Role of ethylene receptors during senescence and ripening in horticultural crops

Plant Signaling and Behavior

Volumn 7, Issue 7, 2012, Pages 827-846

  Agarwal, Gaurav ^a   Choudhary, Divya ^a   Singh, Virendra P ^a   Arora, Ajay ^a  

^a INDIAN AGRICULTURAL RESEARCH INSTITUTE   (India)

Author keywords

Ethylene; Ethylene insensitive; Ethylene receptors; Negative regulation; Perception; Sensitivity; Transgenic

Indexed keywords

EID: 84863796939     PISSN: 15592316     EISSN: 15592324     Source Type: Journal    
DOI: 10.4161/psb.20321     Document Type: Review

References (177)

1. Abeles FB, Morgan PW, Saltveit ME. Ethylene in Plant Biology. Ed2. Academic Press, San Diego 1992.
2. Knight LI, Rose RC, Crocker W. Effect of various gases and vapors upon etiolated seedlings of the sweet pea. Science 1910; 31:635-6.
3. Rodríguez FI, Esch JJ, Hall AE, Binder BM, Schaller GE, Bleecker AB. A copper cofactor for the ethylene receptor ETR1 from Arabidopsis. Science 1999; 283:996-8; PMID:9974395; http://dx.doi.org/10.1126/science.283.5404.996
4. Gamble RL, Coonfield ML, Schaller GE. Histidine kinase activity of the ETR1 ethylene receptor from Arabidopsis. Proc Natl Acad Sci U S A 1998; 95:7825-9; PMID:9636235; http://dx.doi.org/10.1073/pnas.95.13.7825
5. Moussatche P, Klee HJ. Autophosphorylation activity of the Arabidopsis ethylene receptor multigene family. J Biol Chem 2004; 279:48734-41; PMID:15358768; http://dx.doi.org/10.1074/jbc.M403100200
6. Dong CH, Jang M, Scharein B, Malach A, Rivarola M, Liesch J, et al. Molecular association of the Arabidopsis ETR1 ethylene receptor and a regulator of ethylene signaling, RTE1. J Biol Chem 2010; 285:40706-13; PMID:20952388; http://dx.doi.org/10.1074/jbc.M110.146605
7. Kim H, Helmbrecht EE, Stalans MB, Schmitt C, Patel N, Wen C-K, et al. Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings. Plant Physiol 2011; 156:417-29; PMID:21386032; http://dx.doi.org/10.1104/pp.110.170621
8. Schaller GE, Bleecker AB. Ethylene-binding sites generated in yeast expressing the Arabidopsis ETR1 gene. Science 1995; 270:1809-11; PMID:8525372; http://dx.doi.org/10.1126/science.270.5243.1809
9. Chen YF, Randlett MD, Findell JL, Schaller GE. Localization of the ethylene receptor ETR1 to the endoplasmic reticulum of Arabidopsis. J Biol Chem 2002; 277:19861-6; PMID:11916973; http://dx.doi.org/10.1074/jbc.M201286200
10. Clark KL, Larsen, PB, Wang, X, Chang, C. Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. Proc Natl Acad Sci U S A 1998; 95:5401-6; PMID:9560288; http://dx.doi.org/10.1073/pnas.95.9.5401
11. Hall AE, Findell JL, Schaller GE, Sisler EC, Bleecker AB. Ethylene perception by the ERS1 protein in Arabidopsis. Plant Physiol 2000; 123:1449-58; PMID: 10938361; http://dx.doi.org/10.1104/pp.123.4.1449
12. Binder BM. The ethylene receptors: complex perception for a simple gas. Plant Sci 2008; 175:8-17; http://dx.doi.org/10.1016/j.plantsci.2007.12.001
13. Hua J, Chang C, Sun Q, Meyerowitz EM. Ethylene insensitivity conferred by Arabidopsis ERS gene. Science 1995; 269:1712-4; PMID:7569898; http://dx.doi.org/10.1126/science.7569898
14. Roman G, Lubarsky B, Kieber JJ, Rothenberg M, Ecker JR. Genetic analysis of ethylene signal transduction in Arabidopsis thaliana: five novel mutant loci integrated into a stress response pathway. Genetics 1995; 139:1393-409; PMID:7768447
15. Solano R, Ecker JR. Ethylene gas: perception, signaling and response. Curr Opin Plant Biol 1998; 1:393-8; PMID:10066624; http://dx.doi.org/10.1016/S1369-5266(98)80262-8
16. Gao Z, Chen YF, Randlett MD, Zhao XC, Findell JL, Kieber JJ, et al. Localization of the Raf-like kinase CTR1 to the endoplasmic reticulum of Arabidopsis through participation in ethylene receptor signaling complexes. J Biol Chem 2003; 278:34725-32; PMID: 12821658; http://dx.doi.org/10.1074/jbc.M305548200
17. Sisler EC, Serek M, Dupille E. Comparison of cyclopropene, 1-methylcyclopropene, and 3,3-dimethylcyclopropene as ethylene antagonists in plants. Plant Growth Regul 1996; 18:169-74; http://dx.doi.org/10.1007/BF00024378
18. Serek M, Tamari G, Sisler EC, Borochov A. Inhibition of ethylene-induced senescence symptoms by 1-methyl cyclopropene, a new inhibitor of ethylene action. Physiol Plant 1995; 94:229-32; http://dx.doi.org/10.1111/j.1399-3054.1995.tb05305.x
19. Sisler EC, Serek M. Inhibitors of ethylene responses in plants at the receptor level: recent developments. Physiol Plant 1997; 100:577-82; http://dx.doi.org/10.1111/j.1399-3054.1997.tb03063.x
20. Sisler EC, Serek M. Compounds interacting with the ethylene receptor in plants. Plant Biol 2003; 5:473-80; http://dx.doi.org/10.1055/s-2003-44782
21. Serek M, Woltering EJ, Sisler EC, Frello S, Sriskandarajah S. Controlling ethylene responses in flowers at the receptor level. Biotechnol Adv 2006; 24:368-81; PMID:16584864; http://dx.doi.org/10.1016/j.biotechadv.2006.01.007
22. Kumar V, Parvatam G, Ravishankar GA. AgNO3-a potential regulator of ethylene activity and plant growth modulator. J Biotechnology. 2009; 12: DOI: 10.2225.
23. Pirrung MC, Bleecker AB, Inoue Y, Rodríguez FI, Sugawara N, Wada T, et al. Ethylene receptor antagonists: strained alkenes are necessary but not sufficient. Chem Biol 2008; 15:313-21; PMID: 18420138; http://dx.doi.org/10.1016/j.chembiol.2008.02.018
24. Kazemi M, Zamani S, Aran M. Effect of Some Treatment Chemicals on Keeping Quality and Vase-life of Gebrera Cut Flowers. American J Plant Physiol 2011; 6:99-105; http://dx.doi.org/10.3923/ajpp.2011.99.105
25. Chen JF, Gallie DR. Analysis of the functional conservation of ethylene receptors between maize and Arabidopsis. Plant Mol Biol 2010; 74:405-21; PMID: 20835883; http://dx.doi.org/10.1007/s11103-010-9686-4
26. Liu Q, Wen C-K. Arabidopsis ETR1 and ERS1 differentially 1 repress the ethylene response in 2 combination with other ethylene receptor genes. Plant Physiol 2012; 158; http://dx.doi.org/10.1104/pp.111.187757
27. Csukasi F, Merchante C, Valpuesta V. Modification of plant hormone levels and signaling as a tool in plant biotechnology. Biotechnol J 2009; 4:1293-304; PMID:19585532; http://dx.doi.org/10.1002/biot.200800286
28. Mattoo AK, Suttle JC. The Plant Hormone Ethylene. CRC Press, Boca Raton, FL 1991.
29. Shaharoona B, Muhammad IM, Arshad M, Khalid A. Manipulation of ethylene synthesis in roots through bacterial ACC deaminase for improving nodulation in legumes. Crit Rev Plant Sci 2011; 30:279-91; http://dx.doi.org/10.1080/07352689.2011.572058
30. Binder BM, Patterson SE. Ethylene-dependent and -independent regulation of abscission. Stewart Postharvest Review 2009; 5:1-10; http://dx.doi.org/10.2212/spr.2009.1.1
31. Lin Z, Zhong S, Grierson D. Recent advances in ethylene research. J Exp Bot 2009; 60:3311-36; PMID: 19567479; http://dx.doi.org/10.1093/jxb/erp204
32. Little HA, Gurmet R, Hancock JF. Modified ethylene signaling as an example of engineering for complex Traits: secondary effects and implications for environmental risk assessment. HortScience 2009; 44:94-101.
33. Stearns JC, Glick BR. Transgenic plants with altered ethylene biosynthesis or perception. Biotechnol Adv 2003; 21:193-210; PMID:14499129; http://dx.doi.org/10.1016/S0734-9750(03)00024-7
34. Czarny JC, Grichko VP, Glick BR. Genetic modulation of ethylene biosynthesis and signaling in plants. Biotechnol Adv 2006; 24:410-9; PMID:16524685; http://dx.doi.org/10.1016/j.biotechadv.2006.01.003
35. Dahmani-Mardas F, Troadec C, Boualem A, Lévêque S, Alsadon AA, Aldoss AA, et al. Engineering melon plants with improved fruit shelf life using the TILLING approach. PLoS One 2010; 5:e15776; PMID:21209891; http://dx.doi.org/10.1371/journal.pone.0015776
36. Theologis A, Zarembinski TI, Oeller PW, Liang X, Abel S. Modification of fruit ripening by suppressing gene expression. Plant Physiol 1992; 100:549-51; PMID:16653026; http://dx.doi.org/10.1104/pp.100.2.549
37. Arshad M, Frankenberger WT. Ethylene: Agricultural Sources and Applications. New York, NY: Kluwer Academic/Plenum Publishers 2002; 342.
38. Andersson-Gunnerås S, Hellgren JM, Björklund S, Regan S, Moritz T, Sundberg B. Asymmetric expression of a poplar ACC oxidase controls ethylene production during gravitational induction of tension wood. Plant J 2003; 34:339-49; PMID:12713540; http://dx.doi.org/10.1046/j.1365-313X.2003.01727.x
39. Wang NN, Shih MC, Li N. The GUS reporter-aided analysis of the promoter activities of Arabidopsis ACC synthase genes AtACS4, AtACS5, and AtACS7 induced by hormones and stresses. J Exp Bot 2005; 56:909-20; PMID:15699063; http://dx.doi.org/10.1093/jxb/eri083
40. Oeller PW, Lu MW, Taylor LP, Pike DA, Theologis A. Reversible inhibition of tomato fruit senescence by antisense RNA. Science 1991; 254:437-9; PMID: 1925603; http://dx.doi.org/10.1126/science.1925603
41. Fluhr R, Mattoo AK. Ethylene: biosynthesis and perception. Crit Rev Plant Sci 1996; 15:479-23.
42. Savin KW, Baudinette SC, Graham MW, Michael MZ, Nugent GD, Lu C. Antisense ACC oxidase RNA delays carnation petal senescence. Hort Sci 1995; 30:970-2.
43. Einset JW, Kopperud C. Antisense ethylene genes for Begonia flowers. Acta Hortic 1995; 405:190-6.
44. Good X, Kellogg JA, Wagoner W, Langhoff D, Matsumura W, Bestwick RK. Reduced ethylene synthesis by transgenic tomatoes expressing S-adenosylmethionine hydrolase. Plant Mol Biol 1994; 26: 781-90; PMID:7999994; http://dx.doi.org/10.1007/BF0002884816
45. Kumar A, Taylor MA, Mad ASA, Davies HV. Potato plants expressing antisense and sense S-adenosylmethione decarboxylase (SAMDC) transgenes show altered levels of polyamines and ethylene: antisense plants display abnormal phenotypes. Plant J 1996; 9:147-58; http://dx.doi.org/10.1046/j.1365-313X.1996.09020147.x
46. van Doorn WG. Categories of petal senescence and abscission: a reevaluation. Ann Bot (Lond) 2001; 87:447-56; http://dx.doi.org/10.1006/anbo.2000.1357
47. Jones ML. Ethylene signalling is required for pollination-accelerated corolla senescence in petunias. Plant Sci 2008; 175:190-6; http://dx.doi.org/10.1016/j.plantsci.2008.03.011
48. Hoffman T, Schmidt JS, Zheng X, Bent AF. Isolation of ethylene-insensitive soybean mutants that are altered in pathogen susceptibility and gene-for-gene disease resistance. Plant Physiol 1999; 119:935-50; PMID: 10069832; http://dx.doi.org/10.1104/pp.119.3.935
49. Einset JW. Differential expression of antisense in regenerated tobacco plants transformed with an antisense version of a tomato ACC oxidase gene. Plant Cell Tissue Organ Cult 1996; 46:137-41; http://dx.doi.org/10.1007/BF00034847
50. Picton S, Barton SL, Bouzayen M, Hamilton AJ, Grierson D. Altered fruit ripening and leaf senescence in tomatoes expressing an antisense ethylene-forming enzyme transgene. Plant J 1993; 3:469-81; http://dx.doi.org/10.1111/j.1365-313X.1993.tb00167.x
51. Huang WF, Huang PL, Do YY. Ethylene receptor transcript accumulation patterns during flower senescence in Oncidium 'Gower Ramsey' as affected by exogenous ethylene and pollinia cap dislodgement. Post Biol Tech 2007; 44:87-94; http://dx.doi.org/10.1016/j.postharvbio.2006.12.012
52. Dandekari AM, Teo G, Defilippi BG, Uratsu SL, Passey AJ, Kader AA, et al. Effect of down-regulation of ethylene biosynthesis on fruit flavor complex in apple fruit. Transgenic Res 2004; 13:373-84; PMID: 15517996; http://dx.doi.org/10.1023/B:TRAG.0000040037.90435.45
53. Arora A. Programmed cell death during petal senescence. Postharvest Biology and Technology of fruits, vegetables and flowers. Paliyath G, Murr DP, Handa AK, Lurie S. (Eds). John Wiley and Sons Ltd. 2008; 86-124.
54. Patterson SE, Bleecker AB. Ethylene-dependent and -independent processes associated with floral organ abscission in Arabidopsis. Plant Physiol 2004; 134:194-203; PMID:14701913; http://dx.doi.org/10.1104/pp.103.028027
55. Palma JM, Corpas FJ, del Río LA. Proteomics as an approach to the understanding of the molecular physiology of fruit development and ripening. J Proteomics 2011; 74:1230-43; PMID:21524723; http://dx.doi.org/10.1016/j.jprot.2011.04.010
56. Bapat VA, Trivedi PK, Ghosh A, Sane VA, Ganapathi TR, Nath P. Ripening of fleshy fruit: molecular insight and the role of ethylene. Biotechnol Adv 2010; 28:94-107; PMID:19850118; http://dx.doi.org/10.1016/j.biotechadv.2009.10.002
57. Sriskandarajah S, Mibus H, Serek M. Transgenic Campanula carpatica plants with reduced ethylene sensitivity. Plant Cell Rep 2007; 26:805-13; PMID: 17221226; http://dx.doi.org/10.1007/s00299-006-0291-6
58. ten Have A, Woltering EJ. Ethylene biosynthetic genes are differentially expressed during carnation (Dianthus caryophyllus L.) flower senescence. Plant Mol Biol 1997; 34:89-97; PMID:9177315; http://dx.doi.org/10.1023/A:1005894703444
59. Jones ML, Woodson WR. Differential expression of three members of the 1-aminocyclopropane-1-carboxylate synthase gene family in carnation. Plant Physiol 1999; 119:755-64; PMID:9952472; http://dx.doi.org/10.1104/pp.119.2.755
60. Shibuya K, Yoshioka T, Hashiba T, Satoh S. Role of the gynoecium in natural senescence of carnation (Dianthus caryophyllus L.) flowers. J Exp Bot 2000; 51:2067-73; PMID:11141180; http://dx.doi.org/10.1093/jexbot/51.353.2067
61. Borochov A, Woodson WR. Physiology and biochemistry of flower petal senescence. Hortic Rev (Am Soc Hortic Sci) 1989; 11:15-43.
62. Wang H, Woodson WR. Reversible inhibition of ethylene action and interruption of petal senescence in carnation flowers by norbornadiene. Plant Physiol 1989; 89:434-8; PMID:16666561; http://dx.doi.org/10.1104/pp.89.2.434
63. Charng YY, Sun CW, Yan SL, Chou SJ, Chen YR, Yang SF. cDNA sequence of a putative ethylene receptor from carnation petals (Accession No. AF016250) (PGR97-144). Plant Physiol 1997; 115:863; PMID:9411456
64. Shibuya K, Satoh S, Yoshioka T. A cDNA encoding a putative ethylene receptor related to petal senescence in carnation (Dianthus caryophyllus L.) flowers (Accession No. AF034770) (PGR 98-019). Plant Physiol 1998; 116:67.
65. Nagata M, Tanikawa N, Onazaki T, Mori H. Ethylene receptor gene (ETR) homolog from carnation. J Japanese Soc Hort Sci 2000; 69:407.
66. Shibuya K, Nagata M, Tanikawa N, Yoshioka T, Hashiba T, Satoh S. Comparison of mRNA levels of three ethylene receptors in senescing flowers of carnation (Dianthus caryophyllus L.). J Exp Bot 2002; 53:399-406; PMID:11847237; http://dx.doi.org/10.1093/jexbot/53.368.399
67. Onoue T, Mikami M, Yoshioka T, Hashiba T, Satoh S. Characteristics of the inhibitory action of 1,1-dimethyl-4-(phenylsulfonyl) semicarbazide (DPSS) on ethylene production in carnation (Dianthus caryophyllus L.) flowers. Plant Growth Regul 2000; 30:201-7; http://dx.doi.org/10.1023/A:1006324715438
68. Waki K, Shibuya K, Yoshioka T, Hashiba T, Satoh S. Cloning of a cDNA encoding EIN3-like protein (DC-EIL1) and decrease in its mRNA level during senescence in carnation flower tissues. J Exp Bot 2001; 52:377-9; PMID:11283184; http://dx.doi.org/10.1093/jexbot/52.355.377
69. Chao Q, Rothenberg M, Solano R, Roman G, Terzaghi W, Ecker JR. Activation of the ethylene gas response pathway in Arabidopsis by the nuclear protein ETHYLENE-INSENSITIVE3 and related proteins. Cell 1997; 89:1133-44; PMID:9215635; http://dx.doi.org/10.1016/S0092-8674(00)80300-1
70. Kosugi S, Ohashi Y. Cloning and DNA-binding properties of a tobacco Ethylene-Insensitive3 (EIN3) homolog. Nucleic Acids Res 2000; 28:960-7; PMID: 10648789; http://dx.doi.org/10.1093/nar/28.4.960
71. Wang KL, Li H, Ecker JR. Ethylene biosynthesis and signaling networks. Plant Cell 2002; 14(Suppl):S131-S151; PMID:12045274
72. Guo H, Ecker JR. Plant responses to ethylene gas are mediated by SCF(EBF1/EBF2)-dependent proteolysis of EIN3 transcription factor. Cell 2003; 115:667-77; PMID:14675532; http://dx.doi.org/10.1016/S0092-8674(03)00969-3
73. Potuschak T, Lechner E, Parmentier Y, Yanagisawa S, Grava S, Koncz C, et al. EIN3-dependent regulation of plant ethylene hormone signaling by two arabidopsis F box proteins: EBF1 and EBF2. Cell 2003; 115:679-89; PMID:14675533; http://dx.doi.org/10.1016/S0092-8674(03)00968-1
74. Yanagisawa S, Yoo SD, Sheen J. Differential regulation of EIN3 stability by glucose and ethylene signalling in plants. Nature 2003; 425:521-5; PMID:14523448; http://dx.doi.org/10.1038/nature01984
75. Iordachescu M, Verlinden S. Transcriptional regulation of three EIN3-like genes of carnation (Dianthus caryophyllus L. cv. Improved White Sim) during flower development and upon wounding, pollination, and ethylene exposure. J Exp Bot 2005; 56:2011-8; PMID:15983019; http://dx.doi.org/10.1093/jxb/eri199
76. van Doorn WG, Woltering EJ. Senescence and programmed cell death: substance or semantics? J Exp Bot 2004; 55:2147-53; PMID:15361529; http://dx.doi.org/10.1093/jxb/erh264
77. Verlinden S, Garcia JJ. Sucrose loading decreases ethylene responsiveness in carnation (Dianthus caryophyllus cv. White Sim) petals. Post Biol Tech 2004; 31:305-12; http://dx.doi.org/10.1016/j.postharvbio.2003.09.010
78. Jones ML, Woodson WR. Pollination-induced ethylene in carnation: role of stylar ethylene in corolla senescence. Plant Physiol 1997; 115:205-12; PMID: 12223801
79. Bovy AG, Angenent GC, Dons HJM, Van Altvorst AC. Heterologous expression of the Arabidopsis etr1-1 allele inhibits the senescence of carnation flowers. Mol Breed 1999; 5:301-8; http://dx.doi.org/10.1023/A:1009617804359
80. Baudinette SC, Stevenson TW, Savin KW. Isolation and characterisation of the carnation floral-specific MADS box gene, CMB2. Plant Sci 2000; 155:123-31; PMID:10814815; http://dx.doi.org/10.1016/S0168-9452(00)00198-9
81. Ohtsubo N, Mitsuhara I, Koga M, Seo S, Ohashi Y. Ethylene promotes the necrotic lesion formation and basic PR gene expression in TMV-infected tobacco. Plant Cell Physiol 1999; 40:808-17.
82. Angenent GC, Franken J, Busscher M, Colombo L, van Tunen AJ. Petal and stamen formation in petunia is regulated by the homeotic gene fbp1. Plant J 1993; 4:101-12; PMID:8106081; http://dx.doi.org/10.1046/j.1365-313X.1993.04010101.x
83. Papon N, Senoussi MM, Andreu F, Rideau M, Chenieux JC, Creche J. Cloning of a gene encoding a putative ethylene receptor in Catharanthus roseus and its expression in plant and cell cultures. Biol Plant 2004; 48:345-50; http://dx.doi.org/10.1023/B:BIOP.0000041085.82296.9c
84. Narumi T, Kanno Y, Suzuki M, Kishimoto S, Ohmiya A, Satoh S. Cloning of a cDNA encoding an ethylene receptor (DG-ERS1) from Chrysanthemum and comparison of its mRNA level in ethylene-sensitive and -insensitive cultivars. Postharvest Biol Technol 2005. a36:21-30; http://dx.doi.org/10.1016/j.postharvbio.2004.11.001
85. Narumi T, Aida R, Ohmiya A, Satoh S. Transformation of Chrysanthemum with mutated ethylene receptor genes: mDGERS1 transgenes conferring reduced ethylene sensitivity and characterization of the transformants. Postharvest Biol Technol 2005. b37:101-10; http://dx.doi.org/10.1016/j.postharvbio.2005.04.008
86. Sumitomo K, Narumi T, Satoh S, Hisamatsu T. Involvement of the ethylene response pathway in dormancy induction in chrysanthemum. J Exp Bot 2008; 59:4075-82; PMID:18952907; http://dx.doi.org/10.1093/jxb/ern247
87. Satoh S, Watanabe M, Chisaka K, Narumi T. Suppressed leaf senescence in Chrysanthemum transformed with a mutated ethylene receptor gene mDGERS1(etr1-4). J Plant Biol 2008; 51:424-7; http://dx.doi.org/10.1007/BF03036064
88. Satoh S, Narumi T, Watanabe M, Aida R, Ohmiya A. Reduced leaf senescence in Chrysanthemum transformed with a mutated ethylene receptor gene: toward generation of compositae leafy vegetables with a longer shelf-life. Acta Hortic 2006; 721:467-71.
89. Satoh S, Narumi T, Watanabe M, Aida R, Ohmiya A. Reduced leaf senescence in Chrysanthemum transformed with mutated ethylene receptor genes. Acta Hortic 2007; 764:89-94.
90. Shinoyama H, Sano T, Saito M, Ezura H, Aida R, Nomura Y, et al. Induction of male sterility in transgenic chrysanthemums (Chrysanthemum morifolium Ramat.) by expression of a mutated ethylene receptor gene, Cm-ETR1/H69A, and the stability of this sterility at varying growth temperatures. Mol Breed 2012; 29:285-95; http://dx.doi.org/10.1007/s11032-010-9546-6
91. Wang Y, Kumar PP. Heterologous expression of Arabidopsis ERS1 causes delayed senescence in coriander. Plant Cell Rep 2004; 22:678-83; PMID: 14624308; http://dx.doi.org/10.1007/s00299-003-0738-y
92. Ichimura K, Kohata K, Goto R. Soluble carbohydrates in Delphinium and their influence on sepal abscission in cut flowers. Physiol Plant 2000; 108:307-13; http://dx.doi.org/10.1034/j.1399-3054.2000.108003307.x
93. Kuroda S, Hakata M, Hirose Y, Shiraishi M, Abe S. Ethylene production and enhanced transcription of an ethylene receptor gene, ERS1 in Delphinium during abscission of florets. Plant Physiol Biochem 2003; 41:812-20; http://dx.doi.org/10.1016/S0981-9428(03)00115-3
94. Tanase K, Ichimura K. Expression of ethylene receptors Dl-ERS1-3 and Dl-ERS2, and ethylene response during flower senescence in Delphinium. J Plant Physiol 2006; 163:1159-66; PMID:16500725; http://dx.doi.org/10.1016/j.jplph.2005.12.003
95. Hua J, Meyerowitz EM. Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana. Cell 1998; 94:261-71; PMID: 9695954; http://dx.doi.org/10.1016/S0092-8674(00)81425-7
96. Thongkum M, Bhunchoth A, Warin N, Chatchawankanphanich O, Burns P. Cloning and expression of ethylene response sensor 1 (Den-ERS1) gene of dendrobium 'pompadour' flower during development and senescence. Thai J Agri Sci 2009; 42:227-36.
97. Dervinis C, Clark DG, Barrett JE, Nell TA. Effect of pollination and exogenous ethylene on accumulation of ETR1 homologue transcripts during flower petal abscission in geranium (Pelargonium x hortorum L.H. Bailey). Plant Mol Biol 2000; 42:847-56; PMID:10890532; http://dx.doi.org/10.1023/A:1006409827860
98. Clark DG, Richards C, Hilioti Z, Lind-Iversen S, Brown K. Effect of pollination on accumulation of ACC synthase and ACC oxidase transcripts, ethylene production and flower petal abscission in geranium (Pelargonium x hortorum L.H. Bailey). Plant Mol Biol 1997; 34:855-65; PMID:9290638; http://dx.doi.org/10.1023/A:1005877809905
99. Evensen KB, Page AM, Stead AD. Anatomy of ethylene-induced petal abscission in Pelargonium xhortorum. Ann Bot (Lond) 1991; 71:559-66; http://dx.doi.org/10.1006/anbo.1993.1072
100. Arora A, Watanabe S, Ma B, Takada K, Ezura H. A novel ethylene receptor homolog gene isolated from ethylene-insensitive flowers of gladiolus (Gladiolus grandiflora hort.). Biochem Biophys Res Commun 2006; 351:739-44; PMID:17084812; http://dx.doi.org/10.1016/j.bbrc.2006.10.111
101. Sanikhani M, Mibus H, Stummann BM, Serek M. Kalanchoe blossfeldiana plants expressing the Arabidopsis etr1-1 allele show reduced ethylene sensitivity. Plant Cell Rep 2008; 27:729-37; PMID:18080125; http://dx.doi.org/10.1007/s00299-007-0493-6
102. Handberg K, Stougaard J. Lotus japonicus, an autogamous, diploid legume species for classical and molecular genetics. Plant J 1992; 2:487-96; http://dx.doi.org/10.1111/j.1365-313X.1992.00487.x
103. Sato-Nara K, Yuhashi KI, Higashi K, Hosoya K, Kubota MH, Ezura H. Stage-and tissue-specific expression of ethylene receptor homolog genes during fruit development in muskmelon. Plant Physiol 1999; 120:321-30; PMID:10318709; http://dx.doi.org/10.1104/pp.120.1.321
104. Nukui N, Ezura H, Minamisawa K. Transgenic Lotus japonicus with an ethylene receptor gene Cm-ERS1/H70A enhances formation of infection threads and nodule primordia. Plant Cell Physiol 2004; 45:427-35; PMID:15111717; http://dx.doi.org/10.1093/pcp/pch046
105. Lohar D, Stiller J, Kam J, Stacey G, Gresshoff PM. Ethylene insensitivity conferred by a mutated Arabidopsis ethylene receptor gene alters nodulation in transgenic Lotus japonicas. Ann Bot 2009; 104:277-85.
106. Heidstra R, Yang WC, Yalcin Y, Peck S, Emons AM, van Kammen A, et al. Ethylene provides positional information on cortical cell division but is not involved in Nod factor-induced root hair tip growth in Rhizobium-legume interaction. Development 1997; 124:1781-7; PMID:9165125
107. Penmetsa RV, Frugoli JA, Smith LS, Long SR, Cook DR. A dual mechanism of nodule control in Medicago truncatula. Plant Physiol 2003; 131:1-11; http://dx.doi.org/10.1104/pp.900061
108. Penmetsa RV, Uribe P, Anderson J. The Medicago truncatula of the Arabidopsis EIN2 gene, sickle, is a negative regulator of symbiotic and pathogenic microbial interactions. Plant J 2008; 55:580-95; PMID: 18435823; http://dx.doi.org/10.1111/j.1365-313X.2008.03531.x
109. Cui ML, Takada K, Ma B, Ezura H. Over expression of a mutated melon ethylene receptor gene Cm-ETR1/H69A confers reduced ethylene sensitivity in a heterologous plant, Nemesia strumosa. Plant Sci 2004; 167:253-8; http://dx.doi.org/10.1016/j.plantsci.2004.03.024
110. Takada K, Ishimaru K, Minamisawa K, Kamada H, Ezura H. Expression of a mutated melon ethylene receptor gene Cm-ETR1/H69A affects stamen development in Nicotiana tabacum. Plant Sci 2005; 169: 935-42; http://dx.doi.org/10.1016/j.plantsci.2005.06.012
111. Huang CC. Ethylene production of Oncidium flower and the change of flower quality affected by ethylene treatment and pollinia cap removal. J Agric Res China 1998; 47:125-34.
112. Wilkinson JQ, Lanahan MB, Clark DG, Bleecker AB, Chang C, Meyerowitz EM. A dominant mutant receptor from Arabidopsis confers ethylene insensitivity in heterologous plants. Nat Biotech 1997; 15: 444-47
113. Giovannoni JJ. Genetic regulation of fruit development and ripening. Plant Cell 2004; 16(Suppl):S170-80; PMID:15010516; http://dx.doi.org/10.1105/tpc.019158
114. Cobb D, Schneiter N, Guo S, Humiston GA, Harriman B, Bolar J. Flower specific expression of an ethylene receptor (ETR1-1) confers ethylene insensitivity in transgenic Petunia. In: XXVIth international horticultural congress, Toronto, Canada. Book of Abstracts 2002; 83.
115. Chen HH, Charng YY, Yang SF, Shaw JF. Isolation and characterization of a broccoli cDNA (Accession No. AF047477) encoding an ERS-type ethylene receptor. PGR98-123. Plant Physiol 1998; 117:26.
116. Clark DG, Gubrium EK, Barrett JE, Nell TA, Klee HJ. Root formation in ethylene-insensitive plants. Plant Physiol 1999; 121:53-60; PMID:10482660; http://dx.doi.org/10.1104/pp.121.1.53
117. Gubrium EK, Clevenger DJ, Clark DG, Barrett JE, Nell TA. Reproduction and horticultural performance of transgenic ethylene-insensitive petunias. J Am Soc Hortic Sci 2000; 125:277-81.
118. Clevenger DJ, Barrett JE, Klee HJ, Clark DG. Factors affecting seed production in transgenic ethyleneinsensitive petunias. J Am Soc Hortic Sci 2004; 129:401-6.
119. Shibuya K, Barry KG, Ciardi JA, Loucas HM, Underwood BA, Nourizadeh S, et al. The central role of PhEIN2 in ethylene responses throughout plant development in petunia. Plant Physiol 2004; 136: 2900-12; PMID:15466231; http://dx.doi.org/10.1104/pp.104.046979
120. Langston BJ, Bai S, Jones ML. Increases in DNA fragmentation and induction of a senescence-specific nuclease are delayed during corolla senescence in ethylene-insensitive (etr1-1) transgenic petunias. J Exp Bot 2005; 56:15-23; PMID:15475372
121. Müller R, Stummann BM, Serek M. Characterization of an ethylene receptor family with differential expression in rose (Rosa hybrida L.) flowers. Plant Cell Rep 2000. b19:1232-9; http://dx.doi.org/10.1007/s002990000251
122. Müller R, Owen CA, Xue ZT, Welander M, Stummann BM. Characterization of two CTR-like protein kinases in Rosa hybrida and their expression during flower senescence and in response to ethylene. J Exp Bot 2002; 53:1223-5; PMID:11971934; http://dx.doi.org/10.1093/jexbot/53.371.1223
123. Tieman DM, Ciardi JA, Taylor MG, Klee HJ. Members of the tomato LeEIL (EIN3-like) gene family are functionally redundant and regulate ethylene responses throughout plant development. Plant J 2001; 26:47-58; PMID:11359609; http://dx.doi.org/10.1046/j.1365-313x.2001.01006.x
124. Müller R, Owen CA, Xue ZT, Welander M, Stummann B. The transcription factor EIN3 is constitutively expressed in miniature roses with differences in postharvest life. J Hort Sci Biotech 2003; 78:10-14.
125. Müller R, Lind-Iversen S, Stummann BM, Serek M. Expression of genes for ethylene biosynthetic enzymes and an ethylene receptor in senescing flowers of miniature potted roses. J Hortic Sci Biotechnol 2000. a75:12-8.
126. Lashbrook CC, Tieman DM, Klee HJ. Differential regulation of the tomato ETR gene family throughout plant development. Plant J 1998; 15:243-52; PMID: 9721682; http://dx.doi.org/10.1046/j.1365-313X.1998.00202.x
127. Ma QH, Wang XM. Characterization of an ethylene receptor homologue from wheat and its expression during leaf senescence. J Exp Bot 2003; 54:1489-90; PMID:12709495; http://dx.doi.org/10.1093/jxb/erg142
128. Xue J, Li Y, Tan H, Yang F, Ma N, Gao J. Expression of ethylene biosynthetic and receptor genes in rose floral tissues during ethylene-enhanced flower opening. J Exp Bot 2008; 59:2161-9; PMID:18535299; http://dx.doi.org/10.1093/jxb/ern078
129. Cin VD, Danesin M, Boschetti A, Dorigoni A, Ramina A. Ethylene biosynthesis and perception in apple fruitlet abscission (Malus domestica L. Borck). J Exp Bot 2005; 56:2995-3005; PMID:16203755; http://dx.doi.org/10.1093/jxb/eri296
130. Wiersma PA, Zhang H, Lu C, Quail A, Toivonen PMA. Survey of the expression of genes for ethylene synthesis and perception during maturation and ripening of 'Sunrise' and 'Golden Delicious' apple fruit. Postharvest Biol Technol 2007; 44:204-11; http://dx.doi.org/10.1016/j.postharvbio.2006.12.01618
131. Wang A, Tan D, Takahashi A, Li TZ, Harada T. MdERFs, two ethylene-response factors involved in apple fruit ripening. J Exp Bot 2007; 58:3743-8; PMID:18057044; http://dx.doi.org/10.1093/jxb/erm224
132. Owino W, Nakano R, Kubo Y, Inaba A. Differential regulation of genes encoding ethylene biosynthesis enzymes and ethylene response sensor ortholog during ripening and in response to wounding in avocados. J Am Soc Hortic Sci 2002; 127:520-7.
133. Katz E, Lagunes PM, Riov J, Weiss D, Goldschmidt EE. Molecular and physiological evidence suggests the existence of a system II-like pathway of ethylene production in non-climacteric Citrus fruit. Planta 2004; 219:243-52; PMID:15014996; http://dx.doi.org/10.1007/s00425-004-1228-3
134. Yamasaki S, Fujii N, Takahashi H. The ethyleneregulated expression of CS-ETR2 and CS-ERS genes in cucmber plants and their possible involvement with sex expression in flowers. Plant Cell Physiol 2000; 41:608-16; PMID:10929944; http://dx.doi.org/10.1093/pcp/41.5.608
135. Manzano S, Martínez C, Gómez P, Garrido D, Jamilena M. Cloning and characterisation of two CTR1-like genes in Cucurbita pepo: regulation of their expression during male and female flower development. Sex Plant Reprod 2010; 23:301-13; PMID:20390430; http://dx.doi.org/10.1007/s00497-010-0140-1
136. Chervin C, Deluc L. Ethylene signalling receptors and transcription factors over the grape berry development: gene expression profiling. Vitis 2010; 49: 129-36.
137. Yin XR, Chen KS, Allan AC, Wu RM, Zhang B, Lallu N, et al. Ethylene-induced modulation of genes associated with the ethylene signalling pathway in ripening kiwifruit. J Exp Bot 2008; 59:2097-108; PMID: 18535296; http://dx.doi.org/10.1093/jxb/ern067
138. Takada K, Ishimaru K, Kamada H, Ezura H. Antherspecific expression of mutated melon ethylene receptor gene Cm-ERS1/H70A affected tapetum degeneration and pollen grain production in transgenic tobacco plants. Plant Cell Rep 2006; 25:936-41; PMID: 16552596; http://dx.doi.org/10.1007/s00299-006-0147-0
139. Ishimaru K, Takada K, Kamada H, Ezura H. Stable male sterility induced by the expression of a mutated melon ethylene receptor genes in Nicotiana tabacum. Plant Sci 2006; 71:355-9; http://dx.doi.org/10.1016/j.plantsci.2006.04.006
140. Takada K, Watanabe S, Sano T, Ma B, Kamada H, Ezura H. Heterologous expression of the mutated melon ethylene receptor gene Cm-ERS1/H70A produces stable sterility in transgenic lettuce (Lactuca sativa). J Plant Physiol 2007; 164:514-20; PMID: 17207555; http://dx.doi.org/10.1016/j.jplph.2006.10.003
141. Martinez PG, Gomez RL, Gomez-Lim LA. Identification of an ETR1-homologue from mango fruit expressing during fruit ripening and wounding. J Plant Physiol 2001; 158:101-8; http://dx.doi.org/10.1078/0176-1617-00238
142. Ish-Shalom M, Dahan Y, Maayan I, Irihimovitch V. Cloning and molecular characterization of an ethylene receptor gene, MiERS1, expressed during mango fruitlet abscission and fruit ripening. Plant Physiol Biochem 2011; 49:931-6; PMID:21676621; http://dx.doi.org/10.1016/j.plaphy.2011.05.010
143. Gillaspy G, Ben-David H, Gruissem W. Fruits: A Developmental Perspective. Plant Cell 1993; 5:1439-51; PMID:12271039; http://dx.doi.org/10.1105/tpc.5.10.1439
144. Takahashi H, Kobayashi T, Sato-Nara K, Tomita KO, Ezura H. Detection of ethylene receptor protein Cm-ERS1 during fruit development in melon (Cucumis melo L.). J Exp Bot 2002; 53:415-22; PMID: 11847239; http://dx.doi.org/10.1093/jexbot/53.368.415
145. Little HA, Papadopoulou E, Hammar SA, Grumet R. The influence of ethylene perception on sex expression in melon (Cucumis melo L.) as assessed by expression of the mutant ethylene receptor, At-etr1-1, under the control of constitutive and floral targeted promoters. Sex Plant Reprod 2007; 20: 123-36.
146. Papadopoulou E, Little HA, Hammar SA, Grumet R. Effect of modified endogenous ethylene production on sex expression, bisexual flower development and fruit production in melon (Cucumis melo L.). Sex Plant Reprod 2005; 18:131-42; http://dx.doi.org/10.1007/s00497-005-0006-0
147. Mita S, Kawamura S, Asai T. Regulation of the expression of a putative ethylene receptor, PeERS2, during the development of passion fruit (Passiflora edulis). Physiol Plant 2002; 114:271-80; PMID: 11903974; http://dx.doi.org/10.1034/j.1399-3054.2002.1140213.x
148. Rasori A, Ruperti B, Bonghi C, Tonutti P, Ramina A. Characterization of two putative ethylene receptor genes expressed during peach fruit development and abscission. J Exp Bot 2002; 53:2333-9; PMID: 12432026
149. El-Sharkawy I, Jones B, Li ZG, Lelièvre JM, Pech JC, Latché A. Isolation and characterization of four ethylene perception elements and their expression during ripening in pears (Pyrus communis L) with/without cold requirement. J Exp Bot 2003; 54:1615-25; PMID:12730273; http://dx.doi.org/10.1093/jxb/erg158
150. Pang JH, Ma B, Sun HJ, Guinevere I, Ortiz Imanishi S, Sugaya S, et al. Identification and characterization of ethylene receptor homologs expressed during fruit development and ripening in persimmon (Diospyros kaki Thumb). Post Biol Tech 2007; 44:195-03; http://dx.doi.org/10.1016/j.postharvbio.2006.12.017
151. El-Sharkawy I, Kim WS, El-Kereamy A, Jayasankar S, Svircev AM, Brown DCW. Isolation and characterization of four ethylene signal transduction elements in plums (Prunus salicina L.). J Exp Bot 2007; 58:3631-43; PMID:18057041; http://dx.doi.org/10.1093/jxb/erm213
152. El-Sharkawy I, Sherif S, Mila I, Bouzayen M, Jayasankar S. Molecular characterization of seven genes encoding ethylene-responsive transcriptional factors during plum fruit development and ripening. J Exp Bot 2009; 60:907-22; PMID:19213809; http://dx.doi.org/10.1093/jxb/ern354
153. Trainotti L, Pavanello A, Casadoro G. Different ethylene receptors show an increased expression during the ripening of strawberries: does such an increment imply a role for ethylene in the ripening of these non-climacteric fruits? J Exp Bot 2005; 56:2037-46; PMID:15955790; http://dx.doi.org/10.1093/jxb/eri202
154. Barry CS, Giovannoni JJ. Ripening in the tomato Green-ripe mutant is inhibited by ectopic expression of a protein that disrupts ethylene signaling. Proc Natl Acad Sci U S A 2006; 103:7923-8; PMID:16682641; http://dx.doi.org/10.1073/pnas.0602319103
155. Klee H. Highly conserved proteins that modify plant ethylene responses. Proc Natl Acad Sci U S A 2006; 103:7537-8; PMID:16682619; http://dx.doi.org/10.1073/pnas.0602599103
156. Osorio S, Alba R, Damascenob CMB, Lopez-Casado G. Marc, Lohse, Zanorc MI, Tohge T, Usadel B, Rose JKC, Fei Z, Giovannoni JJ, Fernie AR. Systems biology of tomato fruit development: combined transcript, protein and metabolite analysi s of tomato transcription factor (nor,rin) and ethylene receptor (Nr) mutants reveals novel regulatory interactions. Plant Physiol 2011; 157; PMID:21795583; http://dx.doi.org/10.1104/pp.111.175463
157. Klee HJ. Ethylene signal transduction. Moving beyond Arabidopsis. Plant Physiol 2004; 135:660-7; PMID: 15208412; http://dx.doi.org/10.1104/pp.104.040998
158. Wilkinson JQ, Lanahan MB, Yen HC, Giovannoni JJ, Klee HJ. An ethylene-inducible component of signal transduction encoded by never-ripe. Science 1995; 270:1807-9; PMID:8525371; http://dx.doi.org/10.1126/science.270.5243.1807
159. Zhou D, Mattoo A, Tucker M. Molecular cloning of a tomato cDNA encoding an ethylene receptor. Plant Physiol 1996. a110:1435-6.
160. Zhou D, Kalaitzís P, Mattoo AK, Tucker ML. The mRNA for an ETR1 homologue in tomato is constitutively expressed in vegetative and reproductive tissues. Plant Mol Biol 1996. b30:1331-8; PMID: 8704141; http://dx.doi.org/10.1007/BF00019564
161. Tieman DM, Klee HJ. Differential expression of two novel members of the tomato ethylene-receptor family. Plant Physiol 1999; 120:165-72; PMID:10318694; http://dx.doi.org/10.1104/pp.120.1.165
162. Klee H, Tieman D. The tomato ethylene receptor gene family: Form and function. Physiol Plant 2002; 115:336-41; PMID:12081525; http://dx.doi.org/10.1034/j.1399-3054.2002.1150302.x
163. Lanahan MB, Yen HC, Giovannoni JJ, Klee HJ. The never ripe mutation blocks ethylene perception in tomato. Plant Cell 1994; 6:521-30; PMID:8205003
164. Tucker GA, Schindler CB, Roberts JA. Flower abscission in mutant tomato plants. Planta 1984; 160:164-7; http://dx.doi.org/10.1007/BF00392865
165. Payton S, Fray RG, Brown S, Grierson D. Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission. Plant Mol Biol 1996; 31: 1227-31.
166. Ciardi JA, Tieman DM, Lund ST, Jones JB, Stall RE, Klee HJ. Response to Xanthomonas campestris pv. vesicatoria in tomato involves regulation of ethylene receptor gene expression. Plant Physiol 2000; 123:81-92; PMID:10806227; http://dx.doi.org/10.1104/pp.123.1.81
167. Tieman DM, Taylor MG, Ciardi JA, Klee HJ. The tomato ethylene receptors NR and LeETR4 are negative regulators of ethylene response and exhibit functional compensation within a multigene family. Proc Natl Acad Sci U S A 2000; 97:5663-8; PMID: 10792050; http://dx.doi.org/10.1073/pnas.090550597
168. Gallie DR. Regulated ethylene insensitivity through the inducible expression of the Arabidopsis etr1-1 mutant ethylene receptor in tomato. Plant Physiol 2010; 152:1928-39; PMID:20181754; http://dx.doi.org/10.1104/pp.109.151688
169. Kevany BM, Tieman DM, Taylor MG, Cin VD, Klee HJ. Ethylene receptor degradation controls the timing of ripening in tomato fruit. Plant J 2007; 51:458-67; PMID:17655616; http://dx.doi.org/10.1111/j.1365-313X.2007.03170.x
170. Wang W, Hall AE, O'Malley R, Bleecker AB. Canonical histidine kinase activity of the transmitter domain of the ETR1 ethylene receptor from Arabidopsis is not required for signal transmission. Proc Natl Acad Sci U S A 2003; 100:352-7; PMID:12509505; http://dx.doi.org/10.1073/pnas.0237085100
171. Kevany BM, Taylor MG, Klee HJ. Fruit-specific suppression of the ethylene receptor LeETR4 results in early-ripening tomato fruit. Plant Biotechnol J 2008; 6:295-300; PMID:18086233; http://dx.doi.org/10.1111/j.1467-7652.2007.00319.x
172. Hackett RM, Ho CW, Lin Z, Foote HC, Fray RG, Grierson D. Antisense inhibition of the Nr gene restores normal ripening to the tomato Never-ripe mutant, consistent with the ethylene receptor-inhibition model. Plant Physiol 2000; 124: 1079-86.
173. Ciardi JA, Tieman DM, Jones JB, Klee HJ. Reduced expression of the tomato ethylene receptor gene LeETR4 enhances the hypersensitive response to Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact 2001; 14:487-95; PMID:11310736; http://dx.doi.org/10.1094/MPMI.2001.14.4.487
174. Zhu H, Zhu B, Shao Y, Wang X, Lin X, Xie Y, et al. Tomato fruit development and ripening are altered by the silencing of LeEIN2 gene. J Integr Plant Biol 2006; 48:1478-85; http://dx.doi.org/10.1111/j.1744-7909.2006.00366.x
175. Chen G, Alexander L, Grierson D. Constitutive expression of EIL-like transcription factor partially restores ripening in the ethylene-insensitive Nr tomato mutant. J Exp Bot 2004; 55:1491-7; PMID: 15181103; http://dx.doi.org/10.1093/jxb/erh168
176. Whitelaw CA, Lyssenko NN, Chen L, Zhou D, Mattoo AK, Tucker ML. Delayed abscission and shorter Internodes correlate with a reduction in the ethylene receptor LeETR1 transcript in transgenic tomato. Plant Physiol 2002; 128:978-87; PMID: 11891253; http://dx.doi.org/10.1104/pp.010782
177. Shaw JF, Chen HH, Tsai MF, Kuo CI, Huang LC. Extended flower longevity of Petunia hybrida plants transformed with boers, a mutated ERS gene of Brassica oleracea. Mol Breed 2002; 9:211-6; http://dx.doi.org/10.1023/A:1019703627019