New molecular insights into CETP structure and function: A review

Journal of Lipid Research

Volumn 53, Issue 8, 2012, Pages 1451-1458

  Charles, M Arthur ^a   Kane, John P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Functional domains of CETP; Lipid transfer biology; Lipid transfer tunnel hypothesis; Molecular biology of CETP

Indexed keywords

AMINO ACID; APOLIPOPROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPHORIN; LIPOPHORIN III; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CARDIOVASCULAR DISEASE; HUMAN; LIPID MEMBRANE; LIPID METABOLISM; LIPID TRANSPORT; LIPOID PROTEINOSIS; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW; STRUCTURE ANALYSIS; THERMODYNAMICS;

CHOLESTEROL ESTER TRANSFER PROTEINS; HUMANS; LIPID METABOLISM; LIPOPROTEINS, HDL; MOVEMENT; SUBSTRATE SPECIFICITY;

EID: 84863795885     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R027011     Document Type: Review

References (54)

1. Qiu, X., A. Mistry, M. J. Ammirati, B. A. Chrunyk, R. W. Clark, Y. Cong, J. S. Culp, D. E. Danley, T. B. Freeman, K. F. Geoghegan, et al. 2007. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat. Struct. Mol. Biol. 14: 106-113.
2. Zhang, L., F. Yan, S. Zhang, D. Lei, M. A. Charles, G. Cavigiollo, M. Oda, R. M. Krauss, K. H. Weisgraber, K. A. Rye, et al. 2012. Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein. Nat. Chem. Biol. 8: 342-349.
3. Deckelbaum, R. J., S. Eisenberg, Y. Oschry, E. Butbul, I. Sharon, and T. Olivecrona. 1982. Reversible modification of human plasma low density lipoproteins toward triglyceride-rich precursors. J. Biol. Chem. 257: 6509-6517. (Pubitemid 12059945)
4. Chapman, M. J., W. Le Goff, M. Guerin, and A. Kontush. 2010. Cholesteryl ester transfer protein: at the heart of action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors. Eur. Heart J. 31: 149-164.
5. Xiao, C., T. Watanabe, Y. Zhang, B. Trigatti, L. Szeto, P. W. Connelly, S. Marcovina, T. Vaisar, J. W. Heinecke, and G. F. Lewis. 2008. Enhanced cellular uptake of remnant high-density lipoprotein particles. Circ. Res. 103: 159-166.
6. Packard, C. J., and J. Shepard. 1997. Lipoprotein heterogeneity and apolipoprotein B metabolism. Arterioscler. Thromb. Vasc. Biol. 17: 3542-3556. (Pubitemid 28028567)
7. Berneis, K. K., and R. M. Krauss. 2002. Metabolic origins and clinical significance of LDL heterogeneity. J. Lipid Res. 43: 1363-1379.
8. Chen, G. C., W. Liu, P. Duchateau, J. Allaart, R. L. Hamilton, D. M. Mendel, K. Lau, D. A. Hardman, P. H. Frost, M. J. Malloy, et al. 1994. Conformational differences in human apolipoprotein B-100 among subspecies of low-density lipoproteins. J. Biol. Chem. 269: 29121-29128.
9. Griffin, B. A., D. J. Freeman, G. W. Tait, J. Thomson, M. J. Caslake, C. J. Packard, and J. Shepherd. 1994. Role of plasma triglyceride in the regulation of plasma low-density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk. Atherosclerosis. 106: 241-253. (Pubitemid 24188766)
10. Van, J., J. Pan, M. A. Charles, R. Krauss, N. Wong, and X. Wu. 2007. Atherogenic lipid phenotype in a general group of subjects. Arch. Pathol. Lab. Med. 131: 1679-1685. (Pubitemid 350077465)
11. Serdyuk, A. P., and R. E. Morton. 1999. Lipid transfer inhibitor protein defines the participation of lipoproteins in lipid transfer reactions. Arterioscler. Thromb. Vasc. Biol. 19: 718-726.
12. Morton, R. E., and D. J. Greene. 2007. Partial suppression of CETP activity beneficially modifies the lipid transfer profile of plasma. Atherosclerosis. 192: 100-107. (Pubitemid 46628808)
13. Stensvold, I., P. Urdal, H. Thurmer, A. Tverdal, P. J. Lund-Larson, and O. P. Foss. 1992. High-density lipoprotein cholesterol and coronary, cardiovascular and all cause mortality among middle-aged Norwegian men and women. Eur. Heart J. 13: 1155-1163.
14. van der Steeg, W. A., I. Holme, S. M. Boekholdt, M. L. Larsen, C. Lindahl, E. S. G. Stroes, M. J. Tikkanen, N. J. Wareham, O. Faergeman, A. G. Olsson, et al. 2008. High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-1: significance for cardiovascular risk, the IDEAL and EPIC-Norfolk studies. J. Am. Coll. Cardiol. 51: 634-642. (Pubitemid 351186873)
15. Barter, P. J., M. Caulfield, M. Eriksson, S. M. Grundy, J. J. P. Kastelein, M. Komajda, J. Lopez-Sendon, L. Mosca, J. C. Tardif, D. D. Waters, et al. 2007. Effects of torcetrapib in patients at high risk for coronary events. N. Engl. J. Med. 357: 2109-2122. (Pubitemid 350146106)
16. Thompson, P. A., J. F. P. Berbee, P. C. N. Rensen, and R. L. Kitchens. 2008. Apolipoprotein A-II augments monocyte responses to LPS by suppressing the inhibitory activity of LPS-binding protein. Innate Immun. 14: 365-374.
17. Niesor, E. J. 2011. Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism. Curr. Opin. Lipidol. 22: 288-295.
18. Vasan, R. S., M. J. Pencina, S. J. Robins, J. P. Zachariah, G. Kaur, R. B. D'Agostino, and J. M. Ordovas. 2009. Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation. 120: 2414-2420.
19. Barter, P. J., and K. A. Rye. Cholesteryl ester transfer protein (CETP) inhibition as a strategy to reduce cardiovascular risk. J. Lipid Res. Epub ahead of print. May 1, 2012; doi: 10.1194/jlr.R024075.
20. Rye, K. A., and P. J. Barter. 2012. The inhibition of cholesteryl ester transfer protein: a long and winding road. J. Lipid Res. 53: 1039-1041.
21. Hall, J., and X. Qiu. 2011. Structural and biophysical insight into cholesteryl ester-transfer protein. Biochem. Soc. Trans. 39: 1000-1005.
22. Wang, S., L. Deng, M. L. Brown, L. B. Agellon, and A. R. Tall. 1991. Structure-function studies of human cholesteryl ester transfer protein by linker insertion scanning mutagenesis. Biochemistry. 30: 3484-3490.
23. Weers, P. M. M., and R. O. Ryan. 2006. Apolipophorin III: role model apolipoprotein. Insect Biochem. Mol. Biol. 36: 231-240.
24. Weers, P. M. M., V. Narayanaswami, C. M. Kay, and R. O. Ryan. 1999. Interaction of an exchangeable apolipoprotein with phospholipid vesicles and lipoprotein particles. J. Biol. Chem. 274: 21804-21810.
25. Narayanaswami, V., J. Wang, D. Schieve, C. M. Kay, and R. O. Ryan. 1999. A molecular trigger of lipid binding-induced opening of a helix bundle exchangeable apolipoprotein. Proc. Natl. Acad. Sci. USA. 96: 4366-4371. (Pubitemid 29190342)
26. Soulages, J. L., Z. Salamon, M. A. Wells, and G. Tollin. 1995. Low concentrations of diacylglycerol promote the binding of apolipophorin III to a phospholipid bilayer: a surface plasmon resonance spectroscopic study. Proc. Natl. Acad. Sci. USA. 92: 5650-5654.
27. Swenson, T. L., R. W. Brocia, and A. R. Tall. 1988. Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phophpolipids. J. Biol. Chem. 263: 5150-5157.
28. Morton, R. E., and D. J. Greene. 2003. The surface cholesteryl ester content of donor and acceptor particles regulates CETP: a liposome-based approach to assess the substrate properties of lipoproteins. J. Lipid Res. 44: 1364-1372. (Pubitemid 37279618)
29. Wang, S., P. Kussie, L. Deng, and A. Tall. 1995. Defective binding of neutral lipids in a carboxyl-terminal deletion mutant of cholesteryl ester transfer protein. J. Biol. Chem. 270: 612-618.
30. Au-Young, J., and C. J. Fielding. 1992. Synthesis and secretion of wild-type and mutant human plasma cholesteryl ester transfer protein in baculovirus-transfected insect cells: the carboxyl-terminal region is required for both lipoprotein binding and catalysis of transfer. Proc. Natl. Acad. Sci. USA. 89: 4094-4098.
31. Wang, S., X. Wang, S. Deng, E. Rassart, R. W. Milne, and A. R. Tall. 1993. Point mutagenesis of carboxyl-terminal amino acids of cholesteryl ester transfer protein. J. Biol. Chem. 268: 1955-1959.
32. Pattnaik, N. M., and D. B. Zilversmit. 1979. Interaction of cholesteryl ester exchange protein with human plasma lipoproteins and phospholipid vesicles. J. Biol. Chem. 254: 2782-2786. (Pubitemid 9196111)
33. Morton, R. E. 1985. Binding of plasma-derived lipid transfer protein to lipoprotein substrates. J. Biol. Chem. 260: 12593-12599.
34. Chen, G. C., M. Krieger, J. P. Kane, C. C. Wu, M. S. Brown, and J. L. Goldstein. 1980. Beta-carotene as a probe of lipid domains of reconstituted human plasma Low-density lipoprotein: induced circular dichroism. Biochemistry. 19: 4706-4712. (Pubitemid 11193993)
35. Ren, G., G. Rudenko, S. J. Ludtke, J. Deisenhofer, W. Chiu, and H. J. Pownall. 2010. Model of human low-density lipoprotein and bound receptor based on Cryo EM. Proc. Natl. Acad. Sci. USA. 107: 1059-1064.
36. Morton, R. E., and D. J. Greene. 2003. CETP and lipid transfer inhibitor protein are uniquely affected by the negative charge density of the lipid and protein domains of LDL. J. Lipid Res. 44: 2287-2296. (Pubitemid 38082487)
37. Marcel, Y. L., R. McPherson, M. Hogue, H. Czetnecka, Z. Zawadzki, P. K. Weech, M. E. Whitlock, A. R. Tall, and R. W. Milne. 1990. Distribution and concentration of cholesteryl ester transfer protein in plasma of normolipemic subjects. J. Clin. Invest. 85: 10-17. (Pubitemid 20030284)
38. Francone, O. L., A. Gurakar, and C. Fielding. 1989. Distribution and functions of lecithin:cholesterol acyl-transferase and cholesteryl ester transfer protein in plasma lipoproteins. J. Biol. Chem. 264: 7066-7072.
39. Bruce, C., W. S. Davidson, P. Kussie, S. Lund-Katz, M. C. Phillips, R. Ghosh, and A. R. Tall. 1995. Molecular determinants of plasma cholesteryl ester transfer protein binding to high-density lipoproteins. J. Biol. Chem. 270: 11532-11542.
40. Morton, R. E., and D. B. Zilversmit. 1982. Purification and characterization of lipid transfer proteins from human lipoprotein-deficient plasma. J. Lipid Res. 23: 1058-1067. (Pubitemid 13207271)
41. Nishida, H. I., H. Arai, and T. Nishida. 1993. Cholesterol ester transfer mediated by lipid transfer protein as influenced by changes in the charge characteristics of plasma lipoproteins. J. Biol. Chem. 268: 16352-16360. (Pubitemid 23229938)
42. Jeyarajah, E. J., W. C. Cromwell, and J. D. Otvos. 2006. Lipoprotein particle analysis by nuclear magnetic resonance spectroscopy. Clin. Lab. Med. 26: 847-870. (Pubitemid 44716510)
43. Morton, R. E., and D. J. Greene. 1994. Regulation of lipid transfer between lipoproteins by an endogenous plasma protein: selective inhibition among lipoprotein classes. J. Lipid Res. 35: 836-847. (Pubitemid 24157235)
44. Gautier, T., D. Masson, J. P. de Barros, A. Athias, P. Gambert, M. H. Metz-Boutique, and L. Lagrost. 2000. Human apolipoprotein accounts for the ability of plasma high- density lipoprotein's to inhibit the cholesteryl ester transfer protein activity. J. Biol. Chem. 275: 37504-37509. (Pubitemid 32004858)
45. Gautier, T., D. Masson, M. C. Jong, L. Duverneuil, N. L. Guern, V. Deckert, J. P. de Barros, L. Dumont, A. Bataille, Z. Zak, et al. 2002. Apolipoprotein CI deficiency markedly augments plasma lipoprotein changes mediated by human cholesteryl ester transfer protein (CETP) in CETP transgenic/apoCI- knocked out mice. J. Biol. Chem. 277: 31354-31363. (Pubitemid 34968934)
46. Barter, P. J., and M. E. Jones. 1980. Kinetic studies of the transfer of esterified cholesterol between human plasma low and high density lipoproteins. J. Lipid Res. 21: 238-249. (Pubitemid 10115826)
47. Ihm, J., D. M. Quinn, S. J. Busch, B. Chataing, and J. A. K. Harmony. 1982. Kinetics of plasma protein-catalyzed exchange of phosphatidylcholine and cholesteryl ester between plasma lipoproteins. J. Lipid Res. 23: 1328-1341. (Pubitemid 13165987)
48. Rye, K. A., and P. J. Barter. 1994. The influence of apolipoproteins on the structure and function of spheroidal, reconstituted, high density lipoproteins. J. Biol. Chem. 269: 10298-10303.
49. Barter, P. J., J. I. Lally, and D. Wattchow. 1979. Metabolism of triglyceride in rabbit plasma low and high density lipoproteins: studies in vivo and in vitro. Metabolism. 28: 614-618. (Pubitemid 9187441)
50. Morton, R. E., and D. B. Zilversmit. 1981. A plasma inhibitor of triglyceride and cholesteryl ester transfer activities. J. Biol. Chem. 256: 11992-11995. (Pubitemid 12139992)
51. Liang, H. Q., K. A. Rye, and P. J. Barter. 1994. Dissociation of lipid-free apolipoprotein A-1 from high density lipoproteins. J. Lipid Res. 35: 1187-1199.
52. Mehta, R., D. L. Gantz, and O. Gursky. 2003. Human plasma high-density lipoproteins are stabilized by kinetic factors. J. Mol. Biol. 328: 183-192. (Pubitemid 36390290)
53. Han, M., B. K. Gillard, H. S. Courtney, K. Ward, C. Rosales, H. Khant, S. J. Ludtke, and H. J. Pownall. 2009. Disruption of human plasma high-density lipoproteins by streptococcal serum opacity factor requires labile apolipoprotein A-I. Biochemistry. 48: 1481-1487.
54. Pownall, H. J., and C. Ehnholm. 2006. The unique role of apolipoprotein A-I in HDL remodeling and metabolism. Curr. Opin. Lipidol. 17: 209-213. (Pubitemid 43786052)