In vitro CpG methylation and garcinol reduce PERV LTR promoter activity

Genes and Genomics

Volumn 34, Issue 2, 2012, Pages 217-222

  Ha, Hong Seok ^a   Lee, Young Choon ^b   Park, Sang Je ^a   Jung, Yi Deun ^a   Ahn, Kung ^a   Moon, Jae Woo ^a   Han, Kyudong ^c   Oh, Keon Bong ^d   Kim, Tae Hun ^d   Seong, Hwan Hoo ^d   Kim, Heui Soo ^a  

^a Pusan National University   (South Korea)

^b Dong A University   (South Korea)

^c Dankook University   (South Korea)

^d National Institute of Animal Science   (South Korea)

Author keywords

CpG islands; DNA methylation; LTR; PERV; Sus scrofa

Indexed keywords

ACYLTRANSFERASE INHIBITOR; DINUCLEOTIDE; GARCINOL; HISTONE ACETYLTRANSFERASE; LUCIFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENDOGENOUS RETROVIRUS; IN VITRO STUDY; LONG TERMINAL REPEAT; NONHUMAN; NUCLEOTIDE SEQUENCE; PORCINE ENDOGENOUS RETROVIRUS; PROMOTER REGION; SWINE;

PORCINE ENDOGENOUS RETROVIRUS; SUIDAE; SUS SCROFA;

EID: 84863784117     PISSN: 19769571     EISSN: 20929293     Source Type: Journal    
DOI: 10.1007/s13258-011-0161-7     Document Type: Article

References (26)

1. Balasubramanyam K, Altaf M, Varier RA, Swaminathan V, Ravindran A, Sadhale PP and Kundu TK (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J. Biol. Chem. 279: 33716-33726. (Pubitemid 39063021)
2. Bird A (2007) Perceptions of epigenetics. Nature 447: 396-398.
3. Blusch JH, Patience C and Martin U (2002) Pig endogenous retroviruses and xenotransplantation. Xenotransplantation 9: 242-251. (Pubitemid 36358948)
4. Czauderna F, Fischer N, Boller K, Kurth R and Tönjes RR (2000) Establishment and characterization of molecular clones of porcine endogenous retroviruses replicating on human cells. J. Virol. 74: 4028-4038.
5. Dieckhoff B, Petersen B, Kues WA, Kurth R, Niemann H and Denner J (2008) Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs. Xenotransplantation 15: 36-45. (Pubitemid 351360240)
6. Ericsson T, Oldmixon B, Blomberg J, Rosa M, Patience C and Andersson G (2001) Identification of novel porcine endogenous betaretrovirus sequences in miniature swine. J. Virol. 75: 2765-2770. (Pubitemid 32185039)
7. Galili U, Clark MR, Shohet SB, Buehler J and Macher BA (1987) Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1-3Gal epitope in primates. Proc. Natl. Acad. Sci. USA 84: 1369-1373. (Pubitemid 17027355)
8. Huh JW, Kim DS, Ha HS, Ahn K, Chang KT, Cho BW and Kim HS (2009) Identification and molecular characterization of PERV gamma1 long terminal repeats. Mol.Cells. 27: 119-123.
9. Karlas A, Kurth R and Denner J (2004) Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation. Virology 325: 18-23. (Pubitemid 38844766)
10. Klymiuk N, Müller M, Brem G and Aigner B (2002) Characterization of porcine endogenous retrovirus gamma pro-pol nucleotide sequences. J. Virol. 76: 11738-11743. (Pubitemid 35231329)
11. Krach U, Fischer N, Czauderna F and Tönjes RR (2001) Comparison of replication-competent molecular clones of porcine endogenous retrovirus class A and class B derived from pig and human cells. J. Virol. 75: 5465-5472. (Pubitemid 32488139)
12. Lavie L, Kitova M, Maldener E, Meese E and Mayer J (2005) CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K(HML-2). J. Virol. 79: 876-883 (Pubitemid 40053871)
13. Le Tissier P, Stoye JP, Takeuchi Y, Patience C and Weiss RA (1997) Two sets of human-tropic pig retrovirus. Nature 389: 681-682. (Pubitemid 27458943)
14. Li LC and Dahiya R (2002) MethPrimer: designing primers for methylation PCRs. Bioinformatics 18: 1427-1431.
15. Magre S, Takeuchi Y and Bartosch B (2003) Xenotransplantation and pig endogenous retroviruses. Rev. Med. Virol. 13: 311-329. (Pubitemid 37082193)
16. Oldmixon BA, Wood JC, Ericsson TA, Wilson CA, White-Scharf ME, Andersson G, Greenstein JL, Schuurman HJ and Patience C (2002) Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. J. Virol. 76: 3045-3048. (Pubitemid 34184890)
17. Park SJ, Huh JW, Kim DS, Ha HS, Jung YD, Ahn K, Oh KB, Park EW, Chang KT and Kim HS (2010) Analysis of the molecular and regulatory properties of active porcine endogenous retrovirus gamma-1 long terminal repeats in kidney tissues of the NIH-Miniature pig. Mol. Cells. 30: 319-325.
18. Patience C, Switzer WM, Takeuchi Y, Griffiths DJ, Goward ME, Heneine W, Stoye JP and Weiss RA (2001) Multiple groups of novel retroviral genomes in pigs and related species. J. Virol. 75: 2771-2775. (Pubitemid 32185040)
19. Patience C, Takeuchi Y and Weiss RA (1997) Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. 3: 282-286. (Pubitemid 27112924)
20. Phelps CJ, Koike C, Vaught TD, Boone J, Wells KD, Chen SH, Ball S, Specht SM, Polejaeva IA, Monahan JA, et al. (2003) Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299: 411-414.
21. Platt JL (2000) Xenotransplantation: New risks, new gains. Nature. 407: 27-30
22. Powell SK, Gates ME, Langford G, Gu ML, Lockey C, Long Z and Otto E (2000) Antiretroviral agents inhibit infection of human cells by porcine endogenous retroviruses. Antimicrob. Agents Chemother. 44: 3432-3433 (Pubitemid 33009506)
23. Scheef G, Fischer N, Krach U and Tönjes RR (2001) The number of a U3 repeat box acting as an enhancer in long terminal repeats of polytropic replication-competent porcine endogenous retroviruses dynamically fluctuates during serial virus passages in human cells. J. Virol. 75: 6933-6940. (Pubitemid 32641580)
24. Sperber GO, Airola T, Jern P, Blomberg J (2007) Automated recognition of retroviral sequences in genomic data - RetroTector. Nucl. Acids Res. 35:4964-4976. (Pubitemid 47394183)
25. Tamura K, Dudley J, Nei M and Kumar S (2007) MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol. Biol. Evol. 24: 1596-1599. (Pubitemid 47236692)
26. Wilson CA, Laeeq S, Ritzhaupt A, Colon-Moran W and Yoshimura FK (2003) Sequence analysis of porcine endogenous retrovirus long terminal repeats and identification of transcriptional regulatory regions. J. Virol. 77: 142-149. (Pubitemid 36004954)