. Berenguer J, Miralles P, Arrizabalaga J, Ribera E, Dronda F, Baraia-Etxaburu J, Domingo P, Márquez M, Rodriguez-Arrondo FJ, Laguna F, Rubio R, Lacruz Rodrigo J, Mallolas J, de Miguel V; GESIDA 11/99 Study Group (2003) Clinical course and prognostic factors of progressive multifocal leukoencephalopathy in patients treated with highly active antiretroviral therapy. Clin Infect Dis 36(8):1047-1052 (Pubitemid 36513291)
33. Cinque P, Bossolasco S, Brambilla AM, Boschini A, Mussini C, Pierotti C, Campi A, Casari S, Bertelli D, Mena M, Lazzarin A (2003) The effect of highly active antiretroviral therapy-induced immune reconstitution on development and outcome of progres- sive multifocal leukoencephalopathy: study of 43 cases with review of the literature. J Neurovirol 9(Suppl 1):73-80 (Pubitemid 36656475)
34. Falcó V, Olmo M, del Saz SV, Guelar A, Santos JR, Gutiérrez M, Colomer D, Deig E, Mateo G, Montero M, Pedrol E, Podzamczer D, Domingo P, Llibre JM (2008) Influence of HAART on the clinical course of HIV-1-infected patients with progressive multifocal leukoencephalopathy: results of an observational multicenter study. J Acquir Immune Defic Syndr 49(1):26-31
35. Gheuens S, Bord E, Kesari S, Simpson DM, Gandhi RT, Clifford DB, Berger JR, Ngo L, Koralnik IJ (2011) Role of CD4+ and CD8+ T-cell responses against JC virus in the outcome of patients with progressive multifocal leukoencephalopathy (PML) and PML with immune reconstitution inflammatory syndrome. J Virol 85(14):7256-7263
36. Travis J, Varma A, duPlessis D, Turnbull I, Vilar FJ (2008) Immune reconstitution associated with progressive multifocal leukoencephalopathy in human immunodeficiency virus: a case discussion and review of the literature. Neurologist 14 (5):321-326
37. Lanoy E, Guiguet M, Bentata M, Rouveix E, Dhiver C, Poizot-Martin I, Costagliola D, Gasnault J; FHDH-ANRS CO4 (2011) Survival after neuroAIDS: association with antiretroviral CNS Penetration-Effectiveness score. Neurology 76(7):644-651
38. Harrison DM, Newsome SD, Skolasky RL, McArthur JC, Nath A (2011) Immune reconstitution is not a prognostic factor in progressive multifocal leukoencephalopathy. J Neuroimmunol. Epub ahead of print
39. Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, Prosperi M, De Luca A, Koralnik IJ (2009) Determinants of survival in progressive multifocal leukoencephalopathy. Neurology 73(19):1551-1558
40. Sidhu N, McCutchan JA (2010) Unmasking of PML by HAART: unusual clinical features and the role of IRIS. J Neuroimmunol 219:100-104
41. Du Pasquier RA, Koralnik IJ (2003) Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial? J Neurovirol 9(Suppl 1):25-31 (Pubitemid 36656467)
42. Gray F, Bazille C, Adle-Biassette H, Mikol J, Moulignier A, Scaravilli F (2005) Central nervous system immune reconstitution disease in acquired immunodeficiency syndrome patients receiving highly active antiretroviral treatment. J Neurovirol 11(Suppl 3):16-22
43. Vendrely A, Bienvenu B, Gasnault J, Thiebault JB, Salmon D, Gray F (2005) Fulminant inflammatory leukoencephalopathy associated with HAART-induced immune restoration in AIDSrelated progressive multifocal leukoencephalopathy. Acta Neuropathol 109(4):449-455 (Pubitemid 40637320)
44. Cinque P, Pierotti C, Viganò MG, Bestetti A, Fausti C, Bertelli D, Lazzarin A (2001) The good and evil of HAART in HIV-related progressive multifocal leukoencephalopathy. J Neurovirol 7 (4):358-363 (Pubitemid 32894242)
45. Miralles P, Berenguer J, García De Viedma D, Padilla B, Cosin J, López-Bernaldo De Quirós JC, Muñoz L, Moreno S, Bouza E (1998) Treatment of AIDS-associated progressive multifocal leukoencephalopathy with highly active antiretroviral therapy. AIDS 12(18):2467-2472 (Pubitemid 28558605)
46. Berger JR (2009) Steroids for PML-IRIS: a double-edged sword? Neurology 72:1454-1455
47. Martinez JV, Mazziotti JV, Efron ED, Bonardo P, Jordan R, Sevlever G, Martinez M, Verbanaz SC, Salazar ZS, Pardal MF, Reisin R (2006) Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder. Neurology 67 (9):1692-1694 (Pubitemid 44747950)
48. Crane M, Oliver B, Matthews G, Avihingsanon A, Ubolyam S, Markovska V, Chang JJ, Dore GJ, Price P, Visvanathan K, French M, Ruxrungtham K, Lewin SR (2009) Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy. J Infect Dis 199:974-981
49. Yunihastuti E, Lee S, Gani RA, Saraswati H, Sundaru H, Lesmana LA, Sukmana N, Price P (2011) Antibody and markers of T-cell activation illuminate the pathogenesis of HCV immune restoration disease in HIV/HCV co-infected patients commencing ART. Clin Immunol 139:32-39
50. John M, Flexman J, French MAH (1998) Hepatitis C virusassociated hepatitis following treatment of HIV-infected patients with HIV protease inhibitors: an immune restoration disease? AIDS 12:2289-2293 (Pubitemid 28526408)
51. Zylberberg H, Pialoux G, Carnot F, Landau A, Bréchot C, Pol S (1998) Rapidly evolving hepatitis C virus-related cirrhosis in a human immunodeficiency virus-infected patient receiving triple antiretroviral therapy. Clin Infect Dis 27:1255-1258 (Pubitemid 29242480)
52. Venkataramana A, Pardo CA, McArthur JC, Kerr DA, Irani DN, Griffin JW, Burger P, Reich DS, Calabresi PA, Nath A (2006) Immune reconstitution inflammatory syndrome in the CNS of HIV-infected patients. Neurology 67:383-388 (Pubitemid 44214957)
53. Miller RF, Isaacson PG, Hall-Craggs M, Lucas S, Gray F, Scaravilli F, An SF (2004) Cerebral CD8+ lymphocytosis in HIV-1 infected patients with immune restoration induced by HAART. Acta Neuropathol 108:17-23 (Pubitemid 38961068)
54. Letang E, Almeida JM, Miró JM, Ayala E, White IE, Carrilho C, Bastos R, Nhampossa T, Menéndez C, Campbell TB, Alonso PL, Naniche D (2010) Predictors of immune reconstitution inflammatory syndrome-associated with Kaposi sarcoma in Mozambique: a prospective study. J Acquir Immune Defic Syndr 53(5):589-597
55. Bower M, Nelson M, Young AM, Thirlwell C, Newsom-Davis T, Mandalia S, Dhillon T, Holmes P, Gazzard BG, Stebbing J (2005) Immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma. J Clin Oncol 23:5224-5228 (Pubitemid 46224033)
56. Leidner RS, Aboulafia DM (2005) Recrudescent Kaposi's sarcoma after initiation of HAART: a manifestation of immune reconstitution syndrome. AIDS Patient Care STDS 19:635-644 (Pubitemid 41527674)
57. Jevtović DJ, Salemović D, Ranin J, Pešić I, Žerjav S, Djurković-Djaković O (2005) The prevalence and risk of immune restoration disease in HIV-infected patients treated with highly active antiretroviral therapy. HIV Med 6:140-143 (Pubitemid 40425979)
58. Huruy K, Mulu A, Mengistu G, Shewa-Amare A, Akalu A, Kassu A, Andargie G, Elias D, Torben W (2008) Immune reconstitution inflammatory syndrome among HIV/AIDS patients during highly active antiretroviral therapy in Addis Ababa, Ethiopia. Jpn J Infect Dis 61:205-209 (Pubitemid 351888591)
59. Klotz SA, Aziz Mohammed A, Girmai Woldemichael M, Worku Mitku M, Handrich M (2009) Immune reconstitution inflammatory syndrome in a resource-poor setting. J Int Assoc Physicians AIDS Care (Chic) 8(2):122-127
60. Tsambiras PE, Larkin JA, Houston SH (2001) Case report. Toxoplasma encephalitis after initiation of HAART. AIDS Read 11:608-610, 615-616
61. González-Castillo J, Blanco F, Soriano V, Barreiro P, Concepción Bravo M, Jiménez-Nácher I, González-Lahoz J (2001) Opportunistic episodes in patients infected with the human immunodeficiency virus during the first 6 months of HAART. Med Clin (Barc) 117:81-84
62. de Boer MGJ, Kroon FP, Kauffmann RH, Vriesendorp R, Zwinderman K, van Dissel JT (2003) Immune restoration disease in HIV-infected individuals receiving highly active antiretroviral therapy: clinical and immunological characteristics. Neth J Med 61(12):408-412
63. Subsai K, Kanoksri S, Siwaporn C, Helen L, Kanokporn O, Wantana P (2006) Neurological complications in AIDS patients receiving HAART: a 2-year retrospective study. Eur J Neurol 13:233-239
64. Tremont-Lukats IW, Garciarena P, Juarbe R, El-Abassi RN (2009) The immune inflammatory reconstitution syndrome and central nervous system toxoplasmosis. Ann Intern Med 150 (9):656-657
65. Pfeffer G, Prout A, Hooge J, Maguire J (2009) Biopsy-proven immune reconstitution syndrome in a patient with AIDS and cerebral toxoplasmosis. Neurology 73:321-322
66. Fernando R, Miller R (2002) Immune reconstitution eosinophilia due to schistosomiasis. Sex Transm Infect 78(1):76 (Pubitemid 34206328)
67. de Silva S, Walsh J, Brown M (2006) Symptomatic Schistosoma mansoni infection as an immune restoration phenomenon in a patient receiving antiretroviral therapy. Clin Infect Dis 42:303- 304 (Pubitemid 43054210)
68. Javid B, Aliyu SH, Save VE, Carmichael AJ, Lever AM (2007) Schistosomal colonic polyposis in an HIV-positive man. AIDS 21 (3):386-388 (Pubitemid 46175059)
69. Muok EMO, Huis in't Veld D, Conesa-Botella A, Ng'ang'a ZW, Ogola GO, Polman K, Kestens L, Karanja DM, Colebunders R, Mwinzi PN (2010) Immune Reconstitution Inflammatory Syndrome (IRIS) In Schistosomiasis Patients Undergoing HAART. Presentation at the 59th ASTMH Annual Meeting, Atlanta, GA, November 2010. Abstract number 1234; scientific session 160: HIV in the tropics 70.
70. Kim AC, Lupatkin HC (2004) Strongyloides stercoralis infection as a manifestation of immune restoration syndrome. Clin Infect Dis 39:439-440 (Pubitemid 39050498)
71. Lanzafame M, Faggian F, Lattuada E, Antolini D, Vento S (2005) Strongyloidiasis in an HIV-1-infected patient after highly active antiretroviral therapy-induced immune restoration. J Infect Dis 191:1027 (Pubitemid 40349823)
72. Taylor CL, Subbarao V, Gayed S, Ustianowski AP (2007) Immune reconstitution syndrome to Strongyloides stercoralis infection. AIDS 21:649-650
73. Haddow LJ, Mahlakwane MS, Ramdial PK, Moosa MY (2009) Histopathology of Strongyloides stercoralis hyperinfection during immune reconstitution in an HIV-infected patient. AIDS 23:1609- 1611
74. Brown M, Cartledge JD, Miller RF (2006) Dissemination of Strongyloides stercoralis as an immune restoration phenomenon in an HIV-1-infected man on antiretroviral therapy. Int J STD AIDS 17:560-561 (Pubitemid 44285733)
75. Albrecht H (1998) Leishmaniosis-new perspectives on an underappreciated opportunistic infection. AIDS 12:2225-2226 (Pubitemid 28495278)
76. Ridolfo AL, Gervasoni C, Antinori S, Pizzuto M, Santambrogio S, Trabattoni D, Clerici M, Galli M (2000) Post-kala-azar dermal leishmaniasis during highly active antiretroviral therapy in an AIDS patient infected with Leishmania infantum. J Infect 40 (2):199-202 (Pubitemid 30312566)
77. Blanche P, Gombert B, Rivoal O, Abad S, Salmon D, Brezin A (2002) Uveitis due to Leishmania major as part of HAARTinduced immune restitution syndrome in a patient with AIDS. Clin Infect Dis 34:1279-1280 (Pubitemid 34450680)
78. Gilad J, Borer A, Hallel-Halevy D, Riesenberg K, Alkan M, Schlaeffer F (2001) Post-kala-azar dermal leishmaniasis manifesting after initiation of highly active anti-retroviral therapy in a patient with human immunodeficiency virus infection. Isr Med Assoc J 3:451-452 (Pubitemid 34176928)
79. Berry A, Abraham B, Dereure J, Pinzani V, Bastien P, Reynes J (2004) Two case reports of symptomatic visceral leishmaniasis in AIDS patients concomitant with immune reconstitution due to antiretroviral therapy. Scand J Infect Dis 36:225-227 (Pubitemid 38618388)
80. Meenken C, van Agtmael MA, ten Kate RW, van den Horn GJ (2004) Fulminant ocular leishmaniasis in an HIV-1-positive patient. AIDS 18(10):1485-1486 (Pubitemid 38925149)
81. Posada-Vergara MP, Lindoso JA, Tolezano JE, Pereira- Chioccola VL, Silva MV, Goto H (2005) Tegumentary leishmaniasis as a manifestation of immune reconstitution inflammatory syndrome in 2 patients with AIDS. J Infect Dis 192:1819-1822 (Pubitemid 41587835)
82. Boumis E, Chinello P, Della Rocca C, Paglia MG, Proietti MF, Petrosillo N (2006) Atypical disseminated leishmaniasis resembling post-kala-azar dermal leishmaniasis in an HIV-infected patient. Int J STD AIDS 17(5):351-353 (Pubitemid 43668178)
83. Alsina-Gibert M, López-Lerma I, Martinez-Chamorro E, Herrero- Mateu C (2006) Cutaneous manifestations of visceral leishmaniasis resistant to liposomal amphotericin B in an HIV-positive patient. Arch Detmatol 142:787-789
84. Dejenie Belay A, Asafa Y, Mesure J, Davidson RN (2006) Successful miltefosine treatment of post-kala-azar dermal leishmaniasis occurring during antiretroviral therapy. Ann Trop Med Parasitol 100(3):223-227 (Pubitemid 46940465)
85. Kérob D, Bouaziz JD, Sarfati C, Pavie J, Vignon-Pennamen MD, Menotti J, Hamane S, Pralong F, Buffet P, Morel P, Lebbe C (2006) First case of cutaneous reconstitution inflammatory syndrome associated with HIV infection and leishmaniasis. Clin Infect Dis 43:664-666 (Pubitemid 44267133)
86. Rihl M, Stoll M, Ulbricht K, Bange FC, Schmidt RE (2006) Successful treatment of post-kala-azar dermal leishmaniasis (PKDL) in a HIV infected patient with multiple relapsing leishmaniasis from Western Europe. J Infect 53:e25-e27 (Pubitemid 43960448)
87. Stark D, Pett S, Marriott D, Harkness J (2006) Post-kala-azar dermal leishmaniasis due to Leishmania infantum in a human immunodeficiency virus type 1-infected patient. J Clin Microbiol 44(3):1178-1180
88. Antinori S, Longhi E, Bestetti G, Piolini R, Acquaviva V, Foschi A, Trovati S, Parravicini C, Corbellino M, Meroni L (2007) Post-kala-azar dermal leishmaniasis as an immune reconstitution inflammatory syndrome in a patient with acquired immune deficiency syndrome. Br J Dermatol 157(5):1032- 1036 (Pubitemid 47583507)
89. Sinha S, Fernández G, Kapila R, Lambert WC, Schwartz RA (2008) Diffuse cutaneous leishmaniasis associated with the immune reconstitution inflammatory syndrome. Int J Dermatol 47(12):1263-1270
90. Chrusciak-Talhari A, Ribeiro-Rodrigues R, Talhari C, Silva RM Jr, Ferreira LC, Botileiro SF, Santos LO, Dietze R, Talhari S (2009) Tegumentary leishmaniasis as the cause of immune reconstitution inflammatory syndrome in a patient co-infected with human immunodeficiency virus and Leishmania guyanensis. Am J Trop Med Hyg 81(4):559-564
91. Patel KK, Patel AK, Sarda P, Shah BA, Ranjan R (2009) Immune reconstitution visceral leishmaniasis presented as hemophagocytic syndrome in a patient with AIDS from a nonendemic area: a case report. J Int Assoc Physicians AIDS Care (Chic) 8:217-220
92. Tadesse A, Hurissa Z (2009) Leishmaniasis (PKDL) as a case of immune reconstitution inflammatory syndrome (IRIS) in HIVpositive patient after initiation of anti-retroviral therapy (ART). Ethiop Med J 47(1):77-79
93. van der Spek BW, Hillebrand-Haverkort ME, Stam F, Kager PA (2009) One of the many faces of immune reconstitution inflammatory syndrome. Clin Infect Dis 48:764-765, 836-838
94. Auyeung P, French MA, Hollingsworth PN (2010) Immune restoration disease associated with Leishmania donovani infection following antiretroviral therapy for HIV infection. J Microbiol Immunol Infect 43(1):74-76
95. Gelanew T, Amogne W, Abebe T, Kuhls K, Hailu A, Schönian G (2010) A clinical isolate of Leishmania donovani with ITS1 sequence polymorphism as a cause of para-kala-azar dermal leishmaniasis in an Ethiopian human immunodeficiency viruspositive patient on highly active antiretroviral therapy. Br J Dermatol 163(4):870-874
96. Plasencia LD, Socas MMA, Valls RA, Fernández EM, Higuera AC, Gutierrez AB (2006) Terminal ileitis as a manifestation of immune reconstitution syndrome following HAART. AIDS 20 (14):1903-1905 (Pubitemid 44358913)
97. Sriaroon C, Mayer CA, Chen L, Accurso C, Greene JN, Vincent AL (2008) Diffuse intra-abdominal granulomatous seeding as a manifestation of immune reconstitution inflammatory syndrome associated with microsporidiosis in a patient with HIV. AIDS Patient Care STDS 22(8):611-612
98. Keiser O, Chi BH, Gsponer T, Boulle A, Orrell C, Phiri S, Maxwell N, Maskew M, Prozesky H, Fox MP, Westfall A, Egger M; for the IeDEA Southern Africa Collaboration (2011) Outcomes of antiretroviral treatment in programmes with and without routine viral load monitoring in Southern Africa. AIDS 25 (14):1761-1769