CETP and lipid transfer inhibitor protein are uniquely affected by the negative charge density of the lipid and protein domains of LDL

Journal of Lipid Research

Volumn 44, Issue 12, 2003, Pages 2287-2296

  Morton, Richard E ^a   Greene, Diane J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Binding kinetics; Cholesteryl ester transfer protein; Surface charge

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; INHIBITOR PROTEIN; LIPID TRANSFER INHIBITOR PROTEIN; LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CONTROLLED STUDY; ELECTRIC POTENTIAL; HUMAN; LIPID TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN;

CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; ELECTROSTATICS; GLYCOPROTEINS; HUMANS; KINETICS; LIPOPROTEINS, HDL; PROTEIN STRUCTURE, TERTIARY;

EID: 0345832335     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300171-JLR200     Document Type: Article

References (56)

1. Morton, R. E. 1990. Interaction of lipid transfer protein with plasma lipoproteins and cell membranes. Experientia. 46: 552-560.
2. Tall, A. 1995. Plasma lipid transfer proteins. Annu. Rev. Biochem. 64: 235-257.
3. Deckelbaum, R. J., S. Eisenberg, Y. Oschry, E. Granot, I. Sharon, and G. Bengtsson-Olivecrona. 1986. Conversion of human plasma high density lipoprotein-2 to high density lipoprotein-3: roles of neutral lipid exchange and triglyceride lipases. J. Biol. Chem. 261: 5201-5208.
4. Deckelbaum, R. J., S. Eisenberg, Y. Oschry, and L. L. Rudel. 1988. Neutral lipid transfer and lipolysis convert high molecular weight LDL from cholesterol-fed nonhuman primates towards normal: a molecular analysis. Biochim. Biophys. Acta. 961: 223-233.
5. Tall, A. R. 1993. Plasma cholesteryl ester transfer protein. J. Lipid Res. 34: 1255-1274.
6. Skeggs, J. W., and R. E. Morton. 2002. LDL and HDL enriched in triglyceride promote abnormal cholesterol transport. J. Lipid Res. 43: 1264-1274.
7. Weinberg, R. B., V. R. Cook, J. B. Jones, P. Kussie, and A. R. Tall. 1994. Interfacial properties of recombinant human cholesterol ester transfer protein. J. Biol. Chem. 269: 29588-29591.
8. Wang, S., P. Kussie, L. Deng, and A. Tall. 1995. Defective binding of neutral lipids by a carboxyl-terminal deletion mutant of cholesteryl ester transfer protein. Evidence for a carboxyl-terminal cholesteryl ester binding site essential for neutral lipid transfer activity. J. Biol. Chem. 270: 612-618.
9. Epps, D. E., K. A. Greenlee, J. S. Harris, E. W. Thomas, C. K. Castle, J. F. Fisher, R. R. Hozak, C. K. Marschke, G. W. Melchior, and F. J. Kézdy. 1995. Kinetics and inhibition of lipid exchange catalyzed by plasma cholesteryl ester transfer protein (lipid transfer protein). Biochemistry. 34: 12560-12569.
10. Connolly, D. T., J. McIntyre, D. Heuvelman, E. E. Remsen, R. E. McKinnie, L. Vu, M. Melton, R. Monsell, E. S. Krul, and K. Glenn. 1996. Physical and kinetic characterization of recombinant human cholesteryl ester transfer protein. Biochem. J. 320: 39-47.
11. Morton, R. E. 1985. Binding of plasma-derived lipid transfer protein to lipoprotein substrates: the role of binding in the lipid transfer process. J. Biol. Chem. 260: 12593-12599.
12. Pattnaik, N. M., and D. B. Zilversmit. 1979. Interaction of cholesteryl ester exchange protein with human plasma lipoproteins and phospholipid vesicles. J. Biol. Chem. 254: 2782-2786.
13. Wang, S., L. Deng, M. L. Brown, L. B. Agellon, and A. R. Tall. 1991. Structure-function studies of human cholesteryl ester transfer protein by linker insertion scanning mutagenesis. Biochemistry. 30: 3484-3490.
14. Morton, R. E., and J. V. Steinbrunner. 1990. Concentration of neutral lipids in the phospholipid surface of substrate particles determines lipid transfer protein activity. J. Lipid Res. 31: 1559-1567.
15. Morton, R. E., and D. J. Greene. 2003. The surface cholesteryl ester content of donor and acceptor particles regulates CETP: a liposome-based approach to assess the substrate properties of lipoproteins. J. Lipid Res. 44: 1364-1372.
16. Wang, X., D. M. Driscoll, and R. E. Morton. 1999. Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F. J. Biol. Chem. 274: 1814-1820.
17. Morton, R. E., and D. J. Greene. 1994. Regulation of lipid transfer between lipoproteins by an endogenous plasma protein: selective inhibition among lipoprotein classes. J. Lipid Res. 35: 836-847.
18. Serdyuk, A. P., and R. E. Morton. 1999. Lipid transfer inhibitor protein defines the participation of lipoproteins in lipid transfer reactions: CETP has no preference for cholesteryl esters in HDL versus LDL. Arterioscler. Thromb. Vasc. Biol. 19: 718-726.
19. Sammett, D., and A. R. Tall. 1985. Mechanisms of enhancement of cholesteryl ester transfer protein activity by lipolysis. J. Biol. Chem. 260: 6687-6697.
20. Tall, A., D. Sammett, and E. Granot. 1986. Mechanisms of enhanced cholesteryl ester transfer from high density lipoproteins to apolipoprotein B-containing lipoproteins during alimentary lipemia. J. Clin. Invest. 77: 1163-1172.
21. Lagrost, L., and P. J. Barter. 1991. Effects of various non-esterified fatty acids on the particle size redistribution of high density lipoproteins induced by the human cholesteryl ester transfer protein. Biochim. Biophys. Acta. 1082: 204-210.
22. Nishida, H. I., H. Arai, and T. Nishida. 1993. Cholesterol ester transfer mediated by lipid transfer protein as influenced by changes in the charge characteristics of plasma lipoproteins. J. Biol. Chem. 268: 16352-16360.
23. Lagrost, L., E. Florentin, V. Guyard-Dangremont, A. Athias, H. Gandjini, C. Lallemant, and P. Gambert. 1995. Evidence for nonesterified fatty acids as modulators of neutral lipid transfers in normolipidemic human plasma. Arterioscler. Thromb. Vasc. Biol. 15: 1388-1396.
24. Masson, D., A. Athias, and L. Lagrost. 1996. Evidence for electronegativity of plasma high density lipoprotein-3 as one major determinant of human cholesteryl ester transfer protein activity. J. Lipid Res. 37: 1579-1590.
25. Rajaram, O. V., and W. H. Sawyer. 1997. Effects of charged lipids on the interaction of cholesteryl ester transfer protein with lipid microemulsions. Biochem. J. 322: 159-165.
26. Braschi, S., D. Masson, G. Rostoker, E. Florentin, A. Athias, C. Martin, B. Jacotot, P. Gambert, C. Lallemant, and L. Lagrost. 1997. Role of lipoprotein-bound NEFAs in enhancing the specific activity of plasma CETP in the nephrotic syndrome. Arterioscler. Thromb. Vasc. Biol. 17: 2559-2567.
27. Morton, R. E., and D. J. Greene. 1997. Suppression of lipid transfer inhibitor protein activity by oleate. A novel mechanism of cholesteryl ester transfer protein regulation by plasma free fatty acids. Artetioscler. Thromb. Vasc. Biol. 17: 3041-3048.
28. Sparks, D. L., and M. C. Phillips. 1992. Quantitative measurement of lipoprotein surface charge by agarose gel electrophoresis. J. Lipid Res. 33: 123-130.
29. Havel, R. J., H. A. Eder, and J. H. Bragdon. 1955. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1345-1353.
30. Peterson, G. L. 1977. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83: 346-356.
31. Bartlett, G. R. 1959. Phosphorus assay in column chromatography. J. Biol. Chem. 234: 466-468.
32. Morton, R. E., and D. J. Greene. 2000. The capacity of various non-esterified fatty acids to suppress lipid transfer inhibitor protein activity is related to their perturbation of the lipoprotein surface. Biochim. Biophys. Acta. 1486: 275-284.
33. Fraenkal-Conrat, H. 1957. Methods for investigating the essential groups for enzyme activity. Methods Enzymol. 4: 247-269.
34. Fields, R. 1972. The rapid determination of amino groups with TNBS. Methods Enzymol. 25: 464-468.
35. Hoff, H. F., T. E. Whitaker, and J. O'Neil. 1992. Oxidation of low density lipoprotein leads to particle aggregation and altered macrophage recognition. J. Biol. Chem. 267: 602-609.
36. Morton, R. E., and D. J. Greene. 1994. Enhanced detection of lipid transfer inhibitor protein activity by an assay involving only low density lipoprotein. J. Lipid Res. 35: 2094-2099.
37. Morton, R. E., and D. B. Zilversmit. 1981. A plasma inhibitor of triglyceride and cholesteryl ester transfer activities. J. Biol. Chem. 256: 11992-11995.
38. Burstein, M., H. R. Scholnick, and R. Morfin. 1970. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11: 583-595.
39. Morton, R. E., and D. B. Zilversmit. 1982. Purification and characterization of lipid transfer protein(s) from human lipoprotein-deficient plasma. J. Lipid Res. 23: 1058-1067.
40. Serdyuk, A. P., and R. E. Morton. 1997. Lipid transfer inhibitor protein activity deficiency in normolipidernic uremic patients on continuous ambulatory peritoneal dialysis. Arterioscler. Thromb. Vasc. Biol. 17: 1716-1724.
41. Kato, H., T. Nakanishi, H. Arai, H. I. Nishida, and T. Nishida. 1989. Purification, microheterogeneity, and stability of human lipid transfer protein. J. Biol. Chem. 264: 4082-4087.
42. Pattnaik, N. M., A. Montes, L. B. Hughes, and D. B. Zilversmit. 1978. Cholesteryl ester exchange protein in human plasma: isolation and characterization. Biochim. Biophys. Acta. 530: 428-438.
43. Morton, R. E., and D. B. Zilversmit. 1981. The separation of apolipoprotein D from cholesteryl ester transfer protein. Biochim. Biophys. Acta. 663: 350-355.
44. Ihm, J., J. L. Ellsworth, B. Chataing, and J. A. K. Harmony. 1982. Plasma protein-facilitated coupled exchange of phosphatidylcholine and cholesteryl ester in the absence of cholesterol esterification. J. Biol. Chem. 257: 4818-4827.
45. 3. J. Biol. Chem. 278: 40859-40866.
46. Foucher, C., L. Lagrost, V. Maupoil, M. Le Meste, L. Rochette, and P. Gambert. 1996. Alterations of lipoprotein fluidity by non-esterified fatty acids known to affect cholesteryl ester transfer protein activity. An electron spin resonance study. Eur. J. Biochem. 236: 436-442.
47. Lagrost, L. 1992. Differential effects of cis and trans fatty acid isomers, oleic and elaidic acids, on the cholesteryl ester transfer protein activity. Biochim. Biophys. Acta. 1124: 159-162.
48. Lagrost, L., and P. J. Barter. 1991. Effects of various non-esterified fatty acids on the transfer of cholesteryl esters from HDL to LDL induced by the cholesteryl ester transfer protein. Biochim. Biophys. Acta. 1085: 209-216.
49. Esterbauer, H., J. Gebicki, H. Puhl, and G. Jürgens. 1992. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13: 341-390.
50. Marcel, Y. L., R. McPherson, M. Hogue, H. Czarnecka, Z. Zawadzki, P. K. Weech, M. E. Whitlock, A. R. Tall, and R. W. Milne. 1990. Distribution and concentration of cholesteryl ester transfer protein in plasma of normolipemic subjects. J. Clin. Invest. 85: 10-17.
51. Jiang, X., C. Bruce, T. Cocke, S. Wang, M. Boguski, and A. R. Tall. 1995. Point mutagenesis of positively charged amino acids of cholesteryl ester transfer protein: conserved residues within the lipid transfer/lipopolysaccharide binding protein gene family essential for function. Biochemistry. 34: 7258-7263.
52. Benitez, S., J. L. Sanchez-Quesada, L. Lucero, R. Arcelus, V. Ribas, O. Jorba, A. Castellvi, E. Alonso, F. Blanco-Vaca, and J. Ordonez-Llanos. 2002. Changes in low-density lipoprotein electronegativity and oxidizability after aerobic exercise are related to the increase in associated non-esterified fatty acids. Atherosclerosis. 160: 223-232.
53. Skipski, V. P. 1972. Lipid composition of lipoproteins in normal and diseased states. In Blood Lipids and Lipoproteins: Quantitation, Composition, and Metabolism. G. J. Nelson, editor. Wiley-Interscience, New York. 471-583.
54. Pickart, L. 1983. Increased ratio of plasma free fatty acids to albumin during normal aging and in patients with coronary heart disease. Atherosclerosis. 46: 21-28.
55. Oliveira, H. C. F., L. M. Ma, R. Milne, S. M. Marcovina, A. Inazu, H. Mabuchi, and A. R. Tall. 1997. Cholesteryl ester transfer protein activity enhances plasma cholesterly ester formation. Studies in CETP transgenic mice and human genetic CETP deficiency. Arterioscler. Thromb. Vasc. Biol. 17: 1045-1052.
56. Chisohn, G. M., and D. Steinberg. 2000. The oxidative modification hypothesis of atherogenesis: an overview: Free Radic. Biol. Med. 28: 1815-1826.