Designing redox potential-controlled protein switches based on mutually exclusive proteins

Protein Science

Volumn 21, Issue 8, 2012, Pages 1222-1230

  Peng, Qing ^a   Kong, Na ^a   Wang, Hui Chuan Eileen ^a   Li, Hongbin ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Mutually exclusive protein; Protein folding and unfolding; Protein switch; Stopped flow spectrofluorometry

Indexed keywords

IMMUNOGLOBULIN G;

ARTICLE; BINDING AFFINITY; DISULFIDE BOND; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN UNFOLDING; THERMOSTABILITY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; DISULFIDES; HUMANS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MUTATION; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN KINASES; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECOMBINANT FUSION PROTEINS; STREPTOCOCCUS; THERMODYNAMICS;

EID: 84863807314     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2109     Document Type: Article

References (34)

1. Donaldson JG, Jackson CL (2011) ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol 12:362-375.
2. Garcia-Mata R, Boulter E, Burridge K (2011) The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol 12:493-504.
3. Hergovich A (2011) MOB control: reviewing a conserved family of kinase regulators. Cell Signal 23:1433-1440.
4. Inman GJ (2011) Switching TGFbeta from a tumor suppressor to a tumor promoter. Curr Opin Genet Dev 21:93-99.
5. Stavnezer J (2011) Complex regulation and function of activation-induced cytidine deaminase. Trends Immunol 32:194-201.
6. Baird GS, Zacharias DA, Tsien RY (1999) Circular permutation and receptor insertion within green fluorescent proteins. Proc Natl Acad Sci USA 96:11241-11246. (Pubitemid 29487365)
7. Ambroggio XI, Kuhlman B (2006) Design of protein conformational switches. Curr Opin Struct Biol 16:525-530. (Pubitemid 44149060)
8. Wright CM, Heins RA, Ostermeier M (2007) As easy as flipping a switch? Curr Opin Chem Biol 11:342-346. (Pubitemid 46963066)
9. Ostermeier M (2009) Designing switchable enzymes. Curr Opin Struct Biol 19:442-448.
10. Koide S (2009) Generation of new protein functions by nonhomologous combinations and rearrangements of domains and modules. Curr Opin Biotech 20:398-404.
11. Vallee-Belisle A, Plaxco KW (2010) Structure-switching biosensors: inspired by Nature. Curr Opin Struct Biol 20:518-526.
12. Stratton MM, Loh SN (2011) Converting a protein into a switch for biosensing and functional regulation. Protein Sci 20:19-29.
13. Palmer AE, Qin Y, Park JG, McCombs JE (2011) Design and application of genetically encoded biosensors. Trends Biotech 29:144-152.
14. Oh KJ, Cash KJ, Plaxco KW (2009) Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides. Chemistry 15:2244-2251.
15. Cerasoli E, Sharpe BK, Woolfson DN (2005) ZiCo: a peptide designed to switch folded state upon binding zinc. J Am Chem Soc 127:15008-15009. (Pubitemid 41547351)
16. Dueber JE, Yeh BJ, Chak K, Lim WA (2003) Reprogramming control of an allosteric signaling switch through modular recombination. Science 301:1904-1908. (Pubitemid 37221395)
17. Guntas G, Mansell TJ, Kim JR, Ostermeier M (2005) Directed evolution of protein switches and their application to the creation of ligand-binding proteins. Proc Natl Acad Sci USA 102:11224-11229. (Pubitemid 41153802)
18. Sallee NA, Yeh BJ, Lim WA (2007) Engineering modular protein interaction switches by sequence overlap. J Am Chem Soc 129:4606-4611. (Pubitemid 46648759)
19. Strickland D, Moffat K, Sosnick TR (2008) Light-activated DNA binding in a designed allosteric protein. Proc Natl Acad Sci USA 105:10709-10714.
20. Yousef MS, Baase WA, Matthews BW (2004) Use of sequence duplication to engineer a ligand-triggered, long-distance molecular switch in T4 lysozyme. Proc Natl Acad Sci USA 101:11583-11586. (Pubitemid 39095339)
21. Radley TL, Markowska AI, Bettinger BT, Ha JH, Loh SN (2003) Allosteric switching by mutually exclusive folding of protein domains. J Mol Biol 332:529-536. (Pubitemid 37075979)
22. Cutler TA, Loh SN (2007) Thermodynamic analysis of an antagonistic folding-unfolding equilibrium between two protein domains. J Mol Biol 371:308-316. (Pubitemid 47048284)
23. Ha JH, Butler JS, Mitrea DM, Loh SN (2006) Modular enzyme design: regulation by mutually exclusive protein folding. J Mol Biol 357:1058-1062. (Pubitemid 43357972)
24. Cutler TA, Mills BM, Lubin DJ, Chong LT, Loh SN (2009) Effect of interdomain linker length on an antagonistic folding-unfolding equilibrium between two protein domains. J Mol Biol 386:854-868.
25. Peng Q, Li H (2009) Direct observation of tug-of-war during the folding of a mutually exclusive protein. J Am Chem Soc 131:13347-13354.
26. Akerstrom B, Brodin T, Reis K, Bjorck L (1985) Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodies. J Immunol 135: 2589-2592. (Pubitemid 16215854)
27. Li H, Wang HC, Cao Y, Sharma D, Wang M (2008) Configurational entropy modulates the mechanical stability of protein GB1. J Mol Biol 379:871-880.
28. Sauer-Eriksson AE, Kleywegt GJ, Uhlen M, Jones TA (1995) Crystal structure of the C2 fragment of streptococcal protein G in complex with the Fc domain of human IgG. Structure 3:265-278.
29. Cao Y, Yoo T, Zhuang S, Li H (2008) Protein-protein interaction regulates proteins' mechanical stability. J Mol Biol 378:1132-1141.
30. Wang H-C (2009) Studies on the mechanical stability of a protein by single molecule atomic force microscopy. Chemistry. University of British Columbia.
31. Morrone A, McCully ME, Bryan PN, Brunori M, Daggett V, Gianni S, Travaglini-Allocatelli C (2011) The denatured state dictates the topology of two proteins with almost identical sequence but different native structure and function. J Biol Chem 286:3863-3872.
32. Park SH, Shastry MC, Roder H (1999) Folding dynamics of the B1 domain of protein G explored by ultrarapid mixing. Nat Struct Biol 6:943-947. (Pubitemid 29463308)
33. Tcherkasskaya O, Knutson JR, Bowley SA, Frank MK, Gronenborn AM (2000) Nanosecond dynamics of the single tryptophan reveals multi-state equilibrium unfolding of protein GB1. Biochemistry 39:11216-11226.
34. Butler JS, Mitrea DM, Mitrousis G, Cingolani G, Loh SN (2009) Structural and thermodynamic analysis of a conformationally strained circular permutant of barnase. Biochemistry 48:3497-3507.