Endothelial injury in transplant glomerulopathy is correlated with transcription factor T-bet expression

Kidney International

Volumn 82, Issue 3, 2012, Pages 321-329

  Sun, Qiquan ^a   Zhang, Mingchao ^a   Xie, Kenan ^a   Li, Xue ^a   Zeng, Caihong ^a   Zhou, Minlin ^a   Liu, Zhihong ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

glomerulitis; kidney transplantation; macrophage; peritubular capillaritis; T bet; transplant glomerulopathy

Indexed keywords

CD68 ANTIGEN; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ADULT; ARTICLE; CAPILLARY DENSITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; COHORT ANALYSIS; DIFFUSE PERITUBULAR CAPILLARY DILATION; DISEASE ASSOCIATION; ENDOTHELIAL DYSFUNCTION; FEMALE; FIBROSING ALVEOLITIS; GLOMERULOPATHY; GLOMERULUS; GLOMERULUS CAPILLARY; GRAFT REJECTION; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOPATHOGENESIS; INFLAMMATION; KIDNEY TUBULE DISORDER; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSPLANT GLOMERULOPATHY;

EID: 84863808821     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.112     Document Type: Article

References (30)

1. Halloran PF, Melk A, Barth C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 1999; 10: 167-181. (Pubitemid 29034957)
2. Meyers CM, Kirk AD. Workshop on late renal allograft dysfunction. Am J Transplant 2005; 5: 1600-1605.
3. Einecke G, Sis B, Reeve J et al. Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant 2009; 9: 2520-2531.
4. Lee PC, Terasaki PI, Takemoto SK et al. All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Transplantation 2002; 74: 1192-1194. (Pubitemid 35216119)
5. Sun Q, Liu ZH, Ji S et al. Late and early C4d-positive acute rejection: different clinico-histopathological subentities in renal transplantation. Kidney Int 2006; 70: 377-383. (Pubitemid 44086589)
6. Pascual J, Samaniego MD, Torrealba JR et al. Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol 2008; 19: 812-824.
7. Suri DL, Tomlanovich SJ, Olson JL et al. Transplant glomerulopathy as a cause of late graft loss. Am J Kidney Dis 2000; 35: 674-680. (Pubitemid 30185513)
8. Solez K, Colvin RB, Racusen LC et al. Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant 2007; 7: 518-526. (Pubitemid 46376465)
9. Cosio FG, Gloor JM, Sethi S et al. Transplant glomerulopathy. Am J Transplant 2008; 8: 492-496. (Pubitemid 351287536)
10. Fotheringham J, Angel CA, McKane W. Transplant glomerulopathy: morphology, associations and mechanism. Nephron Clin Pract 2009; 113: c1-c7 (discussion c7).
11. Gloor JM, Sethi S, Stegall MD et al. Transplant glomerulopathy: subclinical incidence and association with alloantibody. Am J Transplant 2007; 7: 2124-2132. (Pubitemid 47247042)
12. Sis B, Campbell PM, Mueller T et al. Transplant glomerulopathy, late antibody-mediated rejection and the ABCD tetrad in kidney allograft biopsies for cause. Am J Transplant 2007; 7: 1743-1752. (Pubitemid 46905427)
13. Fahim T, Bohmig GA, Exner M et al. The cellular lesion of humoral rejection: predominant recruitment of monocytes to peritubular and glomerular capillaries. Am J Transplant 2007; 7: 385-393. (Pubitemid 46096331)
14. Szabo SJ, Kim ST, Costa GL et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-669.
15. Miller SA, Weinmann AS. Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev 2010; 238: 233-246.
16. Sullivan BM, Juedes A, Szabo SJ et al. Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci USA 2003; 100: 15818-15823. (Pubitemid 38021073)
17. Durali D, de Goer de Herve MG, Giron-Michel J et al. In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood 2003; 102: 4084-4089. (Pubitemid 37486992)
18. Lugo-Villarino G, Maldonado-Lopez R, Possemato R et al. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci USA 2003; 100: 7749-7754. (Pubitemid 36760041)
19. Robbins SH, Tessmer MS, Van Kaer L et al. Direct effects of T-bet and MHC class I expression, but not STAT1, on peripheral NK cell maturation. Eur J Immunol 2005; 35: 757-765. (Pubitemid 40425531)
20. Hoffmann SC, Hale DA, Kleiner DE et al. Functionally significant renal allograft rejection is defined by transcriptional criteria. Am J Transplant 2005; 5: 573-581. (Pubitemid 40313350)
21. Ashton-Chess J, Dugast E, Colvin RB et al. Regulatory, effector, and cytotoxic T cell profiles in long-term kidney transplant patients. J Am Soc Nephrol 2009; 20: 1113-1122.
22. Homs S, Mansour H, Desvaux D et al. Predominant Th1 and cytotoxic phenotype in biopsies from renal transplant recipients with transplant glomerulopathy. Am J Transplant 2009; 9: 1230-1236.
23. Sun Q, Cheng D, Zhang M et al. Predominance of intraglomerular T-bet or GATA3 may determine mechanism of transplant rejection. J Am Soc Nephrol 2011; 22: 246-252.
24. Agnello D, Lankford CS, Bream J et al. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol 2003; 23: 147-161. (Pubitemid 36522792)
25. Sis B, Halloran PF. Endothelial transcripts uncover a previously unknown phenotype: C4d-negative antibody-mediated rejection. Curr Opin Organ Transplant 2010; 15: 42-48.
26. Sis B, Jhangri GS, Bunnag S et al. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am J Transplant 2009; 9: 2312-2323.
27. Colvin RB. Antibody-mediated renal allograft rejection: diagnosis and pathogenesis. J Am Soc Nephrol 2007; 18: 1046-1056. (Pubitemid 46536891)
28. Adair A, Mitchell DR, Kipari T et al. Peritubular capillary rarefaction and lymphangiogenesis in chronic allograft failure. Transplantation 2007; 83: 1542-1550. (Pubitemid 46987904)
29. Racusen LC, Colvin RB, Solez K et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708-714. (Pubitemid 36745243)
30. Sun Q, Liu ZH, Cheng Z et al. Treatment of early mixed cellular and humoral renal allograft rejection with tacrolimus and mycophenolate mofetil. Kidney Int 2007; 71: 24-30. (Pubitemid 44967730)