A big new job for small GTPases

Small GTPases

Volumn 3, Issue 3, 2012, Pages 159-162

  Carmena, Ana ^a  

^a CSIC   (Spain)

Author keywords

Asymmetric cell division; Cell polarity; Ral; Rap1; Small GTPases

Indexed keywords

GUANOSINE TRIPHOSPHATASE; MEMBRANE PROTEIN; PROTEIN AXL2; PROTEIN BAZ; PROTEIN BUD10; PROTEIN CDC42; PROTEIN KIF3A; PROTEIN PAR3; PROTEIN PAR6; PROTEIN RGL; RAL PROTEIN; RAP1 PROTEIN; UNCLASSIFIED DRUG; DROSOPHILA PROTEIN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL POLARITY; CELL PROLIFERATION; CYTOSKELETON; ENZYME ANALYSIS; MICROTUBULE; MITOSIS SPINDLE; NERVE CELL; NEUROBLAST; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SECRETORY VESICLE; SIGNAL TRANSDUCTION; ANIMAL; CYTOLOGY; DROSOPHILA; HUMAN; METABOLISM; SACCHAROMYCES CEREVISIAE;

ANIMALS; CELL POLARITY; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; MONOMERIC GTP-BINDING PROTEINS; RAL GTP-BINDING PROTEINS; RAP1 GTP-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

EID: 84863790444     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.19631     Document Type: Article

References (39)

1. van Dam TJ, Bos JL, Snel B. Evolution of the Ras-like small GTPases and their regulators. Small Gtpases 2011; 2:4-16; PMID:21686276; http:// dx.doi.org/10.4161/sgtp.2.1.15113.
2. Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J Cell Sci 2005; 118:843-6; PMID:15731001; http://dx.doi.org/10.1242/ jcs.01660.
3. Gloerich M, Bos JL. Regulating Rap small G-proteins in time and space. Trends Cell Biol 2011; 21:615-23; PMID:21820312; http://dx.doi.org/10.1016/j. tcb.2011.07.001.
4. Neel NF, Martin TD, Stratford JK, Zand TP, Reiner DJ, Der CJ. The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery. Genes Cancer 2011; 2:275-87; PMID:21779498; http://dx.doi. org/10.1177/1947601911407329.
5. Mirey G, Balakireva M, L'Hoste S, Rossé C, Voegeling S, Camonis J. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras and Rap pathways. Mol Cell Biol 2003; 23:1112-24; PMID:12529414; http://dx.doi. org/10.1128/MCB.23.3.1112-24.2003.
6. Asha H, de Ruiter ND, Wang MG, Hariharan IK. The Rap1 GTPase functions as a regulator of morphogenesis in vivo. EMBO J 1999; 18:605-15; PMID:9927420; http://dx.doi.org/10.1093/ emboj/18.3.605.
7. Bos JL, de Rooij J, Reedquist KA. Rap1 signalling: adhering to new models. Nat Rev Mol Cell Biol 2001; 2:369-77; PMID:11331911; http://dx.doi. org/10.1038/35073073.
8. Caron E. Cellular functions of the Rap1 GTPbinding protein: a pattern emerges. J Cell Sci 2003; 116:435-40; PMID:12508104; http://dx.doi. org/10.1242/jcs.00238.
9. Knox AL, Brown NH. Rap1 GTPase regulation of adherens junction positioning and cell adhesion. Science 2002; 295:1285-8; PMID:11847339; http:// dx.doi.org/10.1126/science.1067549.
10. Kooistra MR, Dubé N, Bos JL. Rap1: a key regulator in cell-cell junction formation. J Cell Sci 2007; 120:17-22; PMID:17182900; http://dx.doi. org/10.1242/jcs.03306.
11. O'Keefe DD, Gonzalez-Niño E, Burnett M, Dylla L, Lambeth SM, Licon E, et al. Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila. Dev Biol 2009; 333:143-60; PMID:19576205; http://dx.doi.org/10.1016/j. ydbio.2009.06.032.
12. Price LS, Hajdo-Milasinovic A, Zhao J, Zwartkruis FJ, Collard JG, Bos JL. Rap1 regulates E-cadherinmediated cell-cell adhesion. J Biol Chem 2004; 279:35127-32; PMID:15166221; http://dx.doi. org/10.1074/jbc.M404917200.
13. Wang H, Singh SR, Zheng Z, Oh SW, Chen X, Edwards K, et al. Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev Cell 2006; 10:117-26; PMID:16399083; http://dx.doi.org/10.1016/j.devcel.2005.11.004.
14. Moskalenko S, Henry DO, Rosse C, Mirey G, Camonis JH, White MA. The exocyst is a Ral effector complex. Nat Cell Biol 2002; 4:66-72; PMID:11740492; http://dx.doi.org/10.1038/ ncb728.
15. González-García A, Pritchard CA, Paterson HF, Mavria G, Stamp G, Marshall CJ. RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell 2005; 7:219-26; PMID:15766660; http://dx.doi.org/10.1016/j.ccr.2005.01.029.
16. Balakireva M, Rossé C, Langevin J, Chien YC, Gho M, Gonzy-Treboul G, et al. The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol 2006; 26:8953-63; PMID:17000765; http:// dx.doi.org/10.1128/MCB.00506-06.
17. Ghiglione C, Devergne O, Cerezo D, Noselli S. Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles. EMBO Rep 2008; 9:676-82; PMID:18552769; http://dx.doi. org/10.1038/embor.2008.79.
18. Camonis JH, White MA. Ral GTPases: corrupting the exocyst in cancer cells. Trends Cell Biol 2005; 15:327-32; PMID:15953551; http://dx.doi. org/10.1016/j.tcb.2005.04.002.
19. Feig LA. Ral-GTPases: approaching their 15 minutes of fame. Trends Cell Biol 2003; 13:419-25; PMID:12888294; http://dx.doi.org/10.1016/S0962-8924(03)00152-1.
20. Doe CQ. Neural stem cells: balancing self-renewal with differentiation. Development 2008; 135:1575-87; PMID:18356248; http://dx.doi.org/10.1242/ dev.014977.
21. Knoblich JA. Mechanisms of asymmetric stem cell division. Cell 2008; 132:583-97; PMID:18295577; http://dx.doi.org/10.1016/j.cell.2008.02.007.
22. Siller KH, Doe CQ. Spindle orientation during asymmetric cell division. Nat Cell Biol 2009; 11:365-74; PMID:19337318; http://dx.doi.org/10.1038/ ncb0409-365.
23. Chia W, Somers WG, Wang H. Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization and tumorigenesis. J Cell Biol 2008; 180:267-72; PMID:18209103; http://dx.doi.org/10.1083/jcb.200708159.
24. Johnston CA, Hirono K, Prehoda KE, Doe CQ. Identification of an Aurora-A/PinsLINKER/ Dlg spindle orientation pathway using induced cell polarity in S2 cells. Cell 2009; 138:1150-63; PMID:19766567; http://dx.doi.org/10.1016/j. cell.2009.07.041.
25. Speicher S, Fischer A, Knoblich J, Carmena A. The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors. Curr Biol 2008; 18:831-7; PMID:18499457; http://dx.doi.org/10.1016/j.cub.2008.04.072.
26. Carmena A. Signaling networks during development: the case of asymmetric cell division in the Drosophila nervous system. Dev Biol 2008; 321:1-17; PMID:18586022; http://dx.doi.org/10.1016/j. ydbio.2008.06.010.
27. Carmena A, Makarova A, Speicher S. The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation. J Cell Biol 2011; 195:553-62; PMID:22084305; http://dx.doi. org/10.1083/jcb.201108112.
28. Boettner B, Harjes P, Ishimaru S, Heke M, Fan HQ, Qin Y, et al. The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo. Genetics 2003; 165:159-69; PMID:14504224.
29. Boettner B, Govek EE, Cross J, Van Aelst L. The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proc Natl Acad Sci USA 2000; 97:9064-9; PMID:10922060; http:// dx.doi.org/10.1073/pnas.97.16.9064.
30. Kuriyama M, Harada N, Kuroda S, Yamamoto T, Nakafuku M, Iwamatsu A, et al. Identification of AF-6 and canoe as putative targets for Ras. J Biol Chem 1996; 271:607-10; PMID:8557659; http:// dx.doi.org/10.1074/jbc.271.2.607.
31. Wee B, Johnston CA, Prehoda KE, Doe CQ. Canoe binds RanGTP to promote Pins(TPR)/ Mud-mediated spindle orientation. J Cell Biol 2011; 195:369-76; PMID:22024168; http://dx.doi. org/10.1083/jcb.201102130.
32. Gulli MP, Peter M. Temporal and spatial regulation of Rho-type guanine-nucleotide exchange factors: the yeast perspective. Genes Dev 2001; 15:365-79; PMID:11230144; http://dx.doi.org/10.1101/ gad.876901.
33. Kang PJ, Sanson A, Lee B, Park HOA. A GDP/ GTP exchange factor involved in linking a spatial landmark to cell polarity. Science 2001; 292:1376-8; PMID:11313501; http://dx.doi.org/10.1126/science. 1060360.
34. Nishimura T, Kato K, Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K. Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol 2004; 6:328-34; PMID:15048131; http://dx.doi. org/10.1038/ncb1118.
35. Schwamborn JC, Khazaei MR, Püschel AW. The interaction of mPar3 with the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. J Biol Chem 2007; 282:35259-68; PMID:17906294; http://dx.doi.org/10.1074/jbc.M703438200.
36. Schwamborn JC, Müller M, Becker AH, Püschel AW. Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. EMBO J 2007; 26:1410-22; PMID:17318188; http://dx.doi.org/10.1038/ sj.emboj.7601580.
37. Schwamborn JC, Püschel AW. The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat Neurosci 2004; 7:923-9; PMID:15286792; http://dx.doi.org/10.1038/ nn1295.
38. Cho B, Fischer JA. Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. Development 2011; 138:1349-59; PMID:21350007; http://dx.doi. org/10.1242/dev.056002.
39. Iden S, Collard JG. Crosstalk between small GTPases and polarity proteins in cell polarization. Nat Rev Mol Cell Biol 2008; 9:846-59; PMID:18946474; http://dx.doi.org/10.1038/nrm2521.