Partial suppression of CETP activity beneficially modifies the lipid transfer profile of plasma

Atherosclerosis

Volumn 192, Issue 1, 2007, Pages 100-107

  Morton, Richard E ^a   Greene, Diane J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Activity inhibition; Cholesterol esterification; Cholesteryl ester transfer protein; HDL; LDL; Lipoprotein remodeling

Indexed keywords

CHOLESTEROL ESTER; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; MONOCLONAL ANTIBODY; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CHOLESTEROL ESTERIFICATION; CONTROLLED STUDY; HUMAN; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPID TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANTIBODIES, BLOCKING; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CHOLESTEROL ESTER TRANSFER PROTEINS; ESTERIFICATION; HUMANS; LIPID METABOLISM; LIPOPROTEINS, HDL2; LIPOPROTEINS, HDL3; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MACROPHAGES; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; PLASMA;

EID: 34247391150     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.06.030     Document Type: Article

References (38)

1. Morton R.E. Interaction of lipid transfer protein with plasma lipoproteins and cell membranes. Experientia 46 (1990) 552-560
2. Tall A. Plasma lipid transfer proteins. Annu Rev Biochem 64 (1995) 235-257
3. Barter P.J., Brewer Jr. H.B., Chapman M.J., et al. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol 23 (2003) 160-167
4. Plump A.S., Masucci-Magoulas L., Bruce C., et al. Increased atherosclerosis in apoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler Thromb Vasc Biol 19 (1999) 1105-1110
5. Hayek T., Masucci-Magoulas L., Jiang X., et al. Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene. J Clin Invest 96 (1995) 2071-2074
6. Föger B., Chase M., Amar M.J., et al. Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice. J Biol Chem 274 (1999) 36912-36920
7. Zhong S.B., Sharp D.S., Grove J.S., et al. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J Clin Invest 97 (1996) 2917-2923
8. de Grooth G.J., Kuivenhoven J.A., Stalenhoef A.F., et al. Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study. Circulation 105 (2002) 2159-2165
9. Clark R.W., Sutfin T.A., Ruggeri R.B., et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol 24 (2004) 490-497
10. Brousseau M.E., Diffenderfer M.R., Millar J.S., et al. Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterioscler Thromb Vasc Biol 25 (2005) 1057-1064
11. Yamashita S., Hirano K., Sakai N., and Matsuzawa Y. Molecular biology and pathophysiological aspects of plasma cholesteryl ester transfer protein. Biochim Biophys Acta 1529 (2000) 257-275
12. Paromov V.M., and Morton R.E. Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesteryl ester transfer protein (CETP). J Biol Chem 278 (2003) 40859-40866
13. Morton R.E., and Zilversmit D.B. Purification and characterization of lipid transfer protein(s) from human lipoprotein-deficient plasma. J Lipid Res 23 (1982) 1058-1067
14. Morton R.E. Interaction of plasma-derived lipid transfer protein with macrophages in culture. J Lipid Res 29 (1988) 1367-1377
15. Morton R.E., and Steinbrunner J.V. Concentration of neutral lipids in the phospholipid surface of substrate particles determines lipid transfer protein activity. J Lipid Res 31 (1990) 1559-1567
16. Havel R.J., Eder H.A., and Bragdon J.H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 34 (1955) 1345-1353
17. Fraenkal-Conrat H. Methods for investigating the essential groups for enzyme activity. Meth Enzymol 4 (1957) 247-269
18. Pattnaik N.M., Montes A., Hughes L.B., and Zilversmit D.B. Cholesteryl ester exchange protein in human plasma: isolation and characterization. Biochim Biophys Acta 530 (1978) 428-438
19. Morton R.E., and Zilversmit D.B. The separation of apolipoprotein D from cholesteryl ester transfer protein. Biochim Biophys Acta 663 (1981) 350-355
20. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83 (1977) 346-356
21. Chen W., Silver D.L., Smith J.D., and Tall A.R. Scavenger receptor-BI inhibits ATP-binding cassette transporter 1-mediated cholesterol efflux in macrophages. J Biol Chem 275 (2000) 30794-30800
22. Stokke K.T., and Norum K.R. Determination of lecithin:cholesterol acyltransfer in human blood plasma. Scand J Clin Lab Invest 27 (1971) 21-27
23. Skeggs J.W., and Morton R.E. LDL and HDL enriched in triglyceride promote abnormal cholesterol transport. J Lipid Res 43 (2002) 1264-1274
24. Morton R.E., and Greene D.J. CETP and lipid transfer inhibitor protein are uniquely affected by the negative charge density of the lipid and protein domains of LDL. J Lipid Res 44 (2003) 2287-2296
25. Swenson T.L., Hesler C.B., Brown M.L., et al. Mechanism of cholesteryl ester transfer protein inhibition by a neutralizing monoclonal antibody and mapping of the monoclonal antibody epitope. J Biol Chem 264 (1989) 14318-14326
26. Clark R.W., Ruggeri R.B., Cunningham D., and Bamberger M.J. Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action. J Lipid Res 47 (2006) 537-552
27. Ishigami M., Yamashita S., Sakai N., et al. Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency cannot protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins. J Biochem (Tokyo) 116 (1994) 257-262
28. Ohta T., Nakamura R., Takata K., et al. Structural and functional differences of subspecies of apoA-I-containing lipoprotein in patients with plasma cholesteryl ester transfer protein deficiency. J Lipid Res 36 (1995) 696-704
29. Sakai N., Yamashita S., Hirano K.I., et al. Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency. Eur J Clin Invest 25 (1995) 332-339
30. Liu M., Bagdade J.D., and Subbaiah P.V. Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species. J Lipid Res 36 (1995) 1813-1824
31. Rudel L.L., Parks J.S., and Sawyer J.K. Compared with dietary monounsaturated and saturated fat, polyunsaturated fat protects African green monkeys from coronary artery atherosclerosis. Arterioscler Thromb Vasc Biol 15 (1995) 2101-2110
32. Hirano K., Yamashita S., and Matsuzawa Y. Pros and cons of inhibiting cholesteryl ester transfer protein. Curr Opin Lipidol 11 (2000) 589-596
33. Mann C.J., Yen F.T., Grant A.M., and Bihain B.E. Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. J Clin Invest 88 (1991) 2059-2066
34. Morton R.E. Binding of plasma-derived lipid transfer protein to lipoprotein substrates: the role of binding in the lipid transfer process. J Biol Chem 260 (1985) 12593-12599
35. Nishida H.I., Arai H., and Nishida T. Cholesterol ester transfer mediated by lipid transfer protein as influenced by changes in the charge characteristics of plasma lipoproteins. J Biol Chem 268 (1993) 16352-16360
36. Morton R.E., and Zilversmit D.B. A plasma inhibitor of triglyceride and cholesteryl ester transfer activities. J Biol Chem 256 (1981) 11992-11995
37. Yen F.T., Deckelbaum R.J., Mann C.J., et al. Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody. Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma. J Clin Invest 83 (1989) 2018-2024
38. Fielding C.J., and Fielding P.E. Regulation of human plasma lecithin:cholesterol acyltransferase activity by lipoprotein acceptor cholesteryl ester content. J Biol Chem 256 (1981) 2102-2104