Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein

Nature Chemical Biology

Volumn 8, Issue 4, 2012, Pages 342-349

  Zhang, Lei ^a,b,c   Yan, Feng ^b   Zhang, Shengli ^c   Lei, Dongsheng ^c   Charles, M Arthur ^b   Cavigiolio, Giorgio ^d   Oda, Michael ^d   Krauss, Ronald M ^d   Weisgraber, Karl H ^e   Rye, Kerry Anne ^f,g,h   Pownall, Henry J ⁱ   Qiu, Xiayang ^j   Ren, Gang ^a,b,c  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c XI'AN JIAOTONG UNIVERSITY   (China)

^d CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f HEART RESEARCH INSTITUTE   (Australia)

^g University of Sydney   (Australia)

^h UNIVERSITY OF MELBOURNE   (Australia)

ⁱ BAYLOR COLLEGE OF MEDICINE   (United States)

^j PFIZER INC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; HIGH DENSITY LIPOPROTEIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; TERNARY COMPLEX FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; ATHEROGENESIS; CARDIOVASCULAR DISEASE; DRUG DESIGN; ELECTRON MICROSCOPY; HUMAN; HYDROPHOBICITY; MOLECULAR DYNAMICS; POROSITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN TRANSPORT; SIMULATION; STRUCTURE ANALYSIS;

EID: 84862829189     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.796     Document Type: Article

References (41)

1. Barter, P.J. et al. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 23, 160-167 (2003). (Pubitemid 36231923)
2. Camejo, G., Waich, S., Quintero, G., Berrizbeitia, M.L. & Lalaguna, F. The affinity of low density lipoproteins for an arterial macromolecular complex. A study in ischemic heart disease and controls. Atherosclerosis 24, 341-354 (1976).
3. Gordon, T., Castelli, W.P., Hjortland, M.C., Kannel, W.B. & Dawber, T.R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 62, 707-714 (1977). (Pubitemid 8110784)
4. Hayek, T. et al. Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice. J. Clin. Invest. 92, 1143-1152 (1993). (Pubitemid 23273885)
5. Brown, M.L. et al. Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins. Nature 342, 448-451 (1989). (Pubitemid 19277523)
6. Inazu, A. et al. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N. Engl. J. Med. 323, 1234-1238 (1990). (Pubitemid 20366528)
7. Niesor, E.J. Different effects of compounds decreasing cholesteryl ester transfer protein activity on lipoprotein metabolism. Curr. Opin. Lipidol. 22, 288-295 (2011).
8. Miyares, M.A. Anacetrapib and dalcetrapib: two novel cholesteryl ester transfer protein inhibitors. Ann. Pharmacother. 45, 84-94 (2011).
9. Kappelle, P.J., van Tol, A., Wolffenbuttel, B.H. & Dullaart, R.P. Cholesteryl ester transfer protein inhibition in cardiovascular risk management: ongoing trials will end the confusion. Cardiovasc. Ther. 29, e89-e99 (2010).
10. Qiu, X. et al. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat. Struct. Mol. Biol. 14, 106-113 (2007).
11. Barter, P.J. & Jones, M.E. Kinetic studies of the transfer of esterified cholesterol between human plasma low and high density lipoproteins. J. Lipid Res. 21, 238-249 (1980). (Pubitemid 10115826)
12. Ihm, J., Quinn, D.M., Busch, S.J., Chataing, B. & Harmony, J.A. Kinetics of plasma protein-catalyzed exchange of phosphatidylcholine and cholesteryl ester between plasma lipoproteins. J. Lipid Res. 23, 1328-1341 (1982). (Pubitemid 13165987)
13. Tall, A.R. Plasma cholesteryl ester transfer protein. J. Lipid Res. 34, 1255-1274 (1993). (Pubitemid 23230305)
14. Zhang, L. et al. Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy. J. Lipid Res. 52, 175-184 (2011).
15. Chen, B. et al. Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Sci. 18, 921-935 (2009).
16. Silva, R.A. et al. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc. Natl. Acad. Sci. USA 105, 12176-12181 (2008).
17. Zhang, L. et al. An optimized negative-staining protocol of electron microscopy for apoE4-POPC lipoprotein. J. Lipid Res. 51, 1228-1236 (2010).
18. Ohi, M., Li, Y., Cheng, Y. & Walz, T. Negative staining and image classification - powerful tools in modern electron microscopy. Biol. Proced. Online 6, 23-34 (2004). (Pubitemid 38597695)
19. Ren, G., Reddy, V.S., Cheng, A., Melnyk, P. & Mitra, A.K. Visualization of a water-selective pore by electron crystallography in vitreous ice. Proc. Natl. Acad. Sci. USA 98, 1398-1403 (2001). (Pubitemid 32165510)
20. Ren, G., Cheng, A., Reddy, V., Melnyk, P. & Mitra, A.K. Three-dimensional fold of the human AQP1 water channel determined at 4 Å resolution by electron crystallography of two-dimensional crystals embedded in ice. J. Mol. Biol. 301, 369-387 (2000).
21. Ren, G. et al. Model of human low-density lipoprotein and bound receptor based on CryoEM. Proc. Natl. Acad. Sci. USA 107, 1059-1064 (2010).
22. Adrian, M., Dubochet, J., Fuller, S.D. & Harris, J.R. Cryo-negative staining. Micron 29, 145-160 (1998). (Pubitemid 28348505)
23. Hayat, M.A. & Miller, S.E. Negative Staining (McGraw-Hill, 1990).
24. Morton, R.E. & Greene, D.J. The surface cholesteryl ester content of donor and acceptor particles regulates CETP: a liposome-based approach to assess the substrate properties of lipoproteins. J. Lipid Res. 44, 1364-1372 (2003). (Pubitemid 37279618)
25. Swenson, T.L., Brocia, R.W. & Tall, A.R. Plasma cholesteryl ester transfer protein has binding sites for neutral lipids and phospholipids. J. Biol. Chem. 263, 5150-5157 (1988).
26. Pettersen, E.F. et al. UCSF Chimera-a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605-1612 (2004).
27. Liu, J., Bartesaghi, A., Borgnia, M.J., Sapiro, G. & Subramaniam, S. Molecular architecture of native HIV-1 gp120 trimers. Nature 455, 109-113 (2008).
28. Flemming, D., Thierbach, K., Stelter, P., Böttcher, B. & Hurt, E. Precise mapping of subunits in multiprotein complexes by a versatile electron microscopy label. Nat. Struct. Mol. Biol. 17, 775-778 (2010).
29. Phillips, J.C. et al. Scalable molecular dynamics with NAMD. J. Comput. Chem. 26, 1781-1802 (2005). (Pubitemid 43078511)
30. Atilgan, A.R. et al. Anisotropy of fluctuation dynamics of proteins with an elastic network model. Biophys. J. 80, 505-515 (2001).
31. Doruker, P., Atilgan, A.R. & Bahar, I. Dynamics of proteins predicted by molecular dynamics simulations and analytical approaches: application to α-amylase inhibitor. Proteins 40, 512-524 (2000). (Pubitemid 30624460)
32. Weers, P.M. & Ryan, R.O. Apolipophorin III: role model apolipoprotein. Insect Biochem. Mol. Biol. 36, 231-240 (2006).
33. Saito, H. et al. Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model. J. Biol. Chem. 278, 23227-23232 (2003). (Pubitemid 36830135)
34. Mehta, R., Gantz, D.L. & Gursky, O. Human plasma high-density lipoproteins are stabilized by kinetic factors. J. Mol. Biol. 328, 183-192 (2003). (Pubitemid 36390290)
35. Han, M. et al. Disruption of human plasma high-density lipoproteins by streptococcal serum opacity factor requires labile apolipoprotein A-I. Biochemistry 48, 1481-1487 (2009).
36. Wang, S., Kussie, P., Deng, L. & Tall, A. Defective binding of neutral lipids by a carboxyl-terminal deletion mutant of cholesteryl ester transfer protein. Evidence for a carboxyl-terminal cholesteryl ester binding site essential for neutral lipid transfer activity. J. Biol. Chem. 270, 612-618 (1995).
37. Grigorieff, N. FREALIGN: high-resolution refinement of single particle structures. J. Struct. Biol. 157, 117-125 (2007). (Pubitemid 44880784)
38. Frank, J. et al. SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J. Struct. Biol. 116, 190-199 (1996). (Pubitemid 26093143)
39. Ludtke, S.J., Baldwin, P.R. & Chiu, W. EMAN: semiautomated software for high-resolution single-particle reconstructions. J. Struct. Biol. 128, 82-97 (1999). (Pubitemid 30013436)
40. Galkin, V.E., Orlova, A., Cherepanova, O., Lebart, M.C. & Egelman, E.H. High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex. Proc. Natl. Acad. Sci. USA 105, 1494-1498 (2008). (Pubitemid 351346542)
41. Böttcher, B., Wynne, S.A. & Crowther, R.A. Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Nature 386, 88-91 (1997). (Pubitemid 27130926)