Small interfering RNA-mediated downregulation of β-catenin inhibits invasion and migration of colon cancer cells in vitro

Medical Science Monitor

Volumn 18, Issue 7, 2012, Pages

  Han, Jianjun ^a   Gao, Binbin ^b   Jin, Xing ^b   Xu, Zhongfa ^a   Li, Zengjun ^a   Sun, Yanlai ^a   Song, Bao ^a  

^a SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Colon cancer; Invasion; Migration; RNA interference; catenin

Indexed keywords

BETA CATENIN; CD44V6 ANTIGEN; FIBRONECTIN; MATRILYSIN; SMALL INTERFERING RNA; UVOMORULIN;

ARTICLE; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL ADHESION; CELL INTERACTION; CELL INVASION; CELL JUNCTION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL TRANSFORMATION; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; MUTATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR GROWTH; WESTERN BLOTTING;

EID: 84863793663     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.883205     Document Type: Article

References (39)

1. Coyle-Rink J, Del Valle L, Sweet T et al: Developmental expression of Wnt signaling factors in mouse brain. Cancer Biol Ther, 2002; 1: 640-45
2. Streaker ED, Beckett D: The biotin regulatory system: kinetic control of a transcriptional switch. Biochemistry, 2006; 45: 6417-25
3. Xing Y, Takemaru K, Liu J et al: Crystal structure of a full-length bcatenin. Structure, 2008; 16: 478-87
4. Dixelius J, Cross MJ, Matsumoto T et al: Endostatin action and intracellular signaling: β-catenin as a potential target?. Cancer Lett, 2003; 196: 1-12
5. López-Knowles E, Zardawi SJ, McNeil CM et al: Cytoplasmic localization of β-catenin is a marker of poor outcome in breast cancer patients. Cancer Epidemiol Biomarkers Prev, 2010; 19: 301-9
6. Nelson WJ, Nusse R: Convergence of Wnt, β-catenin, and cadherin pathways. Science, 2004; 303: 1483-87
7. Jansson EA, Are A, Greicius G et al: The Wnt/β-catenin signaling pathway targets PPARg activity in colon cancer cells. Proc Natl Acad Sci USA, 2005; 102: 1460-65
8. Cheng XX, Wang ZC, Chen XY et al: Correlation of Wnt-2 expression and β-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination. Cancer Lett, 2005; 223: 339-47
9. He TC, Sparks AB, Rago C et al: Identification of c-MYC as a target of the APC pathway. Science, 1998; 281: 1509-12
10. Shtutman M, Zhurinsky J, Simcha I et al: The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc Natl Acad Sci USA, 1999; 96: 5522-27
11. Brabletz T, Jung A, Dag S et al: β-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol, 1999; 155: 1033-38
12. Wielenga VJ, Smits R, Korinek V et al: Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am J Pathol, 1999; 154: 515-23
13. Ge X, Wang X: Role of Wnt canonical pathway in hematological malignancies. J Hematol Oncol, 2010; 3: 33
14. Wong NA, Pignatelli M: The β-catenin a linchpin in colorectal carcinogenesis? Am J Pathol, 2002; 160: 389-401
15. Roh H, Green DW, Boswell CB et al: Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res, 2001; 61: 6563-68
16. Verma UN, Surabhi RM, Schmaltieg A et al: Small interfering RNAs directed against β-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clinical Cancer Res, 2003; 9: 1291-300
17. Faux MC, Ross JL, Meeker C et al: Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. J Cell Sci, 2004; 117: 427-39
18. Albini A, Iwamoto Y, Kleinman HK et al: A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res, 1987; 47: 3239-45
19. Vleminckx K, Vakaet L, Mareel M et al: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 1991; 66: 107-19
20. Romiti A, Zullo A, Borrini F et al: Relationship between β-catenin expression and epithelial cell proliferation in gastric mucosa with intestinal metaplasia. World J Gastroenterol, 2005; 11: 4400-3
21. Wang Y, Yang H, Liu H et al: Effect of staurosporine on the mobility and invasiveness of lung adenocarcinoma A549 cells: an in vitro study. BMC Cancer, 2009; 9: 174
22. Choi BR, Gwak J, Kwon HM et al: Oligodeoxyribozymes that cleave batenin messenger RNA inhibit growth of colon cancer cells via reduction of β-catenin response transcription. Mol Cancer Ther, 2010; 9: 1894-902
23. Dasgupta P, Rizwani W, Pillai S et al: Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer, 2009; 124: 36-45
24. Liotta LA: Tumor invasion and metastasis role of the extracellular matrix: Rhoads Memorial Award lecture. Cancer Res, 1986; 46: l-7
25. Yuan K, Singh R, Rezonzew G, Siegal G: In vitro matrices for studying tumor cell invasion. In: Wells A (ed.). Cell Motility in Cancer Invasion and Metastasis. Netherlands, Springer, 2006; 25-54
26. Su F, Li H, Yan C et al: Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cacer cells. J Cancer Res Clin Oncol, 2009; 135: 1655-63
27. Larkins TL, Nowell M, Singh S, Sanford GL: Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression. BMC Cancer, 2006; 6: 181
28. Luo GQ, Li JH, Wen JF et al: Effect and mechanism of the Twist gene on invasion and metastasis of gastric carcinoma cells. World J Gastroenterol, 2008; 14: 2487-93
29. Shiomi T, Okada Y: MT1-MMP and MMP-7 in invasion and metastasis of human cancers. Cancer Metastasis Rev, 2003; 22: 145-52
30. Xu Y, Yu Q: E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis. J Biol Chem, 2003; 278: 8661-68
31. Jawhari A, Farthing M, Pignatelli M: The importance of the E-cadherincatenin complex in the maintenance of intestinal epithelial homoeostasis: more than intercellular glue? Gut, 1997; 41: 581-84
32. Verras M, Sun Z: Roles and regulation of Wnt signaling and β-catenin in prostate cancer. Cancer Lett, 2006; 237: 22-32
33. Ponta H, Sherman L, Herrlich PA: CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol, 2003; 4: 33-45
34. Zhang JC, Wang ZR, Cheng YJ et al: Expression of proliferating cell nuclear antigen and CD44 variant exon 6 in primary tumors and corresponding lymph node metastases of colorectal carcinoma with Dukes' stage C or D. World J Gastroenterol, 2003; 9: 1482-86
35. Bellyei S, Schally AV, Zarandi M et al: GHRH antagonists reduce the invasive and metastatic potential of human cancer cell lines in vitro. Cancer Lett, 2010; 293: 31-40
36. Abécassis I, Olofsson B, Schmid M et al: RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion. Exp Cell Res, 2003; 291: 363-76
37. Coussens LM, Fingleton B, Matrisian LM: Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science, 2002; 295: 2387-92
38. Duffy MJ, Maguire TM, Hill A et al: Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res, 2000; 2: 252-57
39. Kioi M, Yamamoto K, Higashi S et al: Matrilysin (MMP-7) induces homotypic adhesion of human colon cancer cells and enhances their metastatic potential in nude mouse model. Oncogene, 2003; 22: 8662-70